Q96HA4 (CA159_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C1orf159

Gene names

Name:	C1orf159
ORF Names:	UNQ2998/PRO9739

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96HA4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Gene prediction based on EST data.

Isoform 2 (identifier: Q96HA4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     25-60: Missing.
     185-221: APALQPGEAAAMIPPPQSSGNSSCRIPLWGFPSLGQS → GPAPAGSLPGRWSSQQFGPQAPALQPGEAVSNPHHPG
     222-380: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q96HA4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     25-60: Missing.
     204-225: GNSSCRIPLWGFPSLGQSQGAL → DVGSAGKEDPPRQGRPPIPAPP
     226-380: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q96HA4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     25-60: Missing.
     204-349: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q96HA4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 380	362	Uncharacterized protein C1orf159		PRO_0000255250
Regions
	Transmembrane	148 – 168	21	Helical; Potential
	Compositional bias	229 – 291	63	Pro-rich
Amino acid modifications
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Glycosylation	111	1	N-linked (GlcNAc...) Potential
	Glycosylation	128	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 126	126	Missing in isoform 5.		VSP_021280
	Alternative sequence	25 – 60	36	Missing in isoform 2, isoform 3 and isoform 4.		VSP_021281
	Alternative sequence	185 – 221	37	APALQ…SLGQS → GPAPAGSLPGRWSSQQFGPQ APALQPGEAVSNPHHPG in isoform 2.		VSP_021282
	Alternative sequence	204 – 349	146	Missing in isoform 4.		VSP_021283
	Alternative sequence	204 – 225	22	GNSSC…SQGAL → DVGSAGKEDPPRQGRPPIPA PP in isoform 3.		VSP_021284
	Alternative sequence	222 – 380	159	Missing in isoform 2.		VSP_021285
	Alternative sequence	226 – 380	155	Missing in isoform 3.		VSP_021286

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 31, 2006. Version 2. Checksum: D82F85CF3D903B81	FASTA	380	40,283
	10 20 30 40 50 60 MALRHLALLA GLLVGVASKS MENTVTRNST AVINTQAEGT LSPPGLSSLP VVREWALTHT 70 80 90 100 110 120 AQLPECCVDV VGVNASCPGA SLCGPGCYRR WNADGSASCV RCGNGTLPAY NGSECRSFAG 130 140 150 160 170 180 PGAPFPMNRS SGTPGRPHPG APRVAASLFL GTFFISSGLI LSVAGFFYLK RSSKLPRACY 190 200 210 220 230 240 RRNKAPALQP GEAAAMIPPP QSSGNSSCRI PLWGFPSLGQ SQGALWVCPQ TGLPGSGSRP 250 260 270 280 290 300 PLPGSPGDPP TRQGQGRIWL VPPALDLSWI WPAPPARPPL IPVTSMLFPV PETWGLQERR 310 320 330 340 350 360 THHDRADPQY LLLLEVQLHP RTDAAGLRQA LLSSHRFSGA GSGGPKSQPV RKPRYVRRER 370 380 PLDRATDPAA FPGEARISNV
	Isoform 2 [UniParc]. Checksum: 2488F40B8F1239C3	FASTA	185	19,097
	10 20 30 40 50 60 MALRHLALLA GLLVGVASKS MENTAQLPEC CVDVVGVNAS CPGASLCGPG CYRRWNADGS 70 80 90 100 110 120 ASCVRCGNGT LPAYNGSECR SFAGPGAPFP MNRSSGTPGR PHPGAPRVAA SLFLGTFFIS 130 140 150 160 170 180 SGLILSVAGF FYLKRSSKLP RACYRRNKGP APAGSLPGRW SSQQFGPQAP ALQPGEAVSN PHHPG
	Isoform 3 [UniParc]. Checksum: B442CB2A09470157	FASTA	189	19,464
	10 20 30 40 50 60 MALRHLALLA GLLVGVASKS MENTAQLPEC CVDVVGVNAS CPGASLCGPG CYRRWNADGS 70 80 90 100 110 120 ASCVRCGNGT LPAYNGSECR SFAGPGAPFP MNRSSGTPGR PHPGAPRVAA SLFLGTFFIS 130 140 150 160 170 180 SGLILSVAGF FYLKRSSKLP RACYRRNKAP ALQPGEAAAM IPPPQSSDVG SAGKEDPPRQ GRPPIPAPP
	Isoform 4 [UniParc]. Checksum: 734467FBB65598A9	FASTA	198	20,820
	10 20 30 40 50 60 MALRHLALLA GLLVGVASKS MENTAQLPEC CVDVVGVNAS CPGASLCGPG CYRRWNADGS 70 80 90 100 110 120 ASCVRCGNGT LPAYNGSECR SFAGPGAPFP MNRSSGTPGR PHPGAPRVAA SLFLGTFFIS 130 140 150 160 170 180 SGLILSVAGF FYLKRSSKLP RACYRRNKAP ALQPGEAAAM IPPPQSSVRK PRYVRRERPL 190 DRATDPAAFP GEARISNV
	Isoform 5 [UniParc]. Checksum: 76175CE950FF64C1	FASTA	254	27,411
	10 20 30 40 50 60 MNRSSGTPGR PHPGAPRVAA SLFLGTFFIS SGLILSVAGF FYLKRSSKLP RACYRRNKAP 70 80 90 100 110 120 ALQPGEAAAM IPPPQSSGNS SCRIPLWGFP SLGQSQGALW VCPQTGLPGS GSRPPLPGSP 130 140 150 160 170 180 GDPPTRQGQG RIWLVPPALD LSWIWPAPPA RPPLIPVTSM LFPVPETWGL QERRTHHDRA 190 200 210 220 230 240 DPQYLLLLEV QLHPRTDAAG LRQALLSSHR FSGAGSGGPK SQPVRKPRYV RRERPLDRAT 250 DPAAFPGEAR ISNV

References

[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 5 AND 4). Tissue: Carcinoma, Testis and Thymus.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Uterus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358490 mRNA. Translation: AAQ88854.1. AK000591 mRNA. Translation: BAA91276.1. AK057368 mRNA. Translation: BAG51908.1. AK128434 mRNA. Translation: BAC87438.1. AL390719 Genomic DNA. Translation: CAI14316.1. AL390719 Genomic DNA. Translation: CAI14318.1. BC008788 mRNA. Translation: AAH08788.1.
IPI	IPI00016627. IPI00062955. IPI00514936. IPI00515131. IPI00883596.
RefSeq	NP_060361.4. NM_017891.4.
UniGene	Hs.235095.
3D structure databases
ProteinModelPortal	Q96HA4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000368623.
PTM databases
PhosphoSite	Q96HA4.
Polymorphism databases
DMDM	119371554.
Proteomic databases
PaxDb	Q96HA4.
PRIDE	Q96HA4.
Protocols and materials databases
DNASU	54991.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000379319; ENSP00000368623; ENSG00000131591. ENST00000379325; ENSP00000368629; ENSG00000131591. ENST00000379339; ENSP00000368644; ENSG00000131591. ENST00000421241; ENSP00000400736; ENSG00000131591. ENST00000437760; ENSP00000399027; ENSG00000131591. ENST00000448924; ENSP00000392290; ENSG00000131591.
GeneID	54991.
KEGG	hsa:54991.
UCSC	uc001act.2. human. uc001acu.2. human.
Organism-specific databases
CTD	54991.
GeneCards	GC01M001018.
H-InvDB	HIX0000013.
HGNC	HGNC:26062. C1orf159.
HPA	HPA010019.
neXtProt	NX_Q96HA4.
PharmGKB	PA142672410.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39970.
HOGENOM	HOG000231900.
HOVERGEN	HBG058261.
InParanoid	Q96HA4.
OMA	PGCYRHW.
OrthoDB	EOG46DM4C.
Gene expression databases
ArrayExpress	Q96HA4.
Bgee	Q96HA4.
CleanEx	HS_C1orf159.
Genevestigator	Q96HA4.
GermOnline	ENSG00000131591. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	C1orf159. human.
GenomeRNAi	54991.
NextBio	58290.

Entry information

Entry name

CA159_HUMAN

Accession

Primary (citable) accession number: Q96HA4
Secondary accession number(s): B3KQ46 , Q5T2W6, Q6UX67, Q6ZR77, Q9NWV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	April 3, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.