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Q96HD9

- ACY3_HUMAN

UniProt

Q96HD9 - ACY3_HUMAN

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Protein

N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

Gene

ACY3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids By similarity.By similarity

Catalytic activityi

An N-acyl-aromatic-L-amino acid + H2O = an aromatic-L-amino acid + a carboxylate.
An N-acetyl-L-cysteine-S-conjugate + H2O = an L-cysteine-S-conjugate + acetate.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi21 – 211ZincBy similarity
Metal bindingi24 – 241ZincBy similarity
Binding sitei63 – 631SubstrateBy similarity
Metal bindingi116 – 1161ZincBy similarity
Binding sitei178 – 1781SubstrateBy similarity
Binding sitei288 – 2881SubstrateBy similarity

GO - Molecular functioni

  1. aminoacylase activity Source: UniProt
  2. hydrolase activity, acting on ester bonds Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Host-virus interaction

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:HS13441-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (EC:3.5.1.114)
Alternative name(s):
Acylase III
Aminoacylase-3
Short name:
ACY-3
Aspartoacylase-2
Hepatitis C virus core-binding protein 1
Short name:
HCBP1
Short name:
HCV core-binding protein 1
Gene namesi
Name:ACY3
Synonyms:ASPA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:24104. ACY3.

Subcellular locationi

Apical cell membrane 1 Publication; Peripheral membrane protein 1 Publication. Cytoplasm 1 Publication
Note: Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm.

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cytoplasm Source: UniProtKB-KW
  3. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134936640.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)PRO_0000216875Add
BLAST

Proteomic databases

MaxQBiQ96HD9.
PaxDbiQ96HD9.
PRIDEiQ96HD9.

PTM databases

PhosphoSiteiQ96HD9.

Expressioni

Gene expression databases

BgeeiQ96HD9.
CleanExiHS_ACY3.
ExpressionAtlasiQ96HD9. baseline and differential.
GenevestigatoriQ96HD9.

Organism-specific databases

HPAiHPA039219.

Interactioni

Subunit structurei

Exists as a mixture of homodimers and homotetramer, both catalytically active By similarity. Interacts with HCV core protein.By similarity1 Publication

Protein-protein interaction databases

BioGridi124869. 4 interactions.
IntActiQ96HD9. 4 interactions.
STRINGi9606.ENSP00000255082.

Structurei

3D structure databases

ProteinModelPortaliQ96HD9.
SMRiQ96HD9. Positions 8-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 210210Hydrolytic domainBy similarityAdd
BLAST
Regioni70 – 712Substrate bindingBy similarity
Regioni211 – 318108Shielding domainBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2988.
GeneTreeiENSGT00390000001189.
HOGENOMiHOG000232489.
HOVERGENiHBG004172.
InParanoidiQ96HD9.
KOiK18458.
OMAiTANMGTC.
OrthoDBiEOG78SQJ6.
PhylomeDBiQ96HD9.
TreeFamiTF328708.

Family and domain databases

HAMAPiMF_00704. Aspartoacylase.
InterProiIPR016708. Aspartoacylase.
IPR007036. Aste_AspA.
[Graphical view]
PfamiPF04952. AstE_AspA. 1 hit.
[Graphical view]
PIRSFiPIRSF018001. Aspartoacylase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96HD9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCSLPVPREP LRRVAVTGGT HGNEMSGVYL ARHWLHAPAE LQRASFSAVP
60 70 80 90 100
VLANPAATSG CRRYVDHDLN RTFTSSFLNS RPTPDDPYEV TRARELNQLL
110 120 130 140 150
GPKASGQAFD FVLDLHNTTA NMGTCLIAKS SHEVFAMHLC RHLQLQYPEL
160 170 180 190 200
SCQVFLYQRS GEESYNLDSV AKNGLGLELG PQPQGVLRAD IFSRMRTLVA
210 220 230 240 250
TVLDFIELFN QGTAFPAFEM EAYRPVGVVD FPRTEAGHLA GTVHPQLQDR
260 270 280 290 300
DFQPLQPGAP IFQMFSGEDL LYEGESTVYP VFINEAAYYE KGVAFVQTEK
310
FTFTVPAMPA LTPAPSPAS
Length:319
Mass (Da):35,241
Last modified:December 1, 2001 - v1
Checksum:i2595358AC8B5BEFB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81R → Q.
Corresponds to variant rs948445 [ dbSNP | Ensembl ].
VAR_048341
Natural varianti281 – 2811V → M.
Corresponds to variant rs2290959 [ dbSNP | Ensembl ].
VAR_048342

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY040761 mRNA. Translation: AAK94770.1.
AY169233 mRNA. Translation: AAN87896.1.
BC008689 mRNA. Translation: AAH08689.1.
CCDSiCCDS8175.1.
RefSeqiNP_542389.1. NM_080658.1.
UniGeneiHs.126265.

Genome annotation databases

EnsembliENST00000255082; ENSP00000255082; ENSG00000132744.
GeneIDi91703.
KEGGihsa:91703.
UCSCiuc001omq.3. human.

Polymorphism databases

DMDMi34395507.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY040761 mRNA. Translation: AAK94770.1 .
AY169233 mRNA. Translation: AAN87896.1 .
BC008689 mRNA. Translation: AAH08689.1 .
CCDSi CCDS8175.1.
RefSeqi NP_542389.1. NM_080658.1.
UniGenei Hs.126265.

3D structure databases

ProteinModelPortali Q96HD9.
SMRi Q96HD9. Positions 8-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124869. 4 interactions.
IntActi Q96HD9. 4 interactions.
STRINGi 9606.ENSP00000255082.

Chemistry

DrugBanki DB00128. L-Aspartic Acid.

PTM databases

PhosphoSitei Q96HD9.

Polymorphism databases

DMDMi 34395507.

Proteomic databases

MaxQBi Q96HD9.
PaxDbi Q96HD9.
PRIDEi Q96HD9.

Protocols and materials databases

DNASUi 91703.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000255082 ; ENSP00000255082 ; ENSG00000132744 .
GeneIDi 91703.
KEGGi hsa:91703.
UCSCi uc001omq.3. human.

Organism-specific databases

CTDi 91703.
GeneCardsi GC11M067411.
HGNCi HGNC:24104. ACY3.
HPAi HPA039219.
MIMi 614413. gene.
neXtProti NX_Q96HD9.
PharmGKBi PA134936640.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2988.
GeneTreei ENSGT00390000001189.
HOGENOMi HOG000232489.
HOVERGENi HBG004172.
InParanoidi Q96HD9.
KOi K18458.
OMAi TANMGTC.
OrthoDBi EOG78SQJ6.
PhylomeDBi Q96HD9.
TreeFami TF328708.

Enzyme and pathway databases

BioCyci MetaCyc:HS13441-MONOMER.

Miscellaneous databases

GenomeRNAii 91703.
NextBioi 77411.
PROi Q96HD9.
SOURCEi Search...

Gene expression databases

Bgeei Q96HD9.
CleanExi HS_ACY3.
ExpressionAtlasi Q96HD9. baseline and differential.
Genevestigatori Q96HD9.

Family and domain databases

HAMAPi MF_00704. Aspartoacylase.
InterProi IPR016708. Aspartoacylase.
IPR007036. Aste_AspA.
[Graphical view ]
Pfami PF04952. AstE_AspA. 1 hit.
[Graphical view ]
PIRSFi PIRSF018001. Aspartoacylase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel aspartoacylase homolog (ACY-3) in human and mouse kidneys."
    Huang C.-H., Chen H., Peng J., Chen Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Pushkin A., Carpenito G., Abuladze N., Newman D., Kurtz I.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  4. "Identification of a novel protein binding to hepatitis C virus core protein."
    Chen Y.R., Chen T.Y., Zhang S.L., Lin S.M., Zhao Y.R., Ye F., Zhang X., Shi L., Dang S.S., Liu M.
    J. Gastroenterol. Hepatol. 24:1300-1304(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HCV CORE PROTEIN, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiACY3_HUMAN
AccessioniPrimary (citable) accession number: Q96HD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3