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Q96HJ5

- MS4A3_HUMAN

UniProt

Q96HJ5 - MS4A3_HUMAN

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Protein

Membrane-spanning 4-domains subfamily A member 3

Gene

MS4A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).1 Publication

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 3
Alternative name(s):
CD20 antigen-like protein
Hematopoietic-specific transmembrane protein 4
Short name:
HTm4
Gene namesi
Name:MS4A3
Synonyms:CD20L, HTM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:7317. MS4A3.

Subcellular locationi

Endomembrane system By similarity; Multi-pass membrane protein By similarity. Cytoplasmperinuclear region By similarity
Note: Located in the perinuclear area.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei50 – 7021HelicalSequence AnalysisAdd
BLAST
Topological domaini71 – 8111ExtracellularSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Topological domaini103 – 12422CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence AnalysisAdd
BLAST
Topological domaini146 – 17530ExtracellularSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Topological domaini197 – 21418CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31112.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Membrane-spanning 4-domains subfamily A member 3PRO_0000158632Add
BLAST

Proteomic databases

PaxDbiQ96HJ5.
PRIDEiQ96HJ5.

Expressioni

Tissue specificityi

Expressed specifically in hematopoietic cells and tissues.

Gene expression databases

BgeeiQ96HJ5.
CleanExiHS_MS4A3.
ExpressionAtlasiQ96HJ5. baseline and differential.
GenevestigatoriQ96HJ5.

Organism-specific databases

HPAiHPA019210.

Interactioni

Subunit structurei

Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes.2 Publications

Protein-protein interaction databases

BioGridi107370. 2 interactions.
STRINGi9606.ENSP00000278865.

Structurei

3D structure databases

ProteinModelPortaliQ96HJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi82 – 876Poly-Phe

Domaini

The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46884.
GeneTreeiENSGT00730000111024.
HOGENOMiHOG000113657.
HOVERGENiHBG052512.
InParanoidiQ96HJ5.
OMAiSTVAMWC.
OrthoDBiEOG7VHSZF.
PhylomeDBiQ96HJ5.
TreeFamiTF335157.

Family and domain databases

InterProiIPR007237. CD20-like.
[Graphical view]
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96HJ5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASHEVDNAE LGSASAHGTP GSEAGPEELN TSVYQPIDGS PDYQKAKLQV
60 70 80 90 100
LGAIQILNAA MILALGVFLG SLQYPYHFQK HFFFFTFYTG YPIWGAVFFC
110 120 130 140 150
SSGTLSVVAG IKPTRTWIQN SFGMNIASAT IALVGTAFLS LNIAVNIQSL
160 170 180 190 200
RSCHSSSESP DLCNYMGSIS NGMVSLLLIL TLLELCVTIS TIAMWCNANC
210
CNSREEISSP PNSV
Length:214
Mass (Da):22,933
Last modified:December 1, 2001 - v1
Checksum:iD30C276213DB8F3D
GO
Isoform 2 (identifier: Q96HJ5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-98: Missing.

Show »
Length:168
Mass (Da):17,601
Checksum:iC62AC47B541A634C
GO
Isoform 3 (identifier: Q96HJ5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.

Show »
Length:91
Mass (Da):9,625
Checksum:i4570C062BADC3B17
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241A → T in AAA62319. (PubMed:7524084)Curated
Sequence conflicti35 – 351Q → H in AAA62319. (PubMed:7524084)Curated
Sequence conflicti38 – 381D → N in AAA62319. (PubMed:7524084)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 123123Missing in isoform 3. 1 PublicationVSP_045798Add
BLAST
Alternative sequencei53 – 9846Missing in isoform 2. 1 PublicationVSP_007109Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35848 mRNA. Translation: AAA62319.1.
AY095480 mRNA. Translation: AAM23312.1.
AY258289 Genomic DNA. Translation: AAP14648.1.
AP000790 Genomic DNA. No translation available.
BC008487 mRNA. Translation: AAH08487.1.
BG494288 mRNA. No translation available.
CCDSiCCDS31567.1. [Q96HJ5-1]
CCDS31568.1. [Q96HJ5-2]
CCDS41651.1. [Q96HJ5-3]
PIRiI59258.
RefSeqiNP_001026836.1. NM_001031666.1. [Q96HJ5-3]
NP_001026979.1. NM_001031809.1. [Q96HJ5-2]
NP_006129.4. NM_006138.4. [Q96HJ5-1]
UniGeneiHs.99960.

Genome annotation databases

EnsembliENST00000278865; ENSP00000278865; ENSG00000149516. [Q96HJ5-1]
ENST00000358152; ENSP00000350872; ENSG00000149516. [Q96HJ5-2]
ENST00000395032; ENSP00000378473; ENSG00000149516. [Q96HJ5-3]
ENST00000534744; ENSP00000434117; ENSG00000149516. [Q96HJ5-2]
GeneIDi932.
KEGGihsa:932.
UCSCiuc001nom.3. human. [Q96HJ5-1]
uc001non.3. human. [Q96HJ5-2]

Polymorphism databases

DMDMi29611825.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35848 mRNA. Translation: AAA62319.1 .
AY095480 mRNA. Translation: AAM23312.1 .
AY258289 Genomic DNA. Translation: AAP14648.1 .
AP000790 Genomic DNA. No translation available.
BC008487 mRNA. Translation: AAH08487.1 .
BG494288 mRNA. No translation available.
CCDSi CCDS31567.1. [Q96HJ5-1 ]
CCDS31568.1. [Q96HJ5-2 ]
CCDS41651.1. [Q96HJ5-3 ]
PIRi I59258.
RefSeqi NP_001026836.1. NM_001031666.1. [Q96HJ5-3 ]
NP_001026979.1. NM_001031809.1. [Q96HJ5-2 ]
NP_006129.4. NM_006138.4. [Q96HJ5-1 ]
UniGenei Hs.99960.

3D structure databases

ProteinModelPortali Q96HJ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107370. 2 interactions.
STRINGi 9606.ENSP00000278865.

Polymorphism databases

DMDMi 29611825.

Proteomic databases

PaxDbi Q96HJ5.
PRIDEi Q96HJ5.

Protocols and materials databases

DNASUi 932.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278865 ; ENSP00000278865 ; ENSG00000149516 . [Q96HJ5-1 ]
ENST00000358152 ; ENSP00000350872 ; ENSG00000149516 . [Q96HJ5-2 ]
ENST00000395032 ; ENSP00000378473 ; ENSG00000149516 . [Q96HJ5-3 ]
ENST00000534744 ; ENSP00000434117 ; ENSG00000149516 . [Q96HJ5-2 ]
GeneIDi 932.
KEGGi hsa:932.
UCSCi uc001nom.3. human. [Q96HJ5-1 ]
uc001non.3. human. [Q96HJ5-2 ]

Organism-specific databases

CTDi 932.
GeneCardsi GC11P059824.
HGNCi HGNC:7317. MS4A3.
HPAi HPA019210.
MIMi 606498. gene.
neXtProti NX_Q96HJ5.
PharmGKBi PA31112.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46884.
GeneTreei ENSGT00730000111024.
HOGENOMi HOG000113657.
HOVERGENi HBG052512.
InParanoidi Q96HJ5.
OMAi STVAMWC.
OrthoDBi EOG7VHSZF.
PhylomeDBi Q96HJ5.
TreeFami TF335157.

Miscellaneous databases

GeneWikii MS4A3.
GenomeRNAii 932.
NextBioi 3866.
PROi Q96HJ5.
SOURCEi Search...

Gene expression databases

Bgeei Q96HJ5.
CleanExi HS_MS4A3.
ExpressionAtlasi Q96HJ5. baseline and differential.
Genevestigatori Q96HJ5.

Family and domain databases

InterProi IPR007237. CD20-like.
[Graphical view ]
Pfami PF04103. CD20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions."
    Adra C.N., Lelias J.-M., Kobayashi H., Kaghad M., Morrison P., Rowley J.D., Lim B.
    Proc. Natl. Acad. Sci. U.S.A. 91:10178-10182(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Hematopoietic.
  2. "Cloning and function analysis of the transcript variant of human hematopoietic cell-specific protein HTm4."
    Xie C., Yuan H.F., Xie X.Y., Li Y.H., Shi W., Wang D.M., Li H.M., Yue W., Bai C.X., Zhang R., Pei X.T.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Bone marrow.
  3. Shirakawa T., Yang X., Lyengar A., Sayegh M., Scadden D., Adra C.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Epidermal carcinoma and Lung.
  6. Cited for: FUNCTION, INTERACTION WITH CDKN3.
  7. "Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2."
    Chinami M., Yano Y., Yang X., Salahuddin S., Moriyama K., Shiroishi M., Turner H., Shirakawa T., Adra C.N.
    J. Biol. Chem. 280:17235-17242(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDKN3.

Entry informationi

Entry nameiMS4A3_HUMAN
AccessioniPrimary (citable) accession number: Q96HJ5
Secondary accession number(s): A8MTP8, Q8NHW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3