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Q96HM7

- PED1B_HUMAN

UniProt

Q96HM7 - PED1B_HUMAN

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Protein

PC-esterase domain-containing protein 1B

Gene

PCED1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. hydrolase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PC-esterase domain-containing protein 1B
Alternative name(s):
Protein FAM113B
Gene namesi
Name:PCED1B
Synonyms:FAM113B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:28255. PCED1B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485471.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432PC-esterase domain-containing protein 1BPRO_0000331356Add
BLAST

Proteomic databases

PaxDbiQ96HM7.
PRIDEiQ96HM7.

Expressioni

Gene expression databases

BgeeiQ96HM7.
CleanExiHS_FAM113B.
ExpressionAtlasiQ96HM7. baseline and differential.
GenevestigatoriQ96HM7.

Organism-specific databases

HPAiHPA043901.

Interactioni

Protein-protein interaction databases

BioGridi124840. 3 interactions.
IntActiQ96HM7. 3 interactions.
STRINGi9606.ENSP00000320848.

Structurei

3D structure databases

ProteinModelPortaliQ96HM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi271 – 431161Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the PC-esterase family.Curated

Phylogenomic databases

eggNOGiNOG83787.
GeneTreeiENSGT00390000002231.
HOGENOMiHOG000232186.
HOVERGENiHBG055737.
InParanoidiQ96HM7.
OMAiTRVYSDY.
OrthoDBiEOG793B8X.
PhylomeDBiQ96HM7.
TreeFamiTF328972.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR026057. PC-Esterase.
IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view]
PfamiPF13839. PC-Esterase. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96HM7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MILLRASEVR QLLHNKFVVI LGDSVHRAVY KDLVLLLQKD RLLTPGQLRA
60 70 80 90 100
RGELNFEQDE LVDGGQRGHM HNGLNYREVR EFRSDHHLVR FYFLTRVYSD
110 120 130 140 150
YLQTILKELQ SGEHAPDLVI MNSCLWDISR YGPNSWRSYL ENLENLFQCL
160 170 180 190 200
GQVLPESCLL VWNTAMPVGE EVTGGFLPPK LRRQKATFLK NEVVKANFHS
210 220 230 240 250
ATEARKHNFD VLDLHFHFRH ARENLHWDGV HWNGRVHRCL SQLLLAHVAD
260 270 280 290 300
AWGVELPHRH PVGEWIKKKK PGPRVEGPPQ ANRNHPALPL SPPLPSPTYR
310 320 330 340 350
PLLGFPPQRL PLLPLLSPQP PPPILHHQGM PRFPQGPPDA CFSSDHTFQS
360 370 380 390 400
DQFYCHSDVP SSAHAGFFVE DNFMVGPQLP MPFFPTPRYQ RPAPVVHRGF
410 420 430
GRYRPRGPYT PWGQRPRPSK RRAPANPEPR PQ
Length:432
Mass (Da):49,727
Last modified:December 1, 2001 - v1
Checksum:iF21497B76A791926
GO
Isoform 2 (identifier: Q96HM7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.
     311-399: PLLPLLSPQP...QRPAPVVHRG → LSSRINSIAI...ILSQGLNRRT
     400-432: Missing.

Note: No experimental confirmation available.

Show »
Length:279
Mass (Da):31,370
Checksum:iF588259FBC6CB34C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti429 – 4291P → A.
Corresponds to variant rs2543737 [ dbSNP | Ensembl ].
VAR_042761

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 120120Missing in isoform 2. 1 PublicationVSP_033182Add
BLAST
Alternative sequencei311 – 39989PLLPL…VVHRG → LSSRINSIAIQMSPHQPMQV SSSKTILWLVLSCLCPSSPH PVISGLPQWYIGVLAGIVPV APIRPGDSGLDLQREGPQPI LSQGLNRRT in isoform 2. 1 PublicationVSP_033183Add
BLAST
Alternative sequencei400 – 43233Missing in isoform 2. 1 PublicationVSP_033184Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471111 Genomic DNA. Translation: EAW57925.1.
BC008360 mRNA. Translation: AAH08360.1.
BC016154 mRNA. Translation: AAH16154.1.
CCDSiCCDS8752.1. [Q96HM7-1]
RefSeqiNP_001268358.1. NM_001281429.1. [Q96HM7-1]
NP_612380.1. NM_138371.2. [Q96HM7-1]
XP_005269281.1. XM_005269224.2. [Q96HM7-1]
XP_005269283.1. XM_005269226.1. [Q96HM7-1]
XP_005269285.1. XM_005269228.2. [Q96HM7-1]
XP_006719753.1. XM_006719690.1. [Q96HM7-1]
XP_006719754.1. XM_006719691.1. [Q96HM7-1]
UniGeneiHs.560100.

Genome annotation databases

EnsembliENST00000432328; ENSP00000396040; ENSG00000179715. [Q96HM7-1]
ENST00000546455; ENSP00000446688; ENSG00000179715. [Q96HM7-1]
GeneIDi91523.
KEGGihsa:91523.
UCSCiuc001rpn.3. human. [Q96HM7-1]

Polymorphism databases

DMDMi74731954.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471111 Genomic DNA. Translation: EAW57925.1 .
BC008360 mRNA. Translation: AAH08360.1 .
BC016154 mRNA. Translation: AAH16154.1 .
CCDSi CCDS8752.1. [Q96HM7-1 ]
RefSeqi NP_001268358.1. NM_001281429.1. [Q96HM7-1 ]
NP_612380.1. NM_138371.2. [Q96HM7-1 ]
XP_005269281.1. XM_005269224.2. [Q96HM7-1 ]
XP_005269283.1. XM_005269226.1. [Q96HM7-1 ]
XP_005269285.1. XM_005269228.2. [Q96HM7-1 ]
XP_006719753.1. XM_006719690.1. [Q96HM7-1 ]
XP_006719754.1. XM_006719691.1. [Q96HM7-1 ]
UniGenei Hs.560100.

3D structure databases

ProteinModelPortali Q96HM7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124840. 3 interactions.
IntActi Q96HM7. 3 interactions.
STRINGi 9606.ENSP00000320848.

Polymorphism databases

DMDMi 74731954.

Proteomic databases

PaxDbi Q96HM7.
PRIDEi Q96HM7.

Protocols and materials databases

DNASUi 91523.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000432328 ; ENSP00000396040 ; ENSG00000179715 . [Q96HM7-1 ]
ENST00000546455 ; ENSP00000446688 ; ENSG00000179715 . [Q96HM7-1 ]
GeneIDi 91523.
KEGGi hsa:91523.
UCSCi uc001rpn.3. human. [Q96HM7-1 ]

Organism-specific databases

CTDi 91523.
GeneCardsi GC12P047474.
HGNCi HGNC:28255. PCED1B.
HPAi HPA043901.
neXtProti NX_Q96HM7.
PharmGKBi PA143485471.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG83787.
GeneTreei ENSGT00390000002231.
HOGENOMi HOG000232186.
HOVERGENi HBG055737.
InParanoidi Q96HM7.
OMAi TRVYSDY.
OrthoDBi EOG793B8X.
PhylomeDBi Q96HM7.
TreeFami TF328972.

Miscellaneous databases

GenomeRNAii 91523.
NextBioi 77276.
PROi Q96HM7.

Gene expression databases

Bgeei Q96HM7.
CleanExi HS_FAM113B.
ExpressionAtlasi Q96HM7. baseline and differential.
Genevestigatori Q96HM7.

Family and domain databases

Gene3Di 3.40.50.1110. 1 hit.
InterProi IPR026057. PC-Esterase.
IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view ]
Pfami PF13839. PC-Esterase. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung and Pancreas.

Entry informationi

Entry nameiPED1B_HUMAN
AccessioniPrimary (citable) accession number: Q96HM7
Secondary accession number(s): Q96B20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3