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Q96HL8

- SH3Y1_HUMAN

UniProt

Q96HL8 - SH3Y1_HUMAN

Protein

SH3 domain-containing YSC84-like protein 1

Gene

SH3YL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. phosphatase binding Source: MGI
    2. phosphatidylinositol binding Source: MGI

    GO - Biological processi

    1. phosphatidylinositol biosynthetic process Source: Ensembl
    2. regulation of ruffle assembly Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH3 domain-containing YSC84-like protein 1
    Gene namesi
    Name:SH3YL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:29546. SH3YL1.

    Subcellular locationi

    GO - Cellular componenti

    1. ruffle membrane Source: MGI

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394643.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342SH3 domain-containing YSC84-like protein 1PRO_0000341560Add
    BLAST

    Proteomic databases

    PaxDbiQ96HL8.
    PRIDEiQ96HL8.

    PTM databases

    PhosphoSiteiQ96HL8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96HL8.
    BgeeiQ96HL8.
    CleanExiHS_SH3YL1.
    GenevestigatoriQ96HL8.

    Organism-specific databases

    HPAiHPA030926.
    HPA030927.

    Interactioni

    Subunit structurei

    Interacts with SH3D19.By similarity

    Protein-protein interaction databases

    BioGridi117811. 6 interactions.
    IntActiQ96HL8. 3 interactions.
    MINTiMINT-1397835.
    STRINGi9606.ENSP00000404143.

    Structurei

    Secondary structure

    1
    342
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi286 – 2894
    Beta strandi309 – 3146
    Beta strandi319 – 3279
    Beta strandi330 – 3356
    Helixi336 – 3383

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2D8HNMR-A276-342[»]
    ProteinModelPortaliQ96HL8.
    SMRiQ96HL8. Positions 273-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96HL8.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini283 – 34260SH3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SH3YL1 family.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiCOG2930.
    HOGENOMiHOG000215564.
    HOVERGENiHBG108487.
    InParanoidiQ96HL8.
    OMAiYCQDVRA.
    OrthoDBiEOG7MPRFM.
    PhylomeDBiQ96HL8.
    TreeFamiTF331022.

    Family and domain databases

    InterProiIPR001452. SH3_domain.
    IPR007461. Ysc84_actin-binding.
    [Graphical view]
    PfamiPF04366. DUF500. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96HL8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAIL    50
    SVIKAGFLVT ARGGSGIVVA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD 100
    LVIILNYDRA VEAFAKGGNL TLGGNLTVAV GPLGRNLEGN VALRSSAAVF 150
    TYCKSRGLFA GVSLEGSCLI ERKETNRKFY CQDIRAYDIL FGDTPRPAQA 200
    EDLYEILDSF TEKYENEGQR INARKAAREQ RKSSAKELPP KPLSRPQQSS 250
    APVQLNSGSQ SNRNEYKLYP GLSSYHERVG NLNQPIEVTA LYSFEGQQPG 300
    DLNFQAGDRI TVISKTDSHF DWWEGKLRGQ TGIFPANYVT MN 342
    Length:342
    Mass (Da):37,148
    Last modified:December 1, 2001 - v1
    Checksum:iA12F0276A870B863
    GO
    Isoform 2 (identifier: Q96HL8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         262-280: Missing.

    Show »
    Length:323
    Mass (Da):34,884
    Checksum:i0978372B41715F8F
    GO
    Isoform 3 (identifier: Q96HL8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-96: Missing.
         97-97: E → M

    Show »
    Length:246
    Mass (Da):27,353
    Checksum:iCCB998B271C72E7E
    GO
    Isoform 4 (identifier: Q96HL8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-96: Missing.
         97-97: E → M
         262-280: Missing.

    Show »
    Length:227
    Mass (Da):25,088
    Checksum:i42B6CACE64E66697
    GO
    Isoform 5 (identifier: Q96HL8-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         98-342: VSDLVIILNY...IFPANYVTMN → THLQLHIPSEHCPGCLP

    Note: No experimental confirmation available.

    Show »
    Length:114
    Mass (Da):11,809
    Checksum:i28BF2A1DA409BE24
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41P → H in AAH34974. (PubMed:15489334)Curated
    Sequence conflicti4 – 41P → H in AAH30778. (PubMed:15489334)Curated
    Sequence conflicti104 – 1041I → V in BAF85001. (PubMed:14702039)Curated
    Sequence conflicti141 – 1411V → M in BAF85001. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9696Missing in isoform 3 and isoform 4. 2 PublicationsVSP_034332Add
    BLAST
    Alternative sequencei97 – 971E → M in isoform 3 and isoform 4. 2 PublicationsVSP_034333
    Alternative sequencei98 – 342245VSDLV…YVTMN → THLQLHIPSEHCPGCLP in isoform 5. 1 PublicationVSP_034334Add
    BLAST
    Alternative sequencei262 – 28019Missing in isoform 2 and isoform 4. 3 PublicationsVSP_034335Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK026507 mRNA. Translation: BAB15493.1.
    AK292312 mRNA. Translation: BAF85001.1.
    CR457361 mRNA. Translation: CAG33642.1.
    AL050373 mRNA. Translation: CAB43679.2.
    AC079779 Genomic DNA. Translation: AAY14957.1.
    BC008374 mRNA. Translation: AAH08374.1.
    BC008375 mRNA. Translation: AAH08375.1.
    BC030778 mRNA. Translation: AAH30778.1.
    BC034974 mRNA. Translation: AAH34974.1.
    CCDSiCCDS42646.2. [Q96HL8-1]
    CCDS54332.1. [Q96HL8-2]
    CCDS62841.1. [Q96HL8-4]
    CCDS62842.1. [Q96HL8-3]
    RefSeqiNP_001153069.1. NM_001159597.2. [Q96HL8-2]
    NP_001269611.1. NM_001282682.1. [Q96HL8-4]
    NP_001269616.1. NM_001282687.1. [Q96HL8-3]
    NP_056492.2. NM_015677.3. [Q96HL8-1]
    UniGeneiHs.515951.
    Hs.731436.

    Genome annotation databases

    EnsembliENST00000356150; ENSP00000348471; ENSG00000035115. [Q96HL8-1]
    ENST00000402632; ENSP00000384910; ENSG00000035115. [Q96HL8-5]
    ENST00000403657; ENSP00000385668; ENSG00000035115. [Q96HL8-4]
    ENST00000403658; ENSP00000383928; ENSG00000035115. [Q96HL8-4]
    ENST00000403712; ENSP00000384276; ENSG00000035115. [Q96HL8-2]
    ENST00000405430; ENSP00000384269; ENSG00000035115. [Q96HL8-1]
    GeneIDi26751.
    KEGGihsa:26751.
    UCSCiuc002qvv.3. human. [Q96HL8-3]
    uc002qvx.3. human. [Q96HL8-1]
    uc002qvy.3. human. [Q96HL8-2]
    uc010ewe.3. human. [Q96HL8-4]

    Polymorphism databases

    DMDMi74751912.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK026507 mRNA. Translation: BAB15493.1 .
    AK292312 mRNA. Translation: BAF85001.1 .
    CR457361 mRNA. Translation: CAG33642.1 .
    AL050373 mRNA. Translation: CAB43679.2 .
    AC079779 Genomic DNA. Translation: AAY14957.1 .
    BC008374 mRNA. Translation: AAH08374.1 .
    BC008375 mRNA. Translation: AAH08375.1 .
    BC030778 mRNA. Translation: AAH30778.1 .
    BC034974 mRNA. Translation: AAH34974.1 .
    CCDSi CCDS42646.2. [Q96HL8-1 ]
    CCDS54332.1. [Q96HL8-2 ]
    CCDS62841.1. [Q96HL8-4 ]
    CCDS62842.1. [Q96HL8-3 ]
    RefSeqi NP_001153069.1. NM_001159597.2. [Q96HL8-2 ]
    NP_001269611.1. NM_001282682.1. [Q96HL8-4 ]
    NP_001269616.1. NM_001282687.1. [Q96HL8-3 ]
    NP_056492.2. NM_015677.3. [Q96HL8-1 ]
    UniGenei Hs.515951.
    Hs.731436.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2D8H NMR - A 276-342 [» ]
    ProteinModelPortali Q96HL8.
    SMRi Q96HL8. Positions 273-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117811. 6 interactions.
    IntActi Q96HL8. 3 interactions.
    MINTi MINT-1397835.
    STRINGi 9606.ENSP00000404143.

    PTM databases

    PhosphoSitei Q96HL8.

    Polymorphism databases

    DMDMi 74751912.

    Proteomic databases

    PaxDbi Q96HL8.
    PRIDEi Q96HL8.

    Protocols and materials databases

    DNASUi 26751.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356150 ; ENSP00000348471 ; ENSG00000035115 . [Q96HL8-1 ]
    ENST00000402632 ; ENSP00000384910 ; ENSG00000035115 . [Q96HL8-5 ]
    ENST00000403657 ; ENSP00000385668 ; ENSG00000035115 . [Q96HL8-4 ]
    ENST00000403658 ; ENSP00000383928 ; ENSG00000035115 . [Q96HL8-4 ]
    ENST00000403712 ; ENSP00000384276 ; ENSG00000035115 . [Q96HL8-2 ]
    ENST00000405430 ; ENSP00000384269 ; ENSG00000035115 . [Q96HL8-1 ]
    GeneIDi 26751.
    KEGGi hsa:26751.
    UCSCi uc002qvv.3. human. [Q96HL8-3 ]
    uc002qvx.3. human. [Q96HL8-1 ]
    uc002qvy.3. human. [Q96HL8-2 ]
    uc010ewe.3. human. [Q96HL8-4 ]

    Organism-specific databases

    CTDi 26751.
    GeneCardsi GC02M000208.
    H-InvDB HIX0001777.
    HGNCi HGNC:29546. SH3YL1.
    HPAi HPA030926.
    HPA030927.
    neXtProti NX_Q96HL8.
    PharmGKBi PA128394643.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2930.
    HOGENOMi HOG000215564.
    HOVERGENi HBG108487.
    InParanoidi Q96HL8.
    OMAi YCQDVRA.
    OrthoDBi EOG7MPRFM.
    PhylomeDBi Q96HL8.
    TreeFami TF331022.

    Miscellaneous databases

    EvolutionaryTracei Q96HL8.
    GenomeRNAii 26751.
    NextBioi 49119.
    PROi Q96HL8.

    Gene expression databases

    ArrayExpressi Q96HL8.
    Bgeei Q96HL8.
    CleanExi HS_SH3YL1.
    Genevestigatori Q96HL8.

    Family and domain databases

    InterProi IPR001452. SH3_domain.
    IPR007461. Ysc84_actin-binding.
    [Graphical view ]
    Pfami PF04366. DUF500. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
      Tissue: Carcinoma and Testis.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Uterus.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
      Tissue: Testis and Urinary bladder.
    6. "Solution structure of the SH3 domain of hypothetical protein SH3YL1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 273-342.

    Entry informationi

    Entry nameiSH3Y1_HUMAN
    AccessioniPrimary (citable) accession number: Q96HL8
    Secondary accession number(s): A8K8E7
    , B7WNJ4, B7WPL6, Q8NEL2, Q9H5X4, Q9Y3V5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3