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Protein

Membrane-spanning 4-domains subfamily A member 3

Gene

MS4A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149516-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 3
Alternative name(s):
CD20 antigen-like protein
Hematopoietic-specific transmembrane protein 4
Short name:
HTm4
Gene namesi
Name:MS4A3
Synonyms:CD20L, HTM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:7317. MS4A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 81ExtracellularSequence analysisAdd BLAST11
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 124CytoplasmicSequence analysisAdd BLAST22
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 175ExtracellularSequence analysisAdd BLAST30
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 214CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi932.
OpenTargetsiENSG00000149516.
PharmGKBiPA31112.

Polymorphism and mutation databases

BioMutaiMS4A3.
DMDMi29611825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586321 – 214Membrane-spanning 4-domains subfamily A member 3Add BLAST214

Proteomic databases

EPDiQ96HJ5.
PaxDbiQ96HJ5.
PeptideAtlasiQ96HJ5.
PRIDEiQ96HJ5.

PTM databases

iPTMnetiQ96HJ5.
PhosphoSitePlusiQ96HJ5.

Expressioni

Tissue specificityi

Expressed specifically in hematopoietic cells and tissues.

Gene expression databases

BgeeiENSG00000149516.
CleanExiHS_MS4A3.
ExpressionAtlasiQ96HJ5. baseline and differential.
GenevisibleiQ96HJ5. HS.

Organism-specific databases

HPAiHPA019210.

Interactioni

Subunit structurei

Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes.2 Publications

Protein-protein interaction databases

BioGridi107370. 2 interactors.
STRINGi9606.ENSP00000278865.

Structurei

3D structure databases

ProteinModelPortaliQ96HJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi82 – 87Poly-Phe6

Domaini

The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZNT. Eukaryota.
ENOG411140Q. LUCA.
GeneTreeiENSGT00730000110654.
HOGENOMiHOG000113657.
HOVERGENiHBG052512.
InParanoidiQ96HJ5.
OMAiINNTHIM.
OrthoDBiEOG091G0IBB.
PhylomeDBiQ96HJ5.
TreeFamiTF335157.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
IPR030419. MS4A3.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PTHR23320:SF74. PTHR23320:SF74. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96HJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASHEVDNAE LGSASAHGTP GSEAGPEELN TSVYQPIDGS PDYQKAKLQV
60 70 80 90 100
LGAIQILNAA MILALGVFLG SLQYPYHFQK HFFFFTFYTG YPIWGAVFFC
110 120 130 140 150
SSGTLSVVAG IKPTRTWIQN SFGMNIASAT IALVGTAFLS LNIAVNIQSL
160 170 180 190 200
RSCHSSSESP DLCNYMGSIS NGMVSLLLIL TLLELCVTIS TIAMWCNANC
210
CNSREEISSP PNSV
Length:214
Mass (Da):22,933
Last modified:December 1, 2001 - v1
Checksum:iD30C276213DB8F3D
GO
Isoform 2 (identifier: Q96HJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-98: Missing.

Show »
Length:168
Mass (Da):17,601
Checksum:iC62AC47B541A634C
GO
Isoform 3 (identifier: Q96HJ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.
Show »
Length:91
Mass (Da):9,625
Checksum:i4570C062BADC3B17
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24A → T in AAA62319 (PubMed:7524084).Curated1
Sequence conflicti35Q → H in AAA62319 (PubMed:7524084).Curated1
Sequence conflicti38D → N in AAA62319 (PubMed:7524084).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0457981 – 123Missing in isoform 3. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_00710953 – 98Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35848 mRNA. Translation: AAA62319.1.
AY095480 mRNA. Translation: AAM23312.1.
AY258289 Genomic DNA. Translation: AAP14648.1.
AP000790 Genomic DNA. No translation available.
BC008487 mRNA. Translation: AAH08487.1.
BG494288 mRNA. No translation available.
CCDSiCCDS31567.1. [Q96HJ5-1]
CCDS31568.1. [Q96HJ5-2]
CCDS41651.1. [Q96HJ5-3]
PIRiI59258.
RefSeqiNP_001026836.1. NM_001031666.1. [Q96HJ5-3]
NP_001026979.1. NM_001031809.1. [Q96HJ5-2]
NP_006129.4. NM_006138.4. [Q96HJ5-1]
UniGeneiHs.99960.

Genome annotation databases

EnsembliENST00000278865; ENSP00000278865; ENSG00000149516. [Q96HJ5-1]
ENST00000358152; ENSP00000350872; ENSG00000149516. [Q96HJ5-2]
ENST00000395032; ENSP00000378473; ENSG00000149516. [Q96HJ5-3]
ENST00000534744; ENSP00000434117; ENSG00000149516. [Q96HJ5-2]
GeneIDi932.
KEGGihsa:932.
UCSCiuc001nom.4. human. [Q96HJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35848 mRNA. Translation: AAA62319.1.
AY095480 mRNA. Translation: AAM23312.1.
AY258289 Genomic DNA. Translation: AAP14648.1.
AP000790 Genomic DNA. No translation available.
BC008487 mRNA. Translation: AAH08487.1.
BG494288 mRNA. No translation available.
CCDSiCCDS31567.1. [Q96HJ5-1]
CCDS31568.1. [Q96HJ5-2]
CCDS41651.1. [Q96HJ5-3]
PIRiI59258.
RefSeqiNP_001026836.1. NM_001031666.1. [Q96HJ5-3]
NP_001026979.1. NM_001031809.1. [Q96HJ5-2]
NP_006129.4. NM_006138.4. [Q96HJ5-1]
UniGeneiHs.99960.

3D structure databases

ProteinModelPortaliQ96HJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107370. 2 interactors.
STRINGi9606.ENSP00000278865.

PTM databases

iPTMnetiQ96HJ5.
PhosphoSitePlusiQ96HJ5.

Polymorphism and mutation databases

BioMutaiMS4A3.
DMDMi29611825.

Proteomic databases

EPDiQ96HJ5.
PaxDbiQ96HJ5.
PeptideAtlasiQ96HJ5.
PRIDEiQ96HJ5.

Protocols and materials databases

DNASUi932.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278865; ENSP00000278865; ENSG00000149516. [Q96HJ5-1]
ENST00000358152; ENSP00000350872; ENSG00000149516. [Q96HJ5-2]
ENST00000395032; ENSP00000378473; ENSG00000149516. [Q96HJ5-3]
ENST00000534744; ENSP00000434117; ENSG00000149516. [Q96HJ5-2]
GeneIDi932.
KEGGihsa:932.
UCSCiuc001nom.4. human. [Q96HJ5-1]

Organism-specific databases

CTDi932.
DisGeNETi932.
GeneCardsiMS4A3.
HGNCiHGNC:7317. MS4A3.
HPAiHPA019210.
MIMi606498. gene.
neXtProtiNX_Q96HJ5.
OpenTargetsiENSG00000149516.
PharmGKBiPA31112.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZNT. Eukaryota.
ENOG411140Q. LUCA.
GeneTreeiENSGT00730000110654.
HOGENOMiHOG000113657.
HOVERGENiHBG052512.
InParanoidiQ96HJ5.
OMAiINNTHIM.
OrthoDBiEOG091G0IBB.
PhylomeDBiQ96HJ5.
TreeFamiTF335157.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149516-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

GeneWikiiMS4A3.
GenomeRNAii932.
PROiQ96HJ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149516.
CleanExiHS_MS4A3.
ExpressionAtlasiQ96HJ5. baseline and differential.
GenevisibleiQ96HJ5. HS.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
IPR030419. MS4A3.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PTHR23320:SF74. PTHR23320:SF74. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMS4A3_HUMAN
AccessioniPrimary (citable) accession number: Q96HJ5
Secondary accession number(s): A8MTP8, Q8NHW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.