Q96HN2 (SAHH3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative adenosylhomocysteinase 3
Short name=AdoHcyase 3
EC=3.3.1.1

Alternative name(s):
S-adenosyl-L-homocysteine hydrolase 3
S-adenosylhomocysteine hydrolase-like protein 2

Gene names

Name:	AHCYL2
Synonyms:	KIAA0828

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	611 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.
Cofactor	Binds 1 NAD per subunit.
Pathway	Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
Subunit structure	Homotetramer Probable. Ref.7
Sequence similarities	Belongs to the adenosylhomocysteinase family.
Sequence caution	The sequence BAA74851.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	One-carbon metabolism
Coding sequence diversity	Alternative splicing
Ligand	NAD
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	adenosylhomocysteinase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96HN2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96HN2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     122-122: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q96HN2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MSVQVVSAAAAAKVPEVE → MLGSKKKYIVNGNSGIKA
     19-121: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q96HN2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MSVQVVSAAAAAKVPEVEL → MEKWDGNEGTSAFHMPEWM
     20-122: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 611

611

Putative adenosylhomocysteinase 3

PRO_0000116909

Regions

Nucleotide binding

336 – 338

3

NAD By similarity

Nucleotide binding

401 – 406

6

NAD

Nucleotide binding

478 – 479

2

NAD

Sites

Binding site

236

1

Substrate By similarity

Binding site

310

1

Substrate By similarity

Binding site

335

1

Substrate By similarity

Binding site

365

1

Substrate By similarity

Binding site

369

1

Substrate By similarity

Binding site

370

1

NAD By similarity

Binding site

422

1

NAD

Binding site

457

1

NAD

Binding site

525

1

NAD

Amino acid modifications

Modified residue

107

1

Phosphoserine Ref.5 Ref.6

Natural variations

Alternative sequence

1 – 19

19

MSVQV…PEVEL → MEKWDGNEGTSAFHMPEWM in isoform 4.

VSP_046278

Alternative sequence

1 – 18

18

MSVQV…VPEVE → MLGSKKKYIVNGNSGIKA in isoform 3.

VSP_043185

Alternative sequence

19 – 121

103

Missing in isoform 3.

VSP_043186

Alternative sequence

20 – 122

103

Missing in isoform 4.

VSP_046279

Alternative sequence

122

1

Missing in isoform 2.

VSP_040095

Secondary structure

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611

Helix Strand Turn

Details...

Helix

191 – 193

3

Helix

194 – 206

13

Helix

209 – 218

10

Turn

223 – 226

4

Beta strand

228 – 233

6

Helix

237 – 248

12

Beta strand

252 – 261

10

Helix

265 – 274

10

Helix

286 – 297

12

Beta strand

305 – 312

8

Helix

313 – 321

9

Helix

323 – 327

5

Beta strand

331 – 334

4

Helix

337 – 343

7

Beta strand

356 – 358

3

Helix

363 – 369

7

Helix

371 – 386

16

Beta strand

394 – 398

5

Helix

402 – 413

12

Beta strand

417 – 421

5

Helix

425 – 433

9

Helix

441 – 444

4

Turn

445 – 447

3

Beta strand

449 – 453

5

Helix

463 – 468

6

Beta strand

473 – 477

5

Turn

481 – 484

4

Helix

487 – 490

4

Beta strand

496 – 501

6

Beta strand

504 – 508

5

Beta strand

514 – 518

5

Helix

519 – 521

3

Helix

524 – 528

5

Helix

533 – 552

20

Turn

555 – 557

3

Beta strand

560 – 564

5

Helix

567 – 577

11

Helix

578 – 581

4

Helix

590 – 596

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: A76B1275FC0D891D	FASTA	611	66,721
	10 20 30 40 50 60 MSVQVVSAAA AAKVPEVELK DLSPSEAESQ LGLSTAAVGA MAPPAGGGDP EAPAPAAERP 70 80 90 100 110 120 PVPGPGSGPA AALSPAAGKV PQASAMKRSD PHHQHQRHRD GGEALVSPDG TVTEAPRTVK 130 140 150 160 170 180 KQIQFADQKQ EFNKRPTKIG RRSLSRSISQ SSTDSYSSAA SYTDSSDDET SPRDKQQKNS 190 200 210 220 230 240 KGSSDFCVKN IKQAEFGRRE IEIAEQEMPA LMALRKRAQG EKPLAGAKIV GCTHITAQTA 250 260 270 280 290 300 VLMETLGALG AQCRWAACNI YSTLNEVAAA LAESGFPVFA WKGESEDDFW WCIDRCVNVE 310 320 330 340 350 360 GWQPNMILDD GGDLTHWIYK KYPNMFKKIK GIVEESVTGV HRLYQLSKAG KLCVPAMNVN 370 380 390 400 410 420 DSVTKQKFDN LYCCRESILD GLKRTTDMMF GGKQVVVCGY GEVGKGCCAA LKAMGSIVYV 430 440 450 460 470 480 TEIDPICALQ ACMDGFRLVK LNEVIRQVDI VITCTGNKNV VTREHLDRMK NSCIVCNMGH 490 500 510 520 530 540 SNTEIDVASL RTPELTWERV RSQVDHVIWP DGKRIVLLAE GRLLNLSCST VPTFVLSITA 550 560 570 580 590 600 TTQALALIEL YNAPEGRYKQ DVYLLPKKMD EYVASLHLPT FDAHLTELTD EQAKYLGLNK 610 NGPFKPNYYR Y
	Isoform 2 [UniParc]. Checksum: D54ED0745D3A286B	FASTA	610	66,593
	10 20 30 40 50 60 MSVQVVSAAA AAKVPEVELK DLSPSEAESQ LGLSTAAVGA MAPPAGGGDP EAPAPAAERP 70 80 90 100 110 120 PVPGPGSGPA AALSPAAGKV PQASAMKRSD PHHQHQRHRD GGEALVSPDG TVTEAPRTVK 130 140 150 160 170 180 KIQFADQKQE FNKRPTKIGR RSLSRSISQS STDSYSSAAS YTDSSDDETS PRDKQQKNSK 190 200 210 220 230 240 GSSDFCVKNI KQAEFGRREI EIAEQEMPAL MALRKRAQGE KPLAGAKIVG CTHITAQTAV 250 260 270 280 290 300 LMETLGALGA QCRWAACNIY STLNEVAAAL AESGFPVFAW KGESEDDFWW CIDRCVNVEG 310 320 330 340 350 360 WQPNMILDDG GDLTHWIYKK YPNMFKKIKG IVEESVTGVH RLYQLSKAGK LCVPAMNVND 370 380 390 400 410 420 SVTKQKFDNL YCCRESILDG LKRTTDMMFG GKQVVVCGYG EVGKGCCAAL KAMGSIVYVT 430 440 450 460 470 480 EIDPICALQA CMDGFRLVKL NEVIRQVDIV ITCTGNKNVV TREHLDRMKN SCIVCNMGHS 490 500 510 520 530 540 NTEIDVASLR TPELTWERVR SQVDHVIWPD GKRIVLLAEG RLLNLSCSTV PTFVLSITAT 550 560 570 580 590 600 TQALALIELY NAPEGRYKQD VYLLPKKMDE YVASLHLPTF DAHLTELTDE QAKYLGLNKN 610 GPFKPNYYRY
	Isoform 3 [UniParc]. Checksum: 1198694128CB2301	FASTA	508	56,697
	10 20 30 40 50 60 MLGSKKKYIV NGNSGIKAQI QFADQKQEFN KRPTKIGRRS LSRSISQSST DSYSSAASYT 70 80 90 100 110 120 DSSDDETSPR DKQQKNSKGS SDFCVKNIKQ AEFGRREIEI AEQEMPALMA LRKRAQGEKP 130 140 150 160 170 180 LAGAKIVGCT HITAQTAVLM ETLGALGAQC RWAACNIYST LNEVAAALAE SGFPVFAWKG 190 200 210 220 230 240 ESEDDFWWCI DRCVNVEGWQ PNMILDDGGD LTHWIYKKYP NMFKKIKGIV EESVTGVHRL 250 260 270 280 290 300 YQLSKAGKLC VPAMNVNDSV TKQKFDNLYC CRESILDGLK RTTDMMFGGK QVVVCGYGEV 310 320 330 340 350 360 GKGCCAALKA MGSIVYVTEI DPICALQACM DGFRLVKLNE VIRQVDIVIT CTGNKNVVTR 370 380 390 400 410 420 EHLDRMKNSC IVCNMGHSNT EIDVASLRTP ELTWERVRSQ VDHVIWPDGK RIVLLAEGRL 430 440 450 460 470 480 LNLSCSTVPT FVLSITATTQ ALALIELYNA PEGRYKQDVY LLPKKMDEYV ASLHLPTFDA 490 500 HLTELTDEQA KYLGLNKNGP FKPNYYRY
	Isoform 4 [UniParc]. Checksum: 197CA80AF2940465	FASTA	508	56,944
	10 20 30 40 50 60 MEKWDGNEGT SAFHMPEWMI QFADQKQEFN KRPTKIGRRS LSRSISQSST DSYSSAASYT 70 80 90 100 110 120 DSSDDETSPR DKQQKNSKGS SDFCVKNIKQ AEFGRREIEI AEQEMPALMA LRKRAQGEKP 130 140 150 160 170 180 LAGAKIVGCT HITAQTAVLM ETLGALGAQC RWAACNIYST LNEVAAALAE SGFPVFAWKG 190 200 210 220 230 240 ESEDDFWWCI DRCVNVEGWQ PNMILDDGGD LTHWIYKKYP NMFKKIKGIV EESVTGVHRL 250 260 270 280 290 300 YQLSKAGKLC VPAMNVNDSV TKQKFDNLYC CRESILDGLK RTTDMMFGGK QVVVCGYGEV 310 320 330 340 350 360 GKGCCAALKA MGSIVYVTEI DPICALQACM DGFRLVKLNE VIRQVDIVIT CTGNKNVVTR 370 380 390 400 410 420 EHLDRMKNSC IVCNMGHSNT EIDVASLRTP ELTWERVRSQ VDHVIWPDGK RIVLLAEGRL 430 440 450 460 470 480 LNLSCSTVPT FVLSITATTQ ALALIELYNA PEGRYKQDVY LLPKKMDEYV ASLHLPTFDA 490 500 HLTELTDEQA KYLGLNKNGP FKPNYYRY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Colon mucosa and Hippocampus.
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung and Uterus.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Human S-adenosyl homocysteine hydrolase-like 2 protein crystal structure." Structural genomics consortium (SGC) Submitted (JUN-2009) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 175-607 IN COMPLEX WITH NAD, SUBUNIT.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB020635 mRNA. Translation: BAA74851.1. Different initiation.
AK025372 mRNA. No translation available.
AK295851 mRNA. Translation: BAG58657.1.
AK316073 mRNA. Translation: BAH14444.1.
AC009244 Genomic DNA. No translation available.
AC011005 Genomic DNA. No translation available.
AC083866 Genomic DNA. No translation available.
AC093149 Genomic DNA. No translation available.
BC008349 mRNA. Translation: AAH08349.1.
BC024325 mRNA. Translation: AAH24325.1.

IPI

IPI00101645.
IPI00908473.
IPI00910338.
IPI00945758.

RefSeq

NP_001124192.1. NM_001130720.2.
NP_001124194.2. NM_001130722.2.
NP_001124195.1. NM_001130723.2.
NP_056143.1. NM_015328.3.

UniGene

Hs.600789.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3GVP	X-ray	2.25	A/B/C/D	175-607	[»]

ProteinModelPortal

Q96HN2.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q96HN2. 6 interactions.

STRING

9606.ENSP00000315931.

PTM databases

PhosphoSite

Q96HN2.

Polymorphism databases

DMDM

21759427.

Proteomic databases

PaxDb

Q96HN2.

PRIDE

Q96HN2.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000325006; ENSP00000315931; ENSG00000158467.
ENST00000446544; ENSP00000413639; ENSG00000158467.
ENST00000474594; ENSP00000420459; ENSG00000158467.
ENST00000490911; ENSP00000420801; ENSG00000158467.

GeneID

23382.

KEGG

hsa:23382.

UCSC

uc003vot.3. human.
uc011kov.2. human.

Organism-specific databases

CTD

23382.

GeneCards

GC07P128865.

HGNC

HGNC:22204. AHCYL2.

HPA

HPA053128.

neXtProt

NX_Q96HN2.

PharmGKB

PA162376046.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0499.

HOGENOM

HOG000227986.

HOVERGEN

HBG005041.

InParanoid

Q96HN2.

KO

K01251.

OMA

NWQPNMI.

OrthoDB

EOG4GMTWR.

PhylomeDB

Q96HN2.

Enzyme and pathway databases

UniPathway

UPA00314; UER00076.

Gene expression databases

ArrayExpress

Q96HN2.

Bgee

Q96HN2.

CleanEx

HS_AHCYL2.

Genevestigator

Q96HN2.

Family and domain databases

Gene3D

3.40.50.720. 1 hit.

InterPro

IPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]

PANTHER

PTHR23420. PTHR23420. 1 hit.

Pfam

PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]

PIRSF

PIRSF001109. Ad_hcy_hydrolase. 1 hit.

SMART

SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00936. ahcY. 1 hit.

PROSITE

PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

AHCYL2. human.

EvolutionaryTrace

Q96HN2.

GenomeRNAi

23382.

NextBio

45489.

Entry information

Entry name

SAHH3_HUMAN

Accession

Primary (citable) accession number: Q96HN2
Secondary accession number(s): B4DIZ5, D9N155, O94917

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.