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Protein

Secreted frizzled-related protein 2

Gene

SFRP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

GO - Molecular functioni

  1. endopeptidase activator activity Source: Ensembl
  2. fibronectin binding Source: BHF-UCL
  3. integrin binding Source: BHF-UCL
  4. metalloenzyme activator activity Source: Ensembl
  5. receptor agonist activity Source: BHF-UCL
  6. Wnt-protein binding Source: GO_Central

GO - Biological processi

  1. bone morphogenesis Source: Ensembl
  2. cardiac left ventricle morphogenesis Source: BHF-UCL
  3. cell-cell signaling Source: BHF-UCL
  4. cellular response to extracellular stimulus Source: Ensembl
  5. cellular response to X-ray Source: Ensembl
  6. chondrocyte development Source: Ensembl
  7. collagen fibril organization Source: Ensembl
  8. convergent extension involved in axis elongation Source: Ensembl
  9. digestive tract morphogenesis Source: Ensembl
  10. embryonic digit morphogenesis Source: Ensembl
  11. hematopoietic stem cell proliferation Source: UniProtKB
  12. male gonad development Source: Ensembl
  13. negative regulation of BMP signaling pathway Source: Ensembl
  14. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  15. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
  16. negative regulation of cell growth Source: UniProtKB
  17. negative regulation of cell migration Source: UniProtKB
  18. negative regulation of cell proliferation Source: UniProtKB
  19. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  20. negative regulation of dermatome development Source: BHF-UCL
  21. negative regulation of epithelial cell proliferation Source: UniProtKB
  22. negative regulation of epithelial to mesenchymal transition Source: UniProtKB
  23. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  24. negative regulation of gene expression Source: UniProtKB
  25. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
  26. negative regulation of JUN kinase activity Source: Ensembl
  27. negative regulation of mesodermal cell fate specification Source: Ensembl
  28. negative regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  29. negative regulation of planar cell polarity pathway involved in axis elongation Source: Ensembl
  30. negative regulation of transcription, DNA-templated Source: UniProtKB
  31. negative regulation of Wnt signaling pathway Source: UniProtKB
  32. neural tube closure Source: Ensembl
  33. non-canonical Wnt signaling pathway Source: GO_Central
  34. outflow tract morphogenesis Source: BHF-UCL
  35. patterning of blood vessels Source: BHF-UCL
  36. planar cell polarity pathway involved in neural tube closure Source: Ensembl
  37. positive regulation of angiogenesis Source: BHF-UCL
  38. positive regulation of apoptotic process Source: BHF-UCL
  39. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  40. positive regulation of catenin import into nucleus Source: Ensembl
  41. positive regulation of cell adhesion mediated by integrin Source: BHF-UCL
  42. positive regulation of cell growth Source: UniProtKB
  43. positive regulation of cell proliferation Source: UniProtKB
  44. positive regulation of fat cell differentiation Source: MGI
  45. positive regulation of osteoblast differentiation Source: Ensembl
  46. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  47. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  48. post-anal tail morphogenesis Source: Ensembl
  49. regulation of stem cell division Source: UniProtKB
  50. response to drug Source: Ensembl
  51. response to nutrient Source: Ensembl
  52. sclerotome development Source: BHF-UCL
  53. Wnt signaling pathway involved in somitogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_264383. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
SignaLinkiQ96HF1.

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 2
Short name:
FRP-2
Short name:
sFRP-2
Alternative name(s):
Secreted apoptosis-related protein 1
Short name:
SARP-1
Gene namesi
Name:SFRP2
Synonyms:FRP2, SARP1
ORF Names:FKSG12, UNQ361/PRO697
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:10777. SFRP2.

Subcellular locationi

  1. Secreted By similarity

GO - Cellular componenti

  1. extracellular matrix Source: BHF-UCL
  2. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35693.

Polymorphism and mutation databases

BioMutaiSFRP2.
DMDMi61216828.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 295271Secreted frizzled-related protein 2PRO_0000032542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 103By similarity
Disulfide bondi50 ↔ 96By similarity
Disulfide bondi87 ↔ 125By similarity
Disulfide bondi114 ↔ 152By similarity
Disulfide bondi118 ↔ 142By similarity
Disulfide bondi172 ↔ 245By similarity
Disulfide bondi175 ↔ 247By similarity
Disulfide bondi190 ↔ 295By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96HF1.
PRIDEiQ96HF1.

PTM databases

PhosphoSiteiQ96HF1.

Expressioni

Tissue specificityi

Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.2 Publications

Gene expression databases

BgeeiQ96HF1.
CleanExiHS_SFRP2.
ExpressionAtlasiQ96HF1. baseline and differential.
GenevestigatoriQ96HF1.

Organism-specific databases

HPAiHPA002652.

Interactioni

Protein-protein interaction databases

BioGridi112321. 6 interactions.
IntActiQ96HF1. 11 interactions.
STRINGi9606.ENSP00000274063.

Structurei

3D structure databases

ProteinModelPortaliQ96HF1.
SMRiQ96HF1. Positions 49-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 155121FZPROSITE-ProRule annotationAdd
BLAST
Domaini172 – 295124NTRPROSITE-ProRule annotationAdd
BLAST

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG240950.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiQ96HF1.
KOiK02176.
OMAiTSLKRWQ.
OrthoDBiEOG789CBZ.
PhylomeDBiQ96HF1.
TreeFamiTF350133.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026558. SFRP2.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF45. PTHR11309:SF45. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96HF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQGPGSLLL LFLASHCCLG SARGLFLFGQ PDFSYKRSNC KPIPANLQLC
60 70 80 90 100
HGIEYQNMRL PNLLGHETMK EVLEQAGAWI PLVMKQCHPD TKKFLCSLFA
110 120 130 140 150
PVCLDDLDET IQPCHSLCVQ VKDRCAPVMS AFGFPWPDML ECDRFPQDND
160 170 180 190 200
LCIPLASSDH LLPATEEAPK VCEACKNKND DDNDIMETLC KNDFALKIKV
210 220 230 240 250
KEITYINRDT KIILETKSKT IYKLNGVSER DLKKSVLWLK DSLQCTCEEM
260 270 280 290
NDINAPYLVM GQKQGGELVI TSVKRWQKGQ REFKRISRSI RKLQC
Length:295
Mass (Da):33,490
Last modified:March 15, 2005 - v2
Checksum:i97597971541BFBC4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1332Missing in AAB70792 (PubMed:9391078).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451A → V.2 Publications
Corresponds to variant rs4643790 [ dbSNP | Ensembl ].
VAR_051963

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311912 mRNA. Translation: AAG24923.1.
AY359001 mRNA. Translation: AAQ89360.1.
AK075372 mRNA. Translation: BAG52124.1.
CH471056 Genomic DNA. Translation: EAX04949.1.
BC008666 mRNA. Translation: AAH08666.1.
AF017986 mRNA. Translation: AAB70792.1.
CCDSiCCDS34082.1.
PIRiJE0174.
RefSeqiNP_003004.1. NM_003013.2.
UniGeneiHs.481022.

Genome annotation databases

EnsembliENST00000274063; ENSP00000274063; ENSG00000145423.
GeneIDi6423.
KEGGihsa:6423.
UCSCiuc003inv.1. human.

Polymorphism and mutation databases

BioMutaiSFRP2.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311912 mRNA. Translation: AAG24923.1.
AY359001 mRNA. Translation: AAQ89360.1.
AK075372 mRNA. Translation: BAG52124.1.
CH471056 Genomic DNA. Translation: EAX04949.1.
BC008666 mRNA. Translation: AAH08666.1.
AF017986 mRNA. Translation: AAB70792.1.
CCDSiCCDS34082.1.
PIRiJE0174.
RefSeqiNP_003004.1. NM_003013.2.
UniGeneiHs.481022.

3D structure databases

ProteinModelPortaliQ96HF1.
SMRiQ96HF1. Positions 49-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112321. 6 interactions.
IntActiQ96HF1. 11 interactions.
STRINGi9606.ENSP00000274063.

Protein family/group databases

MEROPSiI93.001.

PTM databases

PhosphoSiteiQ96HF1.

Polymorphism and mutation databases

BioMutaiSFRP2.
DMDMi61216828.

Proteomic databases

PaxDbiQ96HF1.
PRIDEiQ96HF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274063; ENSP00000274063; ENSG00000145423.
GeneIDi6423.
KEGGihsa:6423.
UCSCiuc003inv.1. human.

Organism-specific databases

CTDi6423.
GeneCardsiGC04M154701.
HGNCiHGNC:10777. SFRP2.
HPAiHPA002652.
MIMi604157. gene.
neXtProtiNX_Q96HF1.
PharmGKBiPA35693.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG240950.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiQ96HF1.
KOiK02176.
OMAiTSLKRWQ.
OrthoDBiEOG789CBZ.
PhylomeDBiQ96HF1.
TreeFamiTF350133.

Enzyme and pathway databases

ReactomeiREACT_264383. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
SignaLinkiQ96HF1.

Miscellaneous databases

ChiTaRSiSFRP2. human.
GeneWikiiSFRP2.
GenomeRNAii6423.
NextBioi24943.
PROiQ96HF1.
SOURCEiSearch...

Gene expression databases

BgeeiQ96HF1.
CleanExiHS_SFRP2.
ExpressionAtlasiQ96HF1. baseline and differential.
GenevestigatoriQ96HF1.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026558. SFRP2.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF45. PTHR11309:SF45. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Tissue restricted expression of two human Frzbs in preadipocytes and pancreas."
    Hu E., Zhu Y., Fredrickson T., Barnes M., Kelsell D., Beeley L., Brooks D.
    Biochem. Biophys. Res. Commun. 247:287-293(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Characterization of FKSG12, a novel protein related to pancreas tumor."
    Wang Y.-G.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-45.
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-45.
    Tissue: Eye.
  7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-208, TISSUE SPECIFICITY.
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-39.

Entry informationi

Entry nameiSFRP2_HUMAN
AccessioniPrimary (citable) accession number: Q96HF1
Secondary accession number(s): B3KQR2, O14778, Q9HAP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 29, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.