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Protein

Peroxisomal membrane protein 11C

Gene

PEX11G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes membrane protrusion and elongation on the peroxisomal surface.1 Publication

GO - Biological processi

  • peroxisome fission Source: UniProtKB
  • regulation of peroxisome size Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein 11C
Alternative name(s):
Peroxin-11C
Peroxisomal biogenesis factor 11C
Protein PEX11 homolog gamma
Short name:
PEX11-gamma
Gene namesi
Name:PEX11G
Synonyms:PEX11C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104883.7.
HGNCiHGNC:20208. PEX11G.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 124CytoplasmicSequence analysisAdd BLAST124
Transmembranei125 – 149HelicalSequence analysisAdd BLAST25
Topological domaini150 – 211LumenalSequence analysisAdd BLAST62
Transmembranei212 – 227HelicalSequence analysisAdd BLAST16
Topological domaini228 – 241CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104883.
PharmGKBiPA134987796.

Polymorphism and mutation databases

DMDMi62901102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001059701 – 241Peroxisomal membrane protein 11CAdd BLAST241

Proteomic databases

EPDiQ96HA9.
MaxQBiQ96HA9.
PaxDbiQ96HA9.
PeptideAtlasiQ96HA9.
PRIDEiQ96HA9.
TopDownProteomicsiQ96HA9-1. [Q96HA9-1]

PTM databases

iPTMnetiQ96HA9.
PhosphoSitePlusiQ96HA9.

Expressioni

Gene expression databases

BgeeiENSG00000104883.
CleanExiHS_PEX11G.
ExpressionAtlasiQ96HA9. baseline and differential.
GenevisibleiQ96HA9. HS.

Organism-specific databases

HPAiHPA069817.

Interactioni

Subunit structurei

Homodimer. Heterodimer with either PEX11A or PEX11B. Interacts with FIS1.1 Publication

Protein-protein interaction databases

BioGridi124990. 5 interactors.
STRINGi9606.ENSP00000221480.

Structurei

3D structure databases

ProteinModelPortaliQ96HA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-11 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4186. Eukaryota.
ENOG4111NS6. LUCA.
GeneTreeiENSGT00390000000427.
HOGENOMiHOG000230635.
HOVERGENiHBG053772.
InParanoidiQ96HA9.
KOiK13353.
OMAiIDDIPMI.
OrthoDBiEOG091G0KVZ.
PhylomeDBiQ96HA9.
TreeFamiTF316770.

Family and domain databases

InterProiView protein in InterPro
IPR008733. PEX11.
IPR026510. PEX11C_met.
PANTHERiPTHR20990. PTHR20990. 1 hit.
PfamiView protein in Pfam
PF05648. PEX11. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96HA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLSGLASA LESYRGRDRL IRVLGYCCQL VGGVLVEQCP ARSEVGTRLL
60 70 80 90 100
VVSTQLSHCR TILRLFDDLA MFVYTKQYGL GAQEEDAFVR CVSVLGNLAD
110 120 130 140 150
QLYYPCEHVA WAADARVLHV DSSRWWTLST TLWALSLLLG VARSLWMLLK
160 170 180 190 200
LRQRLRSPTA PFTSPLPRGK RRAMEAQMQS EALSLLSNLA DLANAVHWLP
210 220 230 240
RGVLWAGRFP PWLVGLMGTI SSILSMYQAA RAGGQAEATT P
Length:241
Mass (Da):26,636
Last modified:December 1, 2001 - v1
Checksum:iE8B64A196C105913
GO
Isoform 2 (identifier: Q96HA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Note: No experimental confirmation available.
Show »
Length:171
Mass (Da):19,016
Checksum:i306ED7CB510BC9C1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02456091C → W. Corresponds to variant dbSNP:rs2303146Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0135391 – 70Missing in isoform 2. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095921 mRNA. Translation: BAD01558.1.
AL833945 mRNA. Translation: CAD38800.1.
BC008780 mRNA. Translation: AAH08780.1.
CCDSiCCDS12178.1. [Q96HA9-1]
CCDS77227.1. [Q96HA9-2]
RefSeqiNP_001257468.1. NM_001270539.1.
NP_001287810.1. NM_001300881.1. [Q96HA9-2]
NP_542393.1. NM_080662.3. [Q96HA9-1]
XP_011526730.1. XM_011528428.1. [Q96HA9-2]
XP_011526731.1. XM_011528429.2. [Q96HA9-2]
XP_011526733.1. XM_011528431.2. [Q96HA9-2]
UniGeneiHs.515100.

Genome annotation databases

EnsembliENST00000221480; ENSP00000221480; ENSG00000104883. [Q96HA9-1]
ENST00000593942; ENSP00000472216; ENSG00000104883. [Q96HA9-2]
GeneIDi92960.
KEGGihsa:92960.
UCSCiuc002mgk.3. human. [Q96HA9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPX11C_HUMAN
AccessioniPrimary (citable) accession number: Q96HA9
Secondary accession number(s): Q8NDM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families