Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96HH6

- TMM19_HUMAN

UniProt

Q96HH6 - TMM19_HUMAN

Protein

Transmembrane protein 19

Gene

TMEM19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 19
    Gene namesi
    Name:TMEM19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:25605. TMEM19.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134909388.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 336336Transmembrane protein 19PRO_0000284794Add
    BLAST

    Proteomic databases

    MaxQBiQ96HH6.
    PaxDbiQ96HH6.
    PRIDEiQ96HH6.

    PTM databases

    PhosphoSiteiQ96HH6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96HH6.
    BgeeiQ96HH6.
    CleanExiHS_TMEM19.
    GenevestigatoriQ96HH6.

    Organism-specific databases

    HPAiHPA016830.

    Interactioni

    Protein-protein interaction databases

    BioGridi120555. 3 interactions.
    IntActiQ96HH6. 2 interactions.
    MINTiMINT-1452520.
    STRINGi9606.ENSP00000266673.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96HH6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei49 – 6921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei313 – 33321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM19 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG129154.
    HOGENOMiHOG000167218.
    HOVERGENiHBG057658.
    InParanoidiQ96HH6.
    OMAiRVPRGTN.
    OrthoDBiEOG786H3Z.
    PhylomeDBiQ96HH6.
    TreeFamiTF300063.

    Family and domain databases

    InterProiIPR002794. DUF92_TMEM19.
    [Graphical view]
    PANTHERiPTHR13353. PTHR13353. 1 hit.
    PfamiPF01940. DUF92. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96HH6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTDLNDNICK RYIKMITNIV ILSLIICISL AFWIISMTAS TYYGNLRPIS    50
    PWRWLFSVVV PVLIVSNGLK KKSLDHSGAL GGLVVGFILT IANFSFFTSL 100
    LMFFLSSSKL TKWKGEVKKR LDSEYKEGGQ RNWVQVFCNG AVPTELALLY 150
    MIENGPGEIP VDFSKQYSAS WMCLSLLAAL ACSAGDTWAS EVGPVLSKSS 200
    PRLITTWEKV PVGTNGGVTV VGLVSSLLGG TFVGIAYFLT QLIFVNDLDI 250
    SAPQWPIIAF GGLAGLLGSI VDSYLGATMQ YTGLDESTGM VVNSPTNKAR 300
    HIAGKPILDN NAVNLFSSVL IALLLPTAAW GFWPRG 336
    Length:336
    Mass (Da):36,392
    Last modified:December 1, 2001 - v1
    Checksum:i95DCD6FAEED621E6
    GO
    Isoform 2 (identifier: Q96HH6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         284-298: LDESTGMVVNSPTNK → KNIPSFLQLIGMLKK
         299-336: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:298
    Mass (Da):32,447
    Checksum:iDD96D0080BC4AC1A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581V → A in BAA91918. (PubMed:14702039)Curated
    Sequence conflicti58 – 581V → L in BAD96868. 1 PublicationCurated
    Sequence conflicti178 – 1781A → V in BAD96868. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei284 – 29815LDEST…SPTNK → KNIPSFLQLIGMLKK in isoform 2. 1 PublicationVSP_024659Add
    BLAST
    Alternative sequencei299 – 33638Missing in isoform 2. 1 PublicationVSP_024660Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001798 mRNA. Translation: BAA91918.1.
    AK223148 mRNA. Translation: BAD96868.1.
    AK315587 mRNA. Translation: BAG37959.1.
    CH471054 Genomic DNA. Translation: EAW97266.1.
    BC008596 mRNA. Translation: AAH08596.1.
    CCDSiCCDS9002.1. [Q96HH6-1]
    RefSeqiNP_060749.2. NM_018279.3. [Q96HH6-1]
    UniGeneiHs.644802.

    Genome annotation databases

    EnsembliENST00000266673; ENSP00000266673; ENSG00000139291. [Q96HH6-1]
    ENST00000549735; ENSP00000449955; ENSG00000139291. [Q96HH6-2]
    GeneIDi55266.
    KEGGihsa:55266.
    UCSCiuc001swr.2. human. [Q96HH6-2]
    uc001sws.3. human. [Q96HH6-1]

    Polymorphism databases

    DMDMi74731932.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001798 mRNA. Translation: BAA91918.1 .
    AK223148 mRNA. Translation: BAD96868.1 .
    AK315587 mRNA. Translation: BAG37959.1 .
    CH471054 Genomic DNA. Translation: EAW97266.1 .
    BC008596 mRNA. Translation: AAH08596.1 .
    CCDSi CCDS9002.1. [Q96HH6-1 ]
    RefSeqi NP_060749.2. NM_018279.3. [Q96HH6-1 ]
    UniGenei Hs.644802.

    3D structure databases

    ProteinModelPortali Q96HH6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120555. 3 interactions.
    IntActi Q96HH6. 2 interactions.
    MINTi MINT-1452520.
    STRINGi 9606.ENSP00000266673.

    PTM databases

    PhosphoSitei Q96HH6.

    Polymorphism databases

    DMDMi 74731932.

    Proteomic databases

    MaxQBi Q96HH6.
    PaxDbi Q96HH6.
    PRIDEi Q96HH6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266673 ; ENSP00000266673 ; ENSG00000139291 . [Q96HH6-1 ]
    ENST00000549735 ; ENSP00000449955 ; ENSG00000139291 . [Q96HH6-2 ]
    GeneIDi 55266.
    KEGGi hsa:55266.
    UCSCi uc001swr.2. human. [Q96HH6-2 ]
    uc001sws.3. human. [Q96HH6-1 ]

    Organism-specific databases

    CTDi 55266.
    GeneCardsi GC12P072079.
    HGNCi HGNC:25605. TMEM19.
    HPAi HPA016830.
    neXtProti NX_Q96HH6.
    PharmGKBi PA134909388.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG129154.
    HOGENOMi HOG000167218.
    HOVERGENi HBG057658.
    InParanoidi Q96HH6.
    OMAi RVPRGTN.
    OrthoDBi EOG786H3Z.
    PhylomeDBi Q96HH6.
    TreeFami TF300063.

    Miscellaneous databases

    GenomeRNAii 55266.
    NextBioi 59368.
    PROi Q96HH6.

    Gene expression databases

    ArrayExpressi Q96HH6.
    Bgeei Q96HH6.
    CleanExi HS_TMEM19.
    Genevestigatori Q96HH6.

    Family and domain databases

    InterProi IPR002794. DUF92_TMEM19.
    [Graphical view ]
    PANTHERi PTHR13353. PTHR13353. 1 hit.
    Pfami PF01940. DUF92. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Ovarian carcinoma and Placenta.
    2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiTMM19_HUMAN
    AccessioniPrimary (citable) accession number: Q96HH6
    Secondary accession number(s): B2RDL2, Q53FY3, Q9NV41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3