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Protein

Peroxisomal membrane protein 11C

Gene

PEX11G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes membrane protrusion and elongation on the peroxisomal surface.1 Publication

GO - Biological processi

  • peroxisome fission Source: UniProtKB
  • regulation of peroxisome size Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein 11C
Alternative name(s):
Peroxin-11C
Peroxisomal biogenesis factor 11C
Protein PEX11 homolog gamma
Short name:
PEX11-gamma
Gene namesi
Name:PEX11G
Synonyms:PEX11C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20208. PEX11G.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 124124CytoplasmicSequence analysisAdd
BLAST
Transmembranei125 – 14925HelicalSequence analysisAdd
BLAST
Topological domaini150 – 21162LumenalSequence analysisAdd
BLAST
Transmembranei212 – 22716HelicalSequence analysisAdd
BLAST
Topological domaini228 – 24114CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of peroxisomal membrane Source: InterPro
  • intrinsic component of peroxisomal membrane Source: UniProtKB
  • peroxisome Source: UniProtKB
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134987796.

Polymorphism and mutation databases

DMDMi62901102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Peroxisomal membrane protein 11CPRO_0000105970Add
BLAST

Proteomic databases

MaxQBiQ96HA9.
PaxDbiQ96HA9.
PeptideAtlasiQ96HA9.
PRIDEiQ96HA9.
TopDownProteomicsiQ96HA9-1. [Q96HA9-1]

PTM databases

iPTMnetiQ96HA9.
PhosphoSiteiQ96HA9.

Expressioni

Gene expression databases

BgeeiQ96HA9.
CleanExiHS_PEX11G.
ExpressionAtlasiQ96HA9. baseline and differential.
GenevisibleiQ96HA9. HS.

Organism-specific databases

HPAiHPA063144.

Interactioni

Subunit structurei

Homodimer. Heterodimer with either PEX11A or PEX11B. Interacts with FIS1.1 Publication

Protein-protein interaction databases

BioGridi124990. 5 interactions.
STRINGi9606.ENSP00000221480.

Structurei

3D structure databases

ProteinModelPortaliQ96HA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-11 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4186. Eukaryota.
ENOG4111NS6. LUCA.
GeneTreeiENSGT00390000000427.
HOGENOMiHOG000230635.
HOVERGENiHBG053772.
InParanoidiQ96HA9.
KOiK13353.
OMAiIDDIPMI.
OrthoDBiEOG786H4M.
PhylomeDBiQ96HA9.
TreeFamiTF316770.

Family and domain databases

InterProiIPR008733. PEX11.
IPR026510. PEX11C_met.
[Graphical view]
PANTHERiPTHR20990. PTHR20990. 1 hit.
PfamiPF05648. PEX11. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96HA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLSGLASA LESYRGRDRL IRVLGYCCQL VGGVLVEQCP ARSEVGTRLL
60 70 80 90 100
VVSTQLSHCR TILRLFDDLA MFVYTKQYGL GAQEEDAFVR CVSVLGNLAD
110 120 130 140 150
QLYYPCEHVA WAADARVLHV DSSRWWTLST TLWALSLLLG VARSLWMLLK
160 170 180 190 200
LRQRLRSPTA PFTSPLPRGK RRAMEAQMQS EALSLLSNLA DLANAVHWLP
210 220 230 240
RGVLWAGRFP PWLVGLMGTI SSILSMYQAA RAGGQAEATT P
Length:241
Mass (Da):26,636
Last modified:December 1, 2001 - v1
Checksum:iE8B64A196C105913
GO
Isoform 2 (identifier: Q96HA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Note: No experimental confirmation available.
Show »
Length:171
Mass (Da):19,016
Checksum:i306ED7CB510BC9C1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911C → W.
Corresponds to variant rs2303146 [ dbSNP | Ensembl ].
VAR_024560

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7070Missing in isoform 2. 1 PublicationVSP_013539Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095921 mRNA. Translation: BAD01558.1.
AL833945 mRNA. Translation: CAD38800.1.
BC008780 mRNA. Translation: AAH08780.1.
CCDSiCCDS12178.1. [Q96HA9-1]
CCDS77227.1. [Q96HA9-2]
RefSeqiNP_001257468.1. NM_001270539.1.
NP_001287810.1. NM_001300881.1. [Q96HA9-2]
NP_542393.1. NM_080662.3. [Q96HA9-1]
XP_005272564.1. XM_005272507.3. [Q96HA9-2]
XP_011526730.1. XM_011528428.1. [Q96HA9-2]
XP_011526731.1. XM_011528429.1. [Q96HA9-2]
XP_011526732.1. XM_011528430.1. [Q96HA9-2]
XP_011526733.1. XM_011528431.1. [Q96HA9-2]
UniGeneiHs.515100.

Genome annotation databases

EnsembliENST00000221480; ENSP00000221480; ENSG00000104883. [Q96HA9-1]
ENST00000593942; ENSP00000472216; ENSG00000104883. [Q96HA9-2]
GeneIDi92960.
KEGGihsa:92960.
UCSCiuc002mgk.3. human. [Q96HA9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095921 mRNA. Translation: BAD01558.1.
AL833945 mRNA. Translation: CAD38800.1.
BC008780 mRNA. Translation: AAH08780.1.
CCDSiCCDS12178.1. [Q96HA9-1]
CCDS77227.1. [Q96HA9-2]
RefSeqiNP_001257468.1. NM_001270539.1.
NP_001287810.1. NM_001300881.1. [Q96HA9-2]
NP_542393.1. NM_080662.3. [Q96HA9-1]
XP_005272564.1. XM_005272507.3. [Q96HA9-2]
XP_011526730.1. XM_011528428.1. [Q96HA9-2]
XP_011526731.1. XM_011528429.1. [Q96HA9-2]
XP_011526732.1. XM_011528430.1. [Q96HA9-2]
XP_011526733.1. XM_011528431.1. [Q96HA9-2]
UniGeneiHs.515100.

3D structure databases

ProteinModelPortaliQ96HA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124990. 5 interactions.
STRINGi9606.ENSP00000221480.

PTM databases

iPTMnetiQ96HA9.
PhosphoSiteiQ96HA9.

Polymorphism and mutation databases

DMDMi62901102.

Proteomic databases

MaxQBiQ96HA9.
PaxDbiQ96HA9.
PeptideAtlasiQ96HA9.
PRIDEiQ96HA9.
TopDownProteomicsiQ96HA9-1. [Q96HA9-1]

Protocols and materials databases

DNASUi92960.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221480; ENSP00000221480; ENSG00000104883. [Q96HA9-1]
ENST00000593942; ENSP00000472216; ENSG00000104883. [Q96HA9-2]
GeneIDi92960.
KEGGihsa:92960.
UCSCiuc002mgk.3. human. [Q96HA9-1]

Organism-specific databases

CTDi92960.
GeneCardsiPEX11G.
H-InvDBHIX0020270.
HGNCiHGNC:20208. PEX11G.
HPAiHPA063144.
MIMi607583. gene.
neXtProtiNX_Q96HA9.
PharmGKBiPA134987796.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4186. Eukaryota.
ENOG4111NS6. LUCA.
GeneTreeiENSGT00390000000427.
HOGENOMiHOG000230635.
HOVERGENiHBG053772.
InParanoidiQ96HA9.
KOiK13353.
OMAiIDDIPMI.
OrthoDBiEOG786H4M.
PhylomeDBiQ96HA9.
TreeFamiTF316770.

Miscellaneous databases

GenomeRNAii92960.
PROiQ96HA9.
SOURCEiSearch...

Gene expression databases

BgeeiQ96HA9.
CleanExiHS_PEX11G.
ExpressionAtlasiQ96HA9. baseline and differential.
GenevisibleiQ96HA9. HS.

Family and domain databases

InterProiIPR008733. PEX11.
IPR026510. PEX11C_met.
[Graphical view]
PANTHERiPTHR20990. PTHR20990. 1 hit.
PfamiPF05648. PEX11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and characterization of the third isoform of human peroxin Pex11p."
    Tanaka A., Okumoto K., Fujiki Y.
    Biochem. Biophys. Res. Commun. 300:819-823(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TOPOLOGY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  4. "PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation."
    Li X., Baumgart E., Dong G.-X., Morrell J.C., Jimenez-Sanchez G., Valle D., Smith K.D., Gould S.J.
    Mol. Cell. Biol. 22:8226-8240(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TOPOLOGY.
  5. "PEX11 family members are membrane elongation factors that coordinate peroxisome proliferation and maintenance."
    Koch J., Pranjic K., Huber A., Ellinger A., Hartig A., Kragler F., Brocard C.
    J. Cell Sci. 123:3389-3400(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INTERACTION WITH FIS1; PEX11A AND PEX11B, SUBCELLULAR LOCATION.
  6. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiPX11C_HUMAN
AccessioniPrimary (citable) accession number: Q96HA9
Secondary accession number(s): Q8NDM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.