Q96H79 (ZCCHL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger CCCH-type antiviral protein 1-like

Gene names

Name:	ZC3HAV1L
Synonyms:	C7orf39

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.4 Ref.5
Caution	Despite its name, it does not contain a canonical C3H1-type zinc-finger.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96H79-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96H79-2)

The sequence of this isoform differs from the canonical sequence as follows:
     87-102: SVRLCARYQRGECQAC → GTIGACHHTQLIFLGF
     103-300: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.3
	Chain	2 – 300	299	Zinc finger CCCH-type antiviral protein 1-like		PRO_0000331459
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.3 Ref.5
	Modified residue	256	1	Phosphoserine Ref.4
	Modified residue	257	1	Phosphoserine Ref.5
	Modified residue	263	1	Phosphoserine Ref.4
Natural variations
	Alternative sequence	87 – 102	16	SVRLC…ECQAC → GTIGACHHTQLIFLGF in isoform 2.		VSP_033210
	Alternative sequence	103 – 300	198	Missing in isoform 2.		VSP_033211
Experimental info
	Sequence conflict	244	1	M → I in AAH08842. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 9F3B6BABA5CA0E3B	FASTA	300	32,962
	10 20 30 40 50 60 MAEPTVCSFL TKVLCAHGGR MFLKDLRGHV ELSEARLRDV LQRAGPERFL LQEVETQEGL 70 80 90 100 110 120 GDAEAEAAAG AVGGGGTSAW RVVAVSSVRL CARYQRGECQ ACDQLHFCRR HMLGKCPNRD 130 140 150 160 170 180 CWSTCTLSHD IHTPVNMQVL KSHGLFGLNE NQLRILLLQN DPCLLPEVCL LYNKGEALYG 190 200 210 220 230 240 YCNLKDKCNK FHVCKSFVKG ECKLQTCKRS HQLIHAASLK LLQDQGLNIP SVVNFQIIST 250 260 270 280 290 300 YKHMKLHKML ENTDNSSPST EHSQGLEKQG VHAAGAAEAG PLASVPAQSA KKPCPVSCEK
	Isoform 2 [UniParc]. Checksum: 18C9E173F4FB939D	FASTA	102	10,778
	10 20 30 40 50 60 MAEPTVCSFL TKVLCAHGGR MFLKDLRGHV ELSEARLRDV LQRAGPERFL LQEVETQEGL 70 80 90 100 GDAEAEAAAG AVGGGGTSAW RVVAVSGTIG ACHHTQLIFL GF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Testis.
[3]	Bienvenut W.V. Submitted (JAN-2010) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-12; 142-154 AND 249-291, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Ovarian carcinoma.
[4]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256 AND SER-263, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[5]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-257, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC083868 Genomic DNA. No translation available. BC008842 mRNA. Translation: AAH08842.1. BC020784 mRNA. Translation: AAH20784.1.
IPI	IPI00062866. IPI00477731.
RefSeq	NP_542391.2. NM_080660.3.
UniGene	Hs.512833. Hs.659143.
3D structure databases
ProteinModelPortal	Q96H79.
SMR	Q96H79. Positions 87-142, 163-212.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96H79. 1 interaction.
PTM databases
PhosphoSite	Q96H79.
Polymorphism databases
DMDM	296453031.
Proteomic databases
PRIDE	Q96H79.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000275766; ENSP00000275766; ENSG00000146858.
GeneID	92092.
KEGG	hsa:92092.
UCSC	uc003vum.1. human.
Organism-specific databases
CTD	92092.
GeneCards	GC07M138706.
H-InvDB	HIX0007127.
HGNC	HGNC:22423. ZC3HAV1L.
HPA	HPA020386.
neXtProt	NX_Q96H79.
PharmGKB	PA145147600.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11794.
GeneTree	ENSGT00600000084343.
HOGENOM	HBG126677.
HOVERGEN	HBG098320.
InParanoid	Q96H79.
OMA	GRMFLQD.
OrthoDB	EOG4FTW19.
PhylomeDB	Q96H79.
Gene expression databases
ArrayExpress	Q96H79.
Bgee	Q96H79.
CleanEx	HS_ZC3HAV1L.
Genevestigator	Q96H79.
Family and domain databases
ProtoNet	Search...
Other
NextBio	77581.

Entry information

Entry name

ZCCHL_HUMAN

Accession

Primary (citable) accession number: Q96H79
Secondary accession number(s): Q8WUD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.