Q96HA9 (PX11C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxisomal membrane protein 11C

Alternative name(s):
Peroxin-11C
Peroxisomal biogenesis factor 11C
Protein PEX11 homolog gamma
Short name=PEX11-gamma

Gene names

Name:	PEX11G
Synonyms:	PEX11C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Peroxisome membrane; Multi-pass membrane protein Ref.1 Ref.4.
Sequence similarities	Belongs to the peroxin-11 family.

Ontologies

Keywords
Cellular component	Membrane Peroxisome
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peroxisome fission Inferred from direct assay PubMed 20826455. Source: UniProtKB regulation of peroxisome size Inferred from direct assay PubMed 20826455. Source: UniProtKB
Cellular_component	integral to peroxisomal membrane Inferred from electronic annotation. Source: InterPro intrinsic to peroxisomal membrane Inferred from direct assay Ref.1. Source: UniProtKB protein complex Inferred from direct assay PubMed 20826455. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96HA9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96HA9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Peroxisomal membrane protein 11C		PRO_0000105970
Regions
	Topological domain	1 – 124	124	Cytoplasmic Potential
	Transmembrane	125 – 149	25	Helical; Potential
	Topological domain	150 – 211	62	Lumenal Potential
	Transmembrane	212 – 227	16	Helical; Potential
	Topological domain	228 – 241	14	Cytoplasmic Potential
Natural variations
	Alternative sequence	1 – 70	70	Missing in isoform 2.		VSP_013539
	Natural variant	91	1	C → W. Corresponds to variant rs2303146 [ dbSNP | Ensembl ].		VAR_024560

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: E8B64A196C105913	FASTA	241	26,636
	10 20 30 40 50 60 MASLSGLASA LESYRGRDRL IRVLGYCCQL VGGVLVEQCP ARSEVGTRLL VVSTQLSHCR 70 80 90 100 110 120 TILRLFDDLA MFVYTKQYGL GAQEEDAFVR CVSVLGNLAD QLYYPCEHVA WAADARVLHV 130 140 150 160 170 180 DSSRWWTLST TLWALSLLLG VARSLWMLLK LRQRLRSPTA PFTSPLPRGK RRAMEAQMQS 190 200 210 220 230 240 EALSLLSNLA DLANAVHWLP RGVLWAGRFP PWLVGLMGTI SSILSMYQAA RAGGQAEATT P
	Isoform 2 [UniParc]. Checksum: 306ED7CB510BC9C1	FASTA	171	19,016
	10 20 30 40 50 60 MFVYTKQYGL GAQEEDAFVR CVSVLGNLAD QLYYPCEHVA WAADARVLHV DSSRWWTLST 70 80 90 100 110 120 TLWALSLLLG VARSLWMLLK LRQRLRSPTA PFTSPLPRGK RRAMEAQMQS EALSLLSNLA 130 140 150 160 170 DLANAVHWLP RGVLWAGRFP PWLVGLMGTI SSILSMYQAA RAGGQAEATT P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning and characterization of the third isoform of human peroxin Pex11p." Tanaka A., Okumoto K., Fujiki Y. Biochem. Biophys. Res. Commun. 300:819-823(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TOPOLOGY.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Pancreas.
[4]	"PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation." Li X., Baumgart E., Dong G.-X., Morrell J.C., Jimenez-Sanchez G., Valle D., Smith K.D., Gould S.J. Mol. Cell. Biol. 22:8226-8240(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TOPOLOGY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB095921 mRNA. Translation: BAD01558.1. AL833945 mRNA. Translation: CAD38800.1. BC008780 mRNA. Translation: AAH08780.1.
IPI	IPI00062958. IPI00556568.
RefSeq	NP_001257468.1. NM_001270539.1. NP_542393.1. NM_080662.3.
UniGene	Hs.515100.
3D structure databases
ProteinModelPortal	Q96HA9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000221480.
PTM databases
PhosphoSite	Q96HA9.
Polymorphism databases
DMDM	62901102.
Proteomic databases
PaxDb	Q96HA9.
PRIDE	Q96HA9.
Protocols and materials databases
DNASU	92960.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000221480; ENSP00000221480; ENSG00000104883. ENST00000593942; ENSP00000472216; ENSG00000104883.
GeneID	92960.
KEGG	hsa:92960.
UCSC	uc002mgk.1. human.
Organism-specific databases
CTD	92960.
GeneCards	GC19M007541.
H-InvDB	HIX0020270.
HGNC	HGNC:20208. PEX11G.
MIM	607583. gene.
neXtProt	NX_Q96HA9.
PharmGKB	PA134987796.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG302274.
HOGENOM	HOG000230635.
HOVERGEN	HBG053772.
InParanoid	Q96HA9.
KO	K13353.
OMA	VLVEQCP.
OrthoDB	EOG4VX266.
PhylomeDB	Q96HA9.
Gene expression databases
Bgee	Q96HA9.
CleanEx	HS_PEX11G.
Genevestigator	Q96HA9.
GermOnline	ENSG00000104883. Homo sapiens.
Family and domain databases
InterPro	IPR008733. PEX11. IPR026510. PEX11C_met. [Graphical view]
PANTHER	PTHR20990. PTHR20990. 1 hit.
Pfam	PF05648. PEX11. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	92960.
NextBio	77930.
SOURCE	Search...

Entry information

Entry name

PX11C_HUMAN

Accession

Primary (citable) accession number: Q96HA9
Secondary accession number(s): Q8NDM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.