Q96H12 (MSD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myb/SANT-like DNA-binding domain-containing protein 3

Gene names

Name:	MSANTD3
Synonyms:	C9orf30
ORF Names:	L8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Expressed in brain. Ref.1
Sequence similarities	Belongs to the MSANTD3 family. Contains 1 Myb-like domain.
Sequence caution	The sequence CAI12539.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI12540.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Myb/SANT-like DNA-binding domain-containing protein 3		PRO_0000292590
Regions
	Domain	13 – 78	66	Myb-like
	Coiled coil	211 – 247	37	Potential
Amino acid modifications
	Modified residue	96	1	Phosphoserine Ref.6
	Modified residue	98	1	Phosphoserine Ref.5 Ref.6
	Modified residue	274	1	Phosphoserine Ref.5 Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q96H12 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 1CB06C2AD26FD135	FASTA	275	32,363
	10 20 30 40 50 60 MQNNEIIKPA KYFSELEKSI LLALVEKYKY VLECKKSDAR TIALKQRTWQ ALAHEYNSQP 70 80 90 100 110 120 SVSLRDFKQL KKCWENIKAR TKKIMAHERR EKVKRSVSPL LSTHVLGKEK IASMLPEQLY 130 140 150 160 170 180 FLQSPPEEEP EYHPDASAQE SFAVSNRELC DDEKEFIHFP VCEGTSQPEP SCSAVRITAN 190 200 210 220 230 240 KNYRSKTSQE GALKKMHEEE HHQQMSILQL QLIQMNEVHV AKIQQIEREC EMAEEEHRIK 250 260 270 MEVLNKKKMY WERKLQTFTK EWPVSSFNRP FPNSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer." Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P. Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98 AND SER-274, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96; SER-98 AND SER-274, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY598327 mRNA. Translation: AAT06738.1. AL353805 Genomic DNA. Translation: CAI12539.1. Sequence problems. AL353805 Genomic DNA. Translation: CAI12540.1. Sequence problems. AL353805 Genomic DNA. Translation: CAI12541.1. Different termination. AL353805 Genomic DNA. Translation: CAI12542.1. BC008993 mRNA. Translation: AAH08993.1.
IPI	IPI00062697.
RefSeq	NP_001185734.1. NM_001198805.1. NP_001185735.1. NM_001198806.1. NP_001185736.1. NM_001198807.1. NP_542386.1. NM_080655.2.
UniGene	Hs.530272. Hs.732964.
3D structure databases
ProteinModelPortal	Q96H12.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-7032147.
STRING	9606.ENSP00000364022.
PTM databases
PhosphoSite	Q96H12.
Polymorphism databases
DMDM	74751897.
Proteomic databases
PaxDb	Q96H12.
PRIDE	Q96H12.
Protocols and materials databases
DNASU	91283.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374885; ENSP00000364020; ENSG00000066697. ENST00000374886; ENSP00000364021; ENSG00000066697. ENST00000395067; ENSP00000378506; ENSG00000066697. ENST00000398977; ENSP00000415830; ENSG00000066697.
GeneID	91283.
KEGG	hsa:91283.
UCSC	uc004baw.3. human.
Organism-specific databases
CTD	91283.
GeneCards	GC09P103190.
H-InvDB	HIX0008239.
HGNC	HGNC:23370. MSANTD3.
neXtProt	NX_Q96H12.
PharmGKB	PA142672311.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG73600.
HOGENOM	HOG000111635.
HOVERGEN	HBG101140.
OMA	ELIHFPV.
OrthoDB	EOG4PG61M.
Gene expression databases
Bgee	Q96H12.
CleanEx	HS_C9orf30.
Genevestigator	Q96H12.
Family and domain databases
InterPro	IPR026709. Msantd3. [Graphical view]
PANTHER	PTHR21632. PTHR21632. 1 hit.
PROSITE	PS50090. MYB_LIKE. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	91283.
NextBio	77155.

Entry information

Entry name

MSD3_HUMAN

Accession

Primary (citable) accession number: Q96H12
Secondary accession number(s): Q5T726, Q5T727, Q5T728

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.