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Q96HH6 (TMM19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 19
Gene names
Name:TMEM19
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMEM19 family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96HH6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96HH6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     284-298: LDESTGMVVNSPTNK → KNIPSFLQLIGMLKK
     299-336: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 336336Transmembrane protein 19
PRO_0000284794

Regions

Transmembrane15 – 3521Helical; Potential
Transmembrane49 – 6921Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane218 – 23821Helical; Potential
Transmembrane257 – 27721Helical; Potential
Transmembrane313 – 33321Helical; Potential

Natural variations

Alternative sequence284 – 29815LDEST…SPTNK → KNIPSFLQLIGMLKK in isoform 2.
VSP_024659
Alternative sequence299 – 33638Missing in isoform 2.
VSP_024660

Experimental info

Sequence conflict581V → A in BAA91918. Ref.1
Sequence conflict581V → L in BAD96868. Ref.2
Sequence conflict1781A → V in BAD96868. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 95DCD6FAEED621E6

FASTA33636,392
        10         20         30         40         50         60 
MTDLNDNICK RYIKMITNIV ILSLIICISL AFWIISMTAS TYYGNLRPIS PWRWLFSVVV 

        70         80         90        100        110        120 
PVLIVSNGLK KKSLDHSGAL GGLVVGFILT IANFSFFTSL LMFFLSSSKL TKWKGEVKKR 

       130        140        150        160        170        180 
LDSEYKEGGQ RNWVQVFCNG AVPTELALLY MIENGPGEIP VDFSKQYSAS WMCLSLLAAL 

       190        200        210        220        230        240 
ACSAGDTWAS EVGPVLSKSS PRLITTWEKV PVGTNGGVTV VGLVSSLLGG TFVGIAYFLT 

       250        260        270        280        290        300 
QLIFVNDLDI SAPQWPIIAF GGLAGLLGSI VDSYLGATMQ YTGLDESTGM VVNSPTNKAR 

       310        320        330 
HIAGKPILDN NAVNLFSSVL IALLLPTAAW GFWPRG 

« Hide

Isoform 2 [UniParc].

Checksum: DD96D0080BC4AC1A
Show »

FASTA29832,447

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Ovarian carcinoma and Placenta.
[2]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK001798 mRNA. Translation: BAA91918.1.
AK223148 mRNA. Translation: BAD96868.1.
AK315587 mRNA. Translation: BAG37959.1.
CH471054 Genomic DNA. Translation: EAW97266.1.
BC008596 mRNA. Translation: AAH08596.1.
RefSeqNP_060749.2. NM_018279.3.
UniGeneHs.644802.

3D structure databases

ProteinModelPortalQ96HH6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120555. 3 interactions.
IntActQ96HH6. 2 interactions.
MINTMINT-1452520.
STRING9606.ENSP00000266673.

PTM databases

PhosphoSiteQ96HH6.

Polymorphism databases

DMDM74731932.

Proteomic databases

PaxDbQ96HH6.
PRIDEQ96HH6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266673; ENSP00000266673; ENSG00000139291. [Q96HH6-1]
ENST00000549735; ENSP00000449955; ENSG00000139291. [Q96HH6-2]
GeneID55266.
KEGGhsa:55266.
UCSCuc001swr.2. human. [Q96HH6-2]
uc001sws.3. human. [Q96HH6-1]

Organism-specific databases

CTD55266.
GeneCardsGC12P072079.
HGNCHGNC:25605. TMEM19.
HPAHPA016830.
neXtProtNX_Q96HH6.
PharmGKBPA134909388.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG129154.
HOGENOMHOG000167218.
HOVERGENHBG057658.
InParanoidQ96HH6.
OMARVPRGTN.
OrthoDBEOG786H3Z.
PhylomeDBQ96HH6.
TreeFamTF300063.

Gene expression databases

ArrayExpressQ96HH6.
BgeeQ96HH6.
CleanExHS_TMEM19.
GenevestigatorQ96HH6.

Family and domain databases

InterProIPR002794. DUF92_TMEM19.
[Graphical view]
PANTHERPTHR13353. PTHR13353. 1 hit.
PfamPF01940. DUF92. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi55266.
NextBio59368.
PROQ96HH6.

Entry information

Entry nameTMM19_HUMAN
AccessionPrimary (citable) accession number: Q96HH6
Secondary accession number(s): B2RDL2, Q53FY3, Q9NV41
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM