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Q96HN2

- SAHH3_HUMAN

UniProt

Q96HN2 - SAHH3_HUMAN

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Protein

Putative adenosylhomocysteinase 3

Gene

AHCYL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.

Cofactori

NAD(+)Note: Binds 1 NAD(+) per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei236 – 2361SubstrateBy similarity
Binding sitei310 – 3101SubstrateBy similarity
Binding sitei335 – 3351SubstrateBy similarity
Binding sitei365 – 3651SubstrateBy similarity
Binding sitei369 – 3691SubstrateBy similarity
Binding sitei370 – 3701NADBy similarity
Binding sitei422 – 4221NAD1 Publication
Binding sitei457 – 4571NAD1 Publication
Binding sitei525 – 5251NAD1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi336 – 3383NADBy similarity
Nucleotide bindingi401 – 4066NAD1 Publication
Nucleotide bindingi478 – 4792NAD1 Publication

GO - Molecular functioni

  1. adenosylhomocysteinase activity Source: UniProtKB-EC

GO - Biological processi

  1. one-carbon metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative adenosylhomocysteinase 3 (EC:3.3.1.1)
Short name:
AdoHcyase 3
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase 3
S-adenosylhomocysteine hydrolase-like protein 2
Gene namesi
Name:AHCYL2
Synonyms:KIAA0828
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:22204. AHCYL2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376046.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 611610Putative adenosylhomocysteinase 3PRO_0000116909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications
Modified residuei107 – 1071Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96HN2.
PaxDbiQ96HN2.
PRIDEiQ96HN2.

PTM databases

PhosphoSiteiQ96HN2.

Expressioni

Gene expression databases

BgeeiQ96HN2.
CleanExiHS_AHCYL2.
ExpressionAtlasiQ96HN2. baseline and differential.
GenevestigatoriQ96HN2.

Organism-specific databases

HPAiHPA053128.

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

BioGridi116958. 21 interactions.
IntActiQ96HN2. 7 interactions.
MINTiMINT-5005542.
STRINGi9606.ENSP00000315931.

Structurei

Secondary structure

1
611
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi191 – 1933Combined sources
Helixi194 – 20613Combined sources
Helixi209 – 21810Combined sources
Turni223 – 2264Combined sources
Beta strandi228 – 2336Combined sources
Helixi237 – 24812Combined sources
Beta strandi252 – 26110Combined sources
Helixi265 – 27410Combined sources
Helixi286 – 29712Combined sources
Beta strandi305 – 3128Combined sources
Helixi313 – 3219Combined sources
Helixi323 – 3275Combined sources
Beta strandi331 – 3344Combined sources
Helixi337 – 3437Combined sources
Beta strandi356 – 3583Combined sources
Helixi363 – 3697Combined sources
Helixi371 – 38616Combined sources
Beta strandi394 – 3985Combined sources
Helixi402 – 41312Combined sources
Beta strandi417 – 4215Combined sources
Helixi425 – 4339Combined sources
Helixi441 – 4444Combined sources
Turni445 – 4473Combined sources
Beta strandi449 – 4535Combined sources
Helixi463 – 4686Combined sources
Beta strandi473 – 4775Combined sources
Turni481 – 4844Combined sources
Helixi487 – 4904Combined sources
Beta strandi496 – 5016Combined sources
Beta strandi504 – 5085Combined sources
Beta strandi514 – 5185Combined sources
Helixi519 – 5213Combined sources
Helixi524 – 5285Combined sources
Helixi533 – 55220Combined sources
Turni555 – 5573Combined sources
Beta strandi560 – 5645Combined sources
Helixi567 – 57711Combined sources
Helixi578 – 5814Combined sources
Helixi590 – 5967Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GVPX-ray2.25A/B/C/D175-607[»]
ProteinModelPortaliQ96HN2.
SMRiQ96HN2. Positions 176-607.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96HN2.

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.Curated

Phylogenomic databases

eggNOGiCOG0499.
GeneTreeiENSGT00390000003626.
HOGENOMiHOG000227986.
HOVERGENiHBG005041.
InParanoidiQ96HN2.
KOiK01251.
OMAiAENWQPN.
OrthoDBiEOG76739S.
PhylomeDBiQ96HN2.
TreeFamiTF300415.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
SMARTiSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96HN2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVQVVSAAA AAKVPEVELK DLSPSEAESQ LGLSTAAVGA MAPPAGGGDP
60 70 80 90 100
EAPAPAAERP PVPGPGSGPA AALSPAAGKV PQASAMKRSD PHHQHQRHRD
110 120 130 140 150
GGEALVSPDG TVTEAPRTVK KQIQFADQKQ EFNKRPTKIG RRSLSRSISQ
160 170 180 190 200
SSTDSYSSAA SYTDSSDDET SPRDKQQKNS KGSSDFCVKN IKQAEFGRRE
210 220 230 240 250
IEIAEQEMPA LMALRKRAQG EKPLAGAKIV GCTHITAQTA VLMETLGALG
260 270 280 290 300
AQCRWAACNI YSTLNEVAAA LAESGFPVFA WKGESEDDFW WCIDRCVNVE
310 320 330 340 350
GWQPNMILDD GGDLTHWIYK KYPNMFKKIK GIVEESVTGV HRLYQLSKAG
360 370 380 390 400
KLCVPAMNVN DSVTKQKFDN LYCCRESILD GLKRTTDMMF GGKQVVVCGY
410 420 430 440 450
GEVGKGCCAA LKAMGSIVYV TEIDPICALQ ACMDGFRLVK LNEVIRQVDI
460 470 480 490 500
VITCTGNKNV VTREHLDRMK NSCIVCNMGH SNTEIDVASL RTPELTWERV
510 520 530 540 550
RSQVDHVIWP DGKRIVLLAE GRLLNLSCST VPTFVLSITA TTQALALIEL
560 570 580 590 600
YNAPEGRYKQ DVYLLPKKMD EYVASLHLPT FDAHLTELTD EQAKYLGLNK
610
NGPFKPNYYR Y
Length:611
Mass (Da):66,721
Last modified:December 1, 2001 - v1
Checksum:iA76B1275FC0D891D
GO
Isoform 2 (identifier: Q96HN2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-122: Missing.

Note: No experimental confirmation available.

Show »
Length:610
Mass (Da):66,593
Checksum:iD54ED0745D3A286B
GO
Isoform 3 (identifier: Q96HN2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MSVQVVSAAAAAKVPEVE → MLGSKKKYIVNGNSGIKA
     19-121: Missing.

Note: No experimental confirmation available.

Show »
Length:508
Mass (Da):56,697
Checksum:i1198694128CB2301
GO
Isoform 4 (identifier: Q96HN2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MSVQVVSAAAAAKVPEVEL → MEKWDGNEGTSAFHMPEWM
     20-122: Missing.

Note: No experimental confirmation available.

Show »
Length:508
Mass (Da):56,944
Checksum:i197CA80AF2940465
GO

Sequence cautioni

The sequence BAA74851.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1919MSVQV…PEVEL → MEKWDGNEGTSAFHMPEWM in isoform 4. 1 PublicationVSP_046278Add
BLAST
Alternative sequencei1 – 1818MSVQV…VPEVE → MLGSKKKYIVNGNSGIKA in isoform 3. 1 PublicationVSP_043185Add
BLAST
Alternative sequencei19 – 121103Missing in isoform 3. 1 PublicationVSP_043186Add
BLAST
Alternative sequencei20 – 122103Missing in isoform 4. 1 PublicationVSP_046279Add
BLAST
Alternative sequencei122 – 1221Missing in isoform 2. 1 PublicationVSP_040095

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020635 mRNA. Translation: BAA74851.1. Different initiation.
AK025372 mRNA. No translation available.
AK295851 mRNA. Translation: BAG58657.1.
AK316073 mRNA. Translation: BAH14444.1.
AC009244 Genomic DNA. No translation available.
AC011005 Genomic DNA. No translation available.
AC083866 Genomic DNA. No translation available.
AC093149 Genomic DNA. No translation available.
BC008349 mRNA. Translation: AAH08349.1.
BC024325 mRNA. Translation: AAH24325.1.
CCDSiCCDS47706.1. [Q96HN2-2]
CCDS47707.2. [Q96HN2-3]
CCDS47708.1. [Q96HN2-4]
CCDS5812.1. [Q96HN2-1]
RefSeqiNP_001124192.1. NM_001130720.2. [Q96HN2-2]
NP_001124194.2. NM_001130722.2. [Q96HN2-3]
NP_001124195.1. NM_001130723.2. [Q96HN2-4]
NP_056143.1. NM_015328.3. [Q96HN2-1]
UniGeneiHs.600789.

Genome annotation databases

EnsembliENST00000325006; ENSP00000315931; ENSG00000158467. [Q96HN2-1]
ENST00000446544; ENSP00000413639; ENSG00000158467. [Q96HN2-2]
ENST00000474594; ENSP00000420459; ENSG00000158467. [Q96HN2-4]
ENST00000490911; ENSP00000420801; ENSG00000158467. [Q96HN2-3]
GeneIDi23382.
KEGGihsa:23382.
UCSCiuc003vot.3. human. [Q96HN2-2]
uc011kov.2. human. [Q96HN2-1]
uc011kox.2. human. [Q96HN2-3]

Polymorphism databases

DMDMi21759427.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020635 mRNA. Translation: BAA74851.1 . Different initiation.
AK025372 mRNA. No translation available.
AK295851 mRNA. Translation: BAG58657.1 .
AK316073 mRNA. Translation: BAH14444.1 .
AC009244 Genomic DNA. No translation available.
AC011005 Genomic DNA. No translation available.
AC083866 Genomic DNA. No translation available.
AC093149 Genomic DNA. No translation available.
BC008349 mRNA. Translation: AAH08349.1 .
BC024325 mRNA. Translation: AAH24325.1 .
CCDSi CCDS47706.1. [Q96HN2-2 ]
CCDS47707.2. [Q96HN2-3 ]
CCDS47708.1. [Q96HN2-4 ]
CCDS5812.1. [Q96HN2-1 ]
RefSeqi NP_001124192.1. NM_001130720.2. [Q96HN2-2 ]
NP_001124194.2. NM_001130722.2. [Q96HN2-3 ]
NP_001124195.1. NM_001130723.2. [Q96HN2-4 ]
NP_056143.1. NM_015328.3. [Q96HN2-1 ]
UniGenei Hs.600789.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3GVP X-ray 2.25 A/B/C/D 175-607 [» ]
ProteinModelPortali Q96HN2.
SMRi Q96HN2. Positions 176-607.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116958. 21 interactions.
IntActi Q96HN2. 7 interactions.
MINTi MINT-5005542.
STRINGi 9606.ENSP00000315931.

PTM databases

PhosphoSitei Q96HN2.

Polymorphism databases

DMDMi 21759427.

Proteomic databases

MaxQBi Q96HN2.
PaxDbi Q96HN2.
PRIDEi Q96HN2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000325006 ; ENSP00000315931 ; ENSG00000158467 . [Q96HN2-1 ]
ENST00000446544 ; ENSP00000413639 ; ENSG00000158467 . [Q96HN2-2 ]
ENST00000474594 ; ENSP00000420459 ; ENSG00000158467 . [Q96HN2-4 ]
ENST00000490911 ; ENSP00000420801 ; ENSG00000158467 . [Q96HN2-3 ]
GeneIDi 23382.
KEGGi hsa:23382.
UCSCi uc003vot.3. human. [Q96HN2-2 ]
uc011kov.2. human. [Q96HN2-1 ]
uc011kox.2. human. [Q96HN2-3 ]

Organism-specific databases

CTDi 23382.
GeneCardsi GC07P128865.
HGNCi HGNC:22204. AHCYL2.
HPAi HPA053128.
neXtProti NX_Q96HN2.
PharmGKBi PA162376046.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0499.
GeneTreei ENSGT00390000003626.
HOGENOMi HOG000227986.
HOVERGENi HBG005041.
InParanoidi Q96HN2.
KOi K01251.
OMAi AENWQPN.
OrthoDBi EOG76739S.
PhylomeDBi Q96HN2.
TreeFami TF300415.

Enzyme and pathway databases

UniPathwayi UPA00314 ; UER00076 .

Miscellaneous databases

ChiTaRSi AHCYL2. human.
EvolutionaryTracei Q96HN2.
GenomeRNAii 23382.
NextBioi 45489.
PROi Q96HN2.

Gene expression databases

Bgeei Q96HN2.
CleanExi HS_AHCYL2.
ExpressionAtlasi Q96HN2. baseline and differential.
Genevestigatori Q96HN2.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view ]
PANTHERi PTHR23420. PTHR23420. 1 hit.
Pfami PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view ]
SMARTi SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00936. ahcY. 1 hit.
PROSITEi PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Tissue: Colon mucosa and Hippocampus.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Uterus.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Human S-adenosyl homocysteine hydrolase-like 2 protein crystal structure."
    Structural genomics consortium (SGC)
    Submitted (JUN-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 175-607 IN COMPLEX WITH NAD, SUBUNIT.

Entry informationi

Entry nameiSAHH3_HUMAN
AccessioniPrimary (citable) accession number: Q96HN2
Secondary accession number(s): B4DIZ5, D9N155, O94917
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3