ID   TMM19_HUMAN             Reviewed;         336 AA.
AC   Q96HH6; B2RDL2; Q53FY3; Q9NV41;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 138.
DE   RecName: Full=Transmembrane protein 19;
GN   Name=TMEM19;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Ovarian carcinoma, and Placenta;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lung;
RA   Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA   Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q96HH6; Q6Q788: APOA5; NbExp=3; IntAct=EBI-741829, EBI-3936819;
CC       Q96HH6; Q13520: AQP6; NbExp=3; IntAct=EBI-741829, EBI-13059134;
CC       Q96HH6; J3KQ12: BSCL2; NbExp=6; IntAct=EBI-741829, EBI-11532900;
CC       Q96HH6; Q96G97: BSCL2; NbExp=4; IntAct=EBI-741829, EBI-741806;
CC       Q96HH6; Q96G97-4: BSCL2; NbExp=4; IntAct=EBI-741829, EBI-10178113;
CC       Q96HH6; Q8IYJ2-2: C10orf67; NbExp=3; IntAct=EBI-741829, EBI-13381098;
CC       Q96HH6; P09693: CD3G; NbExp=3; IntAct=EBI-741829, EBI-3862428;
CC       Q96HH6; P11912: CD79A; NbExp=3; IntAct=EBI-741829, EBI-7797864;
CC       Q96HH6; P34972: CNR2; NbExp=3; IntAct=EBI-741829, EBI-2835940;
CC       Q96HH6; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-741829, EBI-18013275;
CC       Q96HH6; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-741829, EBI-6942903;
CC       Q96HH6; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-741829, EBI-18535450;
CC       Q96HH6; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-741829, EBI-18938272;
CC       Q96HH6; P08034: GJB1; NbExp=3; IntAct=EBI-741829, EBI-17565645;
CC       Q96HH6; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-741829, EBI-3917143;
CC       Q96HH6; O15529: GPR42; NbExp=3; IntAct=EBI-741829, EBI-18076404;
CC       Q96HH6; Q9NZD1: GPRC5D; NbExp=3; IntAct=EBI-741829, EBI-13067820;
CC       Q96HH6; Q8TED1: GPX8; NbExp=3; IntAct=EBI-741829, EBI-11721746;
CC       Q96HH6; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-741829, EBI-18053395;
CC       Q96HH6; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-741829, EBI-749265;
CC       Q96HH6; Q96B96: LDAF1; NbExp=3; IntAct=EBI-741829, EBI-7055862;
CC       Q96HH6; O95214: LEPROTL1; NbExp=3; IntAct=EBI-741829, EBI-750776;
CC       Q96HH6; Q16553: LY6E; NbExp=3; IntAct=EBI-741829, EBI-18234679;
CC       Q96HH6; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-741829, EBI-373355;
CC       Q96HH6; O15173: PGRMC2; NbExp=3; IntAct=EBI-741829, EBI-1050125;
CC       Q96HH6; P57054: PIGP; NbExp=3; IntAct=EBI-741829, EBI-17630288;
CC       Q96HH6; O14684: PTGES; NbExp=3; IntAct=EBI-741829, EBI-11161398;
CC       Q96HH6; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-741829, EBI-7545592;
CC       Q96HH6; Q96GF1: RNF185; NbExp=3; IntAct=EBI-741829, EBI-2340249;
CC       Q96HH6; A2A2V5: SERTM1; NbExp=3; IntAct=EBI-741829, EBI-17284533;
CC       Q96HH6; P30825: SLC7A1; NbExp=3; IntAct=EBI-741829, EBI-4289564;
CC       Q96HH6; Q92537: SUSD6; NbExp=3; IntAct=EBI-741829, EBI-2866213;
CC       Q96HH6; Q8N6K0: TEX29; NbExp=3; IntAct=EBI-741829, EBI-19027521;
CC       Q96HH6; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-741829, EBI-12947623;
CC       Q96HH6; Q8IV31: TMEM139; NbExp=3; IntAct=EBI-741829, EBI-7238458;
CC       Q96HH6; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-741829, EBI-8638294;
CC       Q96HH6; Q9NWC5: TMEM45A; NbExp=3; IntAct=EBI-741829, EBI-10823938;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q96HH6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96HH6-2; Sequence=VSP_024659, VSP_024660;
CC   -!- SIMILARITY: Belongs to the TMEM19 family. {ECO:0000305}.
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DR   EMBL; AK001798; BAA91918.1; -; mRNA.
DR   EMBL; AK223148; BAD96868.1; -; mRNA.
DR   EMBL; AK315587; BAG37959.1; -; mRNA.
DR   EMBL; CH471054; EAW97266.1; -; Genomic_DNA.
DR   EMBL; BC008596; AAH08596.1; -; mRNA.
DR   CCDS; CCDS9002.1; -. [Q96HH6-1]
DR   RefSeq; NP_060749.2; NM_018279.3. [Q96HH6-1]
DR   AlphaFoldDB; Q96HH6; -.
DR   BioGRID; 120555; 42.
DR   IntAct; Q96HH6; 38.
DR   MINT; Q96HH6; -.
DR   STRING; 9606.ENSP00000266673; -.
DR   iPTMnet; Q96HH6; -.
DR   PhosphoSitePlus; Q96HH6; -.
DR   BioMuta; TMEM19; -.
DR   DMDM; 74731932; -.
DR   MassIVE; Q96HH6; -.
DR   MaxQB; Q96HH6; -.
DR   PaxDb; 9606-ENSP00000266673; -.
DR   PeptideAtlas; Q96HH6; -.
DR   ProteomicsDB; 76747; -. [Q96HH6-1]
DR   ProteomicsDB; 76748; -. [Q96HH6-2]
DR   Pumba; Q96HH6; -.
DR   Antibodypedia; 17095; 41 antibodies from 11 providers.
DR   DNASU; 55266; -.
DR   Ensembl; ENST00000266673.10; ENSP00000266673.5; ENSG00000139291.14. [Q96HH6-1]
DR   Ensembl; ENST00000549735.5; ENSP00000449955.1; ENSG00000139291.14. [Q96HH6-2]
DR   GeneID; 55266; -.
DR   KEGG; hsa:55266; -.
DR   MANE-Select; ENST00000266673.10; ENSP00000266673.5; NM_018279.4; NP_060749.2.
DR   UCSC; uc001sws.4; human. [Q96HH6-1]
DR   AGR; HGNC:25605; -.
DR   CTD; 55266; -.
DR   DisGeNET; 55266; -.
DR   GeneCards; TMEM19; -.
DR   HGNC; HGNC:25605; TMEM19.
DR   HPA; ENSG00000139291; Low tissue specificity.
DR   neXtProt; NX_Q96HH6; -.
DR   OpenTargets; ENSG00000139291; -.
DR   PharmGKB; PA134909388; -.
DR   VEuPathDB; HostDB:ENSG00000139291; -.
DR   eggNOG; KOG4491; Eukaryota.
DR   GeneTree; ENSGT00390000017998; -.
DR   HOGENOM; CLU_036918_3_1_1; -.
DR   InParanoid; Q96HH6; -.
DR   OMA; GAFACCN; -.
DR   OrthoDB; 45876at2759; -.
DR   PhylomeDB; Q96HH6; -.
DR   TreeFam; TF300063; -.
DR   PathwayCommons; Q96HH6; -.
DR   SignaLink; Q96HH6; -.
DR   BioGRID-ORCS; 55266; 9 hits in 1157 CRISPR screens.
DR   GenomeRNAi; 55266; -.
DR   Pharos; Q96HH6; Tdark.
DR   PRO; PR:Q96HH6; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q96HH6; Protein.
DR   Bgee; ENSG00000139291; Expressed in ileal mucosa and 186 other cell types or tissues.
DR   ExpressionAtlas; Q96HH6; baseline and differential.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   InterPro; IPR002794; DUF92_TMEM19.
DR   PANTHER; PTHR13353; TRANSMEMBRANE PROTEIN 19; 1.
DR   PANTHER; PTHR13353:SF5; TRANSMEMBRANE PROTEIN 19; 1.
DR   Pfam; PF01940; DUF92; 1.
DR   Genevisible; Q96HH6; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..336
FT                   /note="Transmembrane protein 19"
FT                   /id="PRO_0000284794"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         284..298
FT                   /note="LDESTGMVVNSPTNK -> KNIPSFLQLIGMLKK (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_024659"
FT   VAR_SEQ         299..336
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_024660"
FT   CONFLICT        58
FT                   /note="V -> A (in Ref. 1; BAA91918)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        58
FT                   /note="V -> L (in Ref. 2; BAD96868)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        178
FT                   /note="A -> V (in Ref. 2; BAD96868)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   336 AA;  36392 MW;  95DCD6FAEED621E6 CRC64;
     MTDLNDNICK RYIKMITNIV ILSLIICISL AFWIISMTAS TYYGNLRPIS PWRWLFSVVV
     PVLIVSNGLK KKSLDHSGAL GGLVVGFILT IANFSFFTSL LMFFLSSSKL TKWKGEVKKR
     LDSEYKEGGQ RNWVQVFCNG AVPTELALLY MIENGPGEIP VDFSKQYSAS WMCLSLLAAL
     ACSAGDTWAS EVGPVLSKSS PRLITTWEKV PVGTNGGVTV VGLVSSLLGG TFVGIAYFLT
     QLIFVNDLDI SAPQWPIIAF GGLAGLLGSI VDSYLGATMQ YTGLDESTGM VVNSPTNKAR
     HIAGKPILDN NAVNLFSSVL IALLLPTAAW GFWPRG
//