ID   XAGE2_HUMAN             Reviewed;         111 AA.
AC   Q96GT9; Q5HYR4;
DT   11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   24-JAN-2024, entry version 157.
DE   RecName: Full=X antigen family member 2;
DE            Short=XAGE-2;
DE   AltName: Full=Cancer/testis antigen 12.2;
DE            Short=CT12.2;
DE   AltName: Full=G antigen family D member 3;
GN   Name=XAGE2; Synonyms=GAGED3, XAGE2B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=11992404; DOI=10.1002/ijc.10371;
RA   Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J.,
RA   van Muijen G.N.P.;
RT   "The XAGE family of cancer/testis-associated genes: alignment and
RT   expression profile in normal tissues, melanoma lesions and Ewing's
RT   sarcoma.";
RL   Int. J. Cancer 99:361-369(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=10197611;
RA   Brinkmann U., Vasmatzis G., Lee B., Pastan I.;
RT   "Novel genes in the PAGE and GAGE family of tumor antigens found by
RT   homology walking in the dbEST database.";
RL   Cancer Res. 59:1445-1448(1999).
CC   -!- INTERACTION:
CC       Q96GT9; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-750167, EBI-10172181;
CC       Q96GT9; Q96IK5: GMCL1; NbExp=5; IntAct=EBI-750167, EBI-2548508;
CC       Q96GT9; Q8NEA9: GMCL2; NbExp=3; IntAct=EBI-750167, EBI-745707;
CC       Q96GT9; Q9NYB0: TERF2IP; NbExp=2; IntAct=EBI-750167, EBI-750109;
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ318891; CAC88125.1; -; Genomic_DNA.
DR   EMBL; AJ318892; CAC88125.1; JOINED; Genomic_DNA.
DR   EMBL; AJ318880; CAC83007.1; -; mRNA.
DR   EMBL; BX293536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL953874; CAI41681.1; -; Genomic_DNA.
DR   EMBL; BC009232; AAH09232.1; -; mRNA.
DR   EMBL; BC066311; AAH66311.1; -; mRNA.
DR   CCDS; CCDS59525.1; -.
DR   RefSeq; NP_570133.1; NM_130777.2.
DR   RefSeq; XP_011529138.1; XM_011530836.2.
DR   AlphaFoldDB; Q96GT9; -.
DR   BioGRID; 114881; 14.
DR   IntAct; Q96GT9; 11.
DR   STRING; 9606.ENSP00000286049; -.
DR   iPTMnet; Q96GT9; -.
DR   PhosphoSitePlus; Q96GT9; -.
DR   BioMuta; XAGE2; -.
DR   DMDM; 21759127; -.
DR   jPOST; Q96GT9; -.
DR   MassIVE; Q96GT9; -.
DR   MaxQB; Q96GT9; -.
DR   PaxDb; 9606-ENSP00000286049; -.
DR   PeptideAtlas; Q96GT9; -.
DR   ProteomicsDB; 76665; -.
DR   Antibodypedia; 79627; 100 antibodies from 17 providers.
DR   DNASU; 9502; -.
DR   Ensembl; ENST00000286049.3; ENSP00000286049.2; ENSG00000155622.7.
DR   GeneID; 9502; -.
DR   KEGG; hsa:9502; -.
DR   MANE-Select; ENST00000286049.3; ENSP00000286049.2; NM_130777.3; NP_570133.1.
DR   UCSC; uc004dqe.4; human.
DR   AGR; HGNC:4112; -.
DR   CTD; 9502; -.
DR   GeneCards; XAGE2; -.
DR   HGNC; HGNC:4112; XAGE2.
DR   HPA; ENSG00000155622; Tissue enriched (placenta).
DR   MIM; 300416; gene.
DR   neXtProt; NX_Q96GT9; -.
DR   OpenTargets; ENSG00000155622; -.
DR   PharmGKB; PA28527; -.
DR   VEuPathDB; HostDB:ENSG00000155622; -.
DR   eggNOG; ENOG502TF3A; Eukaryota.
DR   GeneTree; ENSGT00940000153097; -.
DR   HOGENOM; CLU_150116_2_1_1; -.
DR   InParanoid; Q96GT9; -.
DR   OMA; DECGDGH; -.
DR   OrthoDB; 4705021at2759; -.
DR   PhylomeDB; Q96GT9; -.
DR   TreeFam; TF340669; -.
DR   PathwayCommons; Q96GT9; -.
DR   SignaLink; Q96GT9; -.
DR   BioGRID-ORCS; 9502; 9 hits in 669 CRISPR screens.
DR   GenomeRNAi; 9502; -.
DR   Pharos; Q96GT9; Tbio.
DR   PRO; PR:Q96GT9; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q96GT9; Protein.
DR   Bgee; ENSG00000155622; Expressed in placenta and 50 other cell types or tissues.
DR   ExpressionAtlas; Q96GT9; baseline and differential.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047; P ANTIGEN FAMILY MEMBER 5-RELATED; 1.
DR   PANTHER; PTHR14047:SF35; X ANTIGEN FAMILY MEMBER 2; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
DR   Genevisible; Q96GT9; HS.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..111
FT                   /note="X antigen family member 2"
FT                   /id="PRO_0000148350"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          77..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..59
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..104
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   111 AA;  12354 MW;  38C93332C5BA0E14 CRC64;
     MSWRGRSTYR PRPRRSLQPP ELIGAMLEPT DEEPKEEKPP TKSRNPTPDQ KREDDQGAAE
     IQVPDLEADL QELCQTKTGD GCEGGTDVKG KILPKAEHFK MPEAGEGKSQ V
//