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Q96GW7

- PGCB_HUMAN

UniProt

Q96GW7 - PGCB_HUMAN

Protein

Brevican core protein

Gene

BCAN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. hyaluronic acid binding Source: UniProtKB-KW

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. cell adhesion Source: InterPro
    3. chondroitin sulfate biosynthetic process Source: Reactome
    4. chondroitin sulfate catabolic process Source: Reactome
    5. chondroitin sulfate metabolic process Source: Reactome
    6. dermatan sulfate biosynthetic process Source: Reactome
    7. extracellular matrix disassembly Source: Reactome
    8. extracellular matrix organization Source: Reactome
    9. glycosaminoglycan metabolic process Source: Reactome
    10. hippocampus development Source: Ensembl
    11. small molecule metabolic process Source: Reactome

    Keywords - Ligandi

    Hyaluronic acid, Lectin

    Enzyme and pathway databases

    ReactomeiREACT_118572. Degradation of the extracellular matrix.
    REACT_120800. Dermatan sulfate biosynthesis.
    REACT_120888. CS/DS degradation.
    REACT_120989. Chondroitin sulfate biosynthesis.
    REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_163906. ECM proteoglycans.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brevican core protein
    Alternative name(s):
    Brain-enriched hyaluronan-binding protein
    Short name:
    BEHAB
    Chondroitin sulfate proteoglycan 7
    Gene namesi
    Name:BCAN
    Synonyms:BEHAB, CSPG7
    ORF Names:UNQ2525/PRO6018
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:23059. BCAN.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. extracellular region Source: Reactome
    3. Golgi lumen Source: Reactome
    4. lysosomal lumen Source: Reactome
    5. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134868393.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 911889Brevican core proteinPRO_0000017511Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 137By similarity
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi179 ↔ 250By similarity
    Disulfide bondi203 ↔ 224By similarity
    Disulfide bondi277 ↔ 352By similarity
    Disulfide bondi301 ↔ 322By similarity
    Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi650 ↔ 661By similarity
    Disulfide bondi655 ↔ 670By similarity
    Disulfide bondi672 ↔ 681By similarity
    Disulfide bondi688 ↔ 699By similarity
    Disulfide bondi716 ↔ 808By similarity
    Disulfide bondi784 ↔ 800By similarity
    Disulfide bondi815 ↔ 858By similarity
    Disulfide bondi844 ↔ 871By similarity
    Glycosylationi905 – 9051O-linked (GalNAc...)1 Publication
    Glycosylationi906 – 9061O-linked (GalNAc...)1 Publication

    Post-translational modificationi

    Contains mostly chondroitin sulfate By similarity. O-glycosylated with a core 1 or possibly core 8 glycan.By similarity1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Proteoglycan

    Proteomic databases

    PaxDbiQ96GW7.
    PeptideAtlasiQ96GW7.
    PRIDEiQ96GW7.

    PTM databases

    PhosphoSiteiQ96GW7.

    Expressioni

    Developmental stagei

    Isoform 1 is highly expressed from birth through 8 years of age and is down-regulated by 20 years of age to low levels that are maintained in the normal adult cortex. Isoform 2 is expressed at uniformly low levels throughout development.1 Publication

    Gene expression databases

    ArrayExpressiQ96GW7.
    BgeeiQ96GW7.
    CleanExiHS_BCAN.
    GenevestigatoriQ96GW7.

    Organism-specific databases

    HPAiCAB025862.
    HPA007865.

    Interactioni

    Subunit structurei

    Interacts with TNR.By similarity

    Protein-protein interaction databases

    BioGridi121964. 9 interactions.
    IntActiQ96GW7. 2 interactions.
    MINTiMINT-4830140.
    STRINGi9606.ENSP00000331210.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96GW7.
    SMRiQ96GW7. Positions 39-144, 161-251, 267-353, 688-811.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 155120Ig-like V-typeAdd
    BLAST
    Domaini157 – 25296Link 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini257 – 35498Link 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini646 – 68237EGF-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini695 – 809115C-type lectinPROSITE-ProRule annotationAdd
    BLAST
    Domaini813 – 87361SushiPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni520 – 53011O-glycosylated at two sitesAdd
    BLAST
    Regioni540 – 5456O-glycosylated at two sites
    Regioni569 – 5757O-glycosylated at one site

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi385 – 47793Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 2 Link domains.PROSITE-ProRule annotation
    Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

    Phylogenomic databases

    eggNOGiNOG136696.
    HOVERGENiHBG008175.
    InParanoidiQ96GW7.
    KOiK06795.
    OMAiYAFSFAG.
    OrthoDBiEOG7PS1F3.
    PhylomeDBiQ96GW7.
    TreeFamiTF332134.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.100.10. 3 hits.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR000538. Link.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view]
    PfamiPF00008. EGF. 1 hit.
    PF00059. Lectin_C. 1 hit.
    PF00084. Sushi. 1 hit.
    PF07686. V-set. 1 hit.
    PF00193. Xlink. 2 hits.
    [Graphical view]
    PRINTSiPR01265. LINKMODULE.
    SMARTiSM00032. CCP. 1 hit.
    SM00034. CLECT. 1 hit.
    SM00181. EGF. 1 hit.
    SM00406. IGv. 1 hit.
    SM00445. LINK. 2 hits.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 3 hits.
    SSF57535. SSF57535. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    PS01241. LINK_1. 2 hits.
    PS50963. LINK_2. 2 hits.
    PS50923. SUSHI. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96GW7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MAQLFLPLLA ALVLAQAPAA LADVLEGDSS EDRAFRVRIA GDAPLQGVLG    50
    GALTIPCHVH YLRPPPSRRA VLGSPRVKWT FLSRGREAEV LVARGVRVKV 100
    NEAYRFRVAL PAYPASLTDV SLALSELRPN DSGIYRCEVQ HGIDDSSDAV 150
    EVKVKGVVFL YREGSARYAF SFSGAQEACA RIGAHIATPE QLYAAYLGGY 200
    EQCDAGWLSD QTVRYPIQTP REACYGDMDG FPGVRNYGVV DPDDLYDVYC 250
    YAEDLNGELF LGDPPEKLTL EEARAYCQER GAEIATTGQL YAAWDGGLDH 300
    CSPGWLADGS VRYPIVTPSQ RCGGGLPGVK TLFLFPNQTG FPNKHSRFNV 350
    YCFRDSAQPS AIPEASNPAS NPASDGLEAI VTVTETLEEL QLPQEATESE 400
    SRGAIYSIPI MEDGGGGSST PEDPAEAPRT LLEFETQSMV PPTGFSEEEG 450
    KALEEEEKYE DEEEKEEEEE EEEVEDEALW AWPSELSSPG PEASLPTEPA 500
    AQEESLSQAP ARAVLQPGAS PLPDGESEAS RPPRVHGPPT ETLPTPRERN 550
    LASPSPSTLV EAREVGEATG GPELSGVPRG ESEETGSSEG APSLLPATRA 600
    PEGTRELEAP SEDNSGRTAP AGTSVQAQPV LPTDSASRGG VAVVPASGDC 650
    VPSPCHNGGT CLEEEEGVRC LCLPGYGGDL CDVGLRFCNP GWDAFQGACY 700
    KHFSTRRSWE EAETQCRMYG AHLASISTPE EQDFINNRYR EYQWIGLNDR 750
    TIEGDFLWSD GVPLLYENWN PGQPDSYFLS GENCVVMVWH DQGQWSDVPC 800
    NYHLSYTCKM GLVSCGPPPE LPLAQVFGRP RLRYEVDTVL RYRCREGLAQ 850
    RNLPLIRCQE NGRWEAPQIS CVPRRPARAL HPEEDPEGRQ GRLLGRWKAL 900
    LIPPSSPMPG P 911
    Length:911
    Mass (Da):99,118
    Last modified:June 21, 2005 - v2
    Checksum:i5268E796FA3938D2
    GO
    Isoform 2 (identifier: Q96GW7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         649-671: DCVPSPCHNGGTCLEEEEGVRCL → NSAQGSTALSILLLFFPLQLWVT
         672-911: Missing.

    Note: GPI-anchor amidated asparagine on Asn-649.Curated

    Show »
    Length:671
    Mass (Da):71,671
    Checksum:iBAD0E1959546D4B9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti175 – 1751A → T in AAH22938. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti356 – 3561S → L.
    Corresponds to variant rs12065791 [ dbSNP | Ensembl ].
    VAR_050123
    Natural varianti504 – 5041E → K.1 Publication
    Corresponds to variant rs1056695 [ dbSNP | Ensembl ].
    VAR_019551

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei649 – 67123DCVPS…GVRCL → NSAQGSTALSILLLFFPLQL WVT in isoform 2. 1 PublicationVSP_011184Add
    BLAST
    Alternative sequencei672 – 911240Missing in isoform 2. 1 PublicationVSP_011185Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF228710 mRNA. Translation: AAG23134.1.
    AF229053 mRNA. Translation: AAG23135.1.
    AY358372 mRNA. Translation: AAQ88738.1.
    AL365181, AL590666 Genomic DNA. Translation: CAI13056.1.
    AL365181 Genomic DNA. Translation: CAI13060.1.
    AL590666, AL365181 Genomic DNA. Translation: CAI16352.1.
    CH471121 Genomic DNA. Translation: EAW52927.1.
    CH471121 Genomic DNA. Translation: EAW52928.1.
    CH471121 Genomic DNA. Translation: EAW52929.1.
    CH471121 Genomic DNA. Translation: EAW52930.1.
    BC009117 mRNA. Translation: AAH09117.1.
    BC022938 mRNA. Translation: AAH22938.1.
    BC027971 mRNA. Translation: AAH27971.1.
    CCDSiCCDS1149.1. [Q96GW7-1]
    CCDS1150.1. [Q96GW7-2]
    RefSeqiNP_068767.3. NM_021948.4. [Q96GW7-1]
    NP_940819.1. NM_198427.1. [Q96GW7-2]
    UniGeneiHs.516904.

    Genome annotation databases

    EnsembliENST00000329117; ENSP00000331210; ENSG00000132692. [Q96GW7-1]
    ENST00000361588; ENSP00000354925; ENSG00000132692. [Q96GW7-2]
    GeneIDi63827.
    KEGGihsa:63827.
    UCSCiuc001fpo.3. human. [Q96GW7-2]
    uc001fpp.3. human. [Q96GW7-1]

    Polymorphism databases

    DMDMi68067899.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Brevican

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF228710 mRNA. Translation: AAG23134.1 .
    AF229053 mRNA. Translation: AAG23135.1 .
    AY358372 mRNA. Translation: AAQ88738.1 .
    AL365181 , AL590666 Genomic DNA. Translation: CAI13056.1 .
    AL365181 Genomic DNA. Translation: CAI13060.1 .
    AL590666 , AL365181 Genomic DNA. Translation: CAI16352.1 .
    CH471121 Genomic DNA. Translation: EAW52927.1 .
    CH471121 Genomic DNA. Translation: EAW52928.1 .
    CH471121 Genomic DNA. Translation: EAW52929.1 .
    CH471121 Genomic DNA. Translation: EAW52930.1 .
    BC009117 mRNA. Translation: AAH09117.1 .
    BC022938 mRNA. Translation: AAH22938.1 .
    BC027971 mRNA. Translation: AAH27971.1 .
    CCDSi CCDS1149.1. [Q96GW7-1 ]
    CCDS1150.1. [Q96GW7-2 ]
    RefSeqi NP_068767.3. NM_021948.4. [Q96GW7-1 ]
    NP_940819.1. NM_198427.1. [Q96GW7-2 ]
    UniGenei Hs.516904.

    3D structure databases

    ProteinModelPortali Q96GW7.
    SMRi Q96GW7. Positions 39-144, 161-251, 267-353, 688-811.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121964. 9 interactions.
    IntActi Q96GW7. 2 interactions.
    MINTi MINT-4830140.
    STRINGi 9606.ENSP00000331210.

    PTM databases

    PhosphoSitei Q96GW7.

    Polymorphism databases

    DMDMi 68067899.

    Proteomic databases

    PaxDbi Q96GW7.
    PeptideAtlasi Q96GW7.
    PRIDEi Q96GW7.

    Protocols and materials databases

    DNASUi 63827.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329117 ; ENSP00000331210 ; ENSG00000132692 . [Q96GW7-1 ]
    ENST00000361588 ; ENSP00000354925 ; ENSG00000132692 . [Q96GW7-2 ]
    GeneIDi 63827.
    KEGGi hsa:63827.
    UCSCi uc001fpo.3. human. [Q96GW7-2 ]
    uc001fpp.3. human. [Q96GW7-1 ]

    Organism-specific databases

    CTDi 63827.
    GeneCardsi GC01P156611.
    HGNCi HGNC:23059. BCAN.
    HPAi CAB025862.
    HPA007865.
    MIMi 600347. gene.
    neXtProti NX_Q96GW7.
    PharmGKBi PA134868393.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG136696.
    HOVERGENi HBG008175.
    InParanoidi Q96GW7.
    KOi K06795.
    OMAi YAFSFAG.
    OrthoDBi EOG7PS1F3.
    PhylomeDBi Q96GW7.
    TreeFami TF332134.

    Enzyme and pathway databases

    Reactomei REACT_118572. Degradation of the extracellular matrix.
    REACT_120800. Dermatan sulfate biosynthesis.
    REACT_120888. CS/DS degradation.
    REACT_120989. Chondroitin sulfate biosynthesis.
    REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_163906. ECM proteoglycans.

    Miscellaneous databases

    GeneWikii Brevican.
    GenomeRNAii 63827.
    NextBioi 65542.
    PROi Q96GW7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96GW7.
    Bgeei Q96GW7.
    CleanExi HS_BCAN.
    Genevestigatori Q96GW7.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.100.10. 3 hits.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR000538. Link.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view ]
    Pfami PF00008. EGF. 1 hit.
    PF00059. Lectin_C. 1 hit.
    PF00084. Sushi. 1 hit.
    PF07686. V-set. 1 hit.
    PF00193. Xlink. 2 hits.
    [Graphical view ]
    PRINTSi PR01265. LINKMODULE.
    SMARTi SM00032. CCP. 1 hit.
    SM00034. CLECT. 1 hit.
    SM00181. EGF. 1 hit.
    SM00406. IGv. 1 hit.
    SM00445. LINK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 3 hits.
    SSF57535. SSF57535. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    PS01241. LINK_1. 2 hits.
    PS50963. LINK_2. 2 hits.
    PS50923. SUSHI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma."
      Gary S.C., Zerillo C.A., Chiang V.L., Gaw J.U., Gray G., Hockfield S.
      Gene 256:139-147(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), DEVELOPMENTAL STAGE.
      Tissue: Brain cortex.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-504.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. "Enrichment of glycopeptides for glycan structure and attachment site identification."
      Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E., Brinkmalm G., Larson G.
      Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT SER-905 AND SER-906, STRUCTURE OF CARBOHYDRATES.
      Tissue: Cerebrospinal fluid.

    Entry informationi

    Entry nameiPGCB_HUMAN
    AccessioniPrimary (citable) accession number: Q96GW7
    Secondary accession number(s): D3DVC2
    , Q5SZ10, Q5T3I5, Q8TBB9, Q9HBK1, Q9HBK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3