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Protein

Unconventional myosin-XIX

Gene

MYO19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. MYO19 is involved in mitochondrial motility.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141140-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-XIX
Alternative name(s):
Myosin head domain-containing protein 1
Gene namesi
Name:MYO19
Synonyms:MYOHD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26234. MYO19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000278259.
ENSG00000278372.
PharmGKBiPA162396512.

Polymorphism and mutation databases

BioMutaiMYO19.
DMDMi189083208.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003329691 – 970Unconventional myosin-XIXAdd BLAST970

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei685PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96H55.
MaxQBiQ96H55.
PaxDbiQ96H55.
PeptideAtlasiQ96H55.
PRIDEiQ96H55.

PTM databases

iPTMnetiQ96H55.
PhosphoSitePlusiQ96H55.

Expressioni

Tissue specificityi

Widely expressed in multiple tissues and cell lines.1 Publication

Gene expression databases

BgeeiENSG00000141140.
CleanExiHS_MYO19.
ExpressionAtlasiQ96H55. baseline and differential.
GenevisibleiQ96H55. HS.

Organism-specific databases

HPAiHPA021415.
HPA059715.

Interactioni

Protein-protein interaction databases

BioGridi123161. 180 interactors.
IntActiQ96H55. 176 interactors.
MINTiMINT-4994717.
STRINGi9606.ENSP00000409936.

Structurei

3D structure databases

ProteinModelPortaliQ96H55.
SMRiQ96H55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 758Myosin motorAdd BLAST724
Domaini759 – 779IQ 1PROSITE-ProRule annotationAdd BLAST21
Domaini783 – 812IQ 2PROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni829 – 970Mitochondrial targetingAdd BLAST142

Sequence similaritiesi

Contains 2 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00860000133764.
HOGENOMiHOG000008082.
HOVERGENiHBG108164.
InParanoidiQ96H55.
OMAiVPQLYSP.
OrthoDBiEOG091G01I9.
PhylomeDBiQ96H55.
TreeFamiTF328771.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96H55-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQQVNGHNP GSDGQAREYL REDLQEFLGG EVLLYKLDDL TRVNPVTLET
60 70 80 90 100
VLRCLQARYM ADTFYTNAGC TLVALNPFKP VPQLYSPELM REYHAAPQPQ
110 120 130 140 150
KLKPHVFTVG EQTYRNVKSL IEPVNQSIVV SGESGAGKTW TSRCLMKFYA
160 170 180 190 200
VVATSPASWE SHKIAERIEQ RILNSNPVME AFGNACTLRN NNSSRFGKFI
210 220 230 240 250
QLQLNRAQQM TGAAVQTYLL EKTRVACQAS SERNFHIFYQ ICKGASEDER
260 270 280 290 300
LQWHLPEGAA FSWLPNPERS LEEDCFEVTR EAMLHLGIDT PTQNNIFKVL
310 320 330 340 350
AGLLHLGNIQ FAASEDEAQP CQPMDDAKYS VRTAASLLGL PEDVLLEMVQ
360 370 380 390 400
IRTIRAGRQQ QVFRKPCARA ECDTRRDCLA KLIYARLFDW LVSVINSSIC
410 420 430 440 450
ADTDSWTTFI GLLDVYGFES FPDNSLEQLC INYANEKLQQ HFVAHYLRAQ
460 470 480 490 500
QEEYAVEGLE WSFINYQDNQ PCLDLIEGSP ISICSLINEE CRLNRPSSAA
510 520 530 540 550
QLQTRIETAL AGSPCLGHNK LSREPSFIVV HYAGPVRYHT AGLVEKNKDP
560 570 580 590 600
IPPELTRLLQ QSQDPLLMGL FPTNPKEKTQ EEPPGQSRAP VLTVVSKFKA
610 620 630 640 650
SLEQLLQVLH STTPHYIRCI KPNSQGQAQT FLQEEVLSQL EACGLVETIH
660 670 680 690 700
ISAAGFPIRV SHRNFVERYK LLRRLHPCTS SGPDSPYPAK GLPEWCPHSE
710 720 730 740 750
EATLEPLIQD ILHTLPVLTQ AAAITGDSAE AMPAPMHCGR TKVFMTDSML
760 770 780 790 800
ELLECGRARV LEQCARCIQG GWRRHRHREQ ERQWRAVMLI QAAIRSWLTR
810 820 830 840 850
KHIQRLHAAA TVIKRAWQKW RIRMACLAAK ELDGVEEKHF SQAPCSLSTS
860 870 880 890 900
PLQTRLLEAI IRLWPLGLVL ANTAMGVGSF QRKLVVWACL QLPRGSPSSY
910 920 930 940 950
TVQTAQDQAG VTSIRALPQG SIKFHCRKSP LRYADICPEP SPYSITGFNQ
960 970
ILLERHRLIH VTSSAFTGLG
Length:970
Mass (Da):109,135
Last modified:May 20, 2008 - v2
Checksum:i3AB15AD901BE7407
GO
Isoform 2 (identifier: Q96H55-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-317: LAGLLHLGNIQFAASEDE → RRKATPLKFGRDDGQPFA
     318-970: Missing.

Show »
Length:317
Mass (Da):35,934
Checksum:iAB1DF5E7FB346C32
GO
Isoform 3 (identifier: Q96H55-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-636: V → A
     637-970: Missing.

Show »
Length:636
Mass (Da):71,700
Checksum:i87C9E7887746C37E
GO
Isoform 4 (identifier: Q96H55-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     439-638: Missing.

Show »
Length:770
Mass (Da):86,687
Checksum:i67F3567A38DE947A
GO

Sequence cautioni

The sequence BAD92272 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043018176N → S.1 PublicationCorresponds to variant rs2306595dbSNPEnsembl.1
Natural variantiVAR_043019203Q → H.Corresponds to variant rs9890918dbSNPEnsembl.1
Natural variantiVAR_043020475L → I.Corresponds to variant rs7217346dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033402300 – 317LAGLL…ASEDE → RRKATPLKFGRDDGQPFA in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_033403318 – 970Missing in isoform 2. 1 PublicationAdd BLAST653
Alternative sequenceiVSP_033404439 – 638Missing in isoform 4. 1 PublicationAdd BLAST200
Alternative sequenceiVSP_033405636V → A in isoform 3. 1 Publication1
Alternative sequenceiVSP_033406637 – 970Missing in isoform 3. 1 PublicationAdd BLAST334

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026518 mRNA. Translation: BAB15495.1.
AB209035 mRNA. Translation: BAD92272.1. Different initiation.
AC126327 Genomic DNA. No translation available.
CH471199 Genomic DNA. Translation: EAW57557.1.
BC008900 mRNA. Translation: AAH08900.1.
CCDSiCCDS45654.1. [Q96H55-4]
CCDS54112.1. [Q96H55-1]
CCDS59283.1. [Q96H55-2]
RefSeqiNP_001028752.1. NM_001033580.2. [Q96H55-2]
NP_001157207.1. NM_001163735.1. [Q96H55-1]
NP_079385.2. NM_025109.5. [Q96H55-4]
UniGeneiHs.302051.

Genome annotation databases

EnsembliENST00000610930; ENSP00000478437; ENSG00000278259. [Q96H55-4]
ENST00000610992; ENSP00000480125; ENSG00000278259. [Q96H55-3]
ENST00000613929; ENSP00000478355; ENSG00000278372. [Q96H55-4]
ENST00000614623; ENSP00000479518; ENSG00000278259. [Q96H55-1]
ENST00000618519; ENSP00000480242; ENSG00000278372. [Q96H55-1]
ENST00000621344; ENSP00000477559; ENSG00000278259. [Q96H55-2]
ENST00000633264; ENSP00000487617; ENSG00000278372. [Q96H55-3]
ENST00000633938; ENSP00000488204; ENSG00000278372. [Q96H55-2]
GeneIDi80179.
KEGGihsa:80179.
UCSCiuc032fdu.2. human. [Q96H55-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026518 mRNA. Translation: BAB15495.1.
AB209035 mRNA. Translation: BAD92272.1. Different initiation.
AC126327 Genomic DNA. No translation available.
CH471199 Genomic DNA. Translation: EAW57557.1.
BC008900 mRNA. Translation: AAH08900.1.
CCDSiCCDS45654.1. [Q96H55-4]
CCDS54112.1. [Q96H55-1]
CCDS59283.1. [Q96H55-2]
RefSeqiNP_001028752.1. NM_001033580.2. [Q96H55-2]
NP_001157207.1. NM_001163735.1. [Q96H55-1]
NP_079385.2. NM_025109.5. [Q96H55-4]
UniGeneiHs.302051.

3D structure databases

ProteinModelPortaliQ96H55.
SMRiQ96H55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123161. 180 interactors.
IntActiQ96H55. 176 interactors.
MINTiMINT-4994717.
STRINGi9606.ENSP00000409936.

PTM databases

iPTMnetiQ96H55.
PhosphoSitePlusiQ96H55.

Polymorphism and mutation databases

BioMutaiMYO19.
DMDMi189083208.

Proteomic databases

EPDiQ96H55.
MaxQBiQ96H55.
PaxDbiQ96H55.
PeptideAtlasiQ96H55.
PRIDEiQ96H55.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000610930; ENSP00000478437; ENSG00000278259. [Q96H55-4]
ENST00000610992; ENSP00000480125; ENSG00000278259. [Q96H55-3]
ENST00000613929; ENSP00000478355; ENSG00000278372. [Q96H55-4]
ENST00000614623; ENSP00000479518; ENSG00000278259. [Q96H55-1]
ENST00000618519; ENSP00000480242; ENSG00000278372. [Q96H55-1]
ENST00000621344; ENSP00000477559; ENSG00000278259. [Q96H55-2]
ENST00000633264; ENSP00000487617; ENSG00000278372. [Q96H55-3]
ENST00000633938; ENSP00000488204; ENSG00000278372. [Q96H55-2]
GeneIDi80179.
KEGGihsa:80179.
UCSCiuc032fdu.2. human. [Q96H55-1]

Organism-specific databases

CTDi80179.
GeneCardsiMYO19.
H-InvDBHIX0014287.
HGNCiHGNC:26234. MYO19.
HPAiHPA021415.
HPA059715.
neXtProtiNX_Q96H55.
OpenTargetsiENSG00000278259.
ENSG00000278372.
PharmGKBiPA162396512.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00860000133764.
HOGENOMiHOG000008082.
HOVERGENiHBG108164.
InParanoidiQ96H55.
OMAiVPQLYSP.
OrthoDBiEOG091G01I9.
PhylomeDBiQ96H55.
TreeFamiTF328771.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141140-MONOMER.

Miscellaneous databases

ChiTaRSiMYO19. human.
GenomeRNAii80179.
PROiQ96H55.

Gene expression databases

BgeeiENSG00000141140.
CleanExiHS_MYO19.
ExpressionAtlasiQ96H55. baseline and differential.
GenevisibleiQ96H55. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO19_HUMAN
AccessioniPrimary (citable) accession number: Q96H55
Secondary accession number(s): Q59GS4, Q9H5X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.