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Q96HA1

- P121A_HUMAN

UniProt

Q96HA1 - P121A_HUMAN

Protein

Nuclear envelope pore membrane protein POM 121

Gene

POM121

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).1 Publication

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. cytokine-mediated signaling pathway Source: Reactome
    3. glucose transport Source: Reactome
    4. hexose transport Source: Reactome
    5. mitotic cell cycle Source: Reactome
    6. mitotic nuclear envelope disassembly Source: Reactome
    7. mRNA transport Source: UniProtKB-KW
    8. protein transport Source: UniProtKB-KW
    9. regulation of glucose transport Source: Reactome
    10. small molecule metabolic process Source: Reactome
    11. transmembrane transport Source: Reactome
    12. viral process Source: Reactome

    Keywords - Biological processi

    mRNA transport, Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_115831. ISG15 antiviral mechanism.
    REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
    REACT_6190. Rev-mediated nuclear export of HIV RNA.
    REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
    REACT_7991. Vpr-mediated nuclear import of PICs.
    REACT_9395. Nuclear import of Rev protein.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear envelope pore membrane protein POM 121
    Alternative name(s):
    Nuclear envelope pore membrane protein POM 121A
    Nucleoporin Nup121
    Pore membrane protein of 121 kDa
    Gene namesi
    Name:POM121
    Synonyms:KIAA0618, NUP121, POM121A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:19702. POM121.

    Subcellular locationi

    Nucleusnuclear pore complex 1 Publication. Nucleus membrane 1 Publication; Single-pass membrane protein 1 Publication. Endoplasmic reticulum membrane By similarity; Single-pass membrane protein By similarity
    Note: Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. nuclear envelope Source: Reactome
    3. nuclear membrane Source: UniProtKB-SubCell
    4. nuclear pore Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134987951.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12491249Nuclear envelope pore membrane protein POM 121PRO_0000346773Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei345 – 3451PhosphoserineBy similarity
    Modified residuei351 – 3511Phosphoserine1 Publication
    Modified residuei371 – 3711Phosphoserine1 Publication
    Modified residuei393 – 3931PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96HA1.
    PaxDbiQ96HA1.
    PRIDEiQ96HA1.

    PTM databases

    PhosphoSiteiQ96HA1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96HA1.
    BgeeiQ96HA1.
    CleanExiHS_POM121.
    GenevestigatoriQ96HA1.

    Organism-specific databases

    HPAiHPA043809.
    HPA049817.

    Interactioni

    Protein-protein interaction databases

    BioGridi115214. 20 interactions.
    IntActiQ96HA1. 21 interactions.
    MINTiMINT-1437396.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96HA1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 285285Required for targeting to the nucleus and nuclear pore complexAdd
    BLAST
    Regioni1 – 3434Cisternal sideSequence AnalysisAdd
    BLAST
    Regioni56 – 12491194Pore sideSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi144 – 21471Pro-richAdd
    BLAST
    Compositional biasi378 – 44568Ser-richAdd
    BLAST
    Compositional biasi751 – 947197Thr-richAdd
    BLAST

    Domaini

    Contains F-X-F-G repeats.

    Sequence similaritiesi

    Belongs to the POM121 family.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOVERGENiHBG053628.
    InParanoidiQ96HA1.
    KOiK14316.
    OMAiDSKWIRS.
    OrthoDBiEOG7QG440.
    PhylomeDBiQ96HA1.
    TreeFamiTF323517.

    Family and domain databases

    InterProiIPR026090. POM121.
    [Graphical view]
    PANTHERiPTHR23193:SF5. PTHR23193:SF5. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96HA1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSPAAAAAGA GERRRPIASV RDGRGRGCGG PARAVLLGLS LVGLLLYLVP     50
    AAAALAWLTV GATAAWWGLS REPRGSRPLS SFVRKARHRR PLSSFVRKAR 100
    HRRTLFASPL AKSTANGNLL EPRTLLEGPD PAELLLMGSY LGKPGPPQPA 150
    AAPEGQDLRD RPGRRPPARP APRSPPPRSP PPRSPPPSPP THRAHHVYPS 200
    LPTPLLRPSR RPSPRDCGTL PNRFVITPRR RYPIHQAQYS CLGVLPTVCW 250
    NGYHKKAVLS PRNSRMVCSP VTVRIAPPDR RFSRSAIPEQ IISSTLSSPS 300
    SNAPDPCAKE TVLSALKEKE KKRTVEEEDQ IFLDGQENKR RRHDSSGSGH 350
    SAFEPLVANG VPASFVPKPG SLKRGLNSQS SDDHLNKRSR SSSMSSLTGA 400
    YASGIPSSSR NAITSSYSST RGISQLWKRN GPSSSPFSSP ASSRSQTPER 450
    PAKKIREEEL CHHSSSSTPL AADRESQGEK AADTTPRKKQ NSNSQSTPGS 500
    SGQRKRKVQL LPSRRGEQLT LPPPPQLGYS ITAEDLDLEK KASLQWFNQA 550
    LEDKSDAASN SVTETPPITQ PSFTFTLPAA APASPPTSLL APSTNPLLES 600
    LKKMQTPPSL PPCPESAGAA TTEALSPPKT PSLLPPLGLS QSGPPGLLPS 650
    PSFDSKPPTT LLGLIPAPSM VPATDTKAPP TLQAETATKP QATSAPSPAP 700
    KQSFLFGTQN TSPSSPAAPA ASSAPPMFKP IFTAPPKSEK EGPTPPGPSV 750
    TATAPSSSSL PTTTSTTAPT FQPVFSSMGP PASVPLPAPF FKQTTTPATA 800
    PTTTAPLFTG LASATSAVAP ITSASPSTDS ASKPAFGFGI NSVSSSSVST 850
    TTSTATAASQ PFLFGAPQAS AASFTPAMGS IFQFGKPPAL PTTTTVTTFS 900
    QSLHTAVPTA TSSSAADFSG FGSTLATSAP ATSSQPTLTF SNTSTPTFNI 950
    PFGSSAKSPL PSYPGANPQP AFGAAEGQPP GAAKPALAPS FGSSFTFGNS 1000
    AAPAAAPTPA PPSMIKVVPA YVPTPIHPIF GGATHSAFGL KATASAFGAP 1050
    ASSQPAFGGS TAVFFGAATS SGFGATTQTA SSGSSSSVFG STTPSPFTFG 1100
    GSAAPAGSGS FGINVATPGS STTTGAFSFG AGQSGSTATS TPFAGGLGQN 1150
    ALGTTGQSTP FAFNVSSTTE SKPVFGGTAT PTFGLNTPAP GVGTSGSSLS 1200
    FGASSAPAQG FVGVAPFGSA ALSFSIGAGS KTPGARQRLQ ARRQHTRKK 1249
    Length:1,249
    Mass (Da):127,720
    Last modified:September 2, 2008 - v2
    Checksum:iEDBA86CA5D658F61
    GO
    Isoform 2 (identifier: Q96HA1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-265: Missing.

    Show »
    Length:984
    Mass (Da):99,037
    Checksum:i36DEDB4419EEA8E6
    GO
    Isoform 3 (identifier: Q96HA1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-265: Missing.
         1219-1249: SAALSFSIGAGSKTPGARQRLQARRQHTRKK → NTFAHQQEHS...QASSFPTRKE

    Note: No experimental confirmation available.Curated

    Show »
    Length:999
    Mass (Da):100,864
    Checksum:i73F8BEC747A1840E
    GO

    Sequence cautioni

    The sequence BAA31593.2 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB14097.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti689 – 6891K → E in BAF85237. (PubMed:14702039)Curated
    Sequence conflicti904 – 9041H → P in BAB14097. (PubMed:14702039)Curated
    Sequence conflicti971 – 9711A → T in BAB14097. (PubMed:14702039)Curated
    Sequence conflicti1021 – 10211Y → H in BAB14097. (PubMed:14702039)Curated
    Sequence conflicti1113 – 11131I → T in BAF85237. (PubMed:14702039)Curated
    Isoform 3 (identifier: Q96HA1-3)
    Sequence conflicti985 – 9851L → P in BAA31593. (PubMed:9734811)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1215 – 12151A → G.
    Corresponds to variant rs3177261 [ dbSNP | Ensembl ].
    VAR_045905

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 265265Missing in isoform 2 and isoform 3. 3 PublicationsVSP_035010Add
    BLAST
    Alternative sequencei1219 – 124931SAALS…HTRKK → NTFAHQQEHSPRKGPNNLSK RKLLPAVRAQGLPRRGQASS FPTRKE in isoform 3. 1 PublicationVSP_035011Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB014518 mRNA. Translation: BAA31593.2. Different initiation.
    AK022555 mRNA. Translation: BAB14097.1. Different initiation.
    AK292548 mRNA. Translation: BAF85237.1.
    AC005488 Genomic DNA. No translation available.
    BC001518 mRNA. Translation: AAH01518.2.
    BC008794 mRNA. Translation: AAH08794.1.
    AB289621 mRNA. Translation: BAF80887.1.
    AL080109 mRNA. Translation: CAB45713.1.
    AL713666 mRNA. Translation: CAD28472.1.
    CCDSiCCDS5542.1. [Q96HA1-2]
    CCDS59059.1. [Q96HA1-3]
    RefSeqiNP_001244119.1. NM_001257190.2. [Q96HA1-3]
    NP_742017.1. NM_172020.4. [Q96HA1-2]
    XP_005250783.1. XM_005250726.2. [Q96HA1-1]
    XP_005250785.1. XM_005250728.2. [Q96HA1-2]
    XP_005250786.1. XM_005250729.2. [Q96HA1-2]
    XP_005250787.1. XM_005250730.2. [Q96HA1-2]
    XP_005250788.1. XM_005250731.2. [Q96HA1-2]
    XP_005250789.1. XM_005250732.2. [Q96HA1-2]
    XP_006716257.1. XM_006716194.1. [Q96HA1-2]
    XP_006716258.1. XM_006716195.1. [Q96HA1-2]
    XP_006716259.1. XM_006716196.1. [Q96HA1-2]
    UniGeneiHs.655217.
    Hs.737064.

    Genome annotation databases

    EnsembliENST00000358357; ENSP00000351124; ENSG00000196313. [Q96HA1-2]
    ENST00000395270; ENSP00000378687; ENSG00000196313. [Q96HA1-3]
    ENST00000434423; ENSP00000405562; ENSG00000196313. [Q96HA1-1]
    ENST00000446813; ENSP00000393020; ENSG00000196313. [Q96HA1-3]
    GeneIDi9883.
    KEGGihsa:9883.
    UCSCiuc003twk.2. human. [Q96HA1-1]

    Polymorphism databases

    DMDMi205829302.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB014518 mRNA. Translation: BAA31593.2 . Different initiation.
    AK022555 mRNA. Translation: BAB14097.1 . Different initiation.
    AK292548 mRNA. Translation: BAF85237.1 .
    AC005488 Genomic DNA. No translation available.
    BC001518 mRNA. Translation: AAH01518.2 .
    BC008794 mRNA. Translation: AAH08794.1 .
    AB289621 mRNA. Translation: BAF80887.1 .
    AL080109 mRNA. Translation: CAB45713.1 .
    AL713666 mRNA. Translation: CAD28472.1 .
    CCDSi CCDS5542.1. [Q96HA1-2 ]
    CCDS59059.1. [Q96HA1-3 ]
    RefSeqi NP_001244119.1. NM_001257190.2. [Q96HA1-3 ]
    NP_742017.1. NM_172020.4. [Q96HA1-2 ]
    XP_005250783.1. XM_005250726.2. [Q96HA1-1 ]
    XP_005250785.1. XM_005250728.2. [Q96HA1-2 ]
    XP_005250786.1. XM_005250729.2. [Q96HA1-2 ]
    XP_005250787.1. XM_005250730.2. [Q96HA1-2 ]
    XP_005250788.1. XM_005250731.2. [Q96HA1-2 ]
    XP_005250789.1. XM_005250732.2. [Q96HA1-2 ]
    XP_006716257.1. XM_006716194.1. [Q96HA1-2 ]
    XP_006716258.1. XM_006716195.1. [Q96HA1-2 ]
    XP_006716259.1. XM_006716196.1. [Q96HA1-2 ]
    UniGenei Hs.655217.
    Hs.737064.

    3D structure databases

    ProteinModelPortali Q96HA1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115214. 20 interactions.
    IntActi Q96HA1. 21 interactions.
    MINTi MINT-1437396.

    PTM databases

    PhosphoSitei Q96HA1.

    Polymorphism databases

    DMDMi 205829302.

    Proteomic databases

    MaxQBi Q96HA1.
    PaxDbi Q96HA1.
    PRIDEi Q96HA1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358357 ; ENSP00000351124 ; ENSG00000196313 . [Q96HA1-2 ]
    ENST00000395270 ; ENSP00000378687 ; ENSG00000196313 . [Q96HA1-3 ]
    ENST00000434423 ; ENSP00000405562 ; ENSG00000196313 . [Q96HA1-1 ]
    ENST00000446813 ; ENSP00000393020 ; ENSG00000196313 . [Q96HA1-3 ]
    GeneIDi 9883.
    KEGGi hsa:9883.
    UCSCi uc003twk.2. human. [Q96HA1-1 ]

    Organism-specific databases

    CTDi 9883.
    GeneCardsi GC07P072349.
    HGNCi HGNC:19702. POM121.
    HPAi HPA043809.
    HPA049817.
    MIMi 615753. gene.
    neXtProti NX_Q96HA1.
    PharmGKBi PA134987951.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOVERGENi HBG053628.
    InParanoidi Q96HA1.
    KOi K14316.
    OMAi DSKWIRS.
    OrthoDBi EOG7QG440.
    PhylomeDBi Q96HA1.
    TreeFami TF323517.

    Enzyme and pathway databases

    Reactomei REACT_115831. ISG15 antiviral mechanism.
    REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
    REACT_6190. Rev-mediated nuclear export of HIV RNA.
    REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
    REACT_7991. Vpr-mediated nuclear import of PICs.
    REACT_9395. Nuclear import of Rev protein.

    Miscellaneous databases

    ChiTaRSi POM121. human.
    GeneWikii POM121.
    GenomeRNAii 9883.
    NextBioi 37252.
    PROi Q96HA1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96HA1.
    Bgeei Q96HA1.
    CleanExi HS_POM121.
    Genevestigatori Q96HA1.

    Family and domain databases

    InterProi IPR026090. POM121.
    [Graphical view ]
    PANTHERi PTHR23193:SF5. PTHR23193:SF5. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    2. Ohara O., Suyama M., Nagase T., Ishikawa K.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Teratocarcinoma and Testis.
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lymph and Skin.
    6. "Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes."
      Funakoshi T., Maeshima K., Yahata K., Sugano S., Imamoto F., Imamoto N.
      FEBS Lett. 581:4910-4916(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-285 (ISOFORM 1), IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION.
      Tissue: Cervix.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1150-1249 (ISOFORM 1).
      Tissue: Uterus.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-351, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-371, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiP121A_HUMAN
    AccessioniPrimary (citable) accession number: Q96HA1
    Secondary accession number(s): A6NFS9
    , A8CDT4, A8K933, A8MXF9, O75115, Q96DI0, Q9H9X1, Q9Y2N3, Q9Y4S7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3