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Q96H96

- COQ2_HUMAN

UniProt

Q96H96 - COQ2_HUMAN

Protein

4-hydroxybenzoate polyprenyltransferase, mitochondrial

Gene

COQ2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB.1 Publication

    Catalytic activityi

    A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. 4-hydroxybenzoate decaprenyltransferase activity Source: UniProtKB-EC
    2. 4-hydroxybenzoate nonaprenyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell death Source: UniProtKB-KW
    2. glycerol metabolic process Source: UniProtKB
    3. isoprenoid biosynthetic process Source: UniProtKB-KW
    4. small molecule metabolic process Source: Reactome
    5. ubiquinone biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Isoprene biosynthesis, Ubiquinone biosynthesis

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000173085-MONOMER.
    ReactomeiREACT_118595. Mitochondrial protein import.
    REACT_160111. Ubiquinol biosynthesis.
    UniPathwayiUPA00232.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxybenzoate polyprenyltransferase, mitochondrial (EC:2.5.1.39)
    Alternative name(s):
    COQ2 homolog
    Short name:
    hCOQ2
    Para-hydroxybenzoate--polyprenyltransferase
    Short name:
    PHB:polyprenyltransferase
    Gene namesi
    Name:COQ2
    Synonyms:CL640
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:25223. COQ2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    Pathology & Biotechi

    Involvement in diseasei

    Coenzyme Q10 deficiency, primary, 1 (COQ10D1) [MIM:607426]: An autosomal recessive disorder with variable manifestations consistent with 5 major phenotypes. The phenotypes include an encephalomyopathic form with seizures and ataxia; a multisystem infantile form with encephalopathy, cardiomyopathy and renal failure; a predominantly cerebellar form with ataxia and cerebellar atrophy; Leigh syndrome with growth retardation; and an isolated myopathic form.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti96 – 961S → N in COQ10D1. 1 Publication
    VAR_068161
    Natural varianti147 – 1471R → H in COQ10D1. 1 Publication
    VAR_068162
    Natural varianti178 – 1781N → S in COQ10D1. 1 Publication
    VAR_068163
    Natural varianti247 – 2471Y → C in COQ10D1. 2 Publications
    VAR_025701
    Multiple system atrophy 1 (MSA1) [MIM:146500]: A progressive neurodegenerative disorder clinically characterized by parkinsonism, cerebellar ataxia, and autonomic, urogenital, and pyramidal dysfunction in various combinations. Pathologically, it is characterized by degeneration of striatonigral and olivopontocerebellar structures, and glial cytoplasmic inclusions that consist of abnormally phosphorylated alpha-synuclein or tau.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291F → L in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070239
    Natural varianti49 – 491P → H in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070240
    Natural varianti57 – 571S → T in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070241
    Natural varianti78 – 781M → V in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070243
    Natural varianti97 – 971I → T in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070244
    Natural varianti107 – 1071P → S in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070245
    Natural varianti113 – 1131S → F in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070246
    Natural varianti267 – 2671T → A in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070247
    Natural varianti297 – 2971S → C in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070248
    Natural varianti337 – 3371R → Q in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070250
    Natural varianti343 – 3431V → A in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070251

    Keywords - Diseasei

    Disease mutation, Neurodegeneration, Parkinsonism

    Organism-specific databases

    MIMi146500. phenotype.
    607426. phenotype.
    Orphaneti255249. Leigh syndrome with nephrotic syndrome.
    227510. Multiple system atrophy, cerebellar type.
    98933. Multiple system atrophy, parkinsonian type.
    PharmGKBiPA142672084.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3434MitochondrionSequence AnalysisAdd
    BLAST
    Chaini35 – 3713374-hydroxybenzoate polyprenyltransferase, mitochondrialPRO_0000228623Add
    BLAST

    Proteomic databases

    MaxQBiQ96H96.
    PaxDbiQ96H96.
    PRIDEiQ96H96.

    PTM databases

    PhosphoSiteiQ96H96.

    Expressioni

    Tissue specificityi

    Widely expressed. Present in all of the tissues tested. Expressed at higher level in skeletal muscle, adrenal glands and the heart.1 Publication

    Gene expression databases

    ArrayExpressiQ96H96.
    BgeeiQ96H96.
    CleanExiHS_COQ2.
    GenevestigatoriQ96H96.

    Organism-specific databases

    HPAiHPA056599.

    Interactioni

    Protein-protein interaction databases

    BioGridi118083. 2 interactions.
    STRINGi9606.ENSP00000409275.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96H96.
    SMRiQ96H96. Positions 114-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei301 – 32121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei333 – 35321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UbiA prenyltransferase family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0382.
    HOGENOMiHOG000003697.
    HOVERGENiHBG081302.
    InParanoidiQ96H96.
    KOiK06125.
    PhylomeDBiQ96H96.
    TreeFamiTF105873.

    Family and domain databases

    InterProiIPR006370. HB_polyprenyl-transferase.
    IPR000537. UbiA_prenyltransferase.
    [Graphical view]
    PfamiPF01040. UbiA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01474. ubiA_proteo. 1 hit.
    PROSITEiPS00943. UBIA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96H96-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLGSRAAGFA RGLRALALAW LPGWRGRSFA LARAAGAPHG GDLQPPACPE    50
    PRGRQLSLSA AAVVDSAPRP LQPYLRLMRL DKPIGTWLLY LPCTWSIGLA 100
    AEPGCFPDWY MLSLFGTGAI LMRGAGCTIN DMWDQDYDKK VTRTANRPIA 150
    AGDISTFQSF VFLGGQLTLA LGVLLCLNYY SIALGAGSLL LVITYPLMKR 200
    ISYWPQLALG LTFNWGALLG WSAIKGSCDP SVCLPLYFSG VMWTLIYDTI 250
    YAHQDKRDDV LIGLKSTALR FGENTKPWLS GFSVAMLGAL SLVGVNSGQT 300
    APYYAALGAV GAHLTHQIYT LDIHRPEDCW NKFISNRTLG LIVFLGIVLG 350
    NLWKEKKTDK TKKGIENKIE N 371
    Length:371
    Mass (Da):40,489
    Last modified:December 1, 2001 - v1
    Checksum:i92371F0DD373A732
    GO
    Isoform 3 (identifier: Q96H96-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         318-334: IYTLDIHRPEDCWNKFI → KWGLEILPRLV
         335-371: Missing.

    Show »
    Length:328
    Mass (Da):35,468
    Checksum:i386A0430F0BC890B
    GO

    Sequence cautioni

    The sequence AAC72955.1 differs from that shown. Reason: Frameshift at position 172.
    The sequence AAH20728.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAF18241.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161L → V.1 Publication
    Corresponds to variant rs6818847 [ dbSNP | Ensembl ].
    VAR_070237
    Natural varianti22 – 221P → L.1 Publication
    VAR_070238
    Natural varianti29 – 291F → L in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070239
    Natural varianti49 – 491P → H in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070240
    Natural varianti57 – 571S → T in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070241
    Natural varianti69 – 691R → H.1 Publication
    VAR_070242
    Natural varianti78 – 781M → V in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070243
    Natural varianti96 – 961S → N in COQ10D1. 1 Publication
    VAR_068161
    Natural varianti97 – 971I → T in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070244
    Natural varianti107 – 1071P → S in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070245
    Natural varianti113 – 1131S → F in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070246
    Natural varianti147 – 1471R → H in COQ10D1. 1 Publication
    VAR_068162
    Natural varianti178 – 1781N → S in COQ10D1. 1 Publication
    VAR_068163
    Natural varianti247 – 2471Y → C in COQ10D1. 2 Publications
    VAR_025701
    Natural varianti267 – 2671T → A in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070247
    Natural varianti297 – 2971S → C in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070248
    Natural varianti336 – 3361N → H.1 Publication
    VAR_070249
    Natural varianti337 – 3371R → Q in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070250
    Natural varianti343 – 3431V → A in MSA1; associated with disease susceptibility. 1 Publication
    VAR_070251

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei318 – 33417IYTLD…WNKFI → KWGLEILPRLV in isoform 3. 2 PublicationsVSP_017677Add
    BLAST
    Alternative sequencei335 – 37137Missing in isoform 3. 2 PublicationsVSP_017678Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ621061 mRNA. Translation: CAF18241.1. Different initiation.
    AC114781 Genomic DNA. No translation available.
    BC008804 mRNA. Translation: AAH08804.1.
    BC020728 mRNA. Translation: AAH20728.2. Different initiation.
    BC116454 mRNA. Translation: AAI16455.1.
    AF091086 mRNA. Translation: AAC72955.1. Frameshift.
    CR456860 mRNA. Translation: CAG33141.1.
    RefSeqiNP_056512.5. NM_015697.7.
    UniGeneiHs.144304.
    Hs.729069.

    Genome annotation databases

    EnsembliENST00000311469; ENSP00000310873; ENSG00000173085.
    ENST00000439031; ENSP00000409275; ENSG00000173085.
    GeneIDi27235.
    KEGGihsa:27235.
    UCSCiuc003hog.3. human. [Q96H96-1]

    Polymorphism databases

    DMDMi74731901.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ621061 mRNA. Translation: CAF18241.1 . Different initiation.
    AC114781 Genomic DNA. No translation available.
    BC008804 mRNA. Translation: AAH08804.1 .
    BC020728 mRNA. Translation: AAH20728.2 . Different initiation.
    BC116454 mRNA. Translation: AAI16455.1 .
    AF091086 mRNA. Translation: AAC72955.1 . Frameshift.
    CR456860 mRNA. Translation: CAG33141.1 .
    RefSeqi NP_056512.5. NM_015697.7.
    UniGenei Hs.144304.
    Hs.729069.

    3D structure databases

    ProteinModelPortali Q96H96.
    SMRi Q96H96. Positions 114-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118083. 2 interactions.
    STRINGi 9606.ENSP00000409275.

    PTM databases

    PhosphoSitei Q96H96.

    Polymorphism databases

    DMDMi 74731901.

    Proteomic databases

    MaxQBi Q96H96.
    PaxDbi Q96H96.
    PRIDEi Q96H96.

    Protocols and materials databases

    DNASUi 27235.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311469 ; ENSP00000310873 ; ENSG00000173085 .
    ENST00000439031 ; ENSP00000409275 ; ENSG00000173085 .
    GeneIDi 27235.
    KEGGi hsa:27235.
    UCSCi uc003hog.3. human. [Q96H96-1 ]

    Organism-specific databases

    CTDi 27235.
    GeneCardsi GC04M084184.
    H-InvDB HIX0004341.
    HGNCi HGNC:25223. COQ2.
    HPAi HPA056599.
    MIMi 146500. phenotype.
    607426. phenotype.
    609825. gene.
    neXtProti NX_Q96H96.
    Orphaneti 255249. Leigh syndrome with nephrotic syndrome.
    227510. Multiple system atrophy, cerebellar type.
    98933. Multiple system atrophy, parkinsonian type.
    PharmGKBi PA142672084.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0382.
    HOGENOMi HOG000003697.
    HOVERGENi HBG081302.
    InParanoidi Q96H96.
    KOi K06125.
    PhylomeDBi Q96H96.
    TreeFami TF105873.

    Enzyme and pathway databases

    UniPathwayi UPA00232 .
    BioCyci MetaCyc:ENSG00000173085-MONOMER.
    Reactomei REACT_118595. Mitochondrial protein import.
    REACT_160111. Ubiquinol biosynthesis.

    Miscellaneous databases

    GeneWikii COQ2.
    GenomeRNAii 27235.
    NextBioi 50099.
    PROi Q96H96.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96H96.
    Bgeei Q96H96.
    CleanExi HS_COQ2.
    Genevestigatori Q96H96.

    Family and domain databases

    InterProi IPR006370. HB_polyprenyl-transferase.
    IPR000537. UbiA_prenyltransferase.
    [Graphical view ]
    Pfami PF01040. UbiA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01474. ubiA_proteo. 1 hit.
    PROSITEi PS00943. UBIA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ2."
      Forsgren M., Attersand A., Lake S., Gruenler J., Swiezewska E., Dallner G., Climent I.
      Biochem. J. 382:519-526(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
      Tissue: Liver and Muscle.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung, Melanoma and Pancreatic carcinoma.
    4. "Full-insert sequence of mapped XREF EST."
      Barrow I.K.-P., Boguski M.S., Touchman J.W., Spencer F.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 104-334 (ISOFORM 3).
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 198-371 (ISOFORM 3).
    6. "A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency."
      Quinzii C., Naini A., Salviati L., Trevisson E., Navas P., Dimauro S., Hirano M.
      Am. J. Hum. Genet. 78:345-349(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT COQ10D1 CYS-247.
    7. Cited for: VARIANTS COQ10D1 ASN-96; HIS-147; SER-178 AND CYS-247.
    8. "Mutations in COQ2 in familial and sporadic multiple-system atrophy."
      Multiple-System Atrophy Research Collaboration
      N. Engl. J. Med. 369:233-244(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS MSA1 LEU-29; HIS-49; THR-57; VAL-78; THR-97; SER-107; PHE-113; ALA-267; CYS-297; GLN-337 AND ALA-343, VARIANTS VAL-16; LEU-22; HIS-69 AND HIS-336.

    Entry informationi

    Entry nameiCOQ2_HUMAN
    AccessioniPrimary (citable) accession number: Q96H96
    Secondary accession number(s): O95331, Q1JQ78, Q684R2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3