Q96HB5 (CC120_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 120

Gene names

Name:	CCDC120
ORF Names:	JM11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	630 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96HB5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96HB5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     5-16: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 630	630	Coiled-coil domain-containing protein 120		PRO_0000254141
Regions
	Coiled coil	109 – 173	65	Potential
	Compositional bias	377 – 543	167	Pro-rich
Amino acid modifications
	Modified residue	358	1	Phosphoserine Ref.6
	Modified residue	360	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	5 – 16	12	Missing in isoform 2.		VSP_042859

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: E652C8AFD738BF6E	FASTA	630	67,567
	10 20 30 40 50 60 MEVKGQLISS PTFNAPAALF GEAAPQVKSE RLRGLLDRQR TLQEALSLKL QELRKVCLQE 70 80 90 100 110 120 AELTGQLPPE CPLEPGERPQ LVRRRPPTAR AYPPPHPNQA HHSLCPAEEL ALEALEREVS 130 140 150 160 170 180 VQQQIAAAAR RLALAPDLST EQRRRRRQVQ ADALRRLHEL EEQLRDVRAR LGLPVLPLPQ 190 200 210 220 230 240 PLPLSTGSVI TTQGVCLGMR LAQLSQEDVV LHSESSSLSE SGASHDNEEP HGCFSLAERP 250 260 270 280 290 300 SPPKAWDQLR AVSGGSPERR TPWKPPPSDL YGDLKSRRNS VASPTSPTRS LPRSASSFEG 310 320 330 340 350 360 RSVPATPVLT RGAGPQLCKP EGLHSRQWSG SQDSQMGFPR ADPASDRASL FVARTRRSNS 370 380 390 400 410 420 SEALLVDRAA GGGAGSPPAP LAPSASGPPV CKSSEVLYER PQPTPAFSSR TAGPPDPPRA 430 440 450 460 470 480 ARPSSAAPAS RGAPRLPPVC GDFLLDYSLD RGLPRSGGGT GWGELPPAAE VPGPLSRRDG 490 500 510 520 530 540 LLTMLPGPPP VYAADSNSPL LRTKDPHTRA TRTKPCGLPP EAAEGPEVHP NPLLWMPPPT 550 560 570 580 590 600 RIPSAGERSG HKNLALEGLR DWYIRNSGLA AGPQRRPVLP SVGPPHPPFL HARCYEVGQA 610 620 630 LYGAPSQAPL PHSRSFTAPP VSGRYGGCFY
	Isoform 2 [UniParc]. Checksum: 3BB9CCCF52CB53F0	FASTA	618	66,354
	10 20 30 40 50 60 MEVKAALFGE AAPQVKSERL RGLLDRQRTL QEALSLKLQE LRKVCLQEAE LTGQLPPECP 70 80 90 100 110 120 LEPGERPQLV RRRPPTARAY PPPHPNQAHH SLCPAEELAL EALEREVSVQ QQIAAAARRL 130 140 150 160 170 180 ALAPDLSTEQ RRRRRQVQAD ALRRLHELEE QLRDVRARLG LPVLPLPQPL PLSTGSVITT 190 200 210 220 230 240 QGVCLGMRLA QLSQEDVVLH SESSSLSESG ASHDNEEPHG CFSLAERPSP PKAWDQLRAV 250 260 270 280 290 300 SGGSPERRTP WKPPPSDLYG DLKSRRNSVA SPTSPTRSLP RSASSFEGRS VPATPVLTRG 310 320 330 340 350 360 AGPQLCKPEG LHSRQWSGSQ DSQMGFPRAD PASDRASLFV ARTRRSNSSE ALLVDRAAGG 370 380 390 400 410 420 GAGSPPAPLA PSASGPPVCK SSEVLYERPQ PTPAFSSRTA GPPDPPRAAR PSSAAPASRG 430 440 450 460 470 480 APRLPPVCGD FLLDYSLDRG LPRSGGGTGW GELPPAAEVP GPLSRRDGLL TMLPGPPPVY 490 500 510 520 530 540 AADSNSPLLR TKDPHTRATR TKPCGLPPEA AEGPEVHPNP LLWMPPPTRI PSAGERSGHK 550 560 570 580 590 600 NLALEGLRDW YIRNSGLAAG PQRRPVLPSV GPPHPPFLHA RCYEVGQALY GAPSQAPLPH 610 SRSFTAPPVS GRYGGCFY

References

[1]	"Cloning of human full-length CDS FLEXGene in Gateway(TM) recombinational vector system." Rolfs A., Kelley F., McCarron S., Jepson D., Shen B., Shi Z., Hu Y., Taycher E., Zuo D., Ebert L., Hoerlein A., Ernst U., Korn B., LaBaer J. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Choriocarcinoma.
[5]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Embryonic kidney.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ896186 mRNA. No translation available. AK300366 mRNA. Translation: BAG62104.1. AF196779 Genomic DNA. No translation available. BC008769 mRNA. Translation: AAH08769.1.
IPI	IPI00942201. IPI00943718.
RefSeq	NP_001156793.2. NM_001163321.2. NP_001156794.1. NM_001163322.2. NP_001156795.1. NM_001163323.2. NP_001258764.1. NM_001271835.1. NP_001258765.1. NM_001271836.1. NP_296375.1. NM_033626.3.
UniGene	Hs.522643.
3D structure databases
ProteinModelPortal	Q96HB5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96HB5. 7 interactions.
STRING	9606.ENSP00000365577.
PTM databases
PhosphoSite	Q96HB5.
Polymorphism databases
DMDM	74731908.
Proteomic databases
PaxDb	Q96HB5.
PRIDE	Q96HB5.
Protocols and materials databases
DNASU	90060.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376396; ENSP00000365577; ENSG00000147144. ENST00000536628; ENSP00000443351; ENSG00000147144.
GeneID	90060.
KEGG	hsa:90060.
UCSC	uc004dmf.3. human.
Organism-specific databases
CTD	90060.
GeneCards	GC0XP048916.
HGNC	HGNC:28910. CCDC120.
HPA	HPA000561.
neXtProt	NX_Q96HB5.
PharmGKB	PA145149329.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG119122.
HOGENOM	HOG000231367.
HOVERGEN	HBG080242.
InParanoid	Q96HB5.
OrthoDB	EOG4CVG6P.
PhylomeDB	Q96HB5.
Gene expression databases
ArrayExpress	Q96HB5.
Bgee	Q96HB5.
CleanEx	HS_CCDC120.
Genevestigator	Q96HB5.
GermOnline	ENSG00000147144. Homo sapiens.
Family and domain databases
InterPro	IPR021774. DUF3338. [Graphical view]
Pfam	PF11819. DUF3338. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CCDC120. human.
GenomeRNAi	90060.
NextBio	76501.

Entry information

Entry name

CC120_HUMAN

Accession

Primary (citable) accession number: Q96HB5
Secondary accession number(s): B4DTU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.