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Protein

Secreted frizzled-related protein 2

Gene

SFRP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists
SignaLinkiQ96HF1

Protein family/group databases

MEROPSiI93.002

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 2
Short name:
FRP-2
Short name:
sFRP-2
Alternative name(s):
Secreted apoptosis-related protein 1
Short name:
SARP-1
Gene namesi
Name:SFRP2
Synonyms:FRP2, SARP1
ORF Names:FKSG12, UNQ361/PRO697
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000145423.4
HGNCiHGNC:10777 SFRP2
MIMi604157 gene
neXtProtiNX_Q96HF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6423
OpenTargetsiENSG00000145423
PharmGKBiPA35693

Polymorphism and mutation databases

BioMutaiSFRP2
DMDMi61216828

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000003254225 – 295Secreted frizzled-related protein 2Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 103By similarity
Disulfide bondi50 ↔ 96By similarity
Disulfide bondi87 ↔ 125By similarity
Disulfide bondi114 ↔ 152By similarity
Disulfide bondi118 ↔ 142By similarity
Disulfide bondi172 ↔ 245By similarity
Disulfide bondi175 ↔ 247By similarity
Disulfide bondi190 ↔ 295By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ96HF1
PaxDbiQ96HF1
PeptideAtlasiQ96HF1
PRIDEiQ96HF1

PTM databases

iPTMnetiQ96HF1
PhosphoSitePlusiQ96HF1

Expressioni

Tissue specificityi

Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.2 Publications

Gene expression databases

BgeeiENSG00000145423
CleanExiHS_SFRP2
ExpressionAtlasiQ96HF1 baseline and differential
GenevisibleiQ96HF1 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112321, 10 interactors
IntActiQ96HF1, 11 interactors
MINTiQ96HF1
STRINGi9606.ENSP00000274063

Structurei

3D structure databases

ProteinModelPortaliQ96HF1
SMRiQ96HF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 155FZPROSITE-ProRule annotationAdd BLAST121
Domaini172 – 295NTRPROSITE-ProRule annotationAdd BLAST124

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
GeneTreeiENSGT00890000139384
HOGENOMiHOG000231058
HOVERGENiHBG052928
InParanoidiQ96HF1
KOiK02176
OMAiTSLKRWQ
OrthoDBiEOG091G0F7I
PhylomeDBiQ96HF1
TreeFamiTF350133

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR026558 SFRP2
IPR008993 TIMP-like_OB-fold
PANTHERiPTHR11309 PTHR11309, 1 hit
PTHR11309:SF45 PTHR11309:SF45, 1 hit
PfamiView protein in Pfam
PF01392 Fz, 1 hit
PF01759 NTR, 1 hit
SMARTiView protein in SMART
SM00643 C345C, 1 hit
SM00063 FRI, 1 hit
SUPFAMiSSF50242 SSF50242, 1 hit
SSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50189 NTR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96HF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQGPGSLLL LFLASHCCLG SARGLFLFGQ PDFSYKRSNC KPIPANLQLC
60 70 80 90 100
HGIEYQNMRL PNLLGHETMK EVLEQAGAWI PLVMKQCHPD TKKFLCSLFA
110 120 130 140 150
PVCLDDLDET IQPCHSLCVQ VKDRCAPVMS AFGFPWPDML ECDRFPQDND
160 170 180 190 200
LCIPLASSDH LLPATEEAPK VCEACKNKND DDNDIMETLC KNDFALKIKV
210 220 230 240 250
KEITYINRDT KIILETKSKT IYKLNGVSER DLKKSVLWLK DSLQCTCEEM
260 270 280 290
NDINAPYLVM GQKQGGELVI TSVKRWQKGQ REFKRISRSI RKLQC
Length:295
Mass (Da):33,490
Last modified:March 15, 2005 - v2
Checksum:i97597971541BFBC4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132 – 133Missing in AAB70792 (PubMed:9391078).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05196345A → V2 PublicationsCorresponds to variant dbSNP:rs4643790Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311912 mRNA Translation: AAG24923.1
AY359001 mRNA Translation: AAQ89360.1
AK075372 mRNA Translation: BAG52124.1
CH471056 Genomic DNA Translation: EAX04949.1
BC008666 mRNA Translation: AAH08666.1
AF017986 mRNA Translation: AAB70792.1
CCDSiCCDS34082.1
PIRiJE0174
RefSeqiNP_003004.1, NM_003013.2
UniGeneiHs.481022

Genome annotation databases

EnsembliENST00000274063; ENSP00000274063; ENSG00000145423
GeneIDi6423
KEGGihsa:6423
UCSCiuc003inv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSFRP2_HUMAN
AccessioniPrimary (citable) accession number: Q96HF1
Secondary accession number(s): B3KQR2, O14778, Q9HAP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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