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Protein

Zinc finger protein 486

Gene

ZNF486

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri154 – 176C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri210 – 232C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri238 – 260C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 486
Alternative name(s):
KRAB domain only protein 2
Gene namesi
Name:ZNF486
Synonyms:KRBO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000256229.7.
HGNCiHGNC:20807. ZNF486.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000256229.
PharmGKBiPA134919932.

Polymorphism and mutation databases

BioMutaiZNF486.
DMDMi325511409.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476111 – 463Zinc finger protein 486Add BLAST463

Proteomic databases

EPDiQ96H40.
PaxDbiQ96H40.
PeptideAtlasiQ96H40.
PRIDEiQ96H40.

PTM databases

iPTMnetiQ96H40.
PhosphoSitePlusiQ96H40.

Expressioni

Gene expression databases

BgeeiENSG00000256229.
CleanExiHS_ZNF486.
ExpressionAtlasiQ96H40. baseline and differential.
GenevisibleiQ96H40. HS.

Interactioni

Protein-protein interaction databases

BioGridi124749. 1 interactor.
STRINGi9606.ENSP00000335042.

Structurei

3D structure databases

ProteinModelPortaliQ96H40.
SMRiQ96H40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 84KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri154 – 176C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri210 – 232C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri238 – 260C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139354.
HOVERGENiHBG018163.
InParanoidiQ96H40.
KOiK09228.
OMAiRSSHLTM.
OrthoDBiEOG091G02KC.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 6 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.

Sequencei

Sequence statusi: Complete.

Q96H40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPLRSLEM ESLQFRDVAV EFSLEEWHCL DTAQQNLYRD VMLENYRHLV
60 70 80 90 100
FLGIIVSKPD LITCLEQGIK PLTMKRHEMI AKPPVVCSHF AQDLWPEQSI
110 120 130 140 150
KDSYQKVILR KFEKCGHGNL HFKKGCESVD ECKLHKRGYN GLNQCLTTTQ
160 170 180 190 200
SKIFQCGKYV KVFHQFSNSK RHKRRHTEKK PLKYIEGDKA FNQSSTHTTH
210 220 230 240 250
KKIDTGEKPY KCEECGKAFN RSSHLTTHKI THTREKPYKC EECGKVFKYF
260 270 280 290 300
SSFTTHKKIH SGEKPYICEE CGKAFMYPYT LTTHKIIHTG EQPYKCKECD
310 320 330 340 350
KAFNHPATLS SHKKIHTGEK PYTCDKCGKA FISSSILSKH EKIHTGEKPY
360 370 380 390 400
KCEECGKAFT RSSHLTMHKI IHTGEKPYKC EECGKAFTWS AGLHKHRRTH
410 420 430 440 450
TGEKPYKCEE CGKAYTTSSN LTEHKTTHTG EKPYKCKECG KAFNWSSDLN
460
KHKRIHIGQK PRT
Length:463
Mass (Da):53,631
Last modified:March 8, 2011 - v4
Checksum:iC30AE4D7B0EEEA55
GO

Sequence cautioni

The sequence AAH08936 differs from that shown. Aberrant splicing.Curated
The sequence AAH08936 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011447 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84874.1.
BC008936 mRNA. Translation: AAH08936.2. Sequence problems.
BC117268 mRNA. Translation: AAI17269.1.
CCDSiCCDS46029.1.
RefSeqiNP_443084.2. NM_052852.3.
UniGeneiHs.590991.

Genome annotation databases

EnsembliENST00000335117; ENSP00000335042; ENSG00000256229.
GeneIDi90649.
KEGGihsa:90649.
UCSCiuc002nou.4. human.

Similar proteinsi

Entry informationi

Entry nameiZN486_HUMAN
AccessioniPrimary (citable) accession number: Q96H40
Secondary accession number(s): Q0VG00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 8, 2011
Last modified: October 25, 2017
This is version 125 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families