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Protein

Probable RNA-binding protein 18

Gene

RBM18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119446-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable RNA-binding protein 18
Alternative name(s):
RNA-binding motif protein 18
Gene namesi
Name:RBM18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:28413. RBM18.

Pathology & Biotechi

Organism-specific databases

DisGeNETi92400.
OpenTargetsiENSG00000119446.
PharmGKBiPA134928031.

Polymorphism and mutation databases

BioMutaiRBM18.
DMDMi74762658.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002541221 – 190Probable RNA-binding protein 18Add BLAST190

Proteomic databases

EPDiQ96H35.
MaxQBiQ96H35.
PaxDbiQ96H35.
PeptideAtlasiQ96H35.
PRIDEiQ96H35.

PTM databases

iPTMnetiQ96H35.
PhosphoSitePlusiQ96H35.

Expressioni

Gene expression databases

BgeeiENSG00000119446.
CleanExiHS_RBM18.
GenevisibleiQ96H35. HS.

Organism-specific databases

HPAiHPA057281.

Interactioni

Protein-protein interaction databases

BioGridi124945. 12 interactors.
IntActiQ96H35. 5 interactors.
STRINGi9606.ENSP00000409315.

Structurei

3D structure databases

ProteinModelPortaliQ96H35.
SMRiQ96H35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 106RRMPROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGKV. Eukaryota.
ENOG4111FJ0. LUCA.
GeneTreeiENSGT00390000013765.
HOGENOMiHOG000231619.
HOVERGENiHBG057119.
InParanoidiQ96H35.
OMAiEAKLQMM.
OrthoDBiEOG091G0J71.
PhylomeDBiQ96H35.
TreeFamiTF323314.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96H35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAETKTLPL ENASILSEGS LQEGHRLWIG NLDPKITEYH LLKLLQKFGK
60 70 80 90 100
VKQFDFLFHK SGALEGQPRG YCFVNFETKQ EAEQAIQCLN GKLALSKKLV
110 120 130 140 150
VRWAHAQVKR YDHNKNDKIL PISLEPSSST EPTQSNLSVT AKIKAIEAKL
160 170 180 190
KMMAENPDAE YPAAPVYSYF KPPDKKRTTP YSRTAWKSRR
Length:190
Mass (Da):21,649
Last modified:December 1, 2001 - v1
Checksum:i4F86952DAFA8EC42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057676 mRNA. Translation: BAG51951.1.
AL162424 Genomic DNA. Translation: CAI14706.1.
CH471090 Genomic DNA. Translation: EAW87518.1.
BC008942 mRNA. Translation: AAH08942.1.
BC019319 mRNA. Translation: AAH19319.1.
CCDSiCCDS6839.1.
RefSeqiNP_149108.1. NM_033117.3.
XP_006717382.1. XM_006717319.1.
UniGeneiHs.415842.

Genome annotation databases

EnsembliENST00000417201; ENSP00000409315; ENSG00000119446.
GeneIDi92400.
KEGGihsa:92400.
UCSCiuc004bma.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057676 mRNA. Translation: BAG51951.1.
AL162424 Genomic DNA. Translation: CAI14706.1.
CH471090 Genomic DNA. Translation: EAW87518.1.
BC008942 mRNA. Translation: AAH08942.1.
BC019319 mRNA. Translation: AAH19319.1.
CCDSiCCDS6839.1.
RefSeqiNP_149108.1. NM_033117.3.
XP_006717382.1. XM_006717319.1.
UniGeneiHs.415842.

3D structure databases

ProteinModelPortaliQ96H35.
SMRiQ96H35.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124945. 12 interactors.
IntActiQ96H35. 5 interactors.
STRINGi9606.ENSP00000409315.

PTM databases

iPTMnetiQ96H35.
PhosphoSitePlusiQ96H35.

Polymorphism and mutation databases

BioMutaiRBM18.
DMDMi74762658.

Proteomic databases

EPDiQ96H35.
MaxQBiQ96H35.
PaxDbiQ96H35.
PeptideAtlasiQ96H35.
PRIDEiQ96H35.

Protocols and materials databases

DNASUi92400.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000417201; ENSP00000409315; ENSG00000119446.
GeneIDi92400.
KEGGihsa:92400.
UCSCiuc004bma.3. human.

Organism-specific databases

CTDi92400.
DisGeNETi92400.
GeneCardsiRBM18.
HGNCiHGNC:28413. RBM18.
HPAiHPA057281.
neXtProtiNX_Q96H35.
OpenTargetsiENSG00000119446.
PharmGKBiPA134928031.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGKV. Eukaryota.
ENOG4111FJ0. LUCA.
GeneTreeiENSGT00390000013765.
HOGENOMiHOG000231619.
HOVERGENiHBG057119.
InParanoidiQ96H35.
OMAiEAKLQMM.
OrthoDBiEOG091G0J71.
PhylomeDBiQ96H35.
TreeFamiTF323314.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119446-MONOMER.

Miscellaneous databases

ChiTaRSiRBM18. human.
GenomeRNAii92400.
PROiQ96H35.

Gene expression databases

BgeeiENSG00000119446.
CleanExiHS_RBM18.
GenevisibleiQ96H35. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM18_HUMAN
AccessioniPrimary (citable) accession number: Q96H35
Secondary accession number(s): B3KQ89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.