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Protein

Zinc finger protein 764

Gene

ZNF764

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri175 – 197C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 764
Gene namesi
Name:ZNF764
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000169951.9
HGNCiHGNC:28200 ZNF764
neXtProtiNX_Q96H86

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi92595
OpenTargetsiENSG00000169951
PharmGKBiPA162410311

Polymorphism and mutation databases

BioMutaiZNF764
DMDMi218511973

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743981 – 408Zinc finger protein 764Add BLAST408

Proteomic databases

MaxQBiQ96H86
PaxDbiQ96H86
PeptideAtlasiQ96H86
PRIDEiQ96H86

PTM databases

iPTMnetiQ96H86
PhosphoSitePlusiQ96H86

Expressioni

Gene expression databases

BgeeiENSG00000169951
CleanExiHS_ZNF764
ExpressionAtlasiQ96H86 baseline and differential
GenevisibleiQ96H86 HS

Organism-specific databases

HPAiHPA003203

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124959, 37 interactors
IntActiQ96H86, 29 interactors
STRINGi9606.ENSP00000252797

Structurei

3D structure databases

ProteinModelPortaliQ96H86
SMRiQ96H86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 97KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri175 – 197C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00560000077257
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96H86
KOiK09228
OMAiAVAKHQW
OrthoDBiEOG091G02KC
PhylomeDBiQ96H86
TreeFamiTF337922

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96H86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPLAPLPP RDPNGAGPEW REPGAVSFAD VAVYFCREEW GCLRPAQRAL
60 70 80 90 100
YRDVMRETYG HLSALGIGGN KPALISWVEE EAELWGPAAQ DPEVAKCQTQ
110 120 130 140 150
TDPADSRNKK KERQREGTGA LEKPDPVAAG SPGLKSPQAP SAGPPYGWEQ
160 170 180 190 200
LSKAPHRGRP SLCAHPPVPR ADQRHGCYVC GKSFAWRSTL VEHVYSHTGE
210 220 230 240 250
KPFHCTDCGK GFGHASSLSK HRAIHRGERP HRCLECGRAF TQRSALTSHL
260 270 280 290 300
RVHTGEKPYG CADCGRRFSQ SSALYQHRRV HSGETPFPCP DCGRAFAYPS
310 320 330 340 350
DLRRHVRTHT GEKPYPCPDC GRCFRQSSEM AAHRRTHSGE KPYPCPQCGR
360 370 380 390 400
RFGQKSAVAK HQWVHRPGAG GHRGRVAGRL SVTLTPGHGD LDPPVGFQLY

PEIFQECG
Length:408
Mass (Da):44,943
Last modified:December 16, 2008 - v2
Checksum:i9D8A57109ACD38D0
GO
Isoform 2 (identifier: Q96H86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-104: Missing.

Note: No experimental confirmation available.
Show »
Length:407
Mass (Da):44,872
Checksum:i2890E32207A67AD5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti382V → A in BAG52794 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047845332A → V1 PublicationCorresponds to variant dbSNP:rs17850402Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045352104Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093992 mRNA Translation: BAG52794.1
AC002310 Genomic DNA No translation available.
BC000016 mRNA Translation: AAH00016.2
BC008821 mRNA Translation: AAH08821.1
CCDSiCCDS10683.1 [Q96H86-1]
CCDS54001.1 [Q96H86-2]
RefSeqiNP_001166150.1, NM_001172679.1 [Q96H86-2]
NP_219363.2, NM_033410.3 [Q96H86-1]
UniGeneiHs.132227

Genome annotation databases

EnsembliENST00000252797; ENSP00000252797; ENSG00000169951 [Q96H86-1]
ENST00000395091; ENSP00000378526; ENSG00000169951 [Q96H86-2]
GeneIDi92595
KEGGihsa:92595
UCSCiuc002dyq.4 human [Q96H86-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN764_HUMAN
AccessioniPrimary (citable) accession number: Q96H86
Secondary accession number(s): A8MZF4
, B3KSN2, H9KV99, Q9BWS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health