ID   PED1B_HUMAN             Reviewed;         432 AA.
AC   Q96HM7; Q96B20;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   24-JAN-2024, entry version 143.
DE   RecName: Full=PC-esterase domain-containing protein 1B {ECO:0000305};
DE   AltName: Full=Protein FAM113B;
GN   Name=PCED1B {ECO:0000312|HGNC:HGNC:28255}; Synonyms=FAM113B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung, and Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q96HM7; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-1222622, EBI-945833;
CC   -!- SIMILARITY: Belongs to the PC-esterase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH16154.1; Type=Miscellaneous discrepancy; Note=Non-canonical splice intron-exon junction.; Evidence={ECO:0000305};
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DR   EMBL; CH471111; EAW57925.1; -; Genomic_DNA.
DR   EMBL; BC008360; AAH08360.1; -; mRNA.
DR   EMBL; BC016154; AAH16154.1; ALT_SEQ; mRNA.
DR   CCDS; CCDS8752.1; -.
DR   RefSeq; NP_001268358.1; NM_001281429.1.
DR   RefSeq; NP_612380.1; NM_138371.2.
DR   RefSeq; XP_005269281.1; XM_005269224.4.
DR   RefSeq; XP_011537280.1; XM_011538978.2.
DR   RefSeq; XP_016875696.1; XM_017020207.1.
DR   RefSeq; XP_016875697.1; XM_017020208.1.
DR   RefSeq; XP_016875698.1; XM_017020209.1.
DR   RefSeq; XP_016875699.1; XM_017020210.1.
DR   RefSeq; XP_016875700.1; XM_017020211.1.
DR   RefSeq; XP_016875701.1; XM_017020212.1.
DR   RefSeq; XP_016875702.1; XM_017020213.1.
DR   RefSeq; XP_016875703.1; XM_017020214.1.
DR   RefSeq; XP_016875704.1; XM_017020215.1.
DR   RefSeq; XP_016875705.1; XM_017020216.1.
DR   AlphaFoldDB; Q96HM7; -.
DR   BioGRID; 124840; 9.
DR   IntAct; Q96HM7; 5.
DR   PhosphoSitePlus; Q96HM7; -.
DR   BioMuta; PCED1B; -.
DR   DMDM; 74731954; -.
DR   jPOST; Q96HM7; -.
DR   MassIVE; Q96HM7; -.
DR   PaxDb; 9606-ENSP00000446688; -.
DR   PeptideAtlas; Q96HM7; -.
DR   Antibodypedia; 49373; 24 antibodies from 12 providers.
DR   DNASU; 91523; -.
DR   Ensembl; ENST00000432328.2; ENSP00000396040.1; ENSG00000179715.13.
DR   Ensembl; ENST00000546455.6; ENSP00000446688.1; ENSG00000179715.13.
DR   GeneID; 91523; -.
DR   KEGG; hsa:91523; -.
DR   MANE-Select; ENST00000546455.6; ENSP00000446688.1; NM_138371.3; NP_612380.1.
DR   UCSC; uc001rpn.5; human.
DR   AGR; HGNC:28255; -.
DR   CTD; 91523; -.
DR   DisGeNET; 91523; -.
DR   GeneCards; PCED1B; -.
DR   HGNC; HGNC:28255; PCED1B.
DR   HPA; ENSG00000179715; Tissue enhanced (adrenal gland, lymphoid tissue).
DR   neXtProt; NX_Q96HM7; -.
DR   OpenTargets; ENSG00000179715; -.
DR   PharmGKB; PA143485471; -.
DR   VEuPathDB; HostDB:ENSG00000179715; -.
DR   eggNOG; ENOG502QVBZ; Eukaryota.
DR   GeneTree; ENSGT00390000002231; -.
DR   HOGENOM; CLU_053865_0_0_1; -.
DR   InParanoid; Q96HM7; -.
DR   OMA; YFHSDVP; -.
DR   OrthoDB; 2956343at2759; -.
DR   PhylomeDB; Q96HM7; -.
DR   TreeFam; TF328972; -.
DR   PathwayCommons; Q96HM7; -.
DR   SignaLink; Q96HM7; -.
DR   BioGRID-ORCS; 91523; 51 hits in 1153 CRISPR screens.
DR   ChiTaRS; PCED1B; human.
DR   GenomeRNAi; 91523; -.
DR   Pharos; Q96HM7; Tdark.
DR   PRO; PR:Q96HM7; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q96HM7; Protein.
DR   Bgee; ENSG00000179715; Expressed in granulocyte and 112 other cell types or tissues.
DR   ExpressionAtlas; Q96HM7; baseline and differential.
DR   Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR   InterPro; IPR036514; SGNH_hydro_sf.
DR   PANTHER; PTHR14469:SF1; PC-ESTERASE DOMAIN-CONTAINING PROTEIN 1B; 1.
DR   PANTHER; PTHR14469; SARCOMA ANTIGEN NY-SAR-23; 1.
DR   SUPFAM; SSF52266; SGNH hydrolase; 1.
DR   Genevisible; Q96HM7; HS.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..432
FT                   /note="PC-esterase domain-containing protein 1B"
FT                   /id="PRO_0000331356"
FT   REGION          264..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         429
FT                   /note="P -> A (in dbSNP:rs2543737)"
FT                   /id="VAR_042761"
SQ   SEQUENCE   432 AA;  49727 MW;  F21497B76A791926 CRC64;
     MILLRASEVR QLLHNKFVVI LGDSVHRAVY KDLVLLLQKD RLLTPGQLRA RGELNFEQDE
     LVDGGQRGHM HNGLNYREVR EFRSDHHLVR FYFLTRVYSD YLQTILKELQ SGEHAPDLVI
     MNSCLWDISR YGPNSWRSYL ENLENLFQCL GQVLPESCLL VWNTAMPVGE EVTGGFLPPK
     LRRQKATFLK NEVVKANFHS ATEARKHNFD VLDLHFHFRH ARENLHWDGV HWNGRVHRCL
     SQLLLAHVAD AWGVELPHRH PVGEWIKKKK PGPRVEGPPQ ANRNHPALPL SPPLPSPTYR
     PLLGFPPQRL PLLPLLSPQP PPPILHHQGM PRFPQGPPDA CFSSDHTFQS DQFYCHSDVP
     SSAHAGFFVE DNFMVGPQLP MPFFPTPRYQ RPAPVVHRGF GRYRPRGPYT PWGQRPRPSK
     RRAPANPEPR PQ
//