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Q96HM7 (PED1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
PC-esterase domain-containing protein 1B
Alternative name(s):
Protein FAM113B
Gene names
Name:PCED1B
Synonyms:FAM113B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the PC-esterase family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionhydrolase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96HM7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96HM7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.
     311-399: PLLPLLSPQP...QRPAPVVHRG → LSSRINSIAI...ILSQGLNRRT
     400-432: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432PC-esterase domain-containing protein 1B
PRO_0000331356

Regions

Compositional bias271 – 431161Pro-rich

Natural variations

Alternative sequence1 – 120120Missing in isoform 2.
VSP_033182
Alternative sequence311 – 39989PLLPL…VVHRG → LSSRINSIAIQMSPHQPMQV SSSKTILWLVLSCLCPSSPH PVISGLPQWYIGVLAGIVPV APIRPGDSGLDLQREGPQPI LSQGLNRRT in isoform 2.
VSP_033183
Alternative sequence400 – 43233Missing in isoform 2.
VSP_033184
Natural variant4291P → A.
Corresponds to variant rs2543737 [ dbSNP | Ensembl ].
VAR_042761

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: F21497B76A791926

FASTA43249,727
        10         20         30         40         50         60 
MILLRASEVR QLLHNKFVVI LGDSVHRAVY KDLVLLLQKD RLLTPGQLRA RGELNFEQDE 

        70         80         90        100        110        120 
LVDGGQRGHM HNGLNYREVR EFRSDHHLVR FYFLTRVYSD YLQTILKELQ SGEHAPDLVI 

       130        140        150        160        170        180 
MNSCLWDISR YGPNSWRSYL ENLENLFQCL GQVLPESCLL VWNTAMPVGE EVTGGFLPPK 

       190        200        210        220        230        240 
LRRQKATFLK NEVVKANFHS ATEARKHNFD VLDLHFHFRH ARENLHWDGV HWNGRVHRCL 

       250        260        270        280        290        300 
SQLLLAHVAD AWGVELPHRH PVGEWIKKKK PGPRVEGPPQ ANRNHPALPL SPPLPSPTYR 

       310        320        330        340        350        360 
PLLGFPPQRL PLLPLLSPQP PPPILHHQGM PRFPQGPPDA CFSSDHTFQS DQFYCHSDVP 

       370        380        390        400        410        420 
SSAHAGFFVE DNFMVGPQLP MPFFPTPRYQ RPAPVVHRGF GRYRPRGPYT PWGQRPRPSK 

       430 
RRAPANPEPR PQ 

« Hide

Isoform 2 [UniParc].

Checksum: F588259FBC6CB34C
Show »

FASTA27931,370

References

[1]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Lung and Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH471111 Genomic DNA. Translation: EAW57925.1.
BC008360 mRNA. Translation: AAH08360.1.
BC016154 mRNA. Translation: AAH16154.1.
RefSeqNP_001268358.1. NM_001281429.1.
NP_612380.1. NM_138371.2.
XP_005269281.1. XM_005269224.2.
XP_005269283.1. XM_005269226.1.
XP_005269285.1. XM_005269228.2.
UniGeneHs.560100.

3D structure databases

ProteinModelPortalQ96HM7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ96HM7. 3 interactions.
STRING9606.ENSP00000320848.

Polymorphism databases

DMDM74731954.

Proteomic databases

PaxDbQ96HM7.
PRIDEQ96HM7.

Protocols and materials databases

DNASU91523.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000432328; ENSP00000396040; ENSG00000179715. [Q96HM7-1]
ENST00000546455; ENSP00000446688; ENSG00000179715. [Q96HM7-1]
GeneID91523.
KEGGhsa:91523.
UCSCuc001rpn.3. human. [Q96HM7-1]

Organism-specific databases

CTD91523.
GeneCardsGC12P047474.
HGNCHGNC:28255. PCED1B.
HPAHPA043901.
neXtProtNX_Q96HM7.
PharmGKBPA143485471.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG83787.
HOGENOMHOG000232186.
HOVERGENHBG055737.
InParanoidQ96HM7.
OMATRVYSDY.
OrthoDBEOG793B8X.
PhylomeDBQ96HM7.
TreeFamTF328972.

Gene expression databases

ArrayExpressQ96HM7.
BgeeQ96HM7.
CleanExHS_FAM113B.
GenevestigatorQ96HM7.

Family and domain databases

Gene3D3.40.50.1110. 1 hit.
InterProIPR026057. PC-Esterase.
IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view]
PfamPF13839. PC-Esterase. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi91523.
NextBio77276.
PROQ96HM7.

Entry information

Entry namePED1B_HUMAN
AccessionPrimary (citable) accession number: Q96HM7
Secondary accession number(s): Q96B20
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM