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Protein

Glycylpeptide N-tetradecanoyltransferase

Gene

NMT1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.UniRule annotation

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferaseUniRule annotation (EC:2.3.1.97UniRule annotation)
Gene namesi
Name:NMT1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ96HI4.
PRIDEiQ96HI4.

Expressioni

Gene expression databases

BgeeiQ96HI4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000258960.

Structurei

3D structure databases

ProteinModelPortaliQ96HI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini139 – 292154NMTInterPro annotationAdd
BLAST
Domaini306 – 484179NMT_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the NMT family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2779. Eukaryota.
COG5092. LUCA.
HOVERGENiHBG003404.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q96HI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DESETAVKPP APPLPQMMEG NGNGHEHCSD CENEEDNSYN RGGLSPANDT
60 70 80 90 100
GAKKKKKKQK KKKEKGSETD SAQDQPVKMN SLPAERIQEI QKAIELFSVG
110 120 130 140 150
QGPAKTMEEA SKRSYQFWDT QPVPKLGEVV NTHGPVEPDK DNIRQEPYTL
160 170 180 190 200
PQGFTWDALD LGDRGVLKEL YTLLNENYVE DDDNMFRFDY SPEFLLWALR
210 220 230 240 250
PPGWLPQWHC GVRVVSSRKL VGFISAIPAN IHIYDTEKKM VEINFLCVHK
260 270 280 290 300
KLRSKRVAPV LIREITRRVH LEGIFQAVYT AGVVLPKPVG TCRYWHRSLN
310 320 330 340 350
PRKLIEVKFS HLSRNMTMQR TMKLYRLPET PKTAGLRPME TKDIPVVHQL
360 370 380 390 400
LTRYLKQFHL TPVMSQEEVE HWFYPQENII DTFVVENANG EVTDFLSFYT
410 420 430 440 450
LPSTIMNHPT HKSLKAAYSF YNVHTQTPLL DLMSDALVLA KMKGFDVFNA
460 470 480 490
LDLMENKTFL EKLKFGIGDG NLQYYLYNWK CPSMGAEKVG LVLQ
Length:494
Mass (Da):56,604
Last modified:March 29, 2005 - v2
Checksum:i2AC35D29AA7E8212
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC008579 mRNA. Translation: AAH08579.2.
UniGeneiHs.532790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC008579 mRNA. Translation: AAH08579.2.
UniGeneiHs.532790.

3D structure databases

ProteinModelPortaliQ96HI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000258960.

Proteomic databases

PaxDbiQ96HI4.
PRIDEiQ96HI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2779. Eukaryota.
COG5092. LUCA.
HOVERGENiHBG003404.

Miscellaneous databases

ChiTaRSiNMT1. human.

Gene expression databases

BgeeiQ96HI4.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.

Entry informationi

Entry nameiQ96HI4_HUMAN
AccessioniPrimary (citable) accession number: Q96HI4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: March 29, 2005
Last modified: June 8, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.