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Q96HF1

- SFRP2_HUMAN

UniProt

Q96HF1 - SFRP2_HUMAN

Protein

Secreted frizzled-related protein 2

Gene

SFRP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

    GO - Molecular functioni

    1. endopeptidase activator activity Source: Ensembl
    2. fibronectin binding Source: BHF-UCL
    3. integrin binding Source: BHF-UCL
    4. metalloenzyme activator activity Source: Ensembl
    5. PDZ domain binding Source: RefGenome
    6. receptor agonist activity Source: BHF-UCL
    7. Wnt-activated receptor activity Source: RefGenome
    8. Wnt-protein binding Source: RefGenome

    GO - Biological processi

    1. bone morphogenesis Source: Ensembl
    2. brain development Source: RefGenome
    3. cardiac left ventricle morphogenesis Source: BHF-UCL
    4. cell-cell signaling Source: BHF-UCL
    5. cellular response to extracellular stimulus Source: Ensembl
    6. cellular response to X-ray Source: Ensembl
    7. chondrocyte development Source: Ensembl
    8. collagen fibril organization Source: Ensembl
    9. convergent extension involved in axis elongation Source: Ensembl
    10. digestive tract morphogenesis Source: Ensembl
    11. embryonic digit morphogenesis Source: Ensembl
    12. gonad development Source: RefGenome
    13. hematopoietic stem cell proliferation Source: UniProtKB
    14. male gonad development Source: Ensembl
    15. negative regulation of BMP signaling pathway Source: Ensembl
    16. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
    17. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
    18. negative regulation of cell growth Source: UniProtKB
    19. negative regulation of cell migration Source: UniProtKB
    20. negative regulation of cell proliferation Source: UniProtKB
    21. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    22. negative regulation of dermatome development Source: BHF-UCL
    23. negative regulation of epithelial cell proliferation Source: UniProtKB
    24. negative regulation of epithelial to mesenchymal transition Source: UniProtKB
    25. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    26. negative regulation of gene expression Source: UniProtKB
    27. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
    28. negative regulation of JUN kinase activity Source: Ensembl
    29. negative regulation of mesodermal cell fate specification Source: Ensembl
    30. negative regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
    31. negative regulation of planar cell polarity pathway involved in axis elongation Source: Ensembl
    32. negative regulation of transcription, DNA-templated Source: UniProtKB
    33. negative regulation of Wnt signaling pathway Source: UniProtKB
    34. neural tube closure Source: Ensembl
    35. outflow tract morphogenesis Source: BHF-UCL
    36. patterning of blood vessels Source: BHF-UCL
    37. planar cell polarity pathway involved in neural tube closure Source: Ensembl
    38. positive regulation of angiogenesis Source: BHF-UCL
    39. positive regulation of apoptotic process Source: BHF-UCL
    40. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
    41. positive regulation of catenin import into nucleus Source: Ensembl
    42. positive regulation of cell adhesion mediated by integrin Source: BHF-UCL
    43. positive regulation of cell growth Source: UniProtKB
    44. positive regulation of cell proliferation Source: UniProtKB
    45. positive regulation of fat cell differentiation Source: MGI
    46. positive regulation of osteoblast differentiation Source: Ensembl
    47. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
    48. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    49. post-anal tail morphogenesis Source: Ensembl
    50. regulation of stem cell division Source: UniProtKB
    51. response to drug Source: Ensembl
    52. response to nutrient Source: Ensembl
    53. sclerotome development Source: BHF-UCL
    54. vasculature development Source: RefGenome
    55. Wnt signaling pathway involved in somitogenesis Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
    SignaLinkiQ96HF1.

    Protein family/group databases

    MEROPSiI93.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secreted frizzled-related protein 2
    Short name:
    FRP-2
    Short name:
    sFRP-2
    Alternative name(s):
    Secreted apoptosis-related protein 1
    Short name:
    SARP-1
    Gene namesi
    Name:SFRP2
    Synonyms:FRP2, SARP1
    ORF Names:FKSG12, UNQ361/PRO697
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:10777. SFRP2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. extracellular matrix Source: BHF-UCL
    3. extracellular space Source: UniProtKB
    4. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35693.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24241 PublicationAdd
    BLAST
    Chaini25 – 295271Secreted frizzled-related protein 2PRO_0000032542Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi40 ↔ 103By similarity
    Disulfide bondi50 ↔ 96By similarity
    Disulfide bondi87 ↔ 125By similarity
    Disulfide bondi114 ↔ 152By similarity
    Disulfide bondi118 ↔ 142By similarity
    Disulfide bondi172 ↔ 245By similarity
    Disulfide bondi175 ↔ 247By similarity
    Disulfide bondi190 ↔ 295By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ96HF1.
    PRIDEiQ96HF1.

    PTM databases

    PhosphoSiteiQ96HF1.

    Expressioni

    Tissue specificityi

    Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.2 Publications

    Gene expression databases

    ArrayExpressiQ96HF1.
    BgeeiQ96HF1.
    CleanExiHS_SFRP2.
    GenevestigatoriQ96HF1.

    Organism-specific databases

    HPAiHPA002652.

    Interactioni

    Protein-protein interaction databases

    BioGridi112321. 1 interaction.
    STRINGi9606.ENSP00000274063.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96HF1.
    SMRiQ96HF1. Positions 49-150.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 155121FZPROSITE-ProRule annotationAdd
    BLAST
    Domaini172 – 295124NTRPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
    Contains 1 NTR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG240950.
    HOGENOMiHOG000231058.
    HOVERGENiHBG052928.
    InParanoidiQ96HF1.
    KOiK02176.
    OMAiTSLKRWQ.
    OrthoDBiEOG789CBZ.
    PhylomeDBiQ96HF1.
    TreeFamiTF350133.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR026558. SFRP2.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF45. PTHR11309:SF45. 1 hit.
    PfamiPF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view]
    SMARTiSM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96HF1-1 [UniParc]FASTAAdd to Basket

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    MLQGPGSLLL LFLASHCCLG SARGLFLFGQ PDFSYKRSNC KPIPANLQLC    50
    HGIEYQNMRL PNLLGHETMK EVLEQAGAWI PLVMKQCHPD TKKFLCSLFA 100
    PVCLDDLDET IQPCHSLCVQ VKDRCAPVMS AFGFPWPDML ECDRFPQDND 150
    LCIPLASSDH LLPATEEAPK VCEACKNKND DDNDIMETLC KNDFALKIKV 200
    KEITYINRDT KIILETKSKT IYKLNGVSER DLKKSVLWLK DSLQCTCEEM 250
    NDINAPYLVM GQKQGGELVI TSVKRWQKGQ REFKRISRSI RKLQC 295
    Length:295
    Mass (Da):33,490
    Last modified:March 15, 2005 - v2
    Checksum:i97597971541BFBC4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1332Missing in AAB70792. (PubMed:9391078)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451A → V.2 Publications
    Corresponds to variant rs4643790 [ dbSNP | Ensembl ].
    VAR_051963

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF311912 mRNA. Translation: AAG24923.1.
    AY359001 mRNA. Translation: AAQ89360.1.
    AK075372 mRNA. Translation: BAG52124.1.
    CH471056 Genomic DNA. Translation: EAX04949.1.
    BC008666 mRNA. Translation: AAH08666.1.
    AF017986 mRNA. Translation: AAB70792.1.
    CCDSiCCDS34082.1.
    PIRiJE0174.
    RefSeqiNP_003004.1. NM_003013.2.
    UniGeneiHs.481022.

    Genome annotation databases

    EnsembliENST00000274063; ENSP00000274063; ENSG00000145423.
    GeneIDi6423.
    KEGGihsa:6423.
    UCSCiuc003inv.1. human.

    Polymorphism databases

    DMDMi61216828.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF311912 mRNA. Translation: AAG24923.1 .
    AY359001 mRNA. Translation: AAQ89360.1 .
    AK075372 mRNA. Translation: BAG52124.1 .
    CH471056 Genomic DNA. Translation: EAX04949.1 .
    BC008666 mRNA. Translation: AAH08666.1 .
    AF017986 mRNA. Translation: AAB70792.1 .
    CCDSi CCDS34082.1.
    PIRi JE0174.
    RefSeqi NP_003004.1. NM_003013.2.
    UniGenei Hs.481022.

    3D structure databases

    ProteinModelPortali Q96HF1.
    SMRi Q96HF1. Positions 49-150.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112321. 1 interaction.
    STRINGi 9606.ENSP00000274063.

    Protein family/group databases

    MEROPSi I93.001.

    PTM databases

    PhosphoSitei Q96HF1.

    Polymorphism databases

    DMDMi 61216828.

    Proteomic databases

    PaxDbi Q96HF1.
    PRIDEi Q96HF1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274063 ; ENSP00000274063 ; ENSG00000145423 .
    GeneIDi 6423.
    KEGGi hsa:6423.
    UCSCi uc003inv.1. human.

    Organism-specific databases

    CTDi 6423.
    GeneCardsi GC04M154701.
    HGNCi HGNC:10777. SFRP2.
    HPAi HPA002652.
    MIMi 604157. gene.
    neXtProti NX_Q96HF1.
    PharmGKBi PA35693.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240950.
    HOGENOMi HOG000231058.
    HOVERGENi HBG052928.
    InParanoidi Q96HF1.
    KOi K02176.
    OMAi TSLKRWQ.
    OrthoDBi EOG789CBZ.
    PhylomeDBi Q96HF1.
    TreeFami TF350133.

    Enzyme and pathway databases

    Reactomei REACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
    SignaLinki Q96HF1.

    Miscellaneous databases

    GeneWikii SFRP2.
    GenomeRNAii 6423.
    NextBioi 24943.
    PROi Q96HF1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96HF1.
    Bgeei Q96HF1.
    CleanExi HS_SFRP2.
    Genevestigatori Q96HF1.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR026558. SFRP2.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF45. PTHR11309:SF45. 1 hit.
    Pfami PF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view ]
    SMARTi SM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tissue restricted expression of two human Frzbs in preadipocytes and pancreas."
      Hu E., Zhu Y., Fredrickson T., Barnes M., Kelsell D., Beeley L., Brooks D.
      Biochem. Biophys. Res. Commun. 247:287-293(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Characterization of FKSG12, a novel protein related to pancreas tumor."
      Wang Y.-G.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-45.
    4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-45.
      Tissue: Eye.
    7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-208, TISSUE SPECIFICITY.
    8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-39.

    Entry informationi

    Entry nameiSFRP2_HUMAN
    AccessioniPrimary (citable) accession number: Q96HF1
    Secondary accession number(s): B3KQR2, O14778, Q9HAP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3