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Reviewed, UniProtKB/Swiss-Prot Q96HF1 (SFRP2_HUMAN)

Last modified January 19, 2010. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Secreted frizzled-related protein 2
      Short name=sFRP-2
Alternative name(s):
    Secreted apoptosis-related protein 1
      Short name=SARP-1
    Frizzled-related protein 2
      Short name=FRP-2
Gene names
Name: SFRP2
Synonyms: FRP2, SARP1
ORF Names: FKSG12, UNQ361/PRO697
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon. Ref.1 Ref.7

Domain

The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similarities

Belongs to the secreted frizzled-related protein (sFRP) family.

Contains 1 FZ (frizzled) domain.

Contains 1 NTR domain.

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Ontologies

Keywords
   Biological processDifferentiation
Wnt signaling pathway
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processWnt receptor signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

cell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Ref.8
Chain25 – 295271Secreted frizzled-related protein 2
PRO_0000032542

Regions

Domain35 – 155121FZ
Domain172 – 295124NTR

Amino acid modifications

Modified residue2891Phosphoserine Ref.9
Disulfide bond40 ↔ 103 By similarity
Disulfide bond50 ↔ 96 By similarity
Disulfide bond87 ↔ 125 By similarity
Disulfide bond114 ↔ 152 By similarity
Disulfide bond118 ↔ 142 By similarity
Disulfide bond172 ↔ 245 By similarity
Disulfide bond175 ↔ 247 By similarity
Disulfide bond190 ↔ 295 By similarity

Natural variations

Natural variant451A → V: dbSNP rs4643790. Ref.3 Ref.6
VAR_051963

Experimental info

Sequence conflict132 – 1332Missing in AAB70792. Ref.7

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Sequences

Sequence LengthMass (Da)Tools
Q96HF1-1 [UniParc].

Last modified March 15, 2005. Version 2.
Checksum: 97597971541BFBC4

FASTA29533,490
        10         20         30         40         50         60 
MLQGPGSLLL LFLASHCCLG SARGLFLFGQ PDFSYKRSNC KPIPANLQLC HGIEYQNMRL 

        70         80         90        100        110        120 
PNLLGHETMK EVLEQAGAWI PLVMKQCHPD TKKFLCSLFA PVCLDDLDET IQPCHSLCVQ 

       130        140        150        160        170        180 
VKDRCAPVMS AFGFPWPDML ECDRFPQDND LCIPLASSDH LLPATEEAPK VCEACKNKND 

       190        200        210        220        230        240 
DDNDIMETLC KNDFALKIKV KEITYINRDT KIILETKSKT IYKLNGVSER DLKKSVLWLK 

       250        260        270        280        290 
DSLQCTCEEM NDINAPYLVM GQKQGGELVI TSVKRWQKGQ REFKRISRSI RKLQC

« Hide

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References

« Hide 'large scale' references
[1]"Tissue restricted expression of two human Frzbs in preadipocytes and pancreas."
Hu E., Zhu Y., Fredrickson T., Barnes M., Kelsell D., Beeley L., Brooks D.
Biochem. Biophys. Res. Commun. 247:287-293(1998) [PubMed: 9642118] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Characterization of FKSG12, a novel protein related to pancreas tumor."
Wang Y.-G.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-45.
[4]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-45.
Tissue: Eye.
[7]"SARPs: a family of secreted apoptosis-related proteins."
Melkonyan H.S., Chang W.C., Shapiro J.P., Mahadevappa M., Fitzpatrick P.A., Kiefer M.C., Tomei L.D., Umansky S.R.
Proc. Natl. Acad. Sci. U.S.A. 94:13636-13641(1997) [PubMed: 9391078] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-208, TISSUE SPECIFICITY.
[8]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-39.
[9]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289, MASS SPECTROMETRY.
Tissue: Epithelium.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF311912 mRNA. Translation: AAG24923.1.
AY359001 mRNA. Translation: AAQ89360.1.
AK075372 mRNA. Translation: BAG52124.1.
CH471056 Genomic DNA. Translation: EAX04949.1.
BC008666 mRNA. Translation: AAH08666.1.
AF017986 mRNA. Translation: AAB70792.1.
IPIIPI00027596.
PIRJE0174.
RefSeqNP_003004.1.
UniGeneHs.481022

3D structure databases

SMRQ96HF1. Positions 39-154.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ96HF1.

Proteomic databases

PRIDEQ96HF1.

Genome annotation databases

EnsemblENST00000274063; ENSP00000274063; ENSG00000145423; Homo sapiens. [Genome view]
GeneID6423.
KEGGhsa:6423.
UCSCuc003inv.1. human.

Organism-specific databases

CTD6423.
GeneCardsGC04M154921.
H-InvDBHIX0004583.
HGNCHGNC:10777. SFRP2.
HPAHPA002652.
MIM604157. gene.
PharmGKBPA35693.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG08093.
HOGENOMHBG713519.
HOVERGENQ96HF1.
InParanoidQ96HF1.
OMACKNKNED.
OrthoDBEOG9WWV46.
PhylomeDBQ96HF1.

Gene expression databases

ArrayExpressQ96HF1.
BgeeQ96HF1.
CleanExHS_SFRP2.
GenevestigatorQ96HF1.
GermOnlineENSG00000145423. Homo sapiens.

Family and domain databases

InterProIPR020067. Frizzled-like_dom.
IPR000024. Frizzled_Cys-rich.
IPR020068. Frizzled_dom_subgr.
IPR015526. Frizzled_related.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
Gene3DG3DSA:1.10.2000.10. Frizzled_Cys-rich. 1 hit.
PANTHERPTHR11309. Fz_related. 1 hit.
PfamPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
PROSITEPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio24943.
SOURCESearch...

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Entry information

Entry nameSFRP2_HUMAN
AccessionPrimary (citable) accession number: Q96HF1
Secondary accession number(s): B3KQR2, O14778, Q9HAP5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 19, 2010
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents