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Protein

P antigen family member 5

Gene

PAGE5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
P antigen family member 5
Short name:
PAGE-5
Alternative name(s):
Cancer/testis antigen 16.1
Short name:
CT16.1
G antigen family E member 1
Prostate-associated gene 5 protein
Gene namesi
Name:PAGE5
Synonyms:GAGEE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:29992. PAGE5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671204.

Polymorphism and mutation databases

BioMutaiPAGE5.
DMDMi74751892.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 130130P antigen family member 5PRO_0000247361Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131PhosphothreonineCombined sources
Modified residuei116 – 1161PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96GU1.
PaxDbiQ96GU1.
PeptideAtlasiQ96GU1.
PRIDEiQ96GU1.

PTM databases

iPTMnetiQ96GU1.
PhosphoSiteiQ96GU1.

Expressioni

Gene expression databases

BgeeiENSG00000158639.
CleanExiHS_PAGE5.
ExpressionAtlasiQ96GU1. baseline and differential.
GenevisibleiQ96GU1. HS.

Organism-specific databases

HPAiHPA052619.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
POT1Q9NUX52EBI-11305258,EBI-752420

Protein-protein interaction databases

BioGridi124758. 1 interaction.
IntActiQ96GU1. 1 interaction.
STRINGi9606.ENSP00000289619.

Structurei

3D structure databases

ProteinModelPortaliQ96GU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410JGTD. Eukaryota.
ENOG4111340. LUCA.
GeneTreeiENSGT00840000129979.
HOGENOMiHOG000237345.
HOVERGENiHBG099032.
InParanoidiQ96GU1.
OMAiMQAPWAG.
OrthoDBiEOG091G0TET.
PhylomeDBiQ96GU1.
TreeFamiTF340669.

Family and domain databases

InterProiIPR031320. GAGE.
IPR008625. GAGE_fam.
[Graphical view]
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiPF05831. GAGE. 1 hit.
[Graphical view]
SMARTiSM01379. GAGE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96GU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQAPWAGNRG WAGTREEVRD MSEHVTRSQS SERGNDQESS QPVGPVIVQQ
60 70 80 90 100
PTEEKRQEEE PPTDNQGIAP SGEIKNEGAP AVQGTDVEAF QQELALLKIE
110 120 130
DAPGDGPDVR EGTLPTFDPT KVLEAGEGQL
Length:130
Mass (Da):14,046
Last modified:March 1, 2004 - v2
Checksum:i17560A128E103424
GO
Isoform 2 (identifier: Q96GU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Note: No experimental confirmation available.
Show »
Length:110
Mass (Da):11,777
Checksum:i6D6AF4563135BB6C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2020Missing in isoform 2. 1 PublicationVSP_042547Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344352 mRNA. Translation: CAC87642.1.
AL158819 Genomic DNA. Translation: CAI40485.1.
AL158819 Genomic DNA. Translation: CAI40487.1.
BC009230 mRNA. Translation: AAH09230.2.
BC110803 mRNA. Translation: AAI10804.2.
CCDSiCCDS14368.1. [Q96GU1-1]
CCDS35306.1. [Q96GU1-2]
RefSeqiNP_001013453.1. NM_001013435.2. [Q96GU1-2]
NP_569734.2. NM_130467.4. [Q96GU1-1]
UniGeneiHs.668491.

Genome annotation databases

EnsembliENST00000289619; ENSP00000289619; ENSG00000158639. [Q96GU1-1]
ENST00000374955; ENSP00000364093; ENSG00000158639. [Q96GU1-2]
GeneIDi90737.
KEGGihsa:90737.
UCSCiuc004duj.4. human. [Q96GU1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344352 mRNA. Translation: CAC87642.1.
AL158819 Genomic DNA. Translation: CAI40485.1.
AL158819 Genomic DNA. Translation: CAI40487.1.
BC009230 mRNA. Translation: AAH09230.2.
BC110803 mRNA. Translation: AAI10804.2.
CCDSiCCDS14368.1. [Q96GU1-1]
CCDS35306.1. [Q96GU1-2]
RefSeqiNP_001013453.1. NM_001013435.2. [Q96GU1-2]
NP_569734.2. NM_130467.4. [Q96GU1-1]
UniGeneiHs.668491.

3D structure databases

ProteinModelPortaliQ96GU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124758. 1 interaction.
IntActiQ96GU1. 1 interaction.
STRINGi9606.ENSP00000289619.

PTM databases

iPTMnetiQ96GU1.
PhosphoSiteiQ96GU1.

Polymorphism and mutation databases

BioMutaiPAGE5.
DMDMi74751892.

Proteomic databases

MaxQBiQ96GU1.
PaxDbiQ96GU1.
PeptideAtlasiQ96GU1.
PRIDEiQ96GU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289619; ENSP00000289619; ENSG00000158639. [Q96GU1-1]
ENST00000374955; ENSP00000364093; ENSG00000158639. [Q96GU1-2]
GeneIDi90737.
KEGGihsa:90737.
UCSCiuc004duj.4. human. [Q96GU1-1]

Organism-specific databases

CTDi90737.
GeneCardsiPAGE5.
HGNCiHGNC:29992. PAGE5.
HPAiHPA052619.
neXtProtiNX_Q96GU1.
PharmGKBiPA142671204.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JGTD. Eukaryota.
ENOG4111340. LUCA.
GeneTreeiENSGT00840000129979.
HOGENOMiHOG000237345.
HOVERGENiHBG099032.
InParanoidiQ96GU1.
OMAiMQAPWAG.
OrthoDBiEOG091G0TET.
PhylomeDBiQ96GU1.
TreeFamiTF340669.

Miscellaneous databases

GenomeRNAii90737.
PROiQ96GU1.

Gene expression databases

BgeeiENSG00000158639.
CleanExiHS_PAGE5.
ExpressionAtlasiQ96GU1. baseline and differential.
GenevisibleiQ96GU1. HS.

Family and domain databases

InterProiIPR031320. GAGE.
IPR008625. GAGE_fam.
[Graphical view]
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiPF05831. GAGE. 1 hit.
[Graphical view]
SMARTiSM01379. GAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAGE5_HUMAN
AccessioniPrimary (citable) accession number: Q96GU1
Secondary accession number(s): Q2NL97, Q5JUL0, Q8WWL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2004
Last modified: September 7, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.