Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FMC1 homolog

Gene

FMC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FMC1 homolog
Alternative name(s):
ATP synthase assembly factor FMC1, mitochondrialImported
Formation of mitochondrial complex V assembly factor 1 homologImported
Gene namesi
Name:FMC1Imported
Synonyms:C7orf55
ORF Names:HSPC268
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164898.12
HGNCiHGNC:26946 FMC1
neXtProtiNX_Q96HJ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164898
ENSG00000269955
PharmGKBiPA164717374

Polymorphism and mutation databases

DMDMi182627648

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003287801 – 113Protein FMC1 homologAdd BLAST113

Proteomic databases

EPDiQ96HJ9
MaxQBiQ96HJ9
PaxDbiQ96HJ9
PeptideAtlasiQ96HJ9
PRIDEiQ96HJ9

PTM databases

iPTMnetiQ96HJ9
PhosphoSitePlusiQ96HJ9

Expressioni

Gene expression databases

BgeeiENSG00000164898
GenevisibleiQ96HJ9 HS

Organism-specific databases

HPAiHPA045663
HPA050553
HPA051631

Interactioni

Protein-protein interaction databases

BioGridi127556, 34 interactors
3190610, 3 interactors
STRINGi9606.ENSP00000297534

Structurei

3D structure databases

ProteinModelPortaliQ96HJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMC1 family.Curated

Phylogenomic databases

eggNOGiENOG410J415 Eukaryota
ENOG4111SA8 LUCA
GeneTreeiENSGT00390000012258
ENSGT00730000110670
HOGENOMiHOG000215956
HOVERGENiHBG106720
InParanoidiQ96HJ9
KOiK13212
OMAiLAETYLC
OrthoDBiEOG091G11LV
PhylomeDBiQ96HJ9
TreeFamiTF321497

Family and domain databases

InterProiView protein in InterPro
IPR037667 FMC1_homologue
PANTHERiPTHR31716 PTHR31716, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96HJ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALGSPSHT FRGLLRELRY LSAATGRPYR DTAAYRYLVK AFRAHRVTSE
60 70 80 90 100
KLCRAQHELH FQAATYLCLL RSIRKHVALH QEFHGKGERS VEESAGLVGL
110
KLPHQPGGKG WEP
Length:113
Mass (Da):12,749
Last modified:April 8, 2008 - v2
Checksum:i98233A93133877C9
GO
Isoform 2 (identifier: Q96HJ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-113: ERSVEESAGLVGLKLPHQPGGKGWEP → DTTRQRIKFS...SSEEREAGEI

Note: No experimental confirmation available.
Show »
Length:458
Mass (Da):54,224
Checksum:i79850BF28BEF3C13
GO

Sequence cautioni

The sequence AAF28946 differs from that shown. Reason: Frameshift at position 64.Curated
The sequence AAF28946 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0425208S → A1 PublicationCorresponds to variant dbSNP:rs10265Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04724488 – 113ERSVE…KGWEP → DTTRQRIKFSDDRVCKSHLL NCCPHDVLSGTRMDLGECLK VHDLALRADYEIASKEQDFF FELDAMDHLQSFIADCDRRT EVAKKRLAETQEEISAEVAA KAERVHELNEEIGKLLAKVE QLGAEGNVEESQKVMDEVEK ARAKKREAEEVYRNSMPASS FQQQKLRVCEVCSAYLGLHD NDRRLADHFGGKLHLGFIEI REKLEELKRVVAEKQEKRNQ ERLKRREEREREEREKLRRS RSHSKNPKRSRSREHRRHRS RSMSRERKRRTRSKSREKRH RHRSRSSSRSRSRSHQRSRH SSRDRSRERSKRRSSKERFR DQDLASCDRDRSSRDRSPRD RDRKDKKRSYESANGRSEDR RSSEEREAGEI in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297642 mRNA Translation: BAH12639.1
AF161386 mRNA Translation: AAF28946.1 Sequence problems.
AC083880 Genomic DNA Translation: AAS07478.1
AC083883 Genomic DNA No translation available.
CH471070 Genomic DNA Translation: EAW83915.1
BC008467 mRNA Translation: AAH08467.1
CCDSiCCDS5853.1 [Q96HJ9-1]
RefSeqiNP_001231513.1, NM_001244584.2 [Q96HJ9-2]
NP_932068.2, NM_197964.4 [Q96HJ9-1]
UniGeneiHs.718441
Hs.731488

Genome annotation databases

EnsembliENST00000297534; ENSP00000297534; ENSG00000164898 [Q96HJ9-1]
GeneIDi100996928
154791
KEGGihsa:100996928
hsa:154791
UCSCiuc003vuw.5 human [Q96HJ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFMC1_HUMAN
AccessioniPrimary (citable) accession number: Q96HJ9
Secondary accession number(s): B7Z4Q3, Q75M90, Q9P0B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: March 28, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health