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Q96GY3

- LIN37_HUMAN

UniProt

Q96GY3 - LIN37_HUMAN

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Protein
Protein lin-37 homolog
Gene
LIN37, MSTP064
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. G2/M transition of mitotic cell cycle Source: Reactome
  2. mitotic cell cycle Source: Reactome
  3. regulation of cell cycle Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_1006. Polo-like kinase mediated events.
REACT_111214. G0 and Early G1.
SignaLinkiQ96GY3.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-37 homolog
Alternative name(s):
Antolefinin
Gene namesi
Name:LIN37
ORF Names:MSTP064
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:33234. LIN37.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
  2. transcriptional repressor complex Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394016.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Protein lin-37 homolog
PRO_0000238479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei138 – 1381Phosphoserine2 Publications
Modified residuei167 – 1671Phosphothreonine1 Publication
Modified residuei182 – 1821Phosphoserine3 Publications
Modified residuei202 – 2021Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96GY3.
PaxDbiQ96GY3.
PRIDEiQ96GY3.

PTM databases

PhosphoSiteiQ96GY3.

Expressioni

Gene expression databases

BgeeiQ96GY3.
CleanExiHS_LIN37.
GenevestigatoriQ96GY3.

Organism-specific databases

HPAiHPA043253.
HPA047809.

Interactioni

Subunit structurei

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TEX11Q8IYF32EBI-748884,EBI-742397

Protein-protein interaction databases

BioGridi121008. 18 interactions.
IntActiQ96GY3. 22 interactions.
MINTiMINT-1484036.
STRINGi9606.ENSP00000301159.

Structurei

3D structure databases

ProteinModelPortaliQ96GY3.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi136 – 20368Pro-rich
Add
BLAST

Phylogenomic databases

eggNOGiNOG43346.
HOGENOMiHOG000006536.
HOVERGENiHBG054424.
InParanoidiQ96GY3.
PhylomeDBiQ96GY3.
TreeFamiTF329230.

Family and domain databases

InterProiIPR028226. LIN37.
[Graphical view]
PfamiPF15306. LIN37. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96GY3-1 [UniParc]FASTAAdd to Basket

« Hide

MFPVKVKVEK SELEMAKARN QLDAVLQCLL EKSHMDRERL DEEAGKTPSD    50
THNKDCSIAA TGKRPSARFP HQRRKKRREM DDGLAEGGPQ RSNTYVIKLF 100
DRSVDLAQFS ENTPLYPICR AWMRNSPSVR ERECSPSSPL PPLPEDEEGS 150
EVTNSKSRDV YKLPPPTPPG PPGDACRSRI PSPLQPEMQG TPDDEPSEPE 200
PSPSTLIYRN MQRWKRIRQR WKEASHRNQL RYSESMKILR EMYERQ 246
Length:246
Mass (Da):28,383
Last modified:December 1, 2001 - v1
Checksum:i8718E1C8FB13C446
GO

Sequence cautioni

The sequence AAB81199.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161A → V.
Corresponds to variant rs170758 [ dbSNP | Ensembl ].
VAR_061674
Natural varianti172 – 1721P → S.
Corresponds to variant rs35617825 [ dbSNP | Ensembl ].
VAR_051093

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK293116 mRNA. Translation: BAF85805.1.
AC002398 Genomic DNA. Translation: AAB81199.1. Sequence problems.
AD000671 Genomic DNA. No translation available.
BC009071 mRNA. Translation: AAH09071.1.
AF162447 mRNA. Translation: AAQ13584.1.
CCDSiCCDS62642.1.
PIRiT00702.
RefSeqiNP_061977.1. NM_019104.2.
UniGeneiHs.529100.

Genome annotation databases

GeneIDi55957.
KEGGihsa:55957.
UCSCiuc021usw.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK293116 mRNA. Translation: BAF85805.1 .
AC002398 Genomic DNA. Translation: AAB81199.1 . Sequence problems.
AD000671 Genomic DNA. No translation available.
BC009071 mRNA. Translation: AAH09071.1 .
AF162447 mRNA. Translation: AAQ13584.1 .
CCDSi CCDS62642.1.
PIRi T00702.
RefSeqi NP_061977.1. NM_019104.2.
UniGenei Hs.529100.

3D structure databases

ProteinModelPortali Q96GY3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121008. 18 interactions.
IntActi Q96GY3. 22 interactions.
MINTi MINT-1484036.
STRINGi 9606.ENSP00000301159.

PTM databases

PhosphoSitei Q96GY3.

Proteomic databases

MaxQBi Q96GY3.
PaxDbi Q96GY3.
PRIDEi Q96GY3.

Protocols and materials databases

DNASUi 55957.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 55957.
KEGGi hsa:55957.
UCSCi uc021usw.1. human.

Organism-specific databases

CTDi 55957.
GeneCardsi GC19P036239.
HGNCi HGNC:33234. LIN37.
HPAi HPA043253.
HPA047809.
neXtProti NX_Q96GY3.
PharmGKBi PA162394016.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43346.
HOGENOMi HOG000006536.
HOVERGENi HBG054424.
InParanoidi Q96GY3.
PhylomeDBi Q96GY3.
TreeFami TF329230.

Enzyme and pathway databases

Reactomei REACT_1006. Polo-like kinase mediated events.
REACT_111214. G0 and Early G1.
SignaLinki Q96GY3.

Miscellaneous databases

GenomeRNAii 55957.
NextBioi 61359.
PROi Q96GY3.

Gene expression databases

Bgeei Q96GY3.
CleanExi HS_LIN37.
Genevestigatori Q96GY3.

Family and domain databases

InterProi IPR028226. LIN37.
[Graphical view ]
Pfami PF15306. LIN37. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. "Homo sapiens normal aorta MST064."
    Qin B.M., Sheng H., Liu Y.Q., Liu B., Zhao B., Wang X.Y., Zhang Q., Xu Y.Y., Song L., Je Y., Gao Y., Zhang C.L., Hui R.T.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 92-246.
    Tissue: Aorta.
  5. "LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes."
    Schmit F., Korenjak M., Mannefeld M., Schmitt K., Franke C., von Eyss B., Gagrica S., Haenel F., Brehm A., Gaubatz S.
    Cell Cycle 6:1903-1913(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE DREAM COMPLEX.
  6. "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence."
    Litovchick L., Sadasivam S., Florens L., Zhu X., Swanson S.K., Velmurugan S., Chen R., Washburn M.P., Liu X.S., DeCaprio J.A.
    Mol. Cell 26:539-551(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE DREAM COMPLEX.
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-167, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138; SER-182 AND SER-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138; SER-182 AND SER-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLIN37_HUMAN
AccessioniPrimary (citable) accession number: Q96GY3
Secondary accession number(s): A8KAQ1, O14557, Q7Z2T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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