Q96HD9 (ACY3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartoacylase-2
EC=3.5.1.-

Alternative name(s):
Acylase III
Aminoacylase-3
Short name=ACY-3
Hepatitis C virus core-binding protein 1
Short name=HCBP1
Short name=HCV core-binding protein 1

Gene names

Name:	ACY3
Synonyms:	ASPA2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important role in deacetylating mercapturic acids in kidney proximal tubules By similarity.
Cofactor	Binds 1 zinc ion per subunit Potential.
Subunit structure	Homotetramer By similarity. Interacts with HCV core protein. Ref.4
Subcellular location	Apical cell membrane; Peripheral membrane protein. Cytoplasm. Note: Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm. Ref.4
Sequence similarities	Belongs to the AspA/AstE family. Aspartoacylase subfamily.

Ontologies

Keywords
Biological process	Host-virus interaction
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Polymorphism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aminoacylase activity Inferred from electronic annotation. Source: Compara hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Aspartoacylase-2		PRO_0000216875
Regions
	Region	70 – 71	2	Substrate binding Potential
Sites
	Metal binding	21	1	Zinc Potential
	Metal binding	24	1	Zinc Potential
	Metal binding	116	1	Zinc Potential
	Binding site	63	1	Substrate Potential
	Binding site	178	1	Substrate Potential
	Binding site	288	1	Substrate Potential
Natural variations
	Natural variant	8	1	R → Q. Corresponds to variant rs948445 [ dbSNP | Ensembl ].		VAR_048341
	Natural variant	281	1	V → M. Corresponds to variant rs2290959 [ dbSNP | Ensembl ].		VAR_048342

Sequences

	Sequence		Length	Mass (Da)
	Q96HD9 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 2595358AC8B5BEFB	FASTA	319	35,241
	10 20 30 40 50 60 MCSLPVPREP LRRVAVTGGT HGNEMSGVYL ARHWLHAPAE LQRASFSAVP VLANPAATSG 70 80 90 100 110 120 CRRYVDHDLN RTFTSSFLNS RPTPDDPYEV TRARELNQLL GPKASGQAFD FVLDLHNTTA 130 140 150 160 170 180 NMGTCLIAKS SHEVFAMHLC RHLQLQYPEL SCQVFLYQRS GEESYNLDSV AKNGLGLELG 190 200 210 220 230 240 PQPQGVLRAD IFSRMRTLVA TVLDFIELFN QGTAFPAFEM EAYRPVGVVD FPRTEAGHLA 250 260 270 280 290 300 GTVHPQLQDR DFQPLQPGAP IFQMFSGEDL LYEGESTVYP VFINEAAYYE KGVAFVQTEK 310 FTFTVPAMPA LTPAPSPAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel aspartoacylase homolog (ACY-3) in human and mouse kidneys." Huang C.-H., Chen H., Peng J., Chen Y. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Pushkin A., Carpenito G., Abuladze N., Newman D., Kurtz I. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[4]	"Identification of a novel protein binding to hepatitis C virus core protein." Chen Y.R., Chen T.Y., Zhang S.L., Lin S.M., Zhao Y.R., Ye F., Zhang X., Shi L., Dang S.S., Liu M. J. Gastroenterol. Hepatol. 24:1300-1304(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HCV CORE PROTEIN, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY040761 mRNA. Translation: AAK94770.1. AY169233 mRNA. Translation: AAN87896.1. BC008689 mRNA. Translation: AAH08689.1.
IPI	IPI00063025.
RefSeq	NP_542389.1. NM_080658.1.
UniGene	Hs.126265.
3D structure databases
ProteinModelPortal	Q96HD9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96HD9. 3 interactions.
STRING	9606.ENSP00000255082.
PTM databases
PhosphoSite	Q96HD9.
Polymorphism databases
DMDM	34395507.
Proteomic databases
PaxDb	Q96HD9.
PRIDE	Q96HD9.
Protocols and materials databases
DNASU	91703.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000255082; ENSP00000255082; ENSG00000132744.
GeneID	91703.
KEGG	hsa:91703.
UCSC	uc001omq.3. human.
Organism-specific databases
CTD	91703.
GeneCards	GC11M067411.
HGNC	HGNC:24104. ACY3.
HPA	HPA039219.
MIM	614413. gene.
neXtProt	NX_Q96HD9.
PharmGKB	PA134936640.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2988.
HOGENOM	HOG000232489.
HOVERGEN	HBG004172.
InParanoid	Q96HD9.
KO	K01437.
OMA	DDPYEVT.
OrthoDB	EOG4M65J9.
PhylomeDB	Q96HD9.
Enzyme and pathway databases
BioCyc	MetaCyc:HS13441-MONOMER.
Gene expression databases
ArrayExpress	Q96HD9.
Bgee	Q96HD9.
CleanEx	HS_ACY3.
Genevestigator	Q96HD9.
GermOnline	ENSG00000132744. Homo sapiens.
Family and domain databases
InterPro	IPR016708. Aspartoacylase. IPR007036. Aste_AspA. [Graphical view]
Pfam	PF04952. AstE_AspA. 1 hit. [Graphical view]
PIRSF	PIRSF018001. Aspartoacylase. 1 hit.
ProtoNet	Search...
Other
DrugBank	DB00128. L-Aspartic Acid.
GenomeRNAi	91703.
NextBio	77411.
SOURCE	Search...

Entry information

Entry name

ACY3_HUMAN

Accession

Primary (citable) accession number: Q96HD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.