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Protein

N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

Gene

ACY3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity).By similarity

Catalytic activityi

An N-acyl-aromatic-L-amino acid + H2O = an aromatic-L-amino acid + a carboxylate.
An N-acetyl-L-cysteine-S-conjugate + H2O = an L-cysteine-S-conjugate + acetate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi21ZincBy similarity1
Metal bindingi24ZincBy similarity1
Binding sitei63SubstrateBy similarity1
Metal bindingi116ZincBy similarity1
Binding sitei178SubstrateBy similarity1
Binding sitei288SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHost-virus interaction
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:HS13441-MONOMER
ReactomeiR-HSA-5423646 Aflatoxin activation and detoxification

Names & Taxonomyi

Protein namesi
Recommended name:
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (EC:3.5.1.114)
Alternative name(s):
Acylase III
Aminoacylase-3
Short name:
ACY-3
Aspartoacylase-2
Hepatitis C virus core-binding protein 1
Short name:
HCBP1
Short name:
HCV core-binding protein 1
Gene namesi
Name:ACY3
Synonyms:ASPA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000132744.7
HGNCiHGNC:24104 ACY3
MIMi614413 gene
neXtProtiNX_Q96HD9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi91703
OpenTargetsiENSG00000132744
PharmGKBiPA134936640

Chemistry databases

DrugBankiDB00128 L-Aspartic Acid

Polymorphism and mutation databases

BioMutaiACY3
DMDMi34395507

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002168751 – 319N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)Add BLAST319

Proteomic databases

MaxQBiQ96HD9
PaxDbiQ96HD9
PeptideAtlasiQ96HD9
PRIDEiQ96HD9

PTM databases

iPTMnetiQ96HD9
PhosphoSitePlusiQ96HD9

Expressioni

Gene expression databases

BgeeiENSG00000132744
CleanExiHS_ACY3
ExpressionAtlasiQ96HD9 baseline and differential
GenevisibleiQ96HD9 HS

Organism-specific databases

HPAiHPA039219
HPA048187

Interactioni

Subunit structurei

Exists as a mixture of homodimers and homotetramer, both catalytically active (By similarity). Interacts with HCV core protein.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124869, 15 interactors
IntActiQ96HD9, 20 interactors
MINTiQ96HD9
STRINGi9606.ENSP00000255082

Structurei

3D structure databases

ProteinModelPortaliQ96HD9
SMRiQ96HD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 210Hydrolytic domainBy similarityAdd BLAST210
Regioni70 – 71Substrate bindingBy similarity2
Regioni211 – 318Shielding domainBy similarityAdd BLAST108

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IERR Eukaryota
COG2988 LUCA
GeneTreeiENSGT00390000001189
HOGENOMiHOG000232489
HOVERGENiHBG004172
InParanoidiQ96HD9
KOiK18458
OMAiDDPYEVT
OrthoDBiEOG091G0BL6
PhylomeDBiQ96HD9
TreeFamiTF328708

Family and domain databases

CDDicd06909 M14_ASPA, 1 hit
HAMAPiMF_00704 Aspartoacylase, 1 hit
InterProiView protein in InterPro
IPR016708 Aspartoacylase
IPR007036 Aste_AspA
PfamiView protein in Pfam
PF04952 AstE_AspA, 1 hit
PIRSFiPIRSF018001 Aspartoacylase, 1 hit

Sequencei

Sequence statusi: Complete.

Q96HD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSLPVPREP LRRVAVTGGT HGNEMSGVYL ARHWLHAPAE LQRASFSAVP
60 70 80 90 100
VLANPAATSG CRRYVDHDLN RTFTSSFLNS RPTPDDPYEV TRARELNQLL
110 120 130 140 150
GPKASGQAFD FVLDLHNTTA NMGTCLIAKS SHEVFAMHLC RHLQLQYPEL
160 170 180 190 200
SCQVFLYQRS GEESYNLDSV AKNGLGLELG PQPQGVLRAD IFSRMRTLVA
210 220 230 240 250
TVLDFIELFN QGTAFPAFEM EAYRPVGVVD FPRTEAGHLA GTVHPQLQDR
260 270 280 290 300
DFQPLQPGAP IFQMFSGEDL LYEGESTVYP VFINEAAYYE KGVAFVQTEK
310
FTFTVPAMPA LTPAPSPAS
Length:319
Mass (Da):35,241
Last modified:December 1, 2001 - v1
Checksum:i2595358AC8B5BEFB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0483418R → Q. Corresponds to variant dbSNP:rs948445Ensembl.1
Natural variantiVAR_048342281V → M. Corresponds to variant dbSNP:rs2290959Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040761 mRNA Translation: AAK94770.1
AY169233 mRNA Translation: AAN87896.1
BC008689 mRNA Translation: AAH08689.1
CCDSiCCDS8175.1
RefSeqiNP_542389.1, NM_080658.1
UniGeneiHs.126265

Genome annotation databases

EnsembliENST00000255082; ENSP00000255082; ENSG00000132744
GeneIDi91703
KEGGihsa:91703
UCSCiuc001omq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiACY3_HUMAN
AccessioniPrimary (citable) accession number: Q96HD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health