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Protein

Transmembrane protein 19

Gene

TMEM19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 19
Gene namesi
Name:TMEM19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139291.13
HGNCiHGNC:25605 TMEM19
neXtProtiNX_Q96HH6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139291
PharmGKBiPA134909388

Polymorphism and mutation databases

BioMutaiTMEM19
DMDMi74731932

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002847941 – 336Transmembrane protein 19Add BLAST336

Proteomic databases

MaxQBiQ96HH6
PaxDbiQ96HH6
PeptideAtlasiQ96HH6
PRIDEiQ96HH6

PTM databases

iPTMnetiQ96HH6
PhosphoSitePlusiQ96HH6

Expressioni

Gene expression databases

BgeeiENSG00000139291
CleanExiHS_TMEM19
ExpressionAtlasiQ96HH6 baseline and differential
GenevisibleiQ96HH6 HS

Organism-specific databases

HPAiHPA016830

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120555, 4 interactors
IntActiQ96HH6, 7 interactors
MINTiQ96HH6
STRINGi9606.ENSP00000266673

Structurei

3D structure databases

ProteinModelPortaliQ96HH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM19 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4491 Eukaryota
ENOG410XQMT LUCA
GeneTreeiENSGT00390000017998
HOGENOMiHOG000167218
HOVERGENiHBG057658
InParanoidiQ96HH6
OMAiFSKQYTA
OrthoDBiEOG091G0LMV
PhylomeDBiQ96HH6
TreeFamiTF300063

Family and domain databases

InterProiView protein in InterPro
IPR002794 DUF92_TMEM19
PANTHERiPTHR13353 PTHR13353, 1 hit
PfamiView protein in Pfam
PF01940 DUF92, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96HH6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDLNDNICK RYIKMITNIV ILSLIICISL AFWIISMTAS TYYGNLRPIS
60 70 80 90 100
PWRWLFSVVV PVLIVSNGLK KKSLDHSGAL GGLVVGFILT IANFSFFTSL
110 120 130 140 150
LMFFLSSSKL TKWKGEVKKR LDSEYKEGGQ RNWVQVFCNG AVPTELALLY
160 170 180 190 200
MIENGPGEIP VDFSKQYSAS WMCLSLLAAL ACSAGDTWAS EVGPVLSKSS
210 220 230 240 250
PRLITTWEKV PVGTNGGVTV VGLVSSLLGG TFVGIAYFLT QLIFVNDLDI
260 270 280 290 300
SAPQWPIIAF GGLAGLLGSI VDSYLGATMQ YTGLDESTGM VVNSPTNKAR
310 320 330
HIAGKPILDN NAVNLFSSVL IALLLPTAAW GFWPRG
Length:336
Mass (Da):36,392
Last modified:December 1, 2001 - v1
Checksum:i95DCD6FAEED621E6
GO
Isoform 2 (identifier: Q96HH6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     284-298: LDESTGMVVNSPTNK → KNIPSFLQLIGMLKK
     299-336: Missing.

Note: No experimental confirmation available.
Show »
Length:298
Mass (Da):32,447
Checksum:iDD96D0080BC4AC1A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58V → A in BAA91918 (PubMed:14702039).Curated1
Sequence conflicti58V → L in BAD96868 (Ref. 2) Curated1
Sequence conflicti178A → V in BAD96868 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024659284 – 298LDEST…SPTNK → KNIPSFLQLIGMLKK in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_024660299 – 336Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001798 mRNA Translation: BAA91918.1
AK223148 mRNA Translation: BAD96868.1
AK315587 mRNA Translation: BAG37959.1
CH471054 Genomic DNA Translation: EAW97266.1
BC008596 mRNA Translation: AAH08596.1
CCDSiCCDS9002.1 [Q96HH6-1]
RefSeqiNP_060749.2, NM_018279.3 [Q96HH6-1]
UniGeneiHs.644802

Genome annotation databases

EnsembliENST00000266673; ENSP00000266673; ENSG00000139291 [Q96HH6-1]
ENST00000549735; ENSP00000449955; ENSG00000139291 [Q96HH6-2]
GeneIDi55266
KEGGihsa:55266
UCSCiuc001sws.4 human [Q96HH6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTMM19_HUMAN
AccessioniPrimary (citable) accession number: Q96HH6
Secondary accession number(s): B2RDL2, Q53FY3, Q9NV41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health