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Q96H12

- MSD3_HUMAN

UniProt

Q96H12 - MSD3_HUMAN

Protein

Myb/SANT-like DNA-binding domain-containing protein 3

Gene

MSANTD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myb/SANT-like DNA-binding domain-containing protein 3
    Gene namesi
    Name:MSANTD3
    Synonyms:C9orf30
    ORF Names:L8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:23370. MSANTD3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672311.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275Myb/SANT-like DNA-binding domain-containing protein 3PRO_0000292590Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei96 – 961Phosphoserine1 Publication
    Modified residuei98 – 981Phosphoserine2 Publications
    Modified residuei274 – 2741Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96H12.
    PaxDbiQ96H12.
    PRIDEiQ96H12.

    PTM databases

    PhosphoSiteiQ96H12.

    Expressioni

    Tissue specificityi

    Expressed in brain.1 Publication

    Gene expression databases

    BgeeiQ96H12.
    CleanExiHS_C9orf30.
    GenevestigatoriQ96H12.

    Interactioni

    Protein-protein interaction databases

    BioGridi124810. 3 interactions.
    IntActiQ96H12. 3 interactions.
    MINTiMINT-7032147.
    STRINGi9606.ENSP00000364022.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96H12.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 7866Myb-likeAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili211 – 24737Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MSANTD3 family.Curated
    Contains 1 Myb-like domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG73600.
    HOGENOMiHOG000111635.
    HOVERGENiHBG101140.
    OMAiCSDVRIA.
    OrthoDBiEOG7HQN7S.
    PhylomeDBiQ96H12.
    TreeFamiTF328595.

    Family and domain databases

    InterProiIPR026709. Msantd3.
    IPR028002. Myb_DNA-bind_5.
    [Graphical view]
    PANTHERiPTHR21632. PTHR21632. 1 hit.
    PfamiPF13873. Myb_DNA-bind_5. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96H12-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQNNEIIKPA KYFSELEKSI LLALVEKYKY VLECKKSDAR TIALKQRTWQ    50
    ALAHEYNSQP SVSLRDFKQL KKCWENIKAR TKKIMAHERR EKVKRSVSPL 100
    LSTHVLGKEK IASMLPEQLY FLQSPPEEEP EYHPDASAQE SFAVSNRELC 150
    DDEKEFIHFP VCEGTSQPEP SCSAVRITAN KNYRSKTSQE GALKKMHEEE 200
    HHQQMSILQL QLIQMNEVHV AKIQQIEREC EMAEEEHRIK MEVLNKKKMY 250
    WERKLQTFTK EWPVSSFNRP FPNSP 275
    Length:275
    Mass (Da):32,363
    Last modified:December 1, 2001 - v1
    Checksum:i1CB06C2AD26FD135
    GO
    Isoform 2 (identifier: Q96H12-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         140-159: ESFAVSNRELCDDEKEFIHF → VFFQERKRSLELSIILSGTW
         160-275: Missing.

    Show »
    Length:159
    Mass (Da):18,665
    Checksum:i2D0742D6201C1596
    GO

    Sequence cautioni

    The sequence CAI12539.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI12540.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei140 – 15920ESFAV…EFIHF → VFFQERKRSLELSIILSGTW in isoform 2. CuratedVSP_053346Add
    BLAST
    Alternative sequencei160 – 275116Missing in isoform 2. CuratedVSP_053347Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY598327 mRNA. Translation: AAT06738.1.
    AK314924 mRNA. Translation: BAG37432.1.
    AL353805 Genomic DNA. Translation: CAI12539.1. Sequence problems.
    AL353805 Genomic DNA. Translation: CAI12540.1. Sequence problems.
    AL353805 Genomic DNA. Translation: CAI12541.1. Different termination.
    AL353805 Genomic DNA. Translation: CAI12542.1.
    BC008993 mRNA. Translation: AAH08993.1.
    CCDSiCCDS56579.1. [Q96H12-2]
    CCDS6749.1. [Q96H12-1]
    RefSeqiNP_001185734.1. NM_001198805.1. [Q96H12-1]
    NP_001185735.1. NM_001198806.1. [Q96H12-1]
    NP_001185736.1. NM_001198807.1. [Q96H12-2]
    NP_542386.1. NM_080655.2. [Q96H12-1]
    UniGeneiHs.530272.
    Hs.732964.

    Genome annotation databases

    EnsembliENST00000374885; ENSP00000364020; ENSG00000066697. [Q96H12-2]
    ENST00000395067; ENSP00000378506; ENSG00000066697. [Q96H12-1]
    GeneIDi91283.
    KEGGihsa:91283.
    UCSCiuc004baw.3. human. [Q96H12-1]

    Polymorphism databases

    DMDMi74751897.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY598327 mRNA. Translation: AAT06738.1 .
    AK314924 mRNA. Translation: BAG37432.1 .
    AL353805 Genomic DNA. Translation: CAI12539.1 . Sequence problems.
    AL353805 Genomic DNA. Translation: CAI12540.1 . Sequence problems.
    AL353805 Genomic DNA. Translation: CAI12541.1 . Different termination.
    AL353805 Genomic DNA. Translation: CAI12542.1 .
    BC008993 mRNA. Translation: AAH08993.1 .
    CCDSi CCDS56579.1. [Q96H12-2 ]
    CCDS6749.1. [Q96H12-1 ]
    RefSeqi NP_001185734.1. NM_001198805.1. [Q96H12-1 ]
    NP_001185735.1. NM_001198806.1. [Q96H12-1 ]
    NP_001185736.1. NM_001198807.1. [Q96H12-2 ]
    NP_542386.1. NM_080655.2. [Q96H12-1 ]
    UniGenei Hs.530272.
    Hs.732964.

    3D structure databases

    ProteinModelPortali Q96H12.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124810. 3 interactions.
    IntActi Q96H12. 3 interactions.
    MINTi MINT-7032147.
    STRINGi 9606.ENSP00000364022.

    PTM databases

    PhosphoSitei Q96H12.

    Polymorphism databases

    DMDMi 74751897.

    Proteomic databases

    MaxQBi Q96H12.
    PaxDbi Q96H12.
    PRIDEi Q96H12.

    Protocols and materials databases

    DNASUi 91283.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374885 ; ENSP00000364020 ; ENSG00000066697 . [Q96H12-2 ]
    ENST00000395067 ; ENSP00000378506 ; ENSG00000066697 . [Q96H12-1 ]
    GeneIDi 91283.
    KEGGi hsa:91283.
    UCSCi uc004baw.3. human. [Q96H12-1 ]

    Organism-specific databases

    CTDi 91283.
    GeneCardsi GC09P103190.
    H-InvDB HIX0008239.
    HGNCi HGNC:23370. MSANTD3.
    neXtProti NX_Q96H12.
    PharmGKBi PA142672311.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG73600.
    HOGENOMi HOG000111635.
    HOVERGENi HBG101140.
    OMAi CSDVRIA.
    OrthoDBi EOG7HQN7S.
    PhylomeDBi Q96H12.
    TreeFami TF328595.

    Miscellaneous databases

    GenomeRNAii 91283.
    NextBioi 35468135.
    PROi Q96H12.

    Gene expression databases

    Bgeei Q96H12.
    CleanExi HS_C9orf30.
    Genevestigatori Q96H12.

    Family and domain databases

    InterProi IPR026709. Msantd3.
    IPR028002. Myb_DNA-bind_5.
    [Graphical view ]
    PANTHERi PTHR21632. PTHR21632. 1 hit.
    Pfami PF13873. Myb_DNA-bind_5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."
      Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P.
      Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Subthalamic nucleus.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98 AND SER-274, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96; SER-98 AND SER-274, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMSD3_HUMAN
    AccessioniPrimary (citable) accession number: Q96H12
    Secondary accession number(s): B2RC35
    , Q5T726, Q5T727, Q5T728
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3