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Q96HM7

- PED1B_HUMAN

UniProt

Q96HM7 - PED1B_HUMAN

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Protein
PC-esterase domain-containing protein 1B
Gene
PCED1B, FAM113B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. hydrolase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PC-esterase domain-containing protein 1B
    Alternative name(s):
    Protein FAM113B
    Gene namesi
    Name:PCED1B
    Synonyms:FAM113B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:28255. PCED1B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485471.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 432432PC-esterase domain-containing protein 1B
    PRO_0000331356Add
    BLAST

    Proteomic databases

    PaxDbiQ96HM7.
    PRIDEiQ96HM7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96HM7.
    BgeeiQ96HM7.
    CleanExiHS_FAM113B.
    GenevestigatoriQ96HM7.

    Organism-specific databases

    HPAiHPA043901.

    Interactioni

    Protein-protein interaction databases

    IntActiQ96HM7. 3 interactions.
    STRINGi9606.ENSP00000320848.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96HM7.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi271 – 431161Pro-rich
    Add
    BLAST

    Sequence similaritiesi

    Belongs to the PC-esterase family.

    Phylogenomic databases

    eggNOGiNOG83787.
    HOGENOMiHOG000232186.
    HOVERGENiHBG055737.
    InParanoidiQ96HM7.
    OMAiTRVYSDY.
    OrthoDBiEOG793B8X.
    PhylomeDBiQ96HM7.
    TreeFamiTF328972.

    Family and domain databases

    Gene3Di3.40.50.1110. 1 hit.
    InterProiIPR026057. PC-Esterase.
    IPR013831. SGNH_hydro-type_esterase_dom.
    [Graphical view]
    PfamiPF13839. PC-Esterase. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96HM7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MILLRASEVR QLLHNKFVVI LGDSVHRAVY KDLVLLLQKD RLLTPGQLRA    50
    RGELNFEQDE LVDGGQRGHM HNGLNYREVR EFRSDHHLVR FYFLTRVYSD 100
    YLQTILKELQ SGEHAPDLVI MNSCLWDISR YGPNSWRSYL ENLENLFQCL 150
    GQVLPESCLL VWNTAMPVGE EVTGGFLPPK LRRQKATFLK NEVVKANFHS 200
    ATEARKHNFD VLDLHFHFRH ARENLHWDGV HWNGRVHRCL SQLLLAHVAD 250
    AWGVELPHRH PVGEWIKKKK PGPRVEGPPQ ANRNHPALPL SPPLPSPTYR 300
    PLLGFPPQRL PLLPLLSPQP PPPILHHQGM PRFPQGPPDA CFSSDHTFQS 350
    DQFYCHSDVP SSAHAGFFVE DNFMVGPQLP MPFFPTPRYQ RPAPVVHRGF 400
    GRYRPRGPYT PWGQRPRPSK RRAPANPEPR PQ 432
    Length:432
    Mass (Da):49,727
    Last modified:December 1, 2001 - v1
    Checksum:iF21497B76A791926
    GO
    Isoform 2 (identifier: Q96HM7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-120: Missing.
         311-399: PLLPLLSPQP...QRPAPVVHRG → LSSRINSIAI...ILSQGLNRRT
         400-432: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:279
    Mass (Da):31,370
    Checksum:iF588259FBC6CB34C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti429 – 4291P → A.
    Corresponds to variant rs2543737 [ dbSNP | Ensembl ].
    VAR_042761

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 120120Missing in isoform 2.
    VSP_033182Add
    BLAST
    Alternative sequencei311 – 39989PLLPL…VVHRG → LSSRINSIAIQMSPHQPMQV SSSKTILWLVLSCLCPSSPH PVISGLPQWYIGVLAGIVPV APIRPGDSGLDLQREGPQPI LSQGLNRRT in isoform 2.
    VSP_033183Add
    BLAST
    Alternative sequencei400 – 43233Missing in isoform 2.
    VSP_033184Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471111 Genomic DNA. Translation: EAW57925.1.
    BC008360 mRNA. Translation: AAH08360.1.
    BC016154 mRNA. Translation: AAH16154.1.
    CCDSiCCDS8752.1. [Q96HM7-1]
    RefSeqiNP_001268358.1. NM_001281429.1. [Q96HM7-1]
    NP_612380.1. NM_138371.2. [Q96HM7-1]
    XP_005269281.1. XM_005269224.2. [Q96HM7-1]
    XP_005269283.1. XM_005269226.1. [Q96HM7-1]
    XP_005269285.1. XM_005269228.2. [Q96HM7-1]
    XP_006719753.1. XM_006719690.1. [Q96HM7-1]
    XP_006719754.1. XM_006719691.1. [Q96HM7-1]
    UniGeneiHs.560100.

    Genome annotation databases

    EnsembliENST00000432328; ENSP00000396040; ENSG00000179715. [Q96HM7-1]
    ENST00000546455; ENSP00000446688; ENSG00000179715. [Q96HM7-1]
    GeneIDi91523.
    KEGGihsa:91523.
    UCSCiuc001rpn.3. human. [Q96HM7-1]

    Polymorphism databases

    DMDMi74731954.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471111 Genomic DNA. Translation: EAW57925.1 .
    BC008360 mRNA. Translation: AAH08360.1 .
    BC016154 mRNA. Translation: AAH16154.1 .
    CCDSi CCDS8752.1. [Q96HM7-1 ]
    RefSeqi NP_001268358.1. NM_001281429.1. [Q96HM7-1 ]
    NP_612380.1. NM_138371.2. [Q96HM7-1 ]
    XP_005269281.1. XM_005269224.2. [Q96HM7-1 ]
    XP_005269283.1. XM_005269226.1. [Q96HM7-1 ]
    XP_005269285.1. XM_005269228.2. [Q96HM7-1 ]
    XP_006719753.1. XM_006719690.1. [Q96HM7-1 ]
    XP_006719754.1. XM_006719691.1. [Q96HM7-1 ]
    UniGenei Hs.560100.

    3D structure databases

    ProteinModelPortali Q96HM7.
    ModBasei Search...

    Protein-protein interaction databases

    IntActi Q96HM7. 3 interactions.
    STRINGi 9606.ENSP00000320848.

    Polymorphism databases

    DMDMi 74731954.

    Proteomic databases

    PaxDbi Q96HM7.
    PRIDEi Q96HM7.

    Protocols and materials databases

    DNASUi 91523.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000432328 ; ENSP00000396040 ; ENSG00000179715 . [Q96HM7-1 ]
    ENST00000546455 ; ENSP00000446688 ; ENSG00000179715 . [Q96HM7-1 ]
    GeneIDi 91523.
    KEGGi hsa:91523.
    UCSCi uc001rpn.3. human. [Q96HM7-1 ]

    Organism-specific databases

    CTDi 91523.
    GeneCardsi GC12P047474.
    HGNCi HGNC:28255. PCED1B.
    HPAi HPA043901.
    neXtProti NX_Q96HM7.
    PharmGKBi PA143485471.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83787.
    HOGENOMi HOG000232186.
    HOVERGENi HBG055737.
    InParanoidi Q96HM7.
    OMAi TRVYSDY.
    OrthoDBi EOG793B8X.
    PhylomeDBi Q96HM7.
    TreeFami TF328972.

    Miscellaneous databases

    GenomeRNAii 91523.
    NextBioi 77276.
    PROi Q96HM7.

    Gene expression databases

    ArrayExpressi Q96HM7.
    Bgeei Q96HM7.
    CleanExi HS_FAM113B.
    Genevestigatori Q96HM7.

    Family and domain databases

    Gene3Di 3.40.50.1110. 1 hit.
    InterProi IPR026057. PC-Esterase.
    IPR013831. SGNH_hydro-type_esterase_dom.
    [Graphical view ]
    Pfami PF13839. PC-Esterase. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lung and Pancreas.

    Entry informationi

    Entry nameiPED1B_HUMAN
    AccessioniPrimary (citable) accession number: Q96HM7
    Secondary accession number(s): Q96B20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: December 1, 2001
    Last modified: July 9, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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