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Q96GY3

- LIN37_HUMAN

UniProt

Q96GY3 - LIN37_HUMAN

Protein

Protein lin-37 homolog

Gene

LIN37

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. G2/M transition of mitotic cell cycle Source: Reactome
    2. mitotic cell cycle Source: Reactome
    3. regulation of cell cycle Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_1006. Polo-like kinase mediated events.
    REACT_111214. G0 and Early G1.
    SignaLinkiQ96GY3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein lin-37 homolog
    Alternative name(s):
    Antolefinin
    Gene namesi
    Name:LIN37
    ORF Names:MSTP064
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:33234. LIN37.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. transcriptional repressor complex Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162394016.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Protein lin-37 homologPRO_0000238479Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei138 – 1381Phosphoserine2 Publications
    Modified residuei167 – 1671Phosphothreonine1 Publication
    Modified residuei182 – 1821Phosphoserine3 Publications
    Modified residuei202 – 2021Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ96GY3.
    PaxDbiQ96GY3.
    PRIDEiQ96GY3.

    PTM databases

    PhosphoSiteiQ96GY3.

    Expressioni

    Gene expression databases

    BgeeiQ96GY3.
    CleanExiHS_LIN37.
    GenevestigatoriQ96GY3.

    Organism-specific databases

    HPAiHPA043253.
    HPA047809.

    Interactioni

    Subunit structurei

    Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TEX11Q8IYF32EBI-748884,EBI-742397

    Protein-protein interaction databases

    BioGridi121008. 18 interactions.
    IntActiQ96GY3. 22 interactions.
    MINTiMINT-1484036.
    STRINGi9606.ENSP00000301159.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96GY3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi136 – 20368Pro-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG43346.
    HOGENOMiHOG000006536.
    HOVERGENiHBG054424.
    InParanoidiQ96GY3.
    PhylomeDBiQ96GY3.
    TreeFamiTF329230.

    Family and domain databases

    InterProiIPR028226. LIN37.
    [Graphical view]
    PfamiPF15306. LIN37. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96GY3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPVKVKVEK SELEMAKARN QLDAVLQCLL EKSHMDRERL DEEAGKTPSD    50
    THNKDCSIAA TGKRPSARFP HQRRKKRREM DDGLAEGGPQ RSNTYVIKLF 100
    DRSVDLAQFS ENTPLYPICR AWMRNSPSVR ERECSPSSPL PPLPEDEEGS 150
    EVTNSKSRDV YKLPPPTPPG PPGDACRSRI PSPLQPEMQG TPDDEPSEPE 200
    PSPSTLIYRN MQRWKRIRQR WKEASHRNQL RYSESMKILR EMYERQ 246
    Length:246
    Mass (Da):28,383
    Last modified:December 1, 2001 - v1
    Checksum:i8718E1C8FB13C446
    GO

    Sequence cautioni

    The sequence AAB81199.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161A → V.
    Corresponds to variant rs170758 [ dbSNP | Ensembl ].
    VAR_061674
    Natural varianti172 – 1721P → S.
    Corresponds to variant rs35617825 [ dbSNP | Ensembl ].
    VAR_051093

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK293116 mRNA. Translation: BAF85805.1.
    AC002398 Genomic DNA. Translation: AAB81199.1. Sequence problems.
    AD000671 Genomic DNA. No translation available.
    BC009071 mRNA. Translation: AAH09071.1.
    AF162447 mRNA. Translation: AAQ13584.1.
    CCDSiCCDS62642.1.
    PIRiT00702.
    RefSeqiNP_061977.1. NM_019104.2.
    UniGeneiHs.529100.

    Genome annotation databases

    GeneIDi55957.
    KEGGihsa:55957.
    UCSCiuc021usw.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK293116 mRNA. Translation: BAF85805.1 .
    AC002398 Genomic DNA. Translation: AAB81199.1 . Sequence problems.
    AD000671 Genomic DNA. No translation available.
    BC009071 mRNA. Translation: AAH09071.1 .
    AF162447 mRNA. Translation: AAQ13584.1 .
    CCDSi CCDS62642.1.
    PIRi T00702.
    RefSeqi NP_061977.1. NM_019104.2.
    UniGenei Hs.529100.

    3D structure databases

    ProteinModelPortali Q96GY3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121008. 18 interactions.
    IntActi Q96GY3. 22 interactions.
    MINTi MINT-1484036.
    STRINGi 9606.ENSP00000301159.

    PTM databases

    PhosphoSitei Q96GY3.

    Proteomic databases

    MaxQBi Q96GY3.
    PaxDbi Q96GY3.
    PRIDEi Q96GY3.

    Protocols and materials databases

    DNASUi 55957.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 55957.
    KEGGi hsa:55957.
    UCSCi uc021usw.1. human.

    Organism-specific databases

    CTDi 55957.
    GeneCardsi GC19P036239.
    HGNCi HGNC:33234. LIN37.
    HPAi HPA043253.
    HPA047809.
    neXtProti NX_Q96GY3.
    PharmGKBi PA162394016.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43346.
    HOGENOMi HOG000006536.
    HOVERGENi HBG054424.
    InParanoidi Q96GY3.
    PhylomeDBi Q96GY3.
    TreeFami TF329230.

    Enzyme and pathway databases

    Reactomei REACT_1006. Polo-like kinase mediated events.
    REACT_111214. G0 and Early G1.
    SignaLinki Q96GY3.

    Miscellaneous databases

    GenomeRNAii 55957.
    NextBioi 61359.
    PROi Q96GY3.

    Gene expression databases

    Bgeei Q96GY3.
    CleanExi HS_LIN37.
    Genevestigatori Q96GY3.

    Family and domain databases

    InterProi IPR028226. LIN37.
    [Graphical view ]
    Pfami PF15306. LIN37. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    4. "Homo sapiens normal aorta MST064."
      Qin B.M., Sheng H., Liu Y.Q., Liu B., Zhao B., Wang X.Y., Zhang Q., Xu Y.Y., Song L., Je Y., Gao Y., Zhang C.L., Hui R.T.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 92-246.
      Tissue: Aorta.
    5. "LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes."
      Schmit F., Korenjak M., Mannefeld M., Schmitt K., Franke C., von Eyss B., Gagrica S., Haenel F., Brehm A., Gaubatz S.
      Cell Cycle 6:1903-1913(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE DREAM COMPLEX.
    6. "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence."
      Litovchick L., Sadasivam S., Florens L., Zhu X., Swanson S.K., Velmurugan S., Chen R., Washburn M.P., Liu X.S., DeCaprio J.A.
      Mol. Cell 26:539-551(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE DREAM COMPLEX.
    7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-167, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138; SER-182 AND SER-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138; SER-182 AND SER-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLIN37_HUMAN
    AccessioniPrimary (citable) accession number: Q96GY3
    Secondary accession number(s): A8KAQ1, O14557, Q7Z2T9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3