Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein lin-37 homolog

Gene

LIN37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_1006. Polo-like kinase mediated events.
REACT_111214. G0 and Early G1.
SignaLinkiQ96GY3.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-37 homolog
Alternative name(s):
Antolefinin
Gene namesi
Name:LIN37
ORF Names:MSTP064
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33234. LIN37.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394016.

Polymorphism and mutation databases

BioMutaiLIN37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Protein lin-37 homologPRO_0000238479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei138 – 1381Phosphoserine2 Publications
Modified residuei167 – 1671Phosphothreonine1 Publication
Modified residuei182 – 1821Phosphoserine3 Publications
Modified residuei202 – 2021Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96GY3.
PaxDbiQ96GY3.
PRIDEiQ96GY3.

PTM databases

PhosphoSiteiQ96GY3.

Expressioni

Gene expression databases

BgeeiQ96GY3.
CleanExiHS_LIN37.
ExpressionAtlasiQ96GY3. baseline.
GenevisibleiQ96GY3. HS.

Organism-specific databases

HPAiHPA043253.
HPA047809.

Interactioni

Subunit structurei

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDR2Q018503EBI-748884,EBI-1181367
CEP70Q8NHQ13EBI-748884,EBI-739624
KIFC3Q9BVG83EBI-748884,EBI-2125614
KRT31Q153233EBI-748884,EBI-948001
KRT40Q6A1623EBI-748884,EBI-10171697
LZTS2Q9BRK43EBI-748884,EBI-741037
MAGEA6P433603EBI-748884,EBI-1045155
PNMA1Q8ND903EBI-748884,EBI-302345
TEX11Q8IYF32EBI-748884,EBI-742397
TFIP11Q9UBB93EBI-748884,EBI-1105213
TRIM54Q9BYV23EBI-748884,EBI-2130429

Protein-protein interaction databases

BioGridi121008. 28 interactions.
IntActiQ96GY3. 32 interactions.
MINTiMINT-1484036.
STRINGi9606.ENSP00000301159.

Structurei

3D structure databases

ProteinModelPortaliQ96GY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi136 – 20368Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG43346.
GeneTreeiENSGT00390000002748.
HOGENOMiHOG000006536.
HOVERGENiHBG054424.
InParanoidiQ96GY3.
OMAiKKIRQKW.
PhylomeDBiQ96GY3.
TreeFamiTF329230.

Family and domain databases

InterProiIPR028226. LIN37.
[Graphical view]
PfamiPF15306. LIN37. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96GY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPVKVKVEK SELEMAKARN QLDAVLQCLL EKSHMDRERL DEEAGKTPSD
60 70 80 90 100
THNKDCSIAA TGKRPSARFP HQRRKKRREM DDGLAEGGPQ RSNTYVIKLF
110 120 130 140 150
DRSVDLAQFS ENTPLYPICR AWMRNSPSVR ERECSPSSPL PPLPEDEEGS
160 170 180 190 200
EVTNSKSRDV YKLPPPTPPG PPGDACRSRI PSPLQPEMQG TPDDEPSEPE
210 220 230 240
PSPSTLIYRN MQRWKRIRQR WKEASHRNQL RYSESMKILR EMYERQ
Length:246
Mass (Da):28,383
Last modified:December 1, 2001 - v1
Checksum:i8718E1C8FB13C446
GO

Sequence cautioni

The sequence AAB81199.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161A → V.
Corresponds to variant rs170758 [ dbSNP | Ensembl ].
VAR_061674
Natural varianti172 – 1721P → S.
Corresponds to variant rs35617825 [ dbSNP | Ensembl ].
VAR_051093

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293116 mRNA. Translation: BAF85805.1.
AC002398 Genomic DNA. Translation: AAB81199.1. Sequence problems.
AD000671 Genomic DNA. No translation available.
BC009071 mRNA. Translation: AAH09071.1.
AF162447 mRNA. Translation: AAQ13584.1.
CCDSiCCDS62642.1.
PIRiT00702.
RefSeqiNP_061977.1. NM_019104.2.
UniGeneiHs.529100.

Genome annotation databases

EnsembliENST00000301159; ENSP00000301159; ENSG00000267796.
GeneIDi55957.
KEGGihsa:55957.
UCSCiuc021usw.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293116 mRNA. Translation: BAF85805.1.
AC002398 Genomic DNA. Translation: AAB81199.1. Sequence problems.
AD000671 Genomic DNA. No translation available.
BC009071 mRNA. Translation: AAH09071.1.
AF162447 mRNA. Translation: AAQ13584.1.
CCDSiCCDS62642.1.
PIRiT00702.
RefSeqiNP_061977.1. NM_019104.2.
UniGeneiHs.529100.

3D structure databases

ProteinModelPortaliQ96GY3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121008. 28 interactions.
IntActiQ96GY3. 32 interactions.
MINTiMINT-1484036.
STRINGi9606.ENSP00000301159.

PTM databases

PhosphoSiteiQ96GY3.

Polymorphism and mutation databases

BioMutaiLIN37.

Proteomic databases

MaxQBiQ96GY3.
PaxDbiQ96GY3.
PRIDEiQ96GY3.

Protocols and materials databases

DNASUi55957.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301159; ENSP00000301159; ENSG00000267796.
GeneIDi55957.
KEGGihsa:55957.
UCSCiuc021usw.1. human.

Organism-specific databases

CTDi55957.
GeneCardsiGC19P036239.
HGNCiHGNC:33234. LIN37.
HPAiHPA043253.
HPA047809.
neXtProtiNX_Q96GY3.
PharmGKBiPA162394016.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43346.
GeneTreeiENSGT00390000002748.
HOGENOMiHOG000006536.
HOVERGENiHBG054424.
InParanoidiQ96GY3.
OMAiKKIRQKW.
PhylomeDBiQ96GY3.
TreeFamiTF329230.

Enzyme and pathway databases

ReactomeiREACT_1006. Polo-like kinase mediated events.
REACT_111214. G0 and Early G1.
SignaLinkiQ96GY3.

Miscellaneous databases

GenomeRNAii55957.
NextBioi61359.
PROiQ96GY3.

Gene expression databases

BgeeiQ96GY3.
CleanExiHS_LIN37.
ExpressionAtlasiQ96GY3. baseline.
GenevisibleiQ96GY3. HS.

Family and domain databases

InterProiIPR028226. LIN37.
[Graphical view]
PfamiPF15306. LIN37. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. "Homo sapiens normal aorta MST064."
    Qin B.M., Sheng H., Liu Y.Q., Liu B., Zhao B., Wang X.Y., Zhang Q., Xu Y.Y., Song L., Je Y., Gao Y., Zhang C.L., Hui R.T.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 92-246.
    Tissue: Aorta.
  5. "LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes."
    Schmit F., Korenjak M., Mannefeld M., Schmitt K., Franke C., von Eyss B., Gagrica S., Haenel F., Brehm A., Gaubatz S.
    Cell Cycle 6:1903-1913(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE DREAM COMPLEX.
  6. "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence."
    Litovchick L., Sadasivam S., Florens L., Zhu X., Swanson S.K., Velmurugan S., Chen R., Washburn M.P., Liu X.S., DeCaprio J.A.
    Mol. Cell 26:539-551(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE DREAM COMPLEX.
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-167, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138; SER-182 AND SER-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138; SER-182 AND SER-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLIN37_HUMAN
AccessioniPrimary (citable) accession number: Q96GY3
Secondary accession number(s): A8KAQ1, O14557, Q7Z2T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.