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Protein

Transmembrane protein 19

Gene

TMEM19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 19
Gene namesi
Name:TMEM19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:25605. TMEM19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521HelicalSequence AnalysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence AnalysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence AnalysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Transmembranei313 – 33321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909388.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Transmembrane protein 19PRO_0000284794Add
BLAST

Proteomic databases

MaxQBiQ96HH6.
PaxDbiQ96HH6.
PRIDEiQ96HH6.

PTM databases

PhosphoSiteiQ96HH6.

Expressioni

Gene expression databases

BgeeiQ96HH6.
CleanExiHS_TMEM19.
ExpressionAtlasiQ96HH6. baseline and differential.
GenevestigatoriQ96HH6.

Organism-specific databases

HPAiHPA016830.

Interactioni

Protein-protein interaction databases

BioGridi120555. 2 interactions.
IntActiQ96HH6. 2 interactions.
MINTiMINT-1452520.
STRINGi9606.ENSP00000266673.

Structurei

3D structure databases

ProteinModelPortaliQ96HH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM19 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG129154.
GeneTreeiENSGT00390000017998.
HOGENOMiHOG000167218.
HOVERGENiHBG057658.
InParanoidiQ96HH6.
OMAiQPISPWR.
OrthoDBiEOG786H3Z.
PhylomeDBiQ96HH6.
TreeFamiTF300063.

Family and domain databases

InterProiIPR002794. DUF92_TMEM19.
[Graphical view]
PANTHERiPTHR13353. PTHR13353. 1 hit.
PfamiPF01940. DUF92. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96HH6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDLNDNICK RYIKMITNIV ILSLIICISL AFWIISMTAS TYYGNLRPIS
60 70 80 90 100
PWRWLFSVVV PVLIVSNGLK KKSLDHSGAL GGLVVGFILT IANFSFFTSL
110 120 130 140 150
LMFFLSSSKL TKWKGEVKKR LDSEYKEGGQ RNWVQVFCNG AVPTELALLY
160 170 180 190 200
MIENGPGEIP VDFSKQYSAS WMCLSLLAAL ACSAGDTWAS EVGPVLSKSS
210 220 230 240 250
PRLITTWEKV PVGTNGGVTV VGLVSSLLGG TFVGIAYFLT QLIFVNDLDI
260 270 280 290 300
SAPQWPIIAF GGLAGLLGSI VDSYLGATMQ YTGLDESTGM VVNSPTNKAR
310 320 330
HIAGKPILDN NAVNLFSSVL IALLLPTAAW GFWPRG
Length:336
Mass (Da):36,392
Last modified:December 1, 2001 - v1
Checksum:i95DCD6FAEED621E6
GO
Isoform 2 (identifier: Q96HH6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     284-298: LDESTGMVVNSPTNK → KNIPSFLQLIGMLKK
     299-336: Missing.

Note: No experimental confirmation available.

Show »
Length:298
Mass (Da):32,447
Checksum:iDD96D0080BC4AC1A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581V → A in BAA91918. (PubMed:14702039)Curated
Sequence conflicti58 – 581V → L in BAD96868. 1 PublicationCurated
Sequence conflicti178 – 1781A → V in BAD96868. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei284 – 29815LDEST…SPTNK → KNIPSFLQLIGMLKK in isoform 2. 1 PublicationVSP_024659Add
BLAST
Alternative sequencei299 – 33638Missing in isoform 2. 1 PublicationVSP_024660Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001798 mRNA. Translation: BAA91918.1.
AK223148 mRNA. Translation: BAD96868.1.
AK315587 mRNA. Translation: BAG37959.1.
CH471054 Genomic DNA. Translation: EAW97266.1.
BC008596 mRNA. Translation: AAH08596.1.
CCDSiCCDS9002.1. [Q96HH6-1]
RefSeqiNP_060749.2. NM_018279.3. [Q96HH6-1]
UniGeneiHs.644802.

Genome annotation databases

EnsembliENST00000266673; ENSP00000266673; ENSG00000139291. [Q96HH6-1]
ENST00000549735; ENSP00000449955; ENSG00000139291. [Q96HH6-2]
GeneIDi55266.
KEGGihsa:55266.
UCSCiuc001swr.2. human. [Q96HH6-2]
uc001sws.3. human. [Q96HH6-1]

Polymorphism databases

DMDMi74731932.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001798 mRNA. Translation: BAA91918.1.
AK223148 mRNA. Translation: BAD96868.1.
AK315587 mRNA. Translation: BAG37959.1.
CH471054 Genomic DNA. Translation: EAW97266.1.
BC008596 mRNA. Translation: AAH08596.1.
CCDSiCCDS9002.1. [Q96HH6-1]
RefSeqiNP_060749.2. NM_018279.3. [Q96HH6-1]
UniGeneiHs.644802.

3D structure databases

ProteinModelPortaliQ96HH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120555. 2 interactions.
IntActiQ96HH6. 2 interactions.
MINTiMINT-1452520.
STRINGi9606.ENSP00000266673.

PTM databases

PhosphoSiteiQ96HH6.

Polymorphism databases

DMDMi74731932.

Proteomic databases

MaxQBiQ96HH6.
PaxDbiQ96HH6.
PRIDEiQ96HH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266673; ENSP00000266673; ENSG00000139291. [Q96HH6-1]
ENST00000549735; ENSP00000449955; ENSG00000139291. [Q96HH6-2]
GeneIDi55266.
KEGGihsa:55266.
UCSCiuc001swr.2. human. [Q96HH6-2]
uc001sws.3. human. [Q96HH6-1]

Organism-specific databases

CTDi55266.
GeneCardsiGC12P072079.
HGNCiHGNC:25605. TMEM19.
HPAiHPA016830.
neXtProtiNX_Q96HH6.
PharmGKBiPA134909388.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG129154.
GeneTreeiENSGT00390000017998.
HOGENOMiHOG000167218.
HOVERGENiHBG057658.
InParanoidiQ96HH6.
OMAiQPISPWR.
OrthoDBiEOG786H3Z.
PhylomeDBiQ96HH6.
TreeFamiTF300063.

Miscellaneous databases

GenomeRNAii55266.
NextBioi59368.
PROiQ96HH6.

Gene expression databases

BgeeiQ96HH6.
CleanExiHS_TMEM19.
ExpressionAtlasiQ96HH6. baseline and differential.
GenevestigatoriQ96HH6.

Family and domain databases

InterProiIPR002794. DUF92_TMEM19.
[Graphical view]
PANTHERiPTHR13353. PTHR13353. 1 hit.
PfamiPF01940. DUF92. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Ovarian carcinoma and Placenta.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiTMM19_HUMAN
AccessioniPrimary (citable) accession number: Q96HH6
Secondary accession number(s): B2RDL2, Q53FY3, Q9NV41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.