ID SH3Y1_HUMAN Reviewed; 342 AA. AC Q96HL8; A8K8E7; B7WNJ4; B7WPL6; Q8NEL2; Q9H5X4; Q9Y3V5; DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 27-MAR-2024, entry version 154. DE RecName: Full=SH3 domain-containing YSC84-like protein 1; GN Name=SH3YL1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4). RC TISSUE=Carcinoma, and Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Uterus; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5). RC TISSUE=Testis, and Urinary bladder; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP STRUCTURE BY NMR OF 273-342. RG RIKEN structural genomics initiative (RSGI); RT "Solution structure of the SH3 domain of hypothetical protein SH3YL1."; RL Submitted (FEB-2009) to the PDB data bank. CC -!- SUBUNIT: Interacts with SH3D19. {ECO:0000250}. CC -!- INTERACTION: CC Q96HL8; P14136: GFAP; NbExp=4; IntAct=EBI-722667, EBI-744302; CC Q96HL8; Q5HYK7: SH3D19; NbExp=3; IntAct=EBI-722667, EBI-2563437; CC Q96HL8; Q5HYK7-2: SH3D19; NbExp=7; IntAct=EBI-722667, EBI-14699032; CC Q96HL8; Q9H9H4: VPS37B; NbExp=7; IntAct=EBI-722667, EBI-4400866; CC Q96HL8; O15156: ZBTB7B; NbExp=3; IntAct=EBI-722667, EBI-740434; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=1; CC IsoId=Q96HL8-1; Sequence=Displayed; CC Name=2; CC IsoId=Q96HL8-2; Sequence=VSP_034335; CC Name=3; CC IsoId=Q96HL8-3; Sequence=VSP_034332, VSP_034333; CC Name=4; CC IsoId=Q96HL8-4; Sequence=VSP_034332, VSP_034333, VSP_034335; CC Name=5; CC IsoId=Q96HL8-5; Sequence=VSP_034334; CC -!- SIMILARITY: Belongs to the SH3YL1 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK026507; BAB15493.1; -; mRNA. DR EMBL; AK292312; BAF85001.1; -; mRNA. DR EMBL; CR457361; CAG33642.1; -; mRNA. DR EMBL; AL050373; CAB43679.2; -; mRNA. DR EMBL; AC079779; AAY14957.1; -; Genomic_DNA. DR EMBL; BC008374; AAH08374.1; -; mRNA. DR EMBL; BC008375; AAH08375.1; -; mRNA. DR EMBL; BC030778; AAH30778.1; -; mRNA. DR EMBL; BC034974; AAH34974.1; -; mRNA. DR CCDS; CCDS42646.2; -. [Q96HL8-1] DR CCDS; CCDS54332.1; -. [Q96HL8-2] DR CCDS; CCDS62841.1; -. [Q96HL8-4] DR CCDS; CCDS62842.1; -. [Q96HL8-3] DR RefSeq; NP_001153069.1; NM_001159597.2. [Q96HL8-2] DR RefSeq; NP_001269611.1; NM_001282682.1. [Q96HL8-4] DR RefSeq; NP_001269616.1; NM_001282687.1. [Q96HL8-3] DR RefSeq; NP_056492.2; NM_015677.3. [Q96HL8-1] DR PDB; 2D8H; NMR; -; A=276-342. DR PDBsum; 2D8H; -. DR AlphaFoldDB; Q96HL8; -. DR BMRB; Q96HL8; -. DR SMR; Q96HL8; -. DR BioGRID; 117811; 14. DR IntAct; Q96HL8; 8. DR MINT; Q96HL8; -. DR STRING; 9606.ENSP00000348471; -. DR iPTMnet; Q96HL8; -. DR PhosphoSitePlus; Q96HL8; -. DR BioMuta; SH3YL1; -. DR DMDM; 74751912; -. DR EPD; Q96HL8; -. DR jPOST; Q96HL8; -. DR MassIVE; Q96HL8; -. DR PaxDb; 9606-ENSP00000348471; -. DR PeptideAtlas; Q96HL8; -. DR ProteomicsDB; 76760; -. [Q96HL8-1] DR ProteomicsDB; 76761; -. [Q96HL8-2] DR ProteomicsDB; 76762; -. [Q96HL8-3] DR ProteomicsDB; 76763; -. [Q96HL8-4] DR ProteomicsDB; 76764; -. [Q96HL8-5] DR Antibodypedia; 49866; 46 antibodies from 14 providers. DR DNASU; 26751; -. DR Ensembl; ENST00000356150.10; ENSP00000348471.5; ENSG00000035115.22. [Q96HL8-1] DR Ensembl; ENST00000402632.5; ENSP00000384910.1; ENSG00000035115.22. [Q96HL8-5] DR Ensembl; ENST00000403657.5; ENSP00000385668.1; ENSG00000035115.22. [Q96HL8-4] DR Ensembl; ENST00000403658.5; ENSP00000383928.1; ENSG00000035115.22. [Q96HL8-4] DR Ensembl; ENST00000403712.6; ENSP00000384276.1; ENSG00000035115.22. [Q96HL8-2] DR Ensembl; ENST00000405430.5; ENSP00000384269.1; ENSG00000035115.22. [Q96HL8-1] DR Ensembl; ENST00000626873.2; ENSP00000485824.1; ENSG00000035115.22. [Q96HL8-3] DR GeneID; 26751; -. DR KEGG; hsa:26751; -. DR MANE-Select; ENST00000356150.10; ENSP00000348471.5; NM_015677.4; NP_056492.2. DR UCSC; uc002qvx.5; human. [Q96HL8-1] DR AGR; HGNC:29546; -. DR DisGeNET; 26751; -. DR GeneCards; SH3YL1; -. DR HGNC; HGNC:29546; SH3YL1. DR HPA; ENSG00000035115; Low tissue specificity. DR neXtProt; NX_Q96HL8; -. DR OpenTargets; ENSG00000035115; -. DR PharmGKB; PA128394643; -. DR VEuPathDB; HostDB:ENSG00000035115; -. DR eggNOG; KOG1843; Eukaryota. DR GeneTree; ENSGT00510000048137; -. DR HOGENOM; CLU_015320_2_1_1; -. DR InParanoid; Q96HL8; -. DR OMA; NDAMYND; -. DR OrthoDB; 37167at2759; -. DR PhylomeDB; Q96HL8; -. DR TreeFam; TF331022; -. DR PathwayCommons; Q96HL8; -. DR SignaLink; Q96HL8; -. DR BioGRID-ORCS; 26751; 9 hits in 1156 CRISPR screens. DR ChiTaRS; SH3YL1; human. DR EvolutionaryTrace; Q96HL8; -. DR GenomeRNAi; 26751; -. DR Pharos; Q96HL8; Tdark. DR PRO; PR:Q96HL8; -. DR Proteomes; UP000005640; Chromosome 2. DR RNAct; Q96HL8; Protein. DR Bgee; ENSG00000035115; Expressed in nephron tubule and 210 other cell types or tissues. DR ExpressionAtlas; Q96HL8; baseline and differential. DR GO; GO:0032587; C:ruffle membrane; IDA:MGI. DR GO; GO:0019902; F:phosphatase binding; IDA:MGI. DR GO; GO:0035091; F:phosphatidylinositol binding; IDA:MGI. DR GO; GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:Ensembl. DR GO; GO:1900027; P:regulation of ruffle assembly; IBA:GO_Central. DR CDD; cd11841; SH3_SH3YL1_like; 1. DR CDD; cd11525; SYLF_SH3YL1_like; 1. DR Gene3D; 2.30.30.40; SH3 Domains; 1. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR InterPro; IPR035511; SH3YL1_SH3. DR InterPro; IPR033643; SYLF_SH3YL1-like. DR InterPro; IPR007461; Ysc84_actin-binding. DR PANTHER; PTHR15629:SF2; SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1; 1. DR PANTHER; PTHR15629; SH3YL1 PROTEIN; 1. DR Pfam; PF14604; SH3_9; 1. DR Pfam; PF04366; Ysc84; 1. DR PRINTS; PR00452; SH3DOMAIN. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF50044; SH3-domain; 1. DR PROSITE; PS50002; SH3; 1. DR Genevisible; Q96HL8; HS. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Reference proteome; SH3 domain. FT CHAIN 1..342 FT /note="SH3 domain-containing YSC84-like protein 1" FT /id="PRO_0000341560" FT DOMAIN 283..342 FT /note="SH3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192" FT REGION 218..266 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 218..238 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 243..266 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 1..96 FT /note="Missing (in isoform 3 and isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:17974005" FT /id="VSP_034332" FT VAR_SEQ 97 FT /note="E -> M (in isoform 3 and isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:17974005" FT /id="VSP_034333" FT VAR_SEQ 98..342 FT /note="VSDLVIILNYDRAVEAFAKGGNLTLGGNLTVAVGPLGRNLEGNVALRSSAAV FT FTYCKSRGLFAGVSLEGSCLIERKETNRKFYCQDIRAYDILFGDTPRPAQAEDLYEILD FT SFTEKYENEGQRINARKAAREQRKSSAKELPPKPLSRPQQSSAPVQLNSGSQSNRNEYK FT LYPGLSSYHERVGNLNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGK FT LRGQTGIFPANYVTMN -> THLQLHIPSEHCPGCLP (in isoform 5)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_034334" FT VAR_SEQ 262..280 FT /note="Missing (in isoform 2 and isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2" FT /id="VSP_034335" FT CONFLICT 4 FT /note="P -> H (in Ref. 5; AAH34974/AAH30778)" FT /evidence="ECO:0000305" FT CONFLICT 104 FT /note="I -> V (in Ref. 1; BAF85001)" FT /evidence="ECO:0000305" FT CONFLICT 141 FT /note="V -> M (in Ref. 1; BAF85001)" FT /evidence="ECO:0000305" FT STRAND 286..289 FT /evidence="ECO:0007829|PDB:2D8H" FT STRAND 309..314 FT /evidence="ECO:0007829|PDB:2D8H" FT STRAND 319..327 FT /evidence="ECO:0007829|PDB:2D8H" FT STRAND 330..335 FT /evidence="ECO:0007829|PDB:2D8H" FT HELIX 336..338 FT /evidence="ECO:0007829|PDB:2D8H" SQ SEQUENCE 342 AA; 37148 MW; A12F0276A870B863 CRC64; MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAIL SVIKAGFLVT ARGGSGIVVA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD LVIILNYDRA VEAFAKGGNL TLGGNLTVAV GPLGRNLEGN VALRSSAAVF TYCKSRGLFA GVSLEGSCLI ERKETNRKFY CQDIRAYDIL FGDTPRPAQA EDLYEILDSF TEKYENEGQR INARKAAREQ RKSSAKELPP KPLSRPQQSS APVQLNSGSQ SNRNEYKLYP GLSSYHERVG NLNQPIEVTA LYSFEGQQPG DLNFQAGDRI TVISKTDSHF DWWEGKLRGQ TGIFPANYVT MN //