Reviewed,
UniProtKB/Swiss-Prot Q96GX9 (APIP_HUMAN)
Last modified
November 24, 2009.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: APAF1-interacting protein | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 242 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Has an anti-apoptotic function and prevents muscle ischemic damage. Inhibits the cytochrome c-dependent and APAF1-mediated cell death. Ref.3 |
| Cofactor | Binds 1 zinc ion per subunit Potential. |
| Subunit structure | Interacts with APAF1. Ref.3 |
| Subcellular location | |
| Tissue specificity | Ubiquitously expressed with high expression in skeletal muscle, heart and kidney. Ref.3 |
| Sequence similarities | Belongs to the aldolase class II family. APIP subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Apoptosis |
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Ligand | Metal-binding Zinc |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | apoptosis Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | identical protein binding Inferred from physical interaction. Source: IntAct zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| itself | 3 | EBI-359248,EBI-359248 | ||
| NUDT18 | Q6ZVK8 | 2 | EBI-359248,EBI-740486 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 242 | 242 | APAF1-interacting protein | PRO_0000239022 | |||||
Sites | |||||||||
| Metal binding | 115 | 1 | Zinc By similarity | ||||||
| Metal binding | 117 | 1 | Zinc By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 7 | 1 | R → W: dbSNP rs2956114. Ref.2 | VAR_026575 | |||||
| Natural variant | 23 | 1 | H → R: dbSNP rs17850326. Ref.2 | VAR_026576 | |||||
| Natural variant | 76 | 1 | C → Y: dbSNP rs1977420. Ref.2 | VAR_026577 | |||||
| Natural variant | 181 | 1 | M → V: dbSNP rs17850327. Ref.2 | VAR_026578 | |||||
Experimental info | |||||||||
| Sequence conflict | 7 | 1 | R → G in AAD27738. Ref.1 | ||||||
| Sequence conflict | 172 | 1 | D → T in AAD27738. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed: 10810093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS TRP-7; ARG-23; TYR-76 AND VAL-181. Tissue: Bone marrow, Colon and Eye. |
| [3] | "Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein." Cho D.-H., Hong Y.-M., Lee H.-J., Woo H.-N., Pyo J.-O., Mak T.W., Jung Y.-K. J. Biol. Chem. 279:39942-39950(2004) [PubMed: 15262985] [Abstract] Cited for: FUNCTION, INTERACTION WITH APAF1, TISSUE SPECIFICITY, SUBCELLULAR LOCATION. |
| [4] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AF132963 mRNA. Translation: AAD27738.1. BC008440 mRNA. Translation: AAH08440.1. BC009077 mRNA. Translation: AAH09077.1. BC017594 mRNA. Translation: AAH17594.1. | |
| IPI | IPI00449162. IPI00549730. |
| RefSeq | NP_057041.2. |
| UniGene | Hs.447794 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q96GX9. 8 interactions. |
| STRING | Q96GX9. |
PTM databases | |
| PhosphoSite | Q96GX9. |
Proteomic databases | |
| PeptideAtlas | Q96GX9. |
| PRIDE | Q96GX9. |
Genome annotation databases | |
| Ensembl | ENST00000278359; ENSP00000278359; ENSG00000149089; Homo sapiens. [Genome view] |
| GeneID | 51074. |
| KEGG | hsa:51074. |
| UCSC | uc001mvs.2. human. uc009ykg.1. human. |
Organism-specific databases | |
| CTD | 51074. |
| GeneCards | GC11M034861. |
| H-InvDB | HIX0009553. |
| HGNC | HGNC:17581. APIP. |
| MIM | 612491. gene. |
| PharmGKB | PA142672601. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q96GX9. |
| HOVERGEN | Q96GX9. |
| OrthoDB | EOG9V9X9G |
Gene expression databases | |
| ArrayExpress | Q96GX9. |
| Bgee | Q96GX9. |
| CleanEx | HS_APIP. |
| Genevestigator | Q96GX9. |
| GermOnline | ENSG00000149089. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001303. Aldolase_II/adducin_N. IPR017714. MethylthioRu-1-P_deHdtase_MtnB. [Graphical view] |
| Gene3D | G3DSA:3.40.225.10. Aldolase_II/adducin_N. 1 hit. |
| Pfam | PF00596. Aldolase_II. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR03328. salvage_mtnB. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 53699. |
| SOURCE | Search... |
Entry information
| Entry name | APIP_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96GX9 Secondary accession number(s): Q6PJX6 Q9Y318 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


