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Q96H12

- MSD3_HUMAN

UniProt

Q96H12 - MSD3_HUMAN

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Protein

Myb/SANT-like DNA-binding domain-containing protein 3

Gene
MSANTD3, C9orf30, L8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Myb/SANT-like DNA-binding domain-containing protein 3
Gene namesi
Name:MSANTD3
Synonyms:C9orf30
ORF Names:L8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:23370. MSANTD3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672311.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Myb/SANT-like DNA-binding domain-containing protein 3PRO_0000292590Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei96 – 961Phosphoserine1 Publication
Modified residuei98 – 981Phosphoserine2 Publications
Modified residuei274 – 2741Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96H12.
PaxDbiQ96H12.
PRIDEiQ96H12.

PTM databases

PhosphoSiteiQ96H12.

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Gene expression databases

BgeeiQ96H12.
CleanExiHS_C9orf30.
GenevestigatoriQ96H12.

Interactioni

Protein-protein interaction databases

BioGridi124810. 3 interactions.
IntActiQ96H12. 3 interactions.
MINTiMINT-7032147.
STRINGi9606.ENSP00000364022.

Structurei

3D structure databases

ProteinModelPortaliQ96H12.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 7866Myb-likeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili211 – 24737 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the MSANTD3 family.
Contains 1 Myb-like domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG73600.
HOGENOMiHOG000111635.
HOVERGENiHBG101140.
OMAiCSDVRIA.
OrthoDBiEOG7HQN7S.
PhylomeDBiQ96H12.
TreeFamiTF328595.

Family and domain databases

InterProiIPR026709. Msantd3.
IPR028002. Myb_DNA-bind_5.
[Graphical view]
PANTHERiPTHR21632. PTHR21632. 1 hit.
PfamiPF13873. Myb_DNA-bind_5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96H12-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQNNEIIKPA KYFSELEKSI LLALVEKYKY VLECKKSDAR TIALKQRTWQ    50
ALAHEYNSQP SVSLRDFKQL KKCWENIKAR TKKIMAHERR EKVKRSVSPL 100
LSTHVLGKEK IASMLPEQLY FLQSPPEEEP EYHPDASAQE SFAVSNRELC 150
DDEKEFIHFP VCEGTSQPEP SCSAVRITAN KNYRSKTSQE GALKKMHEEE 200
HHQQMSILQL QLIQMNEVHV AKIQQIEREC EMAEEEHRIK MEVLNKKKMY 250
WERKLQTFTK EWPVSSFNRP FPNSP 275
Length:275
Mass (Da):32,363
Last modified:December 1, 2001 - v1
Checksum:i1CB06C2AD26FD135
GO
Isoform 2 (identifier: Q96H12-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-159: ESFAVSNRELCDDEKEFIHF → VFFQERKRSLELSIILSGTW
     160-275: Missing.

Show »
Length:159
Mass (Da):18,665
Checksum:i2D0742D6201C1596
GO

Sequence cautioni

The sequence CAI12539.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI12540.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei140 – 15920ESFAV…EFIHF → VFFQERKRSLELSIILSGTW in isoform 2. VSP_053346Add
BLAST
Alternative sequencei160 – 275116Missing in isoform 2. VSP_053347Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY598327 mRNA. Translation: AAT06738.1.
AK314924 mRNA. Translation: BAG37432.1.
AL353805 Genomic DNA. Translation: CAI12539.1. Sequence problems.
AL353805 Genomic DNA. Translation: CAI12540.1. Sequence problems.
AL353805 Genomic DNA. Translation: CAI12541.1. Different termination.
AL353805 Genomic DNA. Translation: CAI12542.1.
BC008993 mRNA. Translation: AAH08993.1.
CCDSiCCDS56579.1. [Q96H12-2]
CCDS6749.1. [Q96H12-1]
RefSeqiNP_001185734.1. NM_001198805.1. [Q96H12-1]
NP_001185735.1. NM_001198806.1. [Q96H12-1]
NP_001185736.1. NM_001198807.1. [Q96H12-2]
NP_542386.1. NM_080655.2. [Q96H12-1]
UniGeneiHs.530272.
Hs.732964.

Genome annotation databases

EnsembliENST00000374885; ENSP00000364020; ENSG00000066697. [Q96H12-2]
ENST00000395067; ENSP00000378506; ENSG00000066697. [Q96H12-1]
GeneIDi91283.
KEGGihsa:91283.
UCSCiuc004baw.3. human. [Q96H12-1]

Polymorphism databases

DMDMi74751897.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY598327 mRNA. Translation: AAT06738.1 .
AK314924 mRNA. Translation: BAG37432.1 .
AL353805 Genomic DNA. Translation: CAI12539.1 . Sequence problems.
AL353805 Genomic DNA. Translation: CAI12540.1 . Sequence problems.
AL353805 Genomic DNA. Translation: CAI12541.1 . Different termination.
AL353805 Genomic DNA. Translation: CAI12542.1 .
BC008993 mRNA. Translation: AAH08993.1 .
CCDSi CCDS56579.1. [Q96H12-2 ]
CCDS6749.1. [Q96H12-1 ]
RefSeqi NP_001185734.1. NM_001198805.1. [Q96H12-1 ]
NP_001185735.1. NM_001198806.1. [Q96H12-1 ]
NP_001185736.1. NM_001198807.1. [Q96H12-2 ]
NP_542386.1. NM_080655.2. [Q96H12-1 ]
UniGenei Hs.530272.
Hs.732964.

3D structure databases

ProteinModelPortali Q96H12.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124810. 3 interactions.
IntActi Q96H12. 3 interactions.
MINTi MINT-7032147.
STRINGi 9606.ENSP00000364022.

PTM databases

PhosphoSitei Q96H12.

Polymorphism databases

DMDMi 74751897.

Proteomic databases

MaxQBi Q96H12.
PaxDbi Q96H12.
PRIDEi Q96H12.

Protocols and materials databases

DNASUi 91283.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374885 ; ENSP00000364020 ; ENSG00000066697 . [Q96H12-2 ]
ENST00000395067 ; ENSP00000378506 ; ENSG00000066697 . [Q96H12-1 ]
GeneIDi 91283.
KEGGi hsa:91283.
UCSCi uc004baw.3. human. [Q96H12-1 ]

Organism-specific databases

CTDi 91283.
GeneCardsi GC09P103190.
H-InvDB HIX0008239.
HGNCi HGNC:23370. MSANTD3.
neXtProti NX_Q96H12.
PharmGKBi PA142672311.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG73600.
HOGENOMi HOG000111635.
HOVERGENi HBG101140.
OMAi CSDVRIA.
OrthoDBi EOG7HQN7S.
PhylomeDBi Q96H12.
TreeFami TF328595.

Miscellaneous databases

GenomeRNAii 91283.
NextBioi 35468135.
PROi Q96H12.

Gene expression databases

Bgeei Q96H12.
CleanExi HS_C9orf30.
Genevestigatori Q96H12.

Family and domain databases

InterProi IPR026709. Msantd3.
IPR028002. Myb_DNA-bind_5.
[Graphical view ]
PANTHERi PTHR21632. PTHR21632. 1 hit.
Pfami PF13873. Myb_DNA-bind_5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."
    Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P.
    Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Subthalamic nucleus.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98 AND SER-274, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96; SER-98 AND SER-274, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMSD3_HUMAN
AccessioniPrimary (citable) accession number: Q96H12
Secondary accession number(s): B2RC35
, Q5T726, Q5T727, Q5T728
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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