Q96GZ6 (S41A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 85.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Solute carrier family 41 member 3 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Reference proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 507 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Subcellular location | |
| Sequence similarities | Belongs to the SLC41A transporter family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Transmembrane Transmembrane helix |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular_component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | cation transmembrane transporter activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 8 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q96GZ6-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q96GZ6-2) The sequence of this isoform differs from the canonical sequence as follows: 501-507: Missing. | ||||||
| Isoform 3 (identifier: Q96GZ6-3) The sequence of this isoform differs from the canonical sequence as follows: 92-127: Missing. | ||||||
| Isoform 4 (identifier: Q96GZ6-4) The sequence of this isoform differs from the canonical sequence as follows: 92-127: Missing. 501-507: Missing. | ||||||
| Isoform 5 (identifier: Q96GZ6-5) The sequence of this isoform differs from the canonical sequence as follows: 61-69: Missing. 457-507: SSSVGHTAAV...PFCLLAKTSI → TGLLALCFFTDWLLKSKAELGGISELASGPP | ||||||
| Isoform 6 (identifier: Q96GZ6-6) The sequence of this isoform differs from the canonical sequence as follows: 218-266: Missing. 457-507: SSSVGHTAAV...PFCLLAKTSI → TGLLALCFFTDWLLKSKAELGGISELASGPP | ||||||
| Isoform 7 (identifier: Q96GZ6-7) The sequence of this isoform differs from the canonical sequence as follows: 1-26: Missing. 27-90: STGGLPVASE...SWAGMLLDYF → MVVTQLNLEF...MTAGLVMNTI 457-507: SSSVGHTAAV...PFCLLAKTSI → TGLLALCFFTDWLLKSKAELGGISELASGPP | ||||||
| Isoform 8 (identifier: Q96GZ6-8) The sequence of this isoform differs from the canonical sequence as follows: 1-117: Missing. 457-507: SSSVGHTAAV...PFCLLAKTSI → TGLLALCFFTDWLLKSKAELGGISELASGPP | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 507 | 507 | Solute carrier family 41 member 3 | PRO_0000295592 | |||||
Regions | |||||||||
| Transmembrane | 67 – 87 | 21 | Helical; Potential | ||||||
| Transmembrane | 152 – 172 | 21 | Helical; Potential | ||||||
| Transmembrane | 189 – 209 | 21 | Helical; Potential | ||||||
| Transmembrane | 220 – 240 | 21 | Helical; Potential | ||||||
| Transmembrane | 252 – 272 | 21 | Helical; Potential | ||||||
| Transmembrane | 284 – 304 | 21 | Helical; Potential | ||||||
| Transmembrane | 314 – 334 | 21 | Helical; Potential | ||||||
| Transmembrane | 377 – 397 | 21 | Helical; Potential | ||||||
| Transmembrane | 406 – 426 | 21 | Helical; Potential | ||||||
| Transmembrane | 482 – 502 | 21 | Helical; Potential | ||||||
| Compositional bias | 378 – 381 | 4 | Poly-Leu | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 117 | 117 | Missing in isoform 8. | VSP_043676 | |||||
| Alternative sequence | 1 – 26 | 26 | Missing in isoform 7. | VSP_035505 | |||||
| Alternative sequence | 27 – 90 | 64 | STGGL…LLDYF → MVVTQLNLEFCFQGKKLRGF SCELTRSPHGVLPESFFTIM CQVVVPILLSGLCMMTAGLV MNTI in isoform 7. | VSP_035506 | |||||
| Alternative sequence | 61 – 69 | 9 | Missing in isoform 5. | VSP_026934 | |||||
| Alternative sequence | 92 – 127 | 36 | Missing in isoform 3 and isoform 4. | VSP_026935 | |||||
| Alternative sequence | 218 – 266 | 49 | Missing in isoform 6. | VSP_026936 | |||||
| Alternative sequence | 457 – 507 | 51 | SSSVG…AKTSI → TGLLALCFFTDWLLKSKAEL GGISELASGPP in isoform 5, isoform 6, isoform 7 and isoform 8. | VSP_026937 | |||||
| Alternative sequence | 501 – 507 | 7 | Missing in isoform 2 and isoform 4. | VSP_026938 | |||||
| Natural variant | 62 | 1 | T → A. Ref.1 Ref.3 Corresponds to variant rs4234270 [ dbSNP | Ensembl ]. | VAR_033296 | |||||
| Natural variant | 71 | 1 | V → M. Ref.1 Corresponds to variant rs11543283 [ dbSNP | Ensembl ]. | VAR_046667 | |||||
Experimental info | |||||||||
| Sequence conflict | 331 | 1 | A → G in BAC03717. Ref.1 | ||||||
| Sequence conflict | 387 | 1 | L → P in BAB13938. Ref.1 | ||||||
| Sequence conflict | 405 | 1 | Q → R in BAC03717. Ref.1 | ||||||
| Sequence conflict | 448 | 1 | L → P in BAB13938. Ref.1 | ||||||
| Isoform 7: | |||||||||
| Sequence conflict | 432 | 1 | G → S in BAG52701. Ref.1 | ||||||
Sequences
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References
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4; 5; 6; 7 AND 8), VARIANTS ALA-62 AND MET-71. Tissue: Brain, Lung and Testis. |
| [2] | "The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. Gibbs R.A.Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-62. Tissue: Brain and Colon. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AK000480 mRNA. Translation: BAA91192.1. AK021925 mRNA. Translation: BAB13938.1. AK022780 mRNA. Translation: BAB14241.1. AK091671 mRNA. Translation: BAC03717.1. AK093380 mRNA. Translation: BAG52701.1. AK298070 mRNA. Translation: BAH12718.1. AC079848 Genomic DNA. No translation available. AC092903 Genomic DNA. No translation available. AC117422 Genomic DNA. No translation available. BC009039 mRNA. Translation: AAH09039.1. BC028241 mRNA. Translation: AAH28241.1. |
| IPI | IPI00305733. IPI00333095. IPI00514919. IPI00640697. IPI00798066. IPI00854593. IPI00854829. IPI00872905. |
| RefSeq | NP_001008485.1. NM_001008485.1. NP_001008486.1. NM_001008486.1. NP_001008487.1. NM_001008487.1. NP_001157947.1. NM_001164475.1. |
| UniGene | Hs.573007. |
3D structure databases | |
| ProteinModelPortal | Q96GZ6. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q96GZ6. |
Proteomic databases | |
| PaxDb | Q96GZ6. |
| PRIDE | Q96GZ6. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000315891; ENSP00000326070; ENSG00000114544. ENST00000346785; ENSP00000264471; ENSG00000114544. ENST00000383598; ENSP00000373092; ENSG00000114544. ENST00000508835; ENSP00000427409; ENSG00000114544. |
| GeneID | 54946. |
| KEGG | hsa:54946. |
| UCSC | uc003eii.3. human. uc003eij.3. human. |
Organism-specific databases | |
| CTD | 54946. |
| GeneCards | GC03M125725. |
| HGNC | HGNC:31046. SLC41A3. |
| HPA | HPA045847. |
| MIM | 610803. gene. |
| neXtProt | NX_Q96GZ6. |
| PharmGKB | PA134878151. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | COG1824. |
| HOGENOM | HOG000007017. |
| HOVERGEN | HBG057187. |
| InParanoid | Q96GZ6. |
| KO | K15122. |
| OMA | SHCIPYL. |
| PhylomeDB | Q96GZ6. |
Gene expression databases | |
| ArrayExpress | Q96GZ6. |
| Bgee | Q96GZ6. |
| CleanEx | HS_SLC41A3. |
| Genevestigator | Q96GZ6. |
Family and domain databases | |
| InterPro | IPR006667. MgtE_Mg_transptr_membr. [Graphical view] |
| Pfam | PF01769. MgtE. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other | |
| GenomeRNAi | 54946. |
| NextBio | 58101. |
| SOURCE | Search... |
Entry information
| Entry name | S41A3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96GZ6 Secondary accession number(s): A6ND60 Q9NX30 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
