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Protein

Proline-rich protein 11

Gene

PRR11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a critical role in cell cycle progression.1 Publication

GO - Biological processi

  • regulation of cell cycle Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 11
Gene namesi
Name:PRR11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25619. PRR11.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671131.

Polymorphism and mutation databases

BioMutaiPRR11.
DMDMi74731920.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Proline-rich protein 11PRO_0000243943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331PhosphothreonineCombined sources
Modified residuei40 – 401PhosphoserineCombined sources
Modified residuei287 – 2871PhosphothreonineCombined sources
Modified residuei291 – 2911PhosphoserineCombined sources
Modified residuei344 – 3441PhosphoserineCombined sources
Modified residuei346 – 3461PhosphothreonineCombined sources
Modified residuei348 – 3481PhosphothreonineCombined sources

Post-translational modificationi

Ubiquitinated (Probable). Rapidly degraded by the proteasome; degradation may involve FBXW7-specific phosphorylated phosphodegron motifs.Curated

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96HE9.
MaxQBiQ96HE9.
PaxDbiQ96HE9.
PeptideAtlasiQ96HE9.
PRIDEiQ96HE9.

PTM databases

iPTMnetiQ96HE9.
PhosphoSiteiQ96HE9.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Inductioni

Expression increases from G1 to G2/M phase.2 Publications

Gene expression databases

BgeeiENSG00000068489.
CleanExiHS_PRR11.
ExpressionAtlasiQ96HE9. baseline and differential.
GenevisibleiQ96HE9. HS.

Organism-specific databases

HPAiHPA023923.
HPA052376.

Interactioni

Protein-protein interaction databases

BioGridi120888. 95 interactions.
IntActiQ96HE9. 2 interactions.
STRINGi9606.ENSP00000262293.

Structurei

3D structure databases

ProteinModelPortaliQ96HE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi285 – 2917Phosphodegron
Motifi296 – 3049D-box
Motifi316 – 3183KEN box
Motifi325 – 3306Phosphodegron

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 418Poly-Pro
Compositional biasi174 – 20229Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IJIM. Eukaryota.
ENOG4112CB1. LUCA.
GeneTreeiENSGT00440000034287.
HOGENOMiHOG000059267.
HOVERGENiHBG082197.
InParanoidiQ96HE9.
OMAiSLKQQFC.
OrthoDBiEOG091G0FMR.
PhylomeDBiQ96HE9.
TreeFamiTF333428.

Sequencei

Sequence statusi: Complete.

Q96HE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKFKQRRRK LKAKAERLFK KKEASHFQSK LITPPPPPPS PERVGISSID
60 70 80 90 100
ISQSRSWLTS SWNFNFPNIR DAIKLWTNRV WSIYSWCQNC ITQSLEVLKD
110 120 130 140 150
TIFPSRICHR ELYSVKQQFC ILESKLCKLQ EALKTISESS SCPSCGQTCH
160 170 180 190 200
MSGKLTNVPA CVLITPGDSK AVLPPTLPQP ASHFPPPPPP PPLPPPPPPL
210 220 230 240 250
APVLLRKPSL AKALQAGPLK KDGPMQITVK DLLTVKLKKT QSLDEKRKLI
260 270 280 290 300
PSPKARNPLV TVSDLQHVTL KPNSKVLSTR VTNVLITPGK SQMDLRKLLR
310 320 330 340 350
KVDVERSPGG TPLTNKENME TGTGLTPVMT QALRRKFQLA HPRSPTPTLP
360
LSTSSFDEQN
Length:360
Mass (Da):40,085
Last modified:December 1, 2001 - v1
Checksum:i04757432CA0D9501
GO

Sequence cautioni

The sequence BAA91064 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti307 – 3071S → R in BAA91964 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000296 mRNA. Translation: BAA91064.1. Different initiation.
AK001891 mRNA. Translation: BAA91964.1.
BC008669 mRNA. Translation: AAH08669.1.
CCDSiCCDS11614.1.
RefSeqiNP_060774.2. NM_018304.3.
UniGeneiHs.631750.

Genome annotation databases

EnsembliENST00000262293; ENSP00000262293; ENSG00000068489.
ENST00000578542; ENSP00000464171; ENSG00000068489.
ENST00000580177; ENSP00000463733; ENSG00000068489.
ENST00000614081; ENSP00000481852; ENSG00000068489.
GeneIDi55771.
KEGGihsa:55771.
UCSCiuc002ixf.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000296 mRNA. Translation: BAA91064.1. Different initiation.
AK001891 mRNA. Translation: BAA91964.1.
BC008669 mRNA. Translation: AAH08669.1.
CCDSiCCDS11614.1.
RefSeqiNP_060774.2. NM_018304.3.
UniGeneiHs.631750.

3D structure databases

ProteinModelPortaliQ96HE9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120888. 95 interactions.
IntActiQ96HE9. 2 interactions.
STRINGi9606.ENSP00000262293.

PTM databases

iPTMnetiQ96HE9.
PhosphoSiteiQ96HE9.

Polymorphism and mutation databases

BioMutaiPRR11.
DMDMi74731920.

Proteomic databases

EPDiQ96HE9.
MaxQBiQ96HE9.
PaxDbiQ96HE9.
PeptideAtlasiQ96HE9.
PRIDEiQ96HE9.

Protocols and materials databases

DNASUi55771.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262293; ENSP00000262293; ENSG00000068489.
ENST00000578542; ENSP00000464171; ENSG00000068489.
ENST00000580177; ENSP00000463733; ENSG00000068489.
ENST00000614081; ENSP00000481852; ENSG00000068489.
GeneIDi55771.
KEGGihsa:55771.
UCSCiuc002ixf.3. human.

Organism-specific databases

CTDi55771.
GeneCardsiPRR11.
HGNCiHGNC:25619. PRR11.
HPAiHPA023923.
HPA052376.
MIMi615920. gene.
neXtProtiNX_Q96HE9.
PharmGKBiPA142671131.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJIM. Eukaryota.
ENOG4112CB1. LUCA.
GeneTreeiENSGT00440000034287.
HOGENOMiHOG000059267.
HOVERGENiHBG082197.
InParanoidiQ96HE9.
OMAiSLKQQFC.
OrthoDBiEOG091G0FMR.
PhylomeDBiQ96HE9.
TreeFamiTF333428.

Miscellaneous databases

GenomeRNAii55771.
PROiQ96HE9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000068489.
CleanExiHS_PRR11.
ExpressionAtlasiQ96HE9. baseline and differential.
GenevisibleiQ96HE9. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiPRR11_HUMAN
AccessioniPrimary (citable) accession number: Q96HE9
Secondary accession number(s): Q9NUZ7, Q9NXE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.