Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 764

Gene

ZNF764

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 19723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri203 – 22523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 764
Gene namesi
Name:ZNF764
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28200. ZNF764.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410311.

Polymorphism and mutation databases

BioMutaiZNF764.
DMDMi218511973.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Zinc finger protein 764PRO_0000274398Add
BLAST

Proteomic databases

MaxQBiQ96H86.
PaxDbiQ96H86.
PRIDEiQ96H86.

PTM databases

PhosphoSiteiQ96H86.

Expressioni

Gene expression databases

BgeeiQ96H86.
CleanExiHS_ZNF764.
ExpressionAtlasiQ96H86. baseline and differential.
GenevisibleiQ96H86. HS.

Organism-specific databases

HPAiHPA003203.

Interactioni

Protein-protein interaction databases

BioGridi124959. 35 interactions.
IntActiQ96H86. 6 interactions.
MINTiMINT-1453303.
STRINGi9606.ENSP00000252797.

Structurei

3D structure databases

ProteinModelPortaliQ96H86.
SMRiQ96H86. Positions 145-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 9772KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri175 – 19723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri203 – 22523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96H86.
KOiK09228.
OMAiAVAKHQW.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96H86.
TreeFamiTF337922.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96H86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPLAPLPP RDPNGAGPEW REPGAVSFAD VAVYFCREEW GCLRPAQRAL
60 70 80 90 100
YRDVMRETYG HLSALGIGGN KPALISWVEE EAELWGPAAQ DPEVAKCQTQ
110 120 130 140 150
TDPADSRNKK KERQREGTGA LEKPDPVAAG SPGLKSPQAP SAGPPYGWEQ
160 170 180 190 200
LSKAPHRGRP SLCAHPPVPR ADQRHGCYVC GKSFAWRSTL VEHVYSHTGE
210 220 230 240 250
KPFHCTDCGK GFGHASSLSK HRAIHRGERP HRCLECGRAF TQRSALTSHL
260 270 280 290 300
RVHTGEKPYG CADCGRRFSQ SSALYQHRRV HSGETPFPCP DCGRAFAYPS
310 320 330 340 350
DLRRHVRTHT GEKPYPCPDC GRCFRQSSEM AAHRRTHSGE KPYPCPQCGR
360 370 380 390 400
RFGQKSAVAK HQWVHRPGAG GHRGRVAGRL SVTLTPGHGD LDPPVGFQLY

PEIFQECG
Length:408
Mass (Da):44,943
Last modified:December 16, 2008 - v2
Checksum:i9D8A57109ACD38D0
GO
Isoform 2 (identifier: Q96H86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-104: Missing.

Note: No experimental confirmation available.
Show »
Length:407
Mass (Da):44,872
Checksum:i2890E32207A67AD5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti382 – 3821V → A in BAG52794 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti332 – 3321A → V.1 Publication
Corresponds to variant rs17850402 [ dbSNP | Ensembl ].
VAR_047845

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei104 – 1041Missing in isoform 2. 1 PublicationVSP_045352

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093992 mRNA. Translation: BAG52794.1.
AC002310 Genomic DNA. No translation available.
BC000016 mRNA. Translation: AAH00016.2.
BC008821 mRNA. Translation: AAH08821.1.
CCDSiCCDS10683.1. [Q96H86-1]
CCDS54001.1. [Q96H86-2]
RefSeqiNP_001166150.1. NM_001172679.1. [Q96H86-2]
NP_219363.2. NM_033410.3. [Q96H86-1]
UniGeneiHs.132227.

Genome annotation databases

EnsembliENST00000252797; ENSP00000252797; ENSG00000169951. [Q96H86-1]
ENST00000395091; ENSP00000378526; ENSG00000169951. [Q96H86-2]
GeneIDi92595.
KEGGihsa:92595.
UCSCiuc002dyq.4. human. [Q96H86-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093992 mRNA. Translation: BAG52794.1.
AC002310 Genomic DNA. No translation available.
BC000016 mRNA. Translation: AAH00016.2.
BC008821 mRNA. Translation: AAH08821.1.
CCDSiCCDS10683.1. [Q96H86-1]
CCDS54001.1. [Q96H86-2]
RefSeqiNP_001166150.1. NM_001172679.1. [Q96H86-2]
NP_219363.2. NM_033410.3. [Q96H86-1]
UniGeneiHs.132227.

3D structure databases

ProteinModelPortaliQ96H86.
SMRiQ96H86. Positions 145-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124959. 35 interactions.
IntActiQ96H86. 6 interactions.
MINTiMINT-1453303.
STRINGi9606.ENSP00000252797.

PTM databases

PhosphoSiteiQ96H86.

Polymorphism and mutation databases

BioMutaiZNF764.
DMDMi218511973.

Proteomic databases

MaxQBiQ96H86.
PaxDbiQ96H86.
PRIDEiQ96H86.

Protocols and materials databases

DNASUi92595.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252797; ENSP00000252797; ENSG00000169951. [Q96H86-1]
ENST00000395091; ENSP00000378526; ENSG00000169951. [Q96H86-2]
GeneIDi92595.
KEGGihsa:92595.
UCSCiuc002dyq.4. human. [Q96H86-1]

Organism-specific databases

CTDi92595.
GeneCardsiZNF764.
HGNCiHGNC:28200. ZNF764.
HPAiHPA003203.
neXtProtiNX_Q96H86.
PharmGKBiPA162410311.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00560000077257.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96H86.
KOiK09228.
OMAiAVAKHQW.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96H86.
TreeFamiTF337922.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii92595.
NextBioi77811.
PROiQ96H86.

Gene expression databases

BgeeiQ96H86.
CleanExiHS_ZNF764.
ExpressionAtlasiQ96H86. baseline and differential.
GenevisibleiQ96H86. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-332.
    Tissue: Brain.

Entry informationi

Entry nameiZN764_HUMAN
AccessioniPrimary (citable) accession number: Q96H86
Secondary accession number(s): A8MZF4
, B3KSN2, H9KV99, Q9BWS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 16, 2008
Last modified: March 16, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.