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Protein

SH3 domain-containing YSC84-like protein 1

Gene

SH3YL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • phosphatase binding Source: MGI
  • phosphatidylinositol binding Source: MGI

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-containing YSC84-like protein 1
Gene namesi
Name:SH3YL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29546. SH3YL1.

Subcellular locationi

GO - Cellular componenti

  • ruffle membrane Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000035115.
PharmGKBiPA128394643.

Polymorphism and mutation databases

DMDMi74751912.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003415601 – 342SH3 domain-containing YSC84-like protein 1Add BLAST342

Proteomic databases

EPDiQ96HL8.
PaxDbiQ96HL8.
PeptideAtlasiQ96HL8.
PRIDEiQ96HL8.

PTM databases

iPTMnetiQ96HL8.
PhosphoSitePlusiQ96HL8.

Expressioni

Gene expression databases

BgeeiENSG00000035115.
CleanExiHS_SH3YL1.
ExpressionAtlasiQ96HL8. baseline and differential.
GenevisibleiQ96HL8. HS.

Organism-specific databases

HPAiHPA030926.
HPA030927.

Interactioni

Subunit structurei

Interacts with SH3D19.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GFAPP141364EBI-722667,EBI-744302
SH3D19Q5HYK73EBI-722667,EBI-2563437
VPS37BQ9H9H46EBI-722667,EBI-4400866
ZBTB7BO151563EBI-722667,EBI-740434

GO - Molecular functioni

  • phosphatase binding Source: MGI

Protein-protein interaction databases

BioGridi117811. 9 interactors.
IntActiQ96HL8. 6 interactors.
MINTiMINT-1397835.
STRINGi9606.ENSP00000348471.

Structurei

Secondary structure

1342
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi286 – 289Combined sources4
Beta strandi309 – 314Combined sources6
Beta strandi319 – 327Combined sources9
Beta strandi330 – 335Combined sources6
Helixi336 – 338Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D8HNMR-A276-342[»]
ProteinModelPortaliQ96HL8.
SMRiQ96HL8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96HL8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini283 – 342SH3PROSITE-ProRule annotationAdd BLAST60

Sequence similaritiesi

Belongs to the SH3YL1 family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG1843. Eukaryota.
COG2930. LUCA.
GeneTreeiENSGT00510000048137.
HOGENOMiHOG000215564.
HOVERGENiHBG108487.
InParanoidiQ96HL8.
KOiK20523.
OMAiYDWWEGQ.
OrthoDBiEOG091G0E6Y.
PhylomeDBiQ96HL8.
TreeFamiTF331022.

Family and domain databases

CDDicd11525. SYLF_SH3YL1_like. 1 hit.
InterProiIPR001452. SH3_domain.
IPR033643. SYLF_SH3YL1-like.
IPR007461. Ysc84_actin-binding.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF04366. Ysc84. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96HL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAIL
60 70 80 90 100
SVIKAGFLVT ARGGSGIVVA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD
110 120 130 140 150
LVIILNYDRA VEAFAKGGNL TLGGNLTVAV GPLGRNLEGN VALRSSAAVF
160 170 180 190 200
TYCKSRGLFA GVSLEGSCLI ERKETNRKFY CQDIRAYDIL FGDTPRPAQA
210 220 230 240 250
EDLYEILDSF TEKYENEGQR INARKAAREQ RKSSAKELPP KPLSRPQQSS
260 270 280 290 300
APVQLNSGSQ SNRNEYKLYP GLSSYHERVG NLNQPIEVTA LYSFEGQQPG
310 320 330 340
DLNFQAGDRI TVISKTDSHF DWWEGKLRGQ TGIFPANYVT MN
Length:342
Mass (Da):37,148
Last modified:December 1, 2001 - v1
Checksum:iA12F0276A870B863
GO
Isoform 2 (identifier: Q96HL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-280: Missing.

Show »
Length:323
Mass (Da):34,884
Checksum:i0978372B41715F8F
GO
Isoform 3 (identifier: Q96HL8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.
     97-97: E → M

Show »
Length:246
Mass (Da):27,353
Checksum:iCCB998B271C72E7E
GO
Isoform 4 (identifier: Q96HL8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.
     97-97: E → M
     262-280: Missing.

Show »
Length:227
Mass (Da):25,088
Checksum:i42B6CACE64E66697
GO
Isoform 5 (identifier: Q96HL8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-342: VSDLVIILNY...IFPANYVTMN → THLQLHIPSEHCPGCLP

Note: No experimental confirmation available.
Show »
Length:114
Mass (Da):11,809
Checksum:i28BF2A1DA409BE24
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4P → H in AAH34974 (PubMed:15489334).Curated1
Sequence conflicti4P → H in AAH30778 (PubMed:15489334).Curated1
Sequence conflicti104I → V in BAF85001 (PubMed:14702039).Curated1
Sequence conflicti141V → M in BAF85001 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0343321 – 96Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST96
Alternative sequenceiVSP_03433397E → M in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_03433498 – 342VSDLV…YVTMN → THLQLHIPSEHCPGCLP in isoform 5. 1 PublicationAdd BLAST245
Alternative sequenceiVSP_034335262 – 280Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026507 mRNA. Translation: BAB15493.1.
AK292312 mRNA. Translation: BAF85001.1.
CR457361 mRNA. Translation: CAG33642.1.
AL050373 mRNA. Translation: CAB43679.2.
AC079779 Genomic DNA. Translation: AAY14957.1.
BC008374 mRNA. Translation: AAH08374.1.
BC008375 mRNA. Translation: AAH08375.1.
BC030778 mRNA. Translation: AAH30778.1.
BC034974 mRNA. Translation: AAH34974.1.
CCDSiCCDS42646.2. [Q96HL8-1]
CCDS54332.1. [Q96HL8-2]
CCDS62841.1. [Q96HL8-4]
CCDS62842.1. [Q96HL8-3]
RefSeqiNP_001153069.1. NM_001159597.2. [Q96HL8-2]
NP_001269611.1. NM_001282682.1. [Q96HL8-4]
NP_001269616.1. NM_001282687.1. [Q96HL8-3]
NP_056492.2. NM_015677.3. [Q96HL8-1]
UniGeneiHs.515951.
Hs.731436.

Genome annotation databases

EnsembliENST00000356150; ENSP00000348471; ENSG00000035115. [Q96HL8-1]
ENST00000402632; ENSP00000384910; ENSG00000035115. [Q96HL8-5]
ENST00000403657; ENSP00000385668; ENSG00000035115. [Q96HL8-4]
ENST00000403658; ENSP00000383928; ENSG00000035115. [Q96HL8-4]
ENST00000403712; ENSP00000384276; ENSG00000035115. [Q96HL8-2]
ENST00000405430; ENSP00000384269; ENSG00000035115. [Q96HL8-1]
ENST00000626873; ENSP00000485824; ENSG00000035115. [Q96HL8-3]
GeneIDi26751.
KEGGihsa:26751.
UCSCiuc002qvx.5. human. [Q96HL8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026507 mRNA. Translation: BAB15493.1.
AK292312 mRNA. Translation: BAF85001.1.
CR457361 mRNA. Translation: CAG33642.1.
AL050373 mRNA. Translation: CAB43679.2.
AC079779 Genomic DNA. Translation: AAY14957.1.
BC008374 mRNA. Translation: AAH08374.1.
BC008375 mRNA. Translation: AAH08375.1.
BC030778 mRNA. Translation: AAH30778.1.
BC034974 mRNA. Translation: AAH34974.1.
CCDSiCCDS42646.2. [Q96HL8-1]
CCDS54332.1. [Q96HL8-2]
CCDS62841.1. [Q96HL8-4]
CCDS62842.1. [Q96HL8-3]
RefSeqiNP_001153069.1. NM_001159597.2. [Q96HL8-2]
NP_001269611.1. NM_001282682.1. [Q96HL8-4]
NP_001269616.1. NM_001282687.1. [Q96HL8-3]
NP_056492.2. NM_015677.3. [Q96HL8-1]
UniGeneiHs.515951.
Hs.731436.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D8HNMR-A276-342[»]
ProteinModelPortaliQ96HL8.
SMRiQ96HL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117811. 9 interactors.
IntActiQ96HL8. 6 interactors.
MINTiMINT-1397835.
STRINGi9606.ENSP00000348471.

PTM databases

iPTMnetiQ96HL8.
PhosphoSitePlusiQ96HL8.

Polymorphism and mutation databases

DMDMi74751912.

Proteomic databases

EPDiQ96HL8.
PaxDbiQ96HL8.
PeptideAtlasiQ96HL8.
PRIDEiQ96HL8.

Protocols and materials databases

DNASUi26751.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356150; ENSP00000348471; ENSG00000035115. [Q96HL8-1]
ENST00000402632; ENSP00000384910; ENSG00000035115. [Q96HL8-5]
ENST00000403657; ENSP00000385668; ENSG00000035115. [Q96HL8-4]
ENST00000403658; ENSP00000383928; ENSG00000035115. [Q96HL8-4]
ENST00000403712; ENSP00000384276; ENSG00000035115. [Q96HL8-2]
ENST00000405430; ENSP00000384269; ENSG00000035115. [Q96HL8-1]
ENST00000626873; ENSP00000485824; ENSG00000035115. [Q96HL8-3]
GeneIDi26751.
KEGGihsa:26751.
UCSCiuc002qvx.5. human. [Q96HL8-1]

Organism-specific databases

CTDi26751.
GeneCardsiSH3YL1.
H-InvDBHIX0001777.
HGNCiHGNC:29546. SH3YL1.
HPAiHPA030926.
HPA030927.
neXtProtiNX_Q96HL8.
OpenTargetsiENSG00000035115.
PharmGKBiPA128394643.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1843. Eukaryota.
COG2930. LUCA.
GeneTreeiENSGT00510000048137.
HOGENOMiHOG000215564.
HOVERGENiHBG108487.
InParanoidiQ96HL8.
KOiK20523.
OMAiYDWWEGQ.
OrthoDBiEOG091G0E6Y.
PhylomeDBiQ96HL8.
TreeFamiTF331022.

Miscellaneous databases

ChiTaRSiSH3YL1. human.
EvolutionaryTraceiQ96HL8.
GenomeRNAii26751.
PROiQ96HL8.

Gene expression databases

BgeeiENSG00000035115.
CleanExiHS_SH3YL1.
ExpressionAtlasiQ96HL8. baseline and differential.
GenevisibleiQ96HL8. HS.

Family and domain databases

CDDicd11525. SYLF_SH3YL1_like. 1 hit.
InterProiIPR001452. SH3_domain.
IPR033643. SYLF_SH3YL1-like.
IPR007461. Ysc84_actin-binding.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF04366. Ysc84. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSH3Y1_HUMAN
AccessioniPrimary (citable) accession number: Q96HL8
Secondary accession number(s): A8K8E7
, B7WNJ4, B7WPL6, Q8NEL2, Q9H5X4, Q9Y3V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.