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Protein

Transmembrane protein 80

Gene

TMEM80

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 80
Gene namesi
Name:TMEM80
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000177042.14.
HGNCiHGNC:27453. TMEM80.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177042.
PharmGKBiPA142670734.

Polymorphism and mutation databases

DMDMi209572717.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002878731 – 168Transmembrane protein 80Add BLAST168

Proteomic databases

PaxDbiQ96HE8.
PRIDEiQ96HE8.

PTM databases

iPTMnetiQ96HE8.
PhosphoSitePlusiQ96HE8.

Expressioni

Gene expression databases

BgeeiENSG00000177042.
CleanExiHS_TMEM80.
ExpressionAtlasiQ96HE8. baseline and differential.
GenevisibleiQ96HE8. HS.

Organism-specific databases

HPAiHPA059592.
HPA067046.

Interactioni

Protein-protein interaction databases

IntActiQ96HE8. 1 interactor.
STRINGi9606.ENSP00000380646.

Structurei

3D structure databases

ProteinModelPortaliQ96HE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0JJ. Eukaryota.
ENOG4112C55. LUCA.
GeneTreeiENSGT00390000002170.
HOGENOMiHOG000008106.
HOVERGENiHBG059533.
InParanoidiQ96HE8.
PhylomeDBiQ96HE8.
TreeFamiTF323824.

Family and domain databases

InterProiView protein in InterPro
IPR019184. Uncharacterised_TM-17.
PfamiView protein in Pfam
PF09799. Transmemb_17. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96HE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEGARARGP RGCRDRDGPA GGAGKMAAPR RGRGSSTVLS SVPLQMLFYL
60 70 80 90 100
SGTYYALYFL ATLLMITYKS QVFSYPHRYL VLDLALLFLM GILEAVRLYL
110 120 130 140 150
GTRGNLTEAE RPLAASLALT AGTALLSAHF LLWQALVLWA DWALSATLLA
160
LHGLEAVLQV VAIAAFTR
Length:168
Mass (Da):18,160
Last modified:October 14, 2008 - v3
Checksum:i815104E31E746A52
GO
Isoform 2 (identifier: Q96HE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-31: Missing.

Note: No experimental confirmation available.
Show »
Length:160
Mass (Da):17,292
Checksum:iAAE06786801A0C5D
GO
Isoform 3 (identifier: Q96HE8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Note: Gene prediction based on EST data.
Show »
Length:123
Mass (Da):13,656
Checksum:iC1B3361FE144BB4F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0355031 – 45Missing in isoform 3. CuratedAdd BLAST45
Alternative sequenceiVSP_03550424 – 31Missing in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131934 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02373.1.
BC008671 mRNA. Translation: AAH08671.2.
CB962031 mRNA. No translation available.
RefSeqiNP_001035928.2. NM_001042463.2.
NP_001263182.1. NM_001276253.1.
NP_001263203.1. NM_001276274.1.
NP_777600.3. NM_174940.3.
UniGeneiHs.448664.

Genome annotation databases

EnsembliENST00000397512; ENSP00000380648; ENSG00000177042. [Q96HE8-2]
GeneIDi283232.
KEGGihsa:283232.
UCSCiuc057xju.1. human. [Q96HE8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTMM80_HUMAN
AccessioniPrimary (citable) accession number: Q96HE8
Secondary accession number(s): A8MQ01, A8MXY8, B7WNU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 14, 2008
Last modified: September 27, 2017
This is version 103 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM