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Protein

Zinc finger protein 486

Gene

ZNF486

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri154 – 176C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri210 – 232C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri238 – 260C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160229-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 486
Alternative name(s):
KRAB domain only protein 2
Gene namesi
Name:ZNF486
Synonyms:KRBO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20807. ZNF486.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000256229.
PharmGKBiPA134919932.

Polymorphism and mutation databases

BioMutaiZNF486.
DMDMi325511409.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476111 – 463Zinc finger protein 486Add BLAST463

Proteomic databases

EPDiQ96H40.
PaxDbiQ96H40.
PeptideAtlasiQ96H40.
PRIDEiQ96H40.

PTM databases

iPTMnetiQ96H40.
PhosphoSitePlusiQ96H40.

Expressioni

Gene expression databases

BgeeiENSG00000256229.
CleanExiHS_ZNF486.
ExpressionAtlasiQ96H40. baseline and differential.
GenevisibleiQ96H40. HS.

Interactioni

Protein-protein interaction databases

BioGridi124749. 1 interactor.
STRINGi9606.ENSP00000335042.

Structurei

3D structure databases

ProteinModelPortaliQ96H40.
SMRiQ96H40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 84KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri154 – 176C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri210 – 232C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri238 – 260C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOVERGENiHBG018163.
InParanoidiQ96H40.
KOiK09228.
OMAiRSSHLTM.
OrthoDBiEOG091G02KC.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96H40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPLRSLEM ESLQFRDVAV EFSLEEWHCL DTAQQNLYRD VMLENYRHLV
60 70 80 90 100
FLGIIVSKPD LITCLEQGIK PLTMKRHEMI AKPPVVCSHF AQDLWPEQSI
110 120 130 140 150
KDSYQKVILR KFEKCGHGNL HFKKGCESVD ECKLHKRGYN GLNQCLTTTQ
160 170 180 190 200
SKIFQCGKYV KVFHQFSNSK RHKRRHTEKK PLKYIEGDKA FNQSSTHTTH
210 220 230 240 250
KKIDTGEKPY KCEECGKAFN RSSHLTTHKI THTREKPYKC EECGKVFKYF
260 270 280 290 300
SSFTTHKKIH SGEKPYICEE CGKAFMYPYT LTTHKIIHTG EQPYKCKECD
310 320 330 340 350
KAFNHPATLS SHKKIHTGEK PYTCDKCGKA FISSSILSKH EKIHTGEKPY
360 370 380 390 400
KCEECGKAFT RSSHLTMHKI IHTGEKPYKC EECGKAFTWS AGLHKHRRTH
410 420 430 440 450
TGEKPYKCEE CGKAYTTSSN LTEHKTTHTG EKPYKCKECG KAFNWSSDLN
460
KHKRIHIGQK PRT
Length:463
Mass (Da):53,631
Last modified:March 8, 2011 - v4
Checksum:iC30AE4D7B0EEEA55
GO

Sequence cautioni

The sequence AAH08936 differs from that shown. Aberrant splicing.Curated
The sequence AAH08936 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011447 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84874.1.
BC008936 mRNA. Translation: AAH08936.2. Sequence problems.
BC117268 mRNA. Translation: AAI17269.1.
CCDSiCCDS46029.1.
RefSeqiNP_443084.2. NM_052852.3.
UniGeneiHs.590991.

Genome annotation databases

EnsembliENST00000335117; ENSP00000335042; ENSG00000256229.
GeneIDi90649.
KEGGihsa:90649.
UCSCiuc002nou.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011447 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84874.1.
BC008936 mRNA. Translation: AAH08936.2. Sequence problems.
BC117268 mRNA. Translation: AAI17269.1.
CCDSiCCDS46029.1.
RefSeqiNP_443084.2. NM_052852.3.
UniGeneiHs.590991.

3D structure databases

ProteinModelPortaliQ96H40.
SMRiQ96H40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124749. 1 interactor.
STRINGi9606.ENSP00000335042.

PTM databases

iPTMnetiQ96H40.
PhosphoSitePlusiQ96H40.

Polymorphism and mutation databases

BioMutaiZNF486.
DMDMi325511409.

Proteomic databases

EPDiQ96H40.
PaxDbiQ96H40.
PeptideAtlasiQ96H40.
PRIDEiQ96H40.

Protocols and materials databases

DNASUi90649.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335117; ENSP00000335042; ENSG00000256229.
GeneIDi90649.
KEGGihsa:90649.
UCSCiuc002nou.4. human.

Organism-specific databases

CTDi90649.
GeneCardsiZNF486.
HGNCiHGNC:20807. ZNF486.
neXtProtiNX_Q96H40.
OpenTargetsiENSG00000256229.
PharmGKBiPA134919932.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOVERGENiHBG018163.
InParanoidiQ96H40.
KOiK09228.
OMAiRSSHLTM.
OrthoDBiEOG091G02KC.
TreeFamiTF342117.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160229-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii90649.
PROiQ96H40.

Gene expression databases

BgeeiENSG00000256229.
CleanExiHS_ZNF486.
ExpressionAtlasiQ96H40. baseline and differential.
GenevisibleiQ96H40. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN486_HUMAN
AccessioniPrimary (citable) accession number: Q96H40
Secondary accession number(s): Q0VG00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 8, 2011
Last modified: November 2, 2016
This is version 118 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.