Q96HM7 (PED1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PC-esterase domain-containing protein 1B

Alternative name(s):
Protein FAM113B

Gene names

Name:	PCED1B
Synonyms:	FAM113B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the PCED1 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96HM7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96HM7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.
     311-399: PLLPLLSPQP...QRPAPVVHRG → LSSRINSIAI...ILSQGLNRRT
     400-432: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	PC-esterase domain-containing protein 1B		PRO_0000331356
Regions
	Compositional bias	271 – 431	161	Pro-rich
Natural variations
	Alternative sequence	1 – 120	120	Missing in isoform 2.		VSP_033182
	Alternative sequence	311 – 399	89	PLLPL…VVHRG → LSSRINSIAIQMSPHQPMQV SSSKTILWLVLSCLCPSSPH PVISGLPQWYIGVLAGIVPV APIRPGDSGLDLQREGPQPI LSQGLNRRT in isoform 2.		VSP_033183
	Alternative sequence	400 – 432	33	Missing in isoform 2.		VSP_033184
	Natural variant	429	1	P → A. Corresponds to variant rs2543737 [ dbSNP | Ensembl ].		VAR_042761

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: F21497B76A791926	FASTA	432	49,727
	10 20 30 40 50 60 MILLRASEVR QLLHNKFVVI LGDSVHRAVY KDLVLLLQKD RLLTPGQLRA RGELNFEQDE 70 80 90 100 110 120 LVDGGQRGHM HNGLNYREVR EFRSDHHLVR FYFLTRVYSD YLQTILKELQ SGEHAPDLVI 130 140 150 160 170 180 MNSCLWDISR YGPNSWRSYL ENLENLFQCL GQVLPESCLL VWNTAMPVGE EVTGGFLPPK 190 200 210 220 230 240 LRRQKATFLK NEVVKANFHS ATEARKHNFD VLDLHFHFRH ARENLHWDGV HWNGRVHRCL 250 260 270 280 290 300 SQLLLAHVAD AWGVELPHRH PVGEWIKKKK PGPRVEGPPQ ANRNHPALPL SPPLPSPTYR 310 320 330 340 350 360 PLLGFPPQRL PLLPLLSPQP PPPILHHQGM PRFPQGPPDA CFSSDHTFQS DQFYCHSDVP 370 380 390 400 410 420 SSAHAGFFVE DNFMVGPQLP MPFFPTPRYQ RPAPVVHRGF GRYRPRGPYT PWGQRPRPSK 430 RRAPANPEPR PQ
	Isoform 2 [UniParc]. Checksum: F588259FBC6CB34C	FASTA	279	31,370
	10 20 30 40 50 60 MNSCLWDISR YGPNSWRSYL ENLENLFQCL GQVLPESCLL VWNTAMPVGE EVTGGFLPPK 70 80 90 100 110 120 LRRQKATFLK NEVVKANFHS ATEARKHNFD VLDLHFHFRH ARENLHWDGV HWNGRVHRCL 130 140 150 160 170 180 SQLLLAHVAD AWGVELPHRH PVGEWIKKKK PGPRVEGPPQ ANRNHPALPL SPPLPSPTYR 190 200 210 220 230 240 PLLGFPPQRL LSSRINSIAI QMSPHQPMQV SSSKTILWLV LSCLCPSSPH PVISGLPQWY 250 260 270 IGVLAGIVPV APIRPGDSGL DLQREGPQPI LSQGLNRRT

References

[1]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Lung and Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH471111 Genomic DNA. Translation: EAW57925.1. BC008360 mRNA. Translation: AAH08360.1. BC016154 mRNA. Translation: AAH16154.1.
IPI	IPI00063131. IPI00185029.
RefSeq	NP_612380.1. NM_138371.1.
UniGene	Hs.560100.
3D structure databases
ProteinModelPortal	Q96HM7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96HM7. 3 interactions.
Polymorphism databases
DMDM	74731954.
Proteomic databases
PaxDb	Q96HM7.
PRIDE	Q96HM7.
Protocols and materials databases
DNASU	91523.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000432328; ENSP00000396040; ENSG00000179715. ENST00000546455; ENSP00000446688; ENSG00000179715.
GeneID	91523.
KEGG	hsa:91523.
UCSC	uc001rpn.3. human.
Organism-specific databases
CTD	91523.
GeneCards	GC12P047474.
HGNC	HGNC:28255. PCED1B.
HPA	HPA043901.
neXtProt	NX_Q96HM7.
PharmGKB	PA143485471.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG83787.
HOGENOM	HOG000232186.
HOVERGEN	HBG055737.
InParanoid	Q96HM7.
OMA	TRVYSDY.
OrthoDB	EOG4M0F27.
PhylomeDB	Q96HM7.
Gene expression databases
ArrayExpress	Q96HM7.
Bgee	Q96HM7.
CleanEx	HS_FAM113B.
Genevestigator	Q96HM7.
Family and domain databases
Gene3D	3.40.50.1110. 1 hit.
InterPro	IPR026057. PC-Esterase. IPR013831. SGNH_hydro-type_esterase_dom. [Graphical view]
Pfam	PF13839. PC-Esterase. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	91523.
NextBio	77276.

Entry information

Entry name

PED1B_HUMAN

Accession

Primary (citable) accession number: Q96HM7
Secondary accession number(s): Q96B20

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.