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Protein

Transmembrane protein 176A

Gene

TMEM176A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 176A
Alternative name(s):
Hepatocellular carcinoma-associated antigen 112
Gene namesi
Name:TMEM176A
Synonyms:HCA112
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:24930. TMEM176A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei55 – 7521HelicalSequence analysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405947.

Polymorphism and mutation databases

BioMutaiTMEM176A.
DMDMi74731960.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Transmembrane protein 176APRO_0000279872Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96HP8.
PeptideAtlasiQ96HP8.
PRIDEiQ96HP8.

PTM databases

iPTMnetiQ96HP8.
PhosphoSiteiQ96HP8.

Expressioni

Gene expression databases

BgeeiQ96HP8.
CleanExiHS_TMEM176A.
ExpressionAtlasiQ96HP8. baseline and differential.
GenevisibleiQ96HP8. HS.

Organism-specific databases

HPAiHPA008770.

Interactioni

Protein-protein interaction databases

BioGridi120643. 4 interactions.
IntActiQ96HP8. 4 interactions.
STRINGi9606.ENSP00000004103.

Structurei

3D structure databases

ProteinModelPortaliQ96HP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM176 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX21. Eukaryota.
ENOG410Z9YG. LUCA.
GeneTreeiENSGT00530000064074.
HOGENOMiHOG000290691.
HOVERGENiHBG094019.
InParanoidiQ96HP8.
OMAiSWVMQIV.
OrthoDBiEOG7H1JN3.
PhylomeDBiQ96HP8.
TreeFamiTF335389.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR009281. TMEM176A/TMEM176B.
[Graphical view]
PANTHERiPTHR15756. PTHR15756. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96HP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTADSDEMA PEAPQHTHID VHIHQESALA KLLLTCCSAL RPRATQARGS
60 70 80 90 100
SRLLVASWVM QIVLGILSAV LGGFFYIRDY TLLVTSGAAI WTGAVAVLAG
110 120 130 140 150
AAAFIYEKRG GTYWALLRTL LTLAAFSTAI AALKLWNEDF RYGYSYYNSA
160 170 180 190 200
CRISSSSDWN TPAPTQSPEE VRRLHLCTSF MDMLKALFRT LQAMLLGVWI
210 220 230
LLLLASLTPL WLYCWRMFPT KGKRDQKEML EVSGI
Length:235
Mass (Da):26,116
Last modified:December 1, 2001 - v1
Checksum:iF44045DC0FEA5C82
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti122 – 1221T → A.1 Publication
Corresponds to variant rs741064 [ dbSNP | Ensembl ].
VAR_031032
Natural varianti187 – 1871L → F.
Corresponds to variant rs10378 [ dbSNP | Ensembl ].
VAR_031033
Natural varianti208 – 2081T → A.1 Publication
Corresponds to variant rs9088 [ dbSNP | Ensembl ].
VAR_031034

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF258340 mRNA. Translation: AAF68667.1.
AC006479 Genomic DNA. Translation: AAP21884.1.
CH471173 Genomic DNA. Translation: EAW54089.1.
CH471173 Genomic DNA. Translation: EAW54091.1.
BC008303 mRNA. Translation: AAH08303.1.
CCDSiCCDS5909.1.
RefSeqiNP_060957.2. NM_018487.2.
UniGeneiHs.647116.

Genome annotation databases

EnsembliENST00000004103; ENSP00000004103; ENSG00000002933.
ENST00000484928; ENSP00000417626; ENSG00000002933.
GeneIDi55365.
KEGGihsa:55365.
UCSCiuc003whx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF258340 mRNA. Translation: AAF68667.1.
AC006479 Genomic DNA. Translation: AAP21884.1.
CH471173 Genomic DNA. Translation: EAW54089.1.
CH471173 Genomic DNA. Translation: EAW54091.1.
BC008303 mRNA. Translation: AAH08303.1.
CCDSiCCDS5909.1.
RefSeqiNP_060957.2. NM_018487.2.
UniGeneiHs.647116.

3D structure databases

ProteinModelPortaliQ96HP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120643. 4 interactions.
IntActiQ96HP8. 4 interactions.
STRINGi9606.ENSP00000004103.

PTM databases

iPTMnetiQ96HP8.
PhosphoSiteiQ96HP8.

Polymorphism and mutation databases

BioMutaiTMEM176A.
DMDMi74731960.

Proteomic databases

PaxDbiQ96HP8.
PeptideAtlasiQ96HP8.
PRIDEiQ96HP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000004103; ENSP00000004103; ENSG00000002933.
ENST00000484928; ENSP00000417626; ENSG00000002933.
GeneIDi55365.
KEGGihsa:55365.
UCSCiuc003whx.2. human.

Organism-specific databases

CTDi55365.
GeneCardsiTMEM176A.
HGNCiHGNC:24930. TMEM176A.
HPAiHPA008770.
MIMi610334. gene.
neXtProtiNX_Q96HP8.
PharmGKBiPA162405947.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX21. Eukaryota.
ENOG410Z9YG. LUCA.
GeneTreeiENSGT00530000064074.
HOGENOMiHOG000290691.
HOVERGENiHBG094019.
InParanoidiQ96HP8.
OMAiSWVMQIV.
OrthoDBiEOG7H1JN3.
PhylomeDBiQ96HP8.
TreeFamiTF335389.

Miscellaneous databases

ChiTaRSiTMEM176A. human.
GenomeRNAii55365.
PROiQ96HP8.
SOURCEiSearch...

Gene expression databases

BgeeiQ96HP8.
CleanExiHS_TMEM176A.
ExpressionAtlasiQ96HP8. baseline and differential.
GenevisibleiQ96HP8. HS.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR009281. TMEM176A/TMEM176B.
[Graphical view]
PANTHERiPTHR15756. PTHR15756. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies."
    Wang Y., Han K.-J., Pang X.-W., Vaughan H.A., Qu W., Dong X.-Y., Peng J.-R., Zhao H.-T., Rui J.-A., Leng X.-S., Cebon J., Burgess A.W., Chen W.-F.
    J. Immunol. 169:1102-1109(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-122 AND ALA-208.
    Tissue: Hepatoma.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiT176A_HUMAN
AccessioniPrimary (citable) accession number: Q96HP8
Secondary accession number(s): D3DX00, Q9NYC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.