ID MSD3_HUMAN Reviewed; 275 AA. AC Q96H12; B2RC35; Q5T726; Q5T727; Q5T728; DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 27-MAR-2024, entry version 142. DE RecName: Full=Myb/SANT-like DNA-binding domain-containing protein 3; GN Name=MSANTD3; Synonyms=C9orf30; ORFNames=L8; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY. RX PubMed=15334068; DOI=10.1038/sj.onc.1207921; RA Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., RA Cerveny C., Law C.-L., Wahl A., Carter P.; RT "Suppression subtractive hybridization and expression profiling identifies RT a unique set of genes overexpressed in non-small-cell lung cancer."; RL Oncogene 23:7734-7745(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Subthalamic nucleus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., RA Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026; RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.; RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling RT networks."; RL Cell 127:635-648(2006). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98 AND SER-274, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96; SER-98 AND SER-274, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [10] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-154, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=28112733; DOI=10.1038/nsmb.3366; RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C., RA Nielsen M.L.; RT "Site-specific mapping of the human SUMO proteome reveals co-modification RT with phosphorylation."; RL Nat. Struct. Mol. Biol. 24:325-336(2017). CC -!- INTERACTION: CC Q96H12; P28329-3: CHAT; NbExp=3; IntAct=EBI-8466227, EBI-25837549; CC Q96H12; P22607: FGFR3; NbExp=3; IntAct=EBI-8466227, EBI-348399; CC Q96H12; Q14957: GRIN2C; NbExp=3; IntAct=EBI-8466227, EBI-8285963; CC Q96H12; P06396: GSN; NbExp=3; IntAct=EBI-8466227, EBI-351506; CC Q96H12; Q9Y649; NbExp=3; IntAct=EBI-8466227, EBI-25900580; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q96H12-1; Sequence=Displayed; CC Name=2; CC IsoId=Q96H12-2; Sequence=VSP_053346, VSP_053347; CC -!- TISSUE SPECIFICITY: Expressed in brain. {ECO:0000269|PubMed:15334068}. CC -!- SIMILARITY: Belongs to the MSANTD3 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY598327; AAT06738.1; -; mRNA. DR EMBL; AK314924; BAG37432.1; -; mRNA. DR EMBL; AL353805; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC008993; AAH08993.1; -; mRNA. DR CCDS; CCDS56579.1; -. [Q96H12-2] DR CCDS; CCDS6749.1; -. [Q96H12-1] DR RefSeq; NP_001185734.1; NM_001198805.1. [Q96H12-1] DR RefSeq; NP_001185735.1; NM_001198806.1. [Q96H12-1] DR RefSeq; NP_001185736.1; NM_001198807.1. [Q96H12-2] DR RefSeq; NP_542386.1; NM_080655.2. [Q96H12-1] DR AlphaFoldDB; Q96H12; -. DR SMR; Q96H12; -. DR BioGRID; 124810; 21. DR IntAct; Q96H12; 24. DR MINT; Q96H12; -. DR STRING; 9606.ENSP00000480445; -. DR GlyGen; Q96H12; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q96H12; -. DR PhosphoSitePlus; Q96H12; -. DR BioMuta; MSANTD3; -. DR DMDM; 74751897; -. DR EPD; Q96H12; -. DR jPOST; Q96H12; -. DR MassIVE; Q96H12; -. DR MaxQB; Q96H12; -. DR PaxDb; 9606-ENSP00000480445; -. DR PeptideAtlas; Q96H12; -. DR ProteomicsDB; 76693; -. [Q96H12-1] DR Antibodypedia; 34901; 90 antibodies from 13 providers. DR DNASU; 91283; -. DR Ensembl; ENST00000374885.5; ENSP00000364020.1; ENSG00000066697.15. [Q96H12-2] DR Ensembl; ENST00000395067.7; ENSP00000378506.2; ENSG00000066697.15. [Q96H12-1] DR Ensembl; ENST00000613183.1; ENSP00000480445.1; ENSG00000066697.15. [Q96H12-1] DR Ensembl; ENST00000622639.4; ENSP00000480622.1; ENSG00000066697.15. [Q96H12-1] DR GeneID; 91283; -. DR KEGG; hsa:91283; -. DR MANE-Select; ENST00000395067.7; ENSP00000378506.2; NM_080655.3; NP_542386.1. DR UCSC; uc004baw.4; human. [Q96H12-1] DR AGR; HGNC:23370; -. DR CTD; 91283; -. DR DisGeNET; 91283; -. DR GeneCards; MSANTD3; -. DR HGNC; HGNC:23370; MSANTD3. DR HPA; ENSG00000066697; Low tissue specificity. DR neXtProt; NX_Q96H12; -. DR OpenTargets; ENSG00000066697; -. DR PharmGKB; PA142672311; -. DR VEuPathDB; HostDB:ENSG00000066697; -. DR eggNOG; ENOG502RFDD; Eukaryota. DR GeneTree; ENSGT00390000007901; -. DR HOGENOM; CLU_065066_0_0_1; -. DR InParanoid; Q96H12; -. DR OMA; FQVCEGT; -. DR PhylomeDB; Q96H12; -. DR TreeFam; TF328595; -. DR PathwayCommons; Q96H12; -. DR SignaLink; Q96H12; -. DR BioGRID-ORCS; 91283; 17 hits in 1154 CRISPR screens. DR ChiTaRS; MSANTD3; human. DR GenomeRNAi; 91283; -. DR Pharos; Q96H12; Tdark. DR PRO; PR:Q96H12; -. DR Proteomes; UP000005640; Chromosome 9. DR RNAct; Q96H12; Protein. DR Bgee; ENSG00000066697; Expressed in cartilage tissue and 182 other cell types or tissues. DR ExpressionAtlas; Q96H12; baseline and differential. DR InterPro; IPR028002; Myb_DNA-bind_5. DR PANTHER; PTHR21632:SF3; TOMOREGULIN-1; 1. DR PANTHER; PTHR21632; UNCHARACTERIZED; 1. DR Pfam; PF13873; Myb_DNA-bind_5; 1. DR Genevisible; Q96H12; HS. PE 1: Evidence at protein level; KW Alternative splicing; Coiled coil; Isopeptide bond; Phosphoprotein; KW Reference proteome; Ubl conjugation. FT CHAIN 1..275 FT /note="Myb/SANT-like DNA-binding domain-containing protein FT 3" FT /id="PRO_0000292590" FT DOMAIN 13..78 FT /note="Myb-like" FT COILED 211..247 FT /evidence="ECO:0000255" FT MOD_RES 96 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:20068231" FT MOD_RES 98 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648, FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163" FT MOD_RES 274 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648, FT ECO:0007744|PubMed:20068231" FT CROSSLNK 154 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" FT VAR_SEQ 140..159 FT /note="ESFAVSNRELCDDEKEFIHF -> VFFQERKRSLELSIILSGTW (in FT isoform 2)" FT /evidence="ECO:0000305" FT /id="VSP_053346" FT VAR_SEQ 160..275 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000305" FT /id="VSP_053347" SQ SEQUENCE 275 AA; 32363 MW; 1CB06C2AD26FD135 CRC64; MQNNEIIKPA KYFSELEKSI LLALVEKYKY VLECKKSDAR TIALKQRTWQ ALAHEYNSQP SVSLRDFKQL KKCWENIKAR TKKIMAHERR EKVKRSVSPL LSTHVLGKEK IASMLPEQLY FLQSPPEEEP EYHPDASAQE SFAVSNRELC DDEKEFIHFP VCEGTSQPEP SCSAVRITAN KNYRSKTSQE GALKKMHEEE HHQQMSILQL QLIQMNEVHV AKIQQIEREC EMAEEEHRIK MEVLNKKKMY WERKLQTFTK EWPVSSFNRP FPNSP //