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Q96HL8 (SH3Y1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SH3 domain-containing YSC84-like protein 1
Gene names
Name:SH3YL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with SH3D19 By similarity.

Sequence similarities

Belongs to the SH3YL1 family.

Contains 1 SH3 domain.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96HL8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96HL8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     262-280: Missing.
Isoform 3 (identifier: Q96HL8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.
     97-97: E → M
Isoform 4 (identifier: Q96HL8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.
     97-97: E → M
     262-280: Missing.
Isoform 5 (identifier: Q96HL8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     98-342: VSDLVIILNY...IFPANYVTMN → THLQLHIPSEHCPGCLP
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342SH3 domain-containing YSC84-like protein 1
PRO_0000341560

Regions

Domain283 – 34260SH3

Natural variations

Alternative sequence1 – 9696Missing in isoform 3 and isoform 4.
VSP_034332
Alternative sequence971E → M in isoform 3 and isoform 4.
VSP_034333
Alternative sequence98 – 342245VSDLV…YVTMN → THLQLHIPSEHCPGCLP in isoform 5.
VSP_034334
Alternative sequence262 – 28019Missing in isoform 2 and isoform 4.
VSP_034335

Experimental info

Sequence conflict41P → H in AAH34974. Ref.5
Sequence conflict41P → H in AAH30778. Ref.5
Sequence conflict1041I → V in BAF85001. Ref.1
Sequence conflict1411V → M in BAF85001. Ref.1

Secondary structure

.......... 342
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: A12F0276A870B863

FASTA34237,148
        10         20         30         40         50         60 
MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAIL SVIKAGFLVT 

        70         80         90        100        110        120 
ARGGSGIVVA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD LVIILNYDRA VEAFAKGGNL 

       130        140        150        160        170        180 
TLGGNLTVAV GPLGRNLEGN VALRSSAAVF TYCKSRGLFA GVSLEGSCLI ERKETNRKFY 

       190        200        210        220        230        240 
CQDIRAYDIL FGDTPRPAQA EDLYEILDSF TEKYENEGQR INARKAAREQ RKSSAKELPP 

       250        260        270        280        290        300 
KPLSRPQQSS APVQLNSGSQ SNRNEYKLYP GLSSYHERVG NLNQPIEVTA LYSFEGQQPG 

       310        320        330        340 
DLNFQAGDRI TVISKTDSHF DWWEGKLRGQ TGIFPANYVT MN 

« Hide

Isoform 2 [UniParc].

Checksum: 0978372B41715F8F
Show »

FASTA32334,884
Isoform 3 [UniParc].

Checksum: CCB998B271C72E7E
Show »

FASTA24627,353
Isoform 4 [UniParc].

Checksum: 42B6CACE64E66697
Show »

FASTA22725,088
Isoform 5 [UniParc].

Checksum: 28BF2A1DA409BE24
Show »

FASTA11411,809

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
Tissue: Carcinoma and Testis.
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Uterus.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
Tissue: Testis and Urinary bladder.
[6]"Solution structure of the SH3 domain of hypothetical protein SH3YL1."
RIKEN structural genomics initiative (RSGI)
Submitted (FEB-2009) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 273-342.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK026507 mRNA. Translation: BAB15493.1.
AK292312 mRNA. Translation: BAF85001.1.
CR457361 mRNA. Translation: CAG33642.1.
AL050373 mRNA. Translation: CAB43679.2.
AC079779 Genomic DNA. Translation: AAY14957.1.
BC008374 mRNA. Translation: AAH08374.1.
BC008375 mRNA. Translation: AAH08375.1.
BC030778 mRNA. Translation: AAH30778.1.
BC034974 mRNA. Translation: AAH34974.1.
RefSeqNP_001153069.1. NM_001159597.2.
NP_001269611.1. NM_001282682.1.
NP_001269616.1. NM_001282687.1.
NP_056492.2. NM_015677.3.
UniGeneHs.515951.
Hs.731436.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2D8HNMR-A273-342[»]
ProteinModelPortalQ96HL8.
SMRQ96HL8. Positions 273-342.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117811. 6 interactions.
IntActQ96HL8. 3 interactions.
MINTMINT-1397835.
STRING9606.ENSP00000404143.

PTM databases

PhosphoSiteQ96HL8.

Polymorphism databases

DMDM74751912.

Proteomic databases

PaxDbQ96HL8.
PRIDEQ96HL8.

Protocols and materials databases

DNASU26751.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000356150; ENSP00000348471; ENSG00000035115. [Q96HL8-1]
ENST00000402632; ENSP00000384910; ENSG00000035115. [Q96HL8-5]
ENST00000403657; ENSP00000385668; ENSG00000035115. [Q96HL8-4]
ENST00000403658; ENSP00000383928; ENSG00000035115. [Q96HL8-4]
ENST00000403712; ENSP00000384276; ENSG00000035115. [Q96HL8-2]
ENST00000405430; ENSP00000384269; ENSG00000035115. [Q96HL8-1]
ENST00000415006; ENSP00000404143; ENSG00000035115. [Q96HL8-3]
GeneID26751.
KEGGhsa:26751.
UCSCuc002qvv.3. human. [Q96HL8-3]
uc002qvx.3. human. [Q96HL8-1]
uc002qvy.3. human. [Q96HL8-2]
uc010ewe.3. human. [Q96HL8-4]

Organism-specific databases

CTD26751.
GeneCardsGC02M000208.
H-InvDBHIX0001777.
HGNCHGNC:29546. SH3YL1.
HPAHPA030926.
HPA030927.
neXtProtNX_Q96HL8.
PharmGKBPA128394643.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2930.
HOGENOMHOG000215564.
HOVERGENHBG108487.
InParanoidQ96HL8.
OMALFGDIPR.
OrthoDBEOG7MPRFM.
TreeFamTF331022.

Gene expression databases

ArrayExpressQ96HL8.
BgeeQ96HL8.
CleanExHS_SH3YL1.
GenevestigatorQ96HL8.

Family and domain databases

InterProIPR001452. SH3_domain.
IPR007461. Ysc84_actin-binding.
[Graphical view]
PfamPF04366. DUF500. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ96HL8.
GenomeRNAi26751.
NextBio49119.
PROQ96HL8.

Entry information

Entry nameSH3Y1_HUMAN
AccessionPrimary (citable) accession number: Q96HL8
Secondary accession number(s): A8K8E7 expand/collapse secondary AC list , B7WNJ4, B7WPL6, Q8NEL2, Q9H5X4, Q9Y3V5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 1, 2001
Last modified: March 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM