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Protein

Myb/SANT-like DNA-binding domain-containing protein 3

Gene

MSANTD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Myb/SANT-like DNA-binding domain-containing protein 3
Gene namesi
Name:MSANTD3
Synonyms:C9orf30
ORF Names:L8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23370. MSANTD3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672311.

Polymorphism and mutation databases

BioMutaiMSANTD3.
DMDMi74751897.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Myb/SANT-like DNA-binding domain-containing protein 3PRO_0000292590Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei96 – 961Phosphoserine1 Publication
Modified residuei98 – 981Phosphoserine2 Publications
Modified residuei274 – 2741Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96H12.
PaxDbiQ96H12.
PRIDEiQ96H12.

PTM databases

PhosphoSiteiQ96H12.

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Gene expression databases

BgeeiQ96H12.
CleanExiHS_C9orf30.
ExpressionAtlasiQ96H12. baseline and differential.
GenevisibleiQ96H12. HS.

Interactioni

Protein-protein interaction databases

BioGridi124810. 4 interactions.
IntActiQ96H12. 14 interactions.
MINTiMINT-7032147.
STRINGi9606.ENSP00000378506.

Structurei

3D structure databases

ProteinModelPortaliQ96H12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 7866Myb-likeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili211 – 24737Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the MSANTD3 family.Curated
Contains 1 Myb-like domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG73600.
GeneTreeiENSGT00390000007901.
HOGENOMiHOG000111635.
HOVERGENiHBG101140.
InParanoidiQ96H12.
OMAiCSDVRIA.
OrthoDBiEOG7HQN7S.
PhylomeDBiQ96H12.
TreeFamiTF328595.

Family and domain databases

InterProiIPR026709. Msantd3.
IPR028002. Myb_DNA-bind_5.
[Graphical view]
PANTHERiPTHR21632. PTHR21632. 1 hit.
PfamiPF13873. Myb_DNA-bind_5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96H12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQNNEIIKPA KYFSELEKSI LLALVEKYKY VLECKKSDAR TIALKQRTWQ
60 70 80 90 100
ALAHEYNSQP SVSLRDFKQL KKCWENIKAR TKKIMAHERR EKVKRSVSPL
110 120 130 140 150
LSTHVLGKEK IASMLPEQLY FLQSPPEEEP EYHPDASAQE SFAVSNRELC
160 170 180 190 200
DDEKEFIHFP VCEGTSQPEP SCSAVRITAN KNYRSKTSQE GALKKMHEEE
210 220 230 240 250
HHQQMSILQL QLIQMNEVHV AKIQQIEREC EMAEEEHRIK MEVLNKKKMY
260 270
WERKLQTFTK EWPVSSFNRP FPNSP
Length:275
Mass (Da):32,363
Last modified:December 1, 2001 - v1
Checksum:i1CB06C2AD26FD135
GO
Isoform 2 (identifier: Q96H12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-159: ESFAVSNRELCDDEKEFIHF → VFFQERKRSLELSIILSGTW
     160-275: Missing.

Show »
Length:159
Mass (Da):18,665
Checksum:i2D0742D6201C1596
GO

Sequence cautioni

The sequence CAI12539.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI12540.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei140 – 15920ESFAV…EFIHF → VFFQERKRSLELSIILSGTW in isoform 2. CuratedVSP_053346Add
BLAST
Alternative sequencei160 – 275116Missing in isoform 2. CuratedVSP_053347Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598327 mRNA. Translation: AAT06738.1.
AK314924 mRNA. Translation: BAG37432.1.
AL353805 Genomic DNA. Translation: CAI12539.1. Sequence problems.
AL353805 Genomic DNA. Translation: CAI12540.1. Sequence problems.
AL353805 Genomic DNA. Translation: CAI12541.1. Different termination.
AL353805 Genomic DNA. Translation: CAI12542.1.
BC008993 mRNA. Translation: AAH08993.1.
CCDSiCCDS56579.1. [Q96H12-2]
CCDS6749.1. [Q96H12-1]
RefSeqiNP_001185734.1. NM_001198805.1. [Q96H12-1]
NP_001185735.1. NM_001198806.1. [Q96H12-1]
NP_001185736.1. NM_001198807.1. [Q96H12-2]
NP_542386.1. NM_080655.2. [Q96H12-1]
UniGeneiHs.530272.
Hs.732964.

Genome annotation databases

EnsembliENST00000374885; ENSP00000364020; ENSG00000066697. [Q96H12-2]
ENST00000395067; ENSP00000378506; ENSG00000066697. [Q96H12-1]
ENST00000613183; ENSP00000480445; ENSG00000066697. [Q96H12-1]
ENST00000622639; ENSP00000480622; ENSG00000066697. [Q96H12-1]
GeneIDi91283.
KEGGihsa:91283.
UCSCiuc004baw.3. human. [Q96H12-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598327 mRNA. Translation: AAT06738.1.
AK314924 mRNA. Translation: BAG37432.1.
AL353805 Genomic DNA. Translation: CAI12539.1. Sequence problems.
AL353805 Genomic DNA. Translation: CAI12540.1. Sequence problems.
AL353805 Genomic DNA. Translation: CAI12541.1. Different termination.
AL353805 Genomic DNA. Translation: CAI12542.1.
BC008993 mRNA. Translation: AAH08993.1.
CCDSiCCDS56579.1. [Q96H12-2]
CCDS6749.1. [Q96H12-1]
RefSeqiNP_001185734.1. NM_001198805.1. [Q96H12-1]
NP_001185735.1. NM_001198806.1. [Q96H12-1]
NP_001185736.1. NM_001198807.1. [Q96H12-2]
NP_542386.1. NM_080655.2. [Q96H12-1]
UniGeneiHs.530272.
Hs.732964.

3D structure databases

ProteinModelPortaliQ96H12.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124810. 4 interactions.
IntActiQ96H12. 14 interactions.
MINTiMINT-7032147.
STRINGi9606.ENSP00000378506.

PTM databases

PhosphoSiteiQ96H12.

Polymorphism and mutation databases

BioMutaiMSANTD3.
DMDMi74751897.

Proteomic databases

MaxQBiQ96H12.
PaxDbiQ96H12.
PRIDEiQ96H12.

Protocols and materials databases

DNASUi91283.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374885; ENSP00000364020; ENSG00000066697. [Q96H12-2]
ENST00000395067; ENSP00000378506; ENSG00000066697. [Q96H12-1]
ENST00000613183; ENSP00000480445; ENSG00000066697. [Q96H12-1]
ENST00000622639; ENSP00000480622; ENSG00000066697. [Q96H12-1]
GeneIDi91283.
KEGGihsa:91283.
UCSCiuc004baw.3. human. [Q96H12-1]

Organism-specific databases

CTDi91283.
GeneCardsiGC09P103190.
H-InvDBHIX0008239.
HGNCiHGNC:23370. MSANTD3.
neXtProtiNX_Q96H12.
PharmGKBiPA142672311.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG73600.
GeneTreeiENSGT00390000007901.
HOGENOMiHOG000111635.
HOVERGENiHBG101140.
InParanoidiQ96H12.
OMAiCSDVRIA.
OrthoDBiEOG7HQN7S.
PhylomeDBiQ96H12.
TreeFamiTF328595.

Miscellaneous databases

GenomeRNAii91283.
NextBioi35468135.
PROiQ96H12.

Gene expression databases

BgeeiQ96H12.
CleanExiHS_C9orf30.
ExpressionAtlasiQ96H12. baseline and differential.
GenevisibleiQ96H12. HS.

Family and domain databases

InterProiIPR026709. Msantd3.
IPR028002. Myb_DNA-bind_5.
[Graphical view]
PANTHERiPTHR21632. PTHR21632. 1 hit.
PfamiPF13873. Myb_DNA-bind_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."
    Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P.
    Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Subthalamic nucleus.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98 AND SER-274, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96; SER-98 AND SER-274, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMSD3_HUMAN
AccessioniPrimary (citable) accession number: Q96H12
Secondary accession number(s): B2RC35
, Q5T726, Q5T727, Q5T728
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.