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Q96HD9

- ACY3_HUMAN

UniProt

Q96HD9 - ACY3_HUMAN

Protein

N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

Gene

ACY3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids By similarity.By similarity

    Catalytic activityi

    An N-acyl-aromatic-L-amino acid + H2O = an aromatic-L-amino acid + a carboxylate.
    An N-acetyl-L-cysteine-S-conjugate + H2O = an L-cysteine-S-conjugate + acetate.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi21 – 211ZincBy similarity
    Metal bindingi24 – 241ZincBy similarity
    Binding sitei63 – 631SubstrateBy similarity
    Metal bindingi116 – 1161ZincBy similarity
    Binding sitei178 – 1781SubstrateBy similarity
    Binding sitei288 – 2881SubstrateBy similarity

    GO - Molecular functioni

    1. aminoacylase activity Source: UniProt
    2. hydrolase activity, acting on ester bonds Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Host-virus interaction

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciMetaCyc:HS13441-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (EC:3.5.1.114)
    Alternative name(s):
    Acylase III
    Aminoacylase-3
    Short name:
    ACY-3
    Aspartoacylase-2
    Hepatitis C virus core-binding protein 1
    Short name:
    HCBP1
    Short name:
    HCV core-binding protein 1
    Gene namesi
    Name:ACY3
    Synonyms:ASPA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:24104. ACY3.

    Subcellular locationi

    Apical cell membrane 1 Publication; Peripheral membrane protein 1 Publication. Cytoplasm 1 Publication
    Note: Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm.

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-SubCell
    3. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134936640.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)PRO_0000216875Add
    BLAST

    Proteomic databases

    MaxQBiQ96HD9.
    PaxDbiQ96HD9.
    PRIDEiQ96HD9.

    PTM databases

    PhosphoSiteiQ96HD9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96HD9.
    BgeeiQ96HD9.
    CleanExiHS_ACY3.
    GenevestigatoriQ96HD9.

    Organism-specific databases

    HPAiHPA039219.

    Interactioni

    Subunit structurei

    Exists as a mixture of homodimers and homotetramer, both catalytically active By similarity. Interacts with HCV core protein.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi124869. 4 interactions.
    IntActiQ96HD9. 4 interactions.
    STRINGi9606.ENSP00000255082.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96HD9.
    SMRiQ96HD9. Positions 8-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 210210Hydrolytic domainBy similarityAdd
    BLAST
    Regioni70 – 712Substrate bindingBy similarity
    Regioni211 – 318108Shielding domainBy similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2988.
    HOGENOMiHOG000232489.
    HOVERGENiHBG004172.
    InParanoidiQ96HD9.
    KOiK01437.
    OMAiTANMGTC.
    OrthoDBiEOG78SQJ6.
    PhylomeDBiQ96HD9.
    TreeFamiTF328708.

    Family and domain databases

    HAMAPiMF_00704. Aspartoacylase.
    InterProiIPR016708. Aspartoacylase.
    IPR007036. Aste_AspA.
    [Graphical view]
    PfamiPF04952. AstE_AspA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018001. Aspartoacylase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96HD9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCSLPVPREP LRRVAVTGGT HGNEMSGVYL ARHWLHAPAE LQRASFSAVP    50
    VLANPAATSG CRRYVDHDLN RTFTSSFLNS RPTPDDPYEV TRARELNQLL 100
    GPKASGQAFD FVLDLHNTTA NMGTCLIAKS SHEVFAMHLC RHLQLQYPEL 150
    SCQVFLYQRS GEESYNLDSV AKNGLGLELG PQPQGVLRAD IFSRMRTLVA 200
    TVLDFIELFN QGTAFPAFEM EAYRPVGVVD FPRTEAGHLA GTVHPQLQDR 250
    DFQPLQPGAP IFQMFSGEDL LYEGESTVYP VFINEAAYYE KGVAFVQTEK 300
    FTFTVPAMPA LTPAPSPAS 319
    Length:319
    Mass (Da):35,241
    Last modified:December 1, 2001 - v1
    Checksum:i2595358AC8B5BEFB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti8 – 81R → Q.
    Corresponds to variant rs948445 [ dbSNP | Ensembl ].
    VAR_048341
    Natural varianti281 – 2811V → M.
    Corresponds to variant rs2290959 [ dbSNP | Ensembl ].
    VAR_048342

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY040761 mRNA. Translation: AAK94770.1.
    AY169233 mRNA. Translation: AAN87896.1.
    BC008689 mRNA. Translation: AAH08689.1.
    CCDSiCCDS8175.1.
    RefSeqiNP_542389.1. NM_080658.1.
    UniGeneiHs.126265.

    Genome annotation databases

    EnsembliENST00000255082; ENSP00000255082; ENSG00000132744.
    GeneIDi91703.
    KEGGihsa:91703.
    UCSCiuc001omq.3. human.

    Polymorphism databases

    DMDMi34395507.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY040761 mRNA. Translation: AAK94770.1 .
    AY169233 mRNA. Translation: AAN87896.1 .
    BC008689 mRNA. Translation: AAH08689.1 .
    CCDSi CCDS8175.1.
    RefSeqi NP_542389.1. NM_080658.1.
    UniGenei Hs.126265.

    3D structure databases

    ProteinModelPortali Q96HD9.
    SMRi Q96HD9. Positions 8-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124869. 4 interactions.
    IntActi Q96HD9. 4 interactions.
    STRINGi 9606.ENSP00000255082.

    Chemistry

    DrugBanki DB00128. L-Aspartic Acid.

    PTM databases

    PhosphoSitei Q96HD9.

    Polymorphism databases

    DMDMi 34395507.

    Proteomic databases

    MaxQBi Q96HD9.
    PaxDbi Q96HD9.
    PRIDEi Q96HD9.

    Protocols and materials databases

    DNASUi 91703.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255082 ; ENSP00000255082 ; ENSG00000132744 .
    GeneIDi 91703.
    KEGGi hsa:91703.
    UCSCi uc001omq.3. human.

    Organism-specific databases

    CTDi 91703.
    GeneCardsi GC11M067411.
    HGNCi HGNC:24104. ACY3.
    HPAi HPA039219.
    MIMi 614413. gene.
    neXtProti NX_Q96HD9.
    PharmGKBi PA134936640.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2988.
    HOGENOMi HOG000232489.
    HOVERGENi HBG004172.
    InParanoidi Q96HD9.
    KOi K01437.
    OMAi TANMGTC.
    OrthoDBi EOG78SQJ6.
    PhylomeDBi Q96HD9.
    TreeFami TF328708.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS13441-MONOMER.

    Miscellaneous databases

    GenomeRNAii 91703.
    NextBioi 77411.
    PROi Q96HD9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96HD9.
    Bgeei Q96HD9.
    CleanExi HS_ACY3.
    Genevestigatori Q96HD9.

    Family and domain databases

    HAMAPi MF_00704. Aspartoacylase.
    InterProi IPR016708. Aspartoacylase.
    IPR007036. Aste_AspA.
    [Graphical view ]
    Pfami PF04952. AstE_AspA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018001. Aspartoacylase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel aspartoacylase homolog (ACY-3) in human and mouse kidneys."
      Huang C.-H., Chen H., Peng J., Chen Y.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Pushkin A., Carpenito G., Abuladze N., Newman D., Kurtz I.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    4. "Identification of a novel protein binding to hepatitis C virus core protein."
      Chen Y.R., Chen T.Y., Zhang S.L., Lin S.M., Zhao Y.R., Ye F., Zhang X., Shi L., Dang S.S., Liu M.
      J. Gastroenterol. Hepatol. 24:1300-1304(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HCV CORE PROTEIN, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiACY3_HUMAN
    AccessioniPrimary (citable) accession number: Q96HD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3