Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 25 member 44

Gene

SLC25A44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.14.7. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 44
Gene namesi
Name:SLC25A44
Synonyms:KIAA0446
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29036. SLC25A44.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4223Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei71 – 9020Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei185 – 20117Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei222 – 23918Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei278 – 29619Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403705.

Polymorphism and mutation databases

DMDMi74751902.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Solute carrier family 25 member 44PRO_0000253064Add
BLAST

Proteomic databases

EPDiQ96H78.
MaxQBiQ96H78.
PaxDbiQ96H78.
PeptideAtlasiQ96H78.
PRIDEiQ96H78.

PTM databases

iPTMnetiQ96H78.
PhosphoSiteiQ96H78.

Expressioni

Gene expression databases

BgeeiQ96H78.
CleanExiHS_SLC25A44.
ExpressionAtlasiQ96H78. baseline and differential.
GenevisibleiQ96H78. HS.

Interactioni

Protein-protein interaction databases

BioGridi115028. 6 interactions.
STRINGi9606.ENSP00000352497.

Structurei

3D structure databases

ProteinModelPortaliQ96H78.
SMRiQ96H78. Positions 18-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati18 – 10083Solcar 1Add
BLAST
Repeati107 – 210104Solcar 2Add
BLAST
Repeati220 – 30283Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0765. Eukaryota.
ENOG410XTGQ. LUCA.
GeneTreeiENSGT00530000062944.
HOGENOMiHOG000234169.
HOVERGENiHBG054957.
InParanoidiQ96H78.
KOiK15121.
PhylomeDBiQ96H78.
TreeFamiTF354268.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96H78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDKRNIQII EWEHLDKKKF YVFGVAMTMM IRVSVYPFTL IRTRLQVQKG
60 70 80 90 100
KSLYHGTFDA FIKILRADGI TGLYRGFLVN TFTLISGQCY VTTYELTRKF
110 120 130 140 150
VADYSQSNTV KSLVAGGSAS LVAQSITVPI DVVSQHLMMQ RKGEKMGRFQ
160 170 180 190 200
VRGNPEGQGV VAFGQTKDII RQILQADGLR GFYRGYVASL LTYIPNSAVW
210 220 230 240 250
WPFYHFYAEQ LSYLCPKECP HIVFQAVSGP LAAATASILT NPMDVIRTRV
260 270 280 290 300
QVEGKNSIIL TFRQLMAEEG PWGLMKGLSA RIISATPSTI VIVVGYESLK
310
KLSLRPELVD SRHW
Length:314
Mass (Da):35,392
Last modified:December 1, 2001 - v1
Checksum:i978AE43CBDF0FBDF
GO

Sequence cautioni

The sequence BAA32291.3 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081A → AAIVFPWIP in BAA32291 (PubMed:9455484).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti52 – 521S → I.
Corresponds to variant rs11576750 [ dbSNP | Ensembl ].
VAR_050134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007915 mRNA. Translation: BAA32291.3. Different initiation.
AK074912 mRNA. Translation: BAC11287.1.
AK075002 mRNA. Translation: BAC11347.1.
AL135927 Genomic DNA. Translation: CAI15534.1.
BC008843 mRNA. Translation: AAH08843.1.
BC039854 mRNA. Translation: AAH39854.1.
CCDSiCCDS1133.1.
RefSeqiNP_001273113.1. NM_001286184.1.
NP_055470.1. NM_014655.3.
XP_006711720.1. XM_006711657.2.
XP_011508482.1. XM_011510180.1.
XP_011508483.1. XM_011510181.1.
UniGeneiHs.532375.
Hs.626091.

Genome annotation databases

EnsembliENST00000359511; ENSP00000352497; ENSG00000160785.
GeneIDi9673.
KEGGihsa:9673.
UCSCiuc001fnp.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007915 mRNA. Translation: BAA32291.3. Different initiation.
AK074912 mRNA. Translation: BAC11287.1.
AK075002 mRNA. Translation: BAC11347.1.
AL135927 Genomic DNA. Translation: CAI15534.1.
BC008843 mRNA. Translation: AAH08843.1.
BC039854 mRNA. Translation: AAH39854.1.
CCDSiCCDS1133.1.
RefSeqiNP_001273113.1. NM_001286184.1.
NP_055470.1. NM_014655.3.
XP_006711720.1. XM_006711657.2.
XP_011508482.1. XM_011510180.1.
XP_011508483.1. XM_011510181.1.
UniGeneiHs.532375.
Hs.626091.

3D structure databases

ProteinModelPortaliQ96H78.
SMRiQ96H78. Positions 18-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115028. 6 interactions.
STRINGi9606.ENSP00000352497.

Protein family/group databases

TCDBi2.A.29.14.7. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiQ96H78.
PhosphoSiteiQ96H78.

Polymorphism and mutation databases

DMDMi74751902.

Proteomic databases

EPDiQ96H78.
MaxQBiQ96H78.
PaxDbiQ96H78.
PeptideAtlasiQ96H78.
PRIDEiQ96H78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359511; ENSP00000352497; ENSG00000160785.
GeneIDi9673.
KEGGihsa:9673.
UCSCiuc001fnp.5. human.

Organism-specific databases

CTDi9673.
GeneCardsiSLC25A44.
HGNCiHGNC:29036. SLC25A44.
MIMi610824. gene.
neXtProtiNX_Q96H78.
PharmGKBiPA162403705.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0765. Eukaryota.
ENOG410XTGQ. LUCA.
GeneTreeiENSGT00530000062944.
HOGENOMiHOG000234169.
HOVERGENiHBG054957.
InParanoidiQ96H78.
KOiK15121.
PhylomeDBiQ96H78.
TreeFamiTF354268.

Miscellaneous databases

ChiTaRSiSLC25A44. human.
GenomeRNAii9673.
PROiQ96H78.
SOURCEiSearch...

Gene expression databases

BgeeiQ96H78.
CleanExiHS_SLC25A44.
ExpressionAtlasiQ96H78. baseline and differential.
GenevisibleiQ96H78. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
    Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skin.
  5. "Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system."
    Haitina T., Lindblom J., Renstroem T., Fredriksson R.
    Genomics 88:779-790(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiS2544_HUMAN
AccessioniPrimary (citable) accession number: Q96H78
Secondary accession number(s): O75034
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.