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Protein

Zinc finger C2HC domain-containing protein 1A

Gene

ZC2HC1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 39C2HC-typeAdd BLAST25

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger C2HC domain-containing protein 1A
Gene namesi
Name:ZC2HC1A
Synonyms:C8orf70, FAM164A
ORF Names:CGI-62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104427.11.
HGNCiHGNC:24277. ZC2HC1A.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104427.
PharmGKBiPA162386952.

Polymorphism and mutation databases

BioMutaiZC2HC1A.
DMDMi296434498.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002802461 – 325Zinc finger C2HC domain-containing protein 1AAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei223PhosphoserineCombined sources1
Modified residuei244PhosphothreonineCombined sources1
Modified residuei292PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96GY0.
MaxQBiQ96GY0.
PaxDbiQ96GY0.
PeptideAtlasiQ96GY0.
PRIDEiQ96GY0.

PTM databases

iPTMnetiQ96GY0.
PhosphoSitePlusiQ96GY0.

Expressioni

Gene expression databases

BgeeiENSG00000104427.
CleanExiHS_FAM164A.
ExpressionAtlasiQ96GY0. baseline and differential.
GenevisibleiQ96GY0. HS.

Organism-specific databases

HPAiHPA024726.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119290. 15 interactors.
IntActiQ96GY0. 21 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ96GY0.
SMRiQ96GY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZC2HC1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 39C2HC-typeAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3940. Eukaryota.
ENOG4111J7C. LUCA.
GeneTreeiENSGT00390000003459.
HOGENOMiHOG000068024.
HOVERGENiHBG107871.
InParanoidiQ96GY0.
OMAiCGIRRMV.
OrthoDBiEOG091G0BFY.
PhylomeDBiQ96GY0.
TreeFamiTF319585.

Family and domain databases

InterProiView protein in InterPro
IPR026319. ZC2HC1.
PANTHERiPTHR13555. PTHR13555. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96GY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGLEENGGV VQVGELLPCK ICGRTFFPVA LKKHGPICQK TATKKRKTFD
60 70 80 90 100
SSRQRAEGTD IPTVKPLKPR PEPPKKPSNW RRKHEEFIAT IRAAKGLDQA
110 120 130 140 150
LKEGGKLPPP PPPSYDPDYI QCPYCQRRFN ENAADRHINF CKEQAARISN
160 170 180 190 200
KGKFSTDTKG KPTSRTQVYK PPALKKSNSP GTASSGSSRL PQPSGAGKTV
210 220 230 240 250
VGVPSGKVSS SSSSLGNKLQ TLSPSHKGIA APHAGANVKP RNSTPPSLAR
260 270 280 290 300
NPAPGVLTNK RKTYTESYIA RPDGDCASSL NGGNIKGIEG HSPGNLPKFC
310 320
HECGTKYPVE WAKFCCECGI RRMIL
Length:325
Mass (Da):35,092
Last modified:May 18, 2010 - v2
Checksum:i8ECAA1FB8B00A8BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151K → E in AAD34057 (PubMed:10810093).Curated1
Sequence conflicti153K → E in AAD34057 (PubMed:10810093).Curated1
Sequence conflicti163T → S in AAD34057 (PubMed:10810093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031102156T → A1 PublicationCorresponds to variant dbSNP:rs17850447Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151820 mRNA. Translation: AAD34057.1.
AC100854 Genomic DNA. No translation available.
BC009074 mRNA. Translation: AAH09074.1.
CCDSiCCDS6223.1.
RefSeqiNP_057094.2. NM_016010.2.
UniGeneiHs.271876.

Genome annotation databases

EnsembliENST00000263849; ENSP00000263849; ENSG00000104427.
GeneIDi51101.
KEGGihsa:51101.
UCSCiuc003ybd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZC21A_HUMAN
AccessioniPrimary (citable) accession number: Q96GY0
Secondary accession number(s): Q9Y372
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: September 27, 2017
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries