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Q96HL8

- SH3Y1_HUMAN

UniProt

Q96HL8 - SH3Y1_HUMAN

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Protein

SH3 domain-containing YSC84-like protein 1

Gene

SH3YL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. phosphatase binding Source: MGI
  2. phosphatidylinositol binding Source: MGI

GO - Biological processi

  1. phosphatidylinositol biosynthetic process Source: Ensembl
  2. regulation of ruffle assembly Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-containing YSC84-like protein 1
Gene namesi
Name:SH3YL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:29546. SH3YL1.

Subcellular locationi

GO - Cellular componenti

  1. ruffle membrane Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394643.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342SH3 domain-containing YSC84-like protein 1PRO_0000341560Add
BLAST

Proteomic databases

PaxDbiQ96HL8.
PRIDEiQ96HL8.

PTM databases

PhosphoSiteiQ96HL8.

Expressioni

Gene expression databases

BgeeiQ96HL8.
CleanExiHS_SH3YL1.
ExpressionAtlasiQ96HL8. baseline and differential.
GenevestigatoriQ96HL8.

Organism-specific databases

HPAiHPA030926.
HPA030927.

Interactioni

Subunit structurei

Interacts with SH3D19.By similarity

Protein-protein interaction databases

BioGridi117811. 6 interactions.
IntActiQ96HL8. 3 interactions.
MINTiMINT-1397835.
STRINGi9606.ENSP00000404143.

Structurei

Secondary structure

1
342
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi286 – 2894
Beta strandi309 – 3146
Beta strandi319 – 3279
Beta strandi330 – 3356
Helixi336 – 3383

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D8HNMR-A276-342[»]
ProteinModelPortaliQ96HL8.
SMRiQ96HL8. Positions 273-342.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96HL8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini283 – 34260SH3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SH3YL1 family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiCOG2930.
GeneTreeiENSGT00510000048137.
HOGENOMiHOG000215564.
HOVERGENiHBG108487.
InParanoidiQ96HL8.
OMAiYCQDVRA.
OrthoDBiEOG7MPRFM.
PhylomeDBiQ96HL8.
TreeFamiTF331022.

Family and domain databases

InterProiIPR001452. SH3_domain.
IPR007461. Ysc84_actin-binding.
[Graphical view]
PfamiPF04366. DUF500. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96HL8) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAIL
60 70 80 90 100
SVIKAGFLVT ARGGSGIVVA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD
110 120 130 140 150
LVIILNYDRA VEAFAKGGNL TLGGNLTVAV GPLGRNLEGN VALRSSAAVF
160 170 180 190 200
TYCKSRGLFA GVSLEGSCLI ERKETNRKFY CQDIRAYDIL FGDTPRPAQA
210 220 230 240 250
EDLYEILDSF TEKYENEGQR INARKAAREQ RKSSAKELPP KPLSRPQQSS
260 270 280 290 300
APVQLNSGSQ SNRNEYKLYP GLSSYHERVG NLNQPIEVTA LYSFEGQQPG
310 320 330 340
DLNFQAGDRI TVISKTDSHF DWWEGKLRGQ TGIFPANYVT MN
Length:342
Mass (Da):37,148
Last modified:December 1, 2001 - v1
Checksum:iA12F0276A870B863
GO
Isoform 2 (identifier: Q96HL8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-280: Missing.

Show »
Length:323
Mass (Da):34,884
Checksum:i0978372B41715F8F
GO
Isoform 3 (identifier: Q96HL8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.
     97-97: E → M

Show »
Length:246
Mass (Da):27,353
Checksum:iCCB998B271C72E7E
GO
Isoform 4 (identifier: Q96HL8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.
     97-97: E → M
     262-280: Missing.

Show »
Length:227
Mass (Da):25,088
Checksum:i42B6CACE64E66697
GO
Isoform 5 (identifier: Q96HL8-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-342: VSDLVIILNY...IFPANYVTMN → THLQLHIPSEHCPGCLP

Note: No experimental confirmation available.

Show »
Length:114
Mass (Da):11,809
Checksum:i28BF2A1DA409BE24
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41P → H in AAH34974. (PubMed:15489334)Curated
Sequence conflicti4 – 41P → H in AAH30778. (PubMed:15489334)Curated
Sequence conflicti104 – 1041I → V in BAF85001. (PubMed:14702039)Curated
Sequence conflicti141 – 1411V → M in BAF85001. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9696Missing in isoform 3 and isoform 4. 2 PublicationsVSP_034332Add
BLAST
Alternative sequencei97 – 971E → M in isoform 3 and isoform 4. 2 PublicationsVSP_034333
Alternative sequencei98 – 342245VSDLV…YVTMN → THLQLHIPSEHCPGCLP in isoform 5. 1 PublicationVSP_034334Add
BLAST
Alternative sequencei262 – 28019Missing in isoform 2 and isoform 4. 3 PublicationsVSP_034335Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK026507 mRNA. Translation: BAB15493.1.
AK292312 mRNA. Translation: BAF85001.1.
CR457361 mRNA. Translation: CAG33642.1.
AL050373 mRNA. Translation: CAB43679.2.
AC079779 Genomic DNA. Translation: AAY14957.1.
BC008374 mRNA. Translation: AAH08374.1.
BC008375 mRNA. Translation: AAH08375.1.
BC030778 mRNA. Translation: AAH30778.1.
BC034974 mRNA. Translation: AAH34974.1.
CCDSiCCDS42646.2. [Q96HL8-1]
CCDS54332.1. [Q96HL8-2]
CCDS62841.1. [Q96HL8-4]
RefSeqiNP_001153069.1. NM_001159597.2. [Q96HL8-2]
NP_001269611.1. NM_001282682.1. [Q96HL8-4]
NP_001269616.1. NM_001282687.1. [Q96HL8-3]
NP_056492.2. NM_015677.3. [Q96HL8-1]
UniGeneiHs.515951.
Hs.731436.

Genome annotation databases

EnsembliENST00000356150; ENSP00000348471; ENSG00000035115. [Q96HL8-1]
ENST00000402632; ENSP00000384910; ENSG00000035115. [Q96HL8-5]
ENST00000403657; ENSP00000385668; ENSG00000035115. [Q96HL8-4]
ENST00000403658; ENSP00000383928; ENSG00000035115. [Q96HL8-4]
ENST00000403712; ENSP00000384276; ENSG00000035115. [Q96HL8-2]
ENST00000405430; ENSP00000384269; ENSG00000035115. [Q96HL8-1]
GeneIDi26751.
KEGGihsa:26751.
UCSCiuc002qvv.3. human. [Q96HL8-3]
uc002qvx.3. human. [Q96HL8-1]
uc002qvy.3. human. [Q96HL8-2]
uc010ewe.3. human. [Q96HL8-4]

Polymorphism databases

DMDMi74751912.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK026507 mRNA. Translation: BAB15493.1 .
AK292312 mRNA. Translation: BAF85001.1 .
CR457361 mRNA. Translation: CAG33642.1 .
AL050373 mRNA. Translation: CAB43679.2 .
AC079779 Genomic DNA. Translation: AAY14957.1 .
BC008374 mRNA. Translation: AAH08374.1 .
BC008375 mRNA. Translation: AAH08375.1 .
BC030778 mRNA. Translation: AAH30778.1 .
BC034974 mRNA. Translation: AAH34974.1 .
CCDSi CCDS42646.2. [Q96HL8-1 ]
CCDS54332.1. [Q96HL8-2 ]
CCDS62841.1. [Q96HL8-4 ]
RefSeqi NP_001153069.1. NM_001159597.2. [Q96HL8-2 ]
NP_001269611.1. NM_001282682.1. [Q96HL8-4 ]
NP_001269616.1. NM_001282687.1. [Q96HL8-3 ]
NP_056492.2. NM_015677.3. [Q96HL8-1 ]
UniGenei Hs.515951.
Hs.731436.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2D8H NMR - A 276-342 [» ]
ProteinModelPortali Q96HL8.
SMRi Q96HL8. Positions 273-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117811. 6 interactions.
IntActi Q96HL8. 3 interactions.
MINTi MINT-1397835.
STRINGi 9606.ENSP00000404143.

PTM databases

PhosphoSitei Q96HL8.

Polymorphism databases

DMDMi 74751912.

Proteomic databases

PaxDbi Q96HL8.
PRIDEi Q96HL8.

Protocols and materials databases

DNASUi 26751.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356150 ; ENSP00000348471 ; ENSG00000035115 . [Q96HL8-1 ]
ENST00000402632 ; ENSP00000384910 ; ENSG00000035115 . [Q96HL8-5 ]
ENST00000403657 ; ENSP00000385668 ; ENSG00000035115 . [Q96HL8-4 ]
ENST00000403658 ; ENSP00000383928 ; ENSG00000035115 . [Q96HL8-4 ]
ENST00000403712 ; ENSP00000384276 ; ENSG00000035115 . [Q96HL8-2 ]
ENST00000405430 ; ENSP00000384269 ; ENSG00000035115 . [Q96HL8-1 ]
GeneIDi 26751.
KEGGi hsa:26751.
UCSCi uc002qvv.3. human. [Q96HL8-3 ]
uc002qvx.3. human. [Q96HL8-1 ]
uc002qvy.3. human. [Q96HL8-2 ]
uc010ewe.3. human. [Q96HL8-4 ]

Organism-specific databases

CTDi 26751.
GeneCardsi GC02M000208.
H-InvDB HIX0001777.
HGNCi HGNC:29546. SH3YL1.
HPAi HPA030926.
HPA030927.
neXtProti NX_Q96HL8.
PharmGKBi PA128394643.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2930.
GeneTreei ENSGT00510000048137.
HOGENOMi HOG000215564.
HOVERGENi HBG108487.
InParanoidi Q96HL8.
OMAi YCQDVRA.
OrthoDBi EOG7MPRFM.
PhylomeDBi Q96HL8.
TreeFami TF331022.

Miscellaneous databases

EvolutionaryTracei Q96HL8.
GenomeRNAii 26751.
NextBioi 49119.
PROi Q96HL8.

Gene expression databases

Bgeei Q96HL8.
CleanExi HS_SH3YL1.
ExpressionAtlasi Q96HL8. baseline and differential.
Genevestigatori Q96HL8.

Family and domain databases

InterProi IPR001452. SH3_domain.
IPR007461. Ysc84_actin-binding.
[Graphical view ]
Pfami PF04366. DUF500. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Carcinoma and Testis.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Uterus.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
    Tissue: Testis and Urinary bladder.
  6. "Solution structure of the SH3 domain of hypothetical protein SH3YL1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 273-342.

Entry informationi

Entry nameiSH3Y1_HUMAN
AccessioniPrimary (citable) accession number: Q96HL8
Secondary accession number(s): A8K8E7
, B7WNJ4, B7WPL6, Q8NEL2, Q9H5X4, Q9Y3V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3