Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Oxidoreductase NAD-binding domain-containing protein 1

Gene

OXNAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi178 – 1836NADBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Oxidoreductase NAD-binding domain-containing protein 1 (EC:1.-.-.-)
Gene namesi
Name:OXNAD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25128. OXNAD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671213.

Polymorphism and mutation databases

BioMutaiOXNAD1.
DMDMi74731959.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 312295Oxidoreductase NAD-binding domain-containing protein 1PRO_0000299571Add
BLAST

Proteomic databases

EPDiQ96HP4.
MaxQBiQ96HP4.
PaxDbiQ96HP4.
PRIDEiQ96HP4.

PTM databases

iPTMnetiQ96HP4.
PhosphoSiteiQ96HP4.

Expressioni

Gene expression databases

BgeeiQ96HP4.
CleanExiHS_OXNAD1.
ExpressionAtlasiQ96HP4. baseline and differential.
GenevisibleiQ96HP4. HS.

Organism-specific databases

HPAiHPA059160.

Interactioni

Protein-protein interaction databases

BioGridi124910. 7 interactions.
IntActiQ96HP4. 2 interactions.
STRINGi9606.ENSP00000285083.

Structurei

3D structure databases

ProteinModelPortaliQ96HP4.
SMRiQ96HP4. Positions 170-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 186137FAD-binding FR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FAD-binding FR-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0534. Eukaryota.
COG0543. LUCA.
GeneTreeiENSGT00390000004280.
HOVERGENiHBG108225.
InParanoidiQ96HP4.
PhylomeDBiQ96HP4.
TreeFamiTF329774.

Family and domain databases

InterProiIPR017927. Fd_Rdtase_FAD-bd.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR001221. Phe_hydroxylase.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSiPR00410. PHEHYDRXLASE.
SUPFAMiSSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96HP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACAAVMIPG LLRCSVGAIR IEAASLRLTL STLRHLTLTS IMKSKRKTDH
60 70 80 90 100
MERTASVLRR EIVSAAKVCG AASESPSVKS LRLLVADQDF SFKAGQWVDF
110 120 130 140 150
FIPGVSVVGG FSICSSPRLL EQERVIELAV KYTNHPPALW VHNTCTLDCE
160 170 180 190 200
VAVRVGGEFF FDPQPADASR NLVLIAGGVG INPLLSILRH AADLLREQAN
210 220 230 240 250
KRNGYEIGTI KLFYSAKNTS ELLFKKNILD LVNEFPEKIA CSLHVTKQTT
260 270 280 290 300
QINAELKPYI TEGRITEKEI RDHISKETLF YICGPPPMTD FFSKQLENNH
310
VPKEHICFEK WW
Length:312
Mass (Da):34,854
Last modified:December 1, 2001 - v1
Checksum:iD126C2635E821640
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591R → Q.
Corresponds to variant rs17042066 [ dbSNP | Ensembl ].
VAR_034855
Natural varianti64 – 641S → A.1 Publication
Corresponds to variant rs842274 [ dbSNP | Ensembl ].
VAR_034856
Natural varianti82 – 821R → C.1 Publication
Corresponds to variant rs6777976 [ dbSNP | Ensembl ].
VAR_034857

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ364598 mRNA. Translation: ABC95193.1.
BC008322 mRNA. Translation: AAH08322.1.
AB209556 mRNA. Translation: BAD92793.1.
CCDSiCCDS2630.1.
RefSeqiNP_612390.1. NM_138381.3.
UniGeneiHs.655449.

Genome annotation databases

EnsembliENST00000285083; ENSP00000285083; ENSG00000154814.
ENST00000605932; ENSP00000475547; ENSG00000154814.
GeneIDi92106.
KEGGihsa:92106.
UCSCiuc003caw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ364598 mRNA. Translation: ABC95193.1.
BC008322 mRNA. Translation: AAH08322.1.
AB209556 mRNA. Translation: BAD92793.1.
CCDSiCCDS2630.1.
RefSeqiNP_612390.1. NM_138381.3.
UniGeneiHs.655449.

3D structure databases

ProteinModelPortaliQ96HP4.
SMRiQ96HP4. Positions 170-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124910. 7 interactions.
IntActiQ96HP4. 2 interactions.
STRINGi9606.ENSP00000285083.

PTM databases

iPTMnetiQ96HP4.
PhosphoSiteiQ96HP4.

Polymorphism and mutation databases

BioMutaiOXNAD1.
DMDMi74731959.

Proteomic databases

EPDiQ96HP4.
MaxQBiQ96HP4.
PaxDbiQ96HP4.
PRIDEiQ96HP4.

Protocols and materials databases

DNASUi92106.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285083; ENSP00000285083; ENSG00000154814.
ENST00000605932; ENSP00000475547; ENSG00000154814.
GeneIDi92106.
KEGGihsa:92106.
UCSCiuc003caw.4. human.

Organism-specific databases

CTDi92106.
GeneCardsiOXNAD1.
H-InvDBHIX0003110.
HGNCiHGNC:25128. OXNAD1.
HPAiHPA059160.
neXtProtiNX_Q96HP4.
PharmGKBiPA142671213.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0534. Eukaryota.
COG0543. LUCA.
GeneTreeiENSGT00390000004280.
HOVERGENiHBG108225.
InParanoidiQ96HP4.
PhylomeDBiQ96HP4.
TreeFamiTF329774.

Miscellaneous databases

ChiTaRSiOXNAD1. human.
GenomeRNAii92106.
PROiQ96HP4.

Gene expression databases

BgeeiQ96HP4.
CleanExiHS_OXNAD1.
ExpressionAtlasiQ96HP4. baseline and differential.
GenevisibleiQ96HP4. HS.

Family and domain databases

InterProiIPR017927. Fd_Rdtase_FAD-bd.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR001221. Phe_hydroxylase.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSiPR00410. PHEHYDRXLASE.
SUPFAMiSSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human oxidoreductase NAD-binding domain containing 1."
    Qiu R., Li J., Ji C., Xie Y., Mao Y.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-64.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-312, VARIANT CYS-82.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiOXND1_HUMAN
AccessioniPrimary (citable) accession number: Q96HP4
Secondary accession number(s): Q2HYC7, Q59FA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.