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Q96HI0

- SENP5_HUMAN

UniProt

Q96HI0 - SENP5_HUMAN

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Protein

Sentrin-specific protease 5

Gene
SENP5, FKSG45
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.2 Publications

Catalytic activityi

Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei646 – 6461 By similarity
Active sitei663 – 6631 By similarity
Active sitei713 – 7131 Inferred

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. protein binding Source: IntAct

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cellular protein metabolic process Source: Reactome
  4. post-translational protein modification Source: Reactome
  5. protein sumoylation Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Cell division, Ubl conjugation pathway

Enzyme and pathway databases

BRENDAi3.4.22.68. 2681.
ReactomeiREACT_163725. SUMO is proteolytically processed.

Protein family/group databases

MEROPSiC48.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Sentrin-specific protease 5 (EC:3.4.22.68)
Alternative name(s):
Sentrin/SUMO-specific protease SENP5
Gene namesi
Name:SENP5
ORF Names:FKSG45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:28407. SENP5.

Subcellular locationi

Nucleusnucleolus 2 Publications

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: HPA
  2. nucleolus Source: HPA
  3. nucleoplasm Source: Reactome
  4. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi713 – 7131C → A: Abolishes enzymatic activity. 2 Publications

Organism-specific databases

PharmGKBiPA134917083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 755755Sentrin-specific protease 5PRO_0000101723Add
BLAST

Proteomic databases

MaxQBiQ96HI0.
PaxDbiQ96HI0.
PRIDEiQ96HI0.

PTM databases

PhosphoSiteiQ96HI0.

Expressioni

Gene expression databases

ArrayExpressiQ96HI0.
BgeeiQ96HI0.
CleanExiHS_SENP5.
GenevestigatoriQ96HI0.

Organism-specific databases

HPAiHPA055536.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ESR1P033722EBI-3895753,EBI-78473

Protein-protein interaction databases

BioGridi128497. 2 interactions.
IntActiQ96HI0. 1 interaction.
STRINGi9606.ENSP00000327197.

Structurei

3D structure databases

ProteinModelPortaliQ96HI0.
SMRiQ96HI0. Positions 515-754.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni567 – 724158ProteaseAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C48 family.

Phylogenomic databases

eggNOGiCOG5160.
HOGENOMiHOG000070166.
HOVERGENiHBG062231.
InParanoidiQ96HI0.
KOiK08594.
OMAiAFPDQQN.
OrthoDBiEOG7D59MP.
PhylomeDBiQ96HI0.
TreeFamiTF316289.

Family and domain databases

InterProiIPR003653. Peptidase_C48.
[Graphical view]
PfamiPF02902. Peptidase_C48. 1 hit.
[Graphical view]
PROSITEiPS50600. ULP_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96HI0-1 [UniParc]FASTAAdd to Basket

« Hide

MKKQRKILWR KGIHLAFSEK WNTGFGGFKK FYFHQHLCIL KAKLGRPVTW    50
NRQLRHFQGR KKALQIQKTW IKDEPLCAKT KFNVATQNVS TLSSKVKRKD 100
AKHFISSSKT LLRLQAEKLL SSAKNSDHEY CREKNLLKAV TDFPSNSALG 150
QANGHRPRTD PQPSDFPMKF NGESQSPGES GTIVVTLNNH KRKGFCYGCC 200
QGPEHHRNGG PLIPKKFQLN QHRRIKLSPL MMYEKLSMIR FRYRILRSQH 250
FRTKSKVCKL RKAQRSWVQK VTGDHQETRR ENGEGGSCSP FPSPEPKDPS 300
CRHQPYFPDM DSSAVVKGTN SHVPDCHTKG SSFLGKELSL DEAFPDQQNG 350
SATNAWDQSS CSSPKWECTE LIHDIPLPEH RSNTMFISET EREIMTLGQE 400
NQTSSVSDDR VKLSVSGADT SVSSVDGPVS QKAVQNENSY QMEEDGSLKQ 450
SILSSELLDH PYCKSPLEAP LVCSGLKLEN QVGGGKNSQK ASPVDDEQLS 500
VCLSGFLDEV MKKYGSLVPL SEKEVLGRLK DVFNEDFSNR KPFINREITN 550
YRARHQKCNF RIFYNKHMLD MDDLATLDGQ NWLNDQVINM YGELIMDAVP 600
DKVHFFNSFF HRQLVTKGYN GVKRWTKKVD LFKKSLLLIP IHLEVHWSLI 650
TVTLSNRIIS FYDSQGIHFK FCVENIRKYL LTEAREKNRP EFLQGWQTAV 700
TKCIPQQKND SDCGVFVLQY CKCLALEQPF QFSQEDMPRV RKRIYKELCE 750
CRLMD 755
Length:755
Mass (Da):86,693
Last modified:May 18, 2010 - v3
Checksum:i90D7B34B2853CEE4
GO

Sequence cautioni

The sequence AAK69630.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831N → S.
Corresponds to variant rs35434690 [ dbSNP | Ensembl ].
VAR_057045
Natural varianti340 – 3401L → F.
Corresponds to variant rs34251880 [ dbSNP | Ensembl ].
VAR_061732

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751P → H in AAH30705. 1 Publication
Sequence conflicti538 – 5381S → C in AAK69630. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC011322 Genomic DNA. No translation available.
AC016949 Genomic DNA. No translation available.
AC127904 Genomic DNA. No translation available.
BC008589 mRNA. Translation: AAH08589.1.
BC030705 mRNA. Translation: AAH30705.1.
AF335474 mRNA. Translation: AAK69630.1. Different initiation.
CCDSiCCDS3322.1.
RefSeqiNP_689912.2. NM_152699.4.
UniGeneiHs.240770.

Genome annotation databases

EnsembliENST00000323460; ENSP00000327197; ENSG00000119231.
GeneIDi205564.
KEGGihsa:205564.
UCSCiuc003fwz.4. human.

Polymorphism databases

DMDMi296452962.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC011322 Genomic DNA. No translation available.
AC016949 Genomic DNA. No translation available.
AC127904 Genomic DNA. No translation available.
BC008589 mRNA. Translation: AAH08589.1 .
BC030705 mRNA. Translation: AAH30705.1 .
AF335474 mRNA. Translation: AAK69630.1 . Different initiation.
CCDSi CCDS3322.1.
RefSeqi NP_689912.2. NM_152699.4.
UniGenei Hs.240770.

3D structure databases

ProteinModelPortali Q96HI0.
SMRi Q96HI0. Positions 515-754.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128497. 2 interactions.
IntActi Q96HI0. 1 interaction.
STRINGi 9606.ENSP00000327197.

Protein family/group databases

MEROPSi C48.008.

PTM databases

PhosphoSitei Q96HI0.

Polymorphism databases

DMDMi 296452962.

Proteomic databases

MaxQBi Q96HI0.
PaxDbi Q96HI0.
PRIDEi Q96HI0.

Protocols and materials databases

DNASUi 205564.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323460 ; ENSP00000327197 ; ENSG00000119231 .
GeneIDi 205564.
KEGGi hsa:205564.
UCSCi uc003fwz.4. human.

Organism-specific databases

CTDi 205564.
GeneCardsi GC03P196594.
H-InvDB HIX0018042.
HGNCi HGNC:28407. SENP5.
HPAi HPA055536.
MIMi 612845. gene.
neXtProti NX_Q96HI0.
PharmGKBi PA134917083.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5160.
HOGENOMi HOG000070166.
HOVERGENi HBG062231.
InParanoidi Q96HI0.
KOi K08594.
OMAi AFPDQQN.
OrthoDBi EOG7D59MP.
PhylomeDBi Q96HI0.
TreeFami TF316289.

Enzyme and pathway databases

BRENDAi 3.4.22.68. 2681.
Reactomei REACT_163725. SUMO is proteolytically processed.

Miscellaneous databases

ChiTaRSi SENP5. human.
GenomeRNAii 205564.
NextBioi 90512.
PROi Q96HI0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96HI0.
Bgeei Q96HI0.
CleanExi HS_SENP5.
Genevestigatori Q96HI0.

Family and domain databases

InterProi IPR003653. Peptidase_C48.
[Graphical view ]
Pfami PF02902. Peptidase_C48. 1 hit.
[Graphical view ]
PROSITEi PS50600. ULP_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Testis.
  3. "Identification of FKSG45, a novel gene located on human chromosome 3."
    Wang Y.-G., Li T.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 305-755.
  4. "Ubiquitin-like proteins: new wines in new bottles."
    Yeh E.T.H., Gong L., Kamitani T.
    Gene 248:1-14(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  5. "Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3."
    Gong L., Yeh E.T.H.
    J. Biol. Chem. 281:15869-15877(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-713.
  6. "The SUMO-specific protease SENP5 is required for cell division."
    Di Bacco A., Ouyang J., Lee H.-Y., Catic A., Ploegh H., Gill G.
    Mol. Cell. Biol. 26:4489-4498(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-713.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiSENP5_HUMAN
AccessioniPrimary (citable) accession number: Q96HI0
Secondary accession number(s): Q96SA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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