Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 419

Gene

ZNF419

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri203 – 22523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 419
Gene namesi
Name:ZNF419
Synonyms:ZNF419A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20648. ZNF419.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871733.

Polymorphism and mutation databases

BioMutaiZNF419.
DMDMi209572704.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Zinc finger protein 419PRO_0000047574Add
BLAST

Proteomic databases

PaxDbiQ96HQ0.
PeptideAtlasiQ96HQ0.
PRIDEiQ96HQ0.

PTM databases

iPTMnetiQ96HQ0.
PhosphoSiteiQ96HQ0.

Expressioni

Gene expression databases

BgeeiENSG00000105136.
CleanExiHS_ZNF419.
ExpressionAtlasiQ96HQ0. baseline and differential.
GenevisibleiQ96HQ0. HS.

Organism-specific databases

HPAiHPA003152.
HPA003274.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10288482,EBI-10172290

Protein-protein interaction databases

BioGridi122856. 3 interactions.
IntActiQ96HQ0. 1 interaction.
STRINGi9606.ENSP00000388864.

Structurei

3D structure databases

ProteinModelPortaliQ96HQ0.
SMRiQ96HQ0. Positions 121-509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 9872KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri203 – 22523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96HQ0.
KOiK09228.
OMAiHNSSLFK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96HQ0.
TreeFamiTF339848.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96HQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAALRDPA QVPVAADLLT DHEEGYVTFE DVAVYFSQEE WRLLDDAQRL
60 70 80 90 100
LYRNVMLENF TLLASLGLAS SKTHEITQLE SWEEPFMPAW EVVTSAIPRG
110 120 130 140 150
CWHGAEAEEA PEQIASVGLL SSNIQQHQKQ HCGEKPLKRQ EGRVPVLRSC
160 170 180 190 200
KVHLSEKSLQ SREVGKALLI SSGVLKHQVT HTGEKSHRSS KSREAFHAGK
210 220 230 240 250
RHYKCSECGK AFGQKYLLVQ HQRLHAGKKT YECSECGKLF RDMSNLFIHQ
260 270 280 290 300
IVHTGERPYG CSNCGKSFSR NAHLIEHQRV HTGEKPFTCS ECGKAFRHNS
310 320 330 340 350
TLVQHHKIHT GVRPYECSEC GKLFSFNSSL MKHQRIHTGE RPYKCSECGK
360 370 380 390 400
FYSHKSNLIK HWRVHTGERP YKCSDCGKFF TQCSSLMQHQ KVHTGEKPFK
410 420 430 440 450
CNECGRFFRE NSTLVRHQRV HTGAKPYECR ECGKFFSQSS TLMQHRKVHI
460 470 480 490 500
GEKPFKCNEC GRLFRENSSL VKHQRVHTGA KPYECRECGK FFRHNSSLFK
510
HRRIHTGEMQ
Length:510
Mass (Da):58,564
Last modified:October 14, 2008 - v2
Checksum:i4B4EDB2D92053826
GO
Isoform 2 (identifier: Q96HQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: E → EQ
     67-99: Missing.

Note: No experimental confirmation available.
Show »
Length:478
Mass (Da):54,982
Checksum:i85F42EFA54C5F720
GO
Isoform 3 (identifier: Q96HQ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-24: Missing.

Note: No experimental confirmation available.
Show »
Length:497
Mass (Da):57,173
Checksum:i3CA8A9B3BFD7A386
GO
Isoform 4 (identifier: Q96HQ0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-24: VPVAADLLTDHEE → Q

Note: No experimental confirmation available.
Show »
Length:498
Mass (Da):57,301
Checksum:i95B02897C6261409
GO
Isoform 5 (identifier: Q96HQ0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: E → EQ

Note: No experimental confirmation available.
Show »
Length:511
Mass (Da):58,692
Checksum:i7BC7CEE5580BC692
GO
Isoform 6 (identifier: Q96HQ0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-24: Missing.
     67-99: Missing.

Show »
Length:464
Mass (Da):53,463
Checksum:iBF7A918F9C05A2CF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti194 – 1941E → G in BAG65360 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti141 – 1411E → Q.2 Publications
Corresponds to variant rs2074076 [ dbSNP | Ensembl ].
VAR_046651
Natural varianti336 – 3361I → V.2 Publications
Corresponds to variant rs2074077 [ dbSNP | Ensembl ].
VAR_046652

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei12 – 2413Missing in isoform 3 and isoform 6. 1 PublicationVSP_046149Add
BLAST
Alternative sequencei12 – 2413VPVAA…TDHEE → Q in isoform 4. CuratedVSP_047106Add
BLAST
Alternative sequencei24 – 241E → EQ in isoform 2 and isoform 5. 1 PublicationVSP_016034
Alternative sequencei67 – 9933Missing in isoform 2 and isoform 6. 1 PublicationVSP_016033Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026886 mRNA. Translation: BAB15582.1.
AK302135 mRNA. Translation: BAG63509.1.
AK304569 mRNA. Translation: BAG65360.1.
AK316156 mRNA. Translation: BAH14527.1.
AK316297 mRNA. Translation: BAH14668.1.
AC003005 Genomic DNA. No translation available.
BC008297 mRNA. Translation: AAH08297.1.
BC024259 mRNA. Translation: AAH24259.1.
CCDSiCCDS42637.1. [Q96HQ0-2]
CCDS46211.1. [Q96HQ0-6]
CCDS54325.1. [Q96HQ0-5]
CCDS54326.1. [Q96HQ0-1]
CCDS54327.1. [Q96HQ0-4]
CCDS54328.1. [Q96HQ0-3]
RefSeqiNP_001091961.1. NM_001098491.1. [Q96HQ0-5]
NP_001091962.1. NM_001098492.1. [Q96HQ0-4]
NP_001091963.1. NM_001098493.1. [Q96HQ0-3]
NP_001091964.1. NM_001098494.1. [Q96HQ0-2]
NP_001091965.1. NM_001098495.1.
NP_001091966.1. NM_001098496.1. [Q96HQ0-6]
NP_001278672.1. NM_001291743.1.
NP_001278673.1. NM_001291744.1.
NP_001278674.1. NM_001291745.1.
NP_078967.3. NM_024691.3. [Q96HQ0-1]
UniGeneiHs.744339.

Genome annotation databases

EnsembliENST00000221735; ENSP00000221735; ENSG00000105136. [Q96HQ0-1]
ENST00000347466; ENSP00000299860; ENSG00000105136. [Q96HQ0-2]
ENST00000415379; ENSP00000392129; ENSG00000105136. [Q96HQ0-6]
ENST00000424930; ENSP00000388864; ENSG00000105136. [Q96HQ0-5]
ENST00000426954; ENSP00000390916; ENSG00000105136. [Q96HQ0-4]
ENST00000442920; ENSP00000414709; ENSG00000105136. [Q96HQ0-3]
GeneIDi79744.
KEGGihsa:79744.
UCSCiuc002qov.3. human. [Q96HQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026886 mRNA. Translation: BAB15582.1.
AK302135 mRNA. Translation: BAG63509.1.
AK304569 mRNA. Translation: BAG65360.1.
AK316156 mRNA. Translation: BAH14527.1.
AK316297 mRNA. Translation: BAH14668.1.
AC003005 Genomic DNA. No translation available.
BC008297 mRNA. Translation: AAH08297.1.
BC024259 mRNA. Translation: AAH24259.1.
CCDSiCCDS42637.1. [Q96HQ0-2]
CCDS46211.1. [Q96HQ0-6]
CCDS54325.1. [Q96HQ0-5]
CCDS54326.1. [Q96HQ0-1]
CCDS54327.1. [Q96HQ0-4]
CCDS54328.1. [Q96HQ0-3]
RefSeqiNP_001091961.1. NM_001098491.1. [Q96HQ0-5]
NP_001091962.1. NM_001098492.1. [Q96HQ0-4]
NP_001091963.1. NM_001098493.1. [Q96HQ0-3]
NP_001091964.1. NM_001098494.1. [Q96HQ0-2]
NP_001091965.1. NM_001098495.1.
NP_001091966.1. NM_001098496.1. [Q96HQ0-6]
NP_001278672.1. NM_001291743.1.
NP_001278673.1. NM_001291744.1.
NP_001278674.1. NM_001291745.1.
NP_078967.3. NM_024691.3. [Q96HQ0-1]
UniGeneiHs.744339.

3D structure databases

ProteinModelPortaliQ96HQ0.
SMRiQ96HQ0. Positions 121-509.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122856. 3 interactions.
IntActiQ96HQ0. 1 interaction.
STRINGi9606.ENSP00000388864.

PTM databases

iPTMnetiQ96HQ0.
PhosphoSiteiQ96HQ0.

Polymorphism and mutation databases

BioMutaiZNF419.
DMDMi209572704.

Proteomic databases

PaxDbiQ96HQ0.
PeptideAtlasiQ96HQ0.
PRIDEiQ96HQ0.

Protocols and materials databases

DNASUi79744.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221735; ENSP00000221735; ENSG00000105136. [Q96HQ0-1]
ENST00000347466; ENSP00000299860; ENSG00000105136. [Q96HQ0-2]
ENST00000415379; ENSP00000392129; ENSG00000105136. [Q96HQ0-6]
ENST00000424930; ENSP00000388864; ENSG00000105136. [Q96HQ0-5]
ENST00000426954; ENSP00000390916; ENSG00000105136. [Q96HQ0-4]
ENST00000442920; ENSP00000414709; ENSG00000105136. [Q96HQ0-3]
GeneIDi79744.
KEGGihsa:79744.
UCSCiuc002qov.3. human. [Q96HQ0-1]

Organism-specific databases

CTDi79744.
GeneCardsiZNF419.
HGNCiHGNC:20648. ZNF419.
HPAiHPA003152.
HPA003274.
neXtProtiNX_Q96HQ0.
PharmGKBiPA134871733.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96HQ0.
KOiK09228.
OMAiHNSSLFK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96HQ0.
TreeFamiTF339848.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii79744.
PROiQ96HQ0.

Gene expression databases

BgeeiENSG00000105136.
CleanExiHS_ZNF419.
ExpressionAtlasiQ96HQ0. baseline and differential.
GenevisibleiQ96HQ0. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN419_HUMAN
AccessioniPrimary (citable) accession number: Q96HQ0
Secondary accession number(s): B4DXU7
, B4E348, B7ZA41, E9PCP4, E9PED0, E9PET3, E9PFX9, Q9H5P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 14, 2008
Last modified: September 7, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.