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Protein

Protein lin-37 homolog

Gene

LIN37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1362277. Transcription of E2F targets under negative control by DREAM complex.
R-HSA-1362300. Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1.
R-HSA-1538133. G0 and Early G1.
R-HSA-156711. Polo-like kinase mediated events.
R-HSA-539107. Activation of E2F1 target genes at G1/S.
R-HSA-69202. Cyclin E associated events during G1/S transition.
R-HSA-69656. Cyclin A:Cdk2-associated events at S phase entry.
SignaLinkiQ96GY3.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-37 homolog
Alternative name(s):
Antolefinin
Gene namesi
Name:LIN37
ORF Names:MSTP064
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000267796.7.
HGNCiHGNC:33234. LIN37.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000267796.
PharmGKBiPA162394016.

Polymorphism and mutation databases

BioMutaiLIN37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002384791 – 246Protein lin-37 homologAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei135PhosphoserineBy similarity1
Modified residuei138PhosphoserineCombined sources1
Modified residuei167PhosphothreonineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96GY3.
MaxQBiQ96GY3.
PaxDbiQ96GY3.
PeptideAtlasiQ96GY3.
PRIDEiQ96GY3.

PTM databases

iPTMnetiQ96GY3.
PhosphoSitePlusiQ96GY3.

Expressioni

Gene expression databases

BgeeiENSG00000267796.
CleanExiHS_LIN37.
ExpressionAtlasiQ96GY3. baseline and differential.
GenevisibleiQ96GY3. HS.

Organism-specific databases

HPAiHPA043253.
HPA047809.

Interactioni

Subunit structurei

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121008. 32 interactors.
CORUMiQ96GY3.
IntActiQ96GY3. 40 interactors.
MINTiMINT-1484036.
STRINGi9606.ENSP00000301159.

Structurei

3D structure databases

ProteinModelPortaliQ96GY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi136 – 203Pro-richAdd BLAST68

Phylogenomic databases

eggNOGiENOG410II8K. Eukaryota.
ENOG4111QJM. LUCA.
GeneTreeiENSGT00390000002748.
HOGENOMiHOG000006536.
HOVERGENiHBG054424.
InParanoidiQ96GY3.
KOiK21774.
OMAiVDLAQFN.
OrthoDBiEOG091G0HEY.
PhylomeDBiQ96GY3.
TreeFamiTF329230.

Family and domain databases

InterProiView protein in InterPro
IPR028226. LIN37.
PfamiView protein in Pfam
PF15306. LIN37. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96GY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPVKVKVEK SELEMAKARN QLDAVLQCLL EKSHMDRERL DEEAGKTPSD
60 70 80 90 100
THNKDCSIAA TGKRPSARFP HQRRKKRREM DDGLAEGGPQ RSNTYVIKLF
110 120 130 140 150
DRSVDLAQFS ENTPLYPICR AWMRNSPSVR ERECSPSSPL PPLPEDEEGS
160 170 180 190 200
EVTNSKSRDV YKLPPPTPPG PPGDACRSRI PSPLQPEMQG TPDDEPSEPE
210 220 230 240
PSPSTLIYRN MQRWKRIRQR WKEASHRNQL RYSESMKILR EMYERQ
Length:246
Mass (Da):28,383
Last modified:December 1, 2001 - v1
Checksum:i8718E1C8FB13C446
GO

Sequence cautioni

The sequence AAB81199 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06167416A → V. Corresponds to variant dbSNP:rs170758Ensembl.1
Natural variantiVAR_051093172P → S. Corresponds to variant dbSNP:rs35617825Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293116 mRNA. Translation: BAF85805.1.
AC002398 Genomic DNA. Translation: AAB81199.1. Sequence problems.
AD000671 Genomic DNA. No translation available.
BC009071 mRNA. Translation: AAH09071.1.
AF162447 mRNA. Translation: AAQ13584.1.
CCDSiCCDS62642.1.
PIRiT00702.
RefSeqiNP_061977.1. NM_019104.2.
UniGeneiHs.529100.

Genome annotation databases

EnsembliENST00000301159; ENSP00000301159; ENSG00000267796.
GeneIDi55957.
KEGGihsa:55957.
UCSCiuc021usw.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLIN37_HUMAN
AccessioniPrimary (citable) accession number: Q96GY3
Secondary accession number(s): A8KAQ1, O14557, Q7Z2T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: October 25, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations