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Q96HH6

- TMM19_HUMAN

UniProt

Q96HH6 - TMM19_HUMAN

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Protein

Transmembrane protein 19

Gene
TMEM19
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 19
Gene namesi
Name:TMEM19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:25605. TMEM19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Reviewed predictionAdd
BLAST
Transmembranei49 – 6921Helical; Reviewed predictionAdd
BLAST
Transmembranei84 – 10421Helical; Reviewed predictionAdd
BLAST
Transmembranei218 – 23821Helical; Reviewed predictionAdd
BLAST
Transmembranei257 – 27721Helical; Reviewed predictionAdd
BLAST
Transmembranei313 – 33321Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909388.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Transmembrane protein 19PRO_0000284794Add
BLAST

Proteomic databases

MaxQBiQ96HH6.
PaxDbiQ96HH6.
PRIDEiQ96HH6.

PTM databases

PhosphoSiteiQ96HH6.

Expressioni

Gene expression databases

ArrayExpressiQ96HH6.
BgeeiQ96HH6.
CleanExiHS_TMEM19.
GenevestigatoriQ96HH6.

Organism-specific databases

HPAiHPA016830.

Interactioni

Protein-protein interaction databases

BioGridi120555. 3 interactions.
IntActiQ96HH6. 2 interactions.
MINTiMINT-1452520.
STRINGi9606.ENSP00000266673.

Structurei

3D structure databases

ProteinModelPortaliQ96HH6.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM19 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG129154.
HOGENOMiHOG000167218.
HOVERGENiHBG057658.
InParanoidiQ96HH6.
OMAiRVPRGTN.
OrthoDBiEOG786H3Z.
PhylomeDBiQ96HH6.
TreeFamiTF300063.

Family and domain databases

InterProiIPR002794. DUF92_TMEM19.
[Graphical view]
PANTHERiPTHR13353. PTHR13353. 1 hit.
PfamiPF01940. DUF92. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96HH6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTDLNDNICK RYIKMITNIV ILSLIICISL AFWIISMTAS TYYGNLRPIS    50
PWRWLFSVVV PVLIVSNGLK KKSLDHSGAL GGLVVGFILT IANFSFFTSL 100
LMFFLSSSKL TKWKGEVKKR LDSEYKEGGQ RNWVQVFCNG AVPTELALLY 150
MIENGPGEIP VDFSKQYSAS WMCLSLLAAL ACSAGDTWAS EVGPVLSKSS 200
PRLITTWEKV PVGTNGGVTV VGLVSSLLGG TFVGIAYFLT QLIFVNDLDI 250
SAPQWPIIAF GGLAGLLGSI VDSYLGATMQ YTGLDESTGM VVNSPTNKAR 300
HIAGKPILDN NAVNLFSSVL IALLLPTAAW GFWPRG 336
Length:336
Mass (Da):36,392
Last modified:December 1, 2001 - v1
Checksum:i95DCD6FAEED621E6
GO
Isoform 2 (identifier: Q96HH6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     284-298: LDESTGMVVNSPTNK → KNIPSFLQLIGMLKK
     299-336: Missing.

Note: No experimental confirmation available.

Show »
Length:298
Mass (Da):32,447
Checksum:iDD96D0080BC4AC1A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei284 – 29815LDEST…SPTNK → KNIPSFLQLIGMLKK in isoform 2. VSP_024659Add
BLAST
Alternative sequencei299 – 33638Missing in isoform 2. VSP_024660Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581V → A in BAA91918. 1 Publication
Sequence conflicti58 – 581V → L in BAD96868. 1 Publication
Sequence conflicti178 – 1781A → V in BAD96868. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001798 mRNA. Translation: BAA91918.1.
AK223148 mRNA. Translation: BAD96868.1.
AK315587 mRNA. Translation: BAG37959.1.
CH471054 Genomic DNA. Translation: EAW97266.1.
BC008596 mRNA. Translation: AAH08596.1.
CCDSiCCDS9002.1. [Q96HH6-1]
RefSeqiNP_060749.2. NM_018279.3. [Q96HH6-1]
UniGeneiHs.644802.

Genome annotation databases

EnsembliENST00000266673; ENSP00000266673; ENSG00000139291. [Q96HH6-1]
ENST00000549735; ENSP00000449955; ENSG00000139291. [Q96HH6-2]
GeneIDi55266.
KEGGihsa:55266.
UCSCiuc001swr.2. human. [Q96HH6-2]
uc001sws.3. human. [Q96HH6-1]

Polymorphism databases

DMDMi74731932.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001798 mRNA. Translation: BAA91918.1 .
AK223148 mRNA. Translation: BAD96868.1 .
AK315587 mRNA. Translation: BAG37959.1 .
CH471054 Genomic DNA. Translation: EAW97266.1 .
BC008596 mRNA. Translation: AAH08596.1 .
CCDSi CCDS9002.1. [Q96HH6-1 ]
RefSeqi NP_060749.2. NM_018279.3. [Q96HH6-1 ]
UniGenei Hs.644802.

3D structure databases

ProteinModelPortali Q96HH6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120555. 3 interactions.
IntActi Q96HH6. 2 interactions.
MINTi MINT-1452520.
STRINGi 9606.ENSP00000266673.

PTM databases

PhosphoSitei Q96HH6.

Polymorphism databases

DMDMi 74731932.

Proteomic databases

MaxQBi Q96HH6.
PaxDbi Q96HH6.
PRIDEi Q96HH6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266673 ; ENSP00000266673 ; ENSG00000139291 . [Q96HH6-1 ]
ENST00000549735 ; ENSP00000449955 ; ENSG00000139291 . [Q96HH6-2 ]
GeneIDi 55266.
KEGGi hsa:55266.
UCSCi uc001swr.2. human. [Q96HH6-2 ]
uc001sws.3. human. [Q96HH6-1 ]

Organism-specific databases

CTDi 55266.
GeneCardsi GC12P072079.
HGNCi HGNC:25605. TMEM19.
HPAi HPA016830.
neXtProti NX_Q96HH6.
PharmGKBi PA134909388.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG129154.
HOGENOMi HOG000167218.
HOVERGENi HBG057658.
InParanoidi Q96HH6.
OMAi RVPRGTN.
OrthoDBi EOG786H3Z.
PhylomeDBi Q96HH6.
TreeFami TF300063.

Miscellaneous databases

GenomeRNAii 55266.
NextBioi 59368.
PROi Q96HH6.

Gene expression databases

ArrayExpressi Q96HH6.
Bgeei Q96HH6.
CleanExi HS_TMEM19.
Genevestigatori Q96HH6.

Family and domain databases

InterProi IPR002794. DUF92_TMEM19.
[Graphical view ]
PANTHERi PTHR13353. PTHR13353. 1 hit.
Pfami PF01940. DUF92. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Ovarian carcinoma and Placenta.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiTMM19_HUMAN
AccessioniPrimary (citable) accession number: Q96HH6
Secondary accession number(s): B2RDL2, Q53FY3, Q9NV41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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