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Q96HF1

- SFRP2_HUMAN

UniProt

Q96HF1 - SFRP2_HUMAN

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Protein
Secreted frizzled-related protein 2
Gene
SFRP2, FRP2, SARP1, FKSG12, UNQ361/PRO697
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

GO - Molecular functioni

  1. PDZ domain binding Source: RefGenome
  2. Wnt-activated receptor activity Source: RefGenome
  3. Wnt-protein binding Source: RefGenome
  4. endopeptidase activator activity Source: Ensembl
  5. fibronectin binding Source: BHF-UCL
  6. integrin binding Source: BHF-UCL
  7. metalloenzyme activator activity Source: Ensembl
  8. receptor agonist activity Source: BHF-UCL

GO - Biological processi

  1. Wnt signaling pathway involved in somitogenesis Source: Ensembl
  2. bone morphogenesis Source: Ensembl
  3. brain development Source: RefGenome
  4. cardiac left ventricle morphogenesis Source: BHF-UCL
  5. cell-cell signaling Source: BHF-UCL
  6. cellular response to X-ray Source: Ensembl
  7. cellular response to extracellular stimulus Source: Ensembl
  8. chondrocyte development Source: Ensembl
  9. collagen fibril organization Source: Ensembl
  10. convergent extension involved in axis elongation Source: Ensembl
  11. digestive tract morphogenesis Source: Ensembl
  12. embryonic digit morphogenesis Source: Ensembl
  13. gonad development Source: RefGenome
  14. hematopoietic stem cell proliferation Source: UniProtKB
  15. male gonad development Source: Ensembl
  16. negative regulation of BMP signaling pathway Source: Ensembl
  17. negative regulation of JUN kinase activity Source: Ensembl
  18. negative regulation of Wnt signaling pathway Source: UniProtKB
  19. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  20. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
  21. negative regulation of cell growth Source: UniProtKB
  22. negative regulation of cell migration Source: UniProtKB
  23. negative regulation of cell proliferation Source: UniProtKB
  24. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  25. negative regulation of dermatome development Source: BHF-UCL
  26. negative regulation of epithelial cell proliferation Source: UniProtKB
  27. negative regulation of epithelial to mesenchymal transition Source: UniProtKB
  28. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  29. negative regulation of gene expression Source: UniProtKB
  30. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
  31. negative regulation of mesodermal cell fate specification Source: Ensembl
  32. negative regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  33. negative regulation of planar cell polarity pathway involved in axis elongation Source: Ensembl
  34. negative regulation of transcription, DNA-templated Source: UniProtKB
  35. neural tube closure Source: Ensembl
  36. outflow tract morphogenesis Source: BHF-UCL
  37. patterning of blood vessels Source: BHF-UCL
  38. planar cell polarity pathway involved in neural tube closure Source: Ensembl
  39. positive regulation of angiogenesis Source: BHF-UCL
  40. positive regulation of apoptotic process Source: BHF-UCL
  41. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  42. positive regulation of catenin import into nucleus Source: Ensembl
  43. positive regulation of cell adhesion mediated by integrin Source: BHF-UCL
  44. positive regulation of cell growth Source: UniProtKB
  45. positive regulation of cell proliferation Source: UniProtKB
  46. positive regulation of fat cell differentiation Source: MGI
  47. positive regulation of osteoblast differentiation Source: Ensembl
  48. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  49. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  50. post-anal tail morphogenesis Source: Ensembl
  51. regulation of stem cell division Source: UniProtKB
  52. response to drug Source: Ensembl
  53. response to nutrient Source: Ensembl
  54. sclerotome development Source: BHF-UCL
  55. vasculature development Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
SignaLinkiQ96HF1.

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 2
Short name:
FRP-2
Short name:
sFRP-2
Alternative name(s):
Secreted apoptosis-related protein 1
Short name:
SARP-1
Gene namesi
Name:SFRP2
Synonyms:FRP2, SARP1
ORF Names:FKSG12, UNQ361/PRO697
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:10777. SFRP2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. extracellular matrix Source: BHF-UCL
  3. extracellular space Source: UniProtKB
  4. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35693.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 Publication
Add
BLAST
Chaini25 – 295271Secreted frizzled-related protein 2
PRO_0000032542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 103 By similarity
Disulfide bondi50 ↔ 96 By similarity
Disulfide bondi87 ↔ 125 By similarity
Disulfide bondi114 ↔ 152 By similarity
Disulfide bondi118 ↔ 142 By similarity
Disulfide bondi172 ↔ 245 By similarity
Disulfide bondi175 ↔ 247 By similarity
Disulfide bondi190 ↔ 295 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96HF1.
PRIDEiQ96HF1.

PTM databases

PhosphoSiteiQ96HF1.

Expressioni

Tissue specificityi

Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.2 Publications

Gene expression databases

ArrayExpressiQ96HF1.
BgeeiQ96HF1.
CleanExiHS_SFRP2.
GenevestigatoriQ96HF1.

Organism-specific databases

HPAiHPA002652.

Interactioni

Protein-protein interaction databases

BioGridi112321. 1 interaction.
STRINGi9606.ENSP00000274063.

Structurei

3D structure databases

ProteinModelPortaliQ96HF1.
SMRiQ96HF1. Positions 49-150.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 155121FZ
Add
BLAST
Domaini172 – 295124NTR
Add
BLAST

Domaini

The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similaritiesi

Contains 1 NTR domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG240950.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiQ96HF1.
KOiK02176.
OMAiTSLKRWQ.
OrthoDBiEOG789CBZ.
PhylomeDBiQ96HF1.
TreeFamiTF350133.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026558. SFRP2.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF45. PTHR11309:SF45. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96HF1-1 [UniParc]FASTAAdd to Basket

« Hide

MLQGPGSLLL LFLASHCCLG SARGLFLFGQ PDFSYKRSNC KPIPANLQLC    50
HGIEYQNMRL PNLLGHETMK EVLEQAGAWI PLVMKQCHPD TKKFLCSLFA 100
PVCLDDLDET IQPCHSLCVQ VKDRCAPVMS AFGFPWPDML ECDRFPQDND 150
LCIPLASSDH LLPATEEAPK VCEACKNKND DDNDIMETLC KNDFALKIKV 200
KEITYINRDT KIILETKSKT IYKLNGVSER DLKKSVLWLK DSLQCTCEEM 250
NDINAPYLVM GQKQGGELVI TSVKRWQKGQ REFKRISRSI RKLQC 295
Length:295
Mass (Da):33,490
Last modified:March 15, 2005 - v2
Checksum:i97597971541BFBC4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451A → V.2 Publications
Corresponds to variant rs4643790 [ dbSNP | Ensembl ].
VAR_051963

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1332Missing in AAB70792. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF311912 mRNA. Translation: AAG24923.1.
AY359001 mRNA. Translation: AAQ89360.1.
AK075372 mRNA. Translation: BAG52124.1.
CH471056 Genomic DNA. Translation: EAX04949.1.
BC008666 mRNA. Translation: AAH08666.1.
AF017986 mRNA. Translation: AAB70792.1.
CCDSiCCDS34082.1.
PIRiJE0174.
RefSeqiNP_003004.1. NM_003013.2.
UniGeneiHs.481022.

Genome annotation databases

EnsembliENST00000274063; ENSP00000274063; ENSG00000145423.
GeneIDi6423.
KEGGihsa:6423.
UCSCiuc003inv.1. human.

Polymorphism databases

DMDMi61216828.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF311912 mRNA. Translation: AAG24923.1 .
AY359001 mRNA. Translation: AAQ89360.1 .
AK075372 mRNA. Translation: BAG52124.1 .
CH471056 Genomic DNA. Translation: EAX04949.1 .
BC008666 mRNA. Translation: AAH08666.1 .
AF017986 mRNA. Translation: AAB70792.1 .
CCDSi CCDS34082.1.
PIRi JE0174.
RefSeqi NP_003004.1. NM_003013.2.
UniGenei Hs.481022.

3D structure databases

ProteinModelPortali Q96HF1.
SMRi Q96HF1. Positions 49-150.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112321. 1 interaction.
STRINGi 9606.ENSP00000274063.

Protein family/group databases

MEROPSi I93.001.

PTM databases

PhosphoSitei Q96HF1.

Polymorphism databases

DMDMi 61216828.

Proteomic databases

PaxDbi Q96HF1.
PRIDEi Q96HF1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274063 ; ENSP00000274063 ; ENSG00000145423 .
GeneIDi 6423.
KEGGi hsa:6423.
UCSCi uc003inv.1. human.

Organism-specific databases

CTDi 6423.
GeneCardsi GC04M154701.
HGNCi HGNC:10777. SFRP2.
HPAi HPA002652.
MIMi 604157. gene.
neXtProti NX_Q96HF1.
PharmGKBi PA35693.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240950.
HOGENOMi HOG000231058.
HOVERGENi HBG052928.
InParanoidi Q96HF1.
KOi K02176.
OMAi TSLKRWQ.
OrthoDBi EOG789CBZ.
PhylomeDBi Q96HF1.
TreeFami TF350133.

Enzyme and pathway databases

Reactomei REACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
SignaLinki Q96HF1.

Miscellaneous databases

GeneWikii SFRP2.
GenomeRNAii 6423.
NextBioi 24943.
PROi Q96HF1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96HF1.
Bgeei Q96HF1.
CleanExi HS_SFRP2.
Genevestigatori Q96HF1.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026558. SFRP2.
IPR008993. TIMP-like_OB-fold.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF45. PTHR11309:SF45. 1 hit.
Pfami PF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view ]
SMARTi SM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tissue restricted expression of two human Frzbs in preadipocytes and pancreas."
    Hu E., Zhu Y., Fredrickson T., Barnes M., Kelsell D., Beeley L., Brooks D.
    Biochem. Biophys. Res. Commun. 247:287-293(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Characterization of FKSG12, a novel protein related to pancreas tumor."
    Wang Y.-G.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-45.
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-45.
    Tissue: Eye.
  7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-208, TISSUE SPECIFICITY.
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-39.

Entry informationi

Entry nameiSFRP2_HUMAN
AccessioniPrimary (citable) accession number: Q96HF1
Secondary accession number(s): B3KQR2, O14778, Q9HAP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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