Reviewed, UniProtKB/Swiss-Prot Q96GT9 (GAGD3_HUMAN)

Names and origin

Protein names

Recommended name:
    G antigen family D member 3
Alternative name(s):
    Protein XAGE-2
    Cancer/testis antigen 12.2
      Short name=CT12.2

Gene names

Name:	XAGE2
Synonyms:	GAGED3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Unknown.
Sequence similarities	Belongs to the GAGE family.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 111	111	G antigen family D member 3		PRO_0000148350

Sequences

	Sequence		Length	Mass (Da)
	Q96GT9-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 38C93332C5BA0E14	FASTA	111	12,354
	10 20 30 40 50 60 MSWRGRSTYR PRPRRSLQPP ELIGAMLEPT DEEPKEEKPP TKSRNPTPDQ KREDDQGAAE 70 80 90 100 110 IQVPDLEADL QELCQTKTGD GCEGGTDVKG KILPKAEHFK MPEAGEGKSQ V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma." Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J., van Muijen G.N.P. Int. J. Cancer 99:361-369(2002) [PubMed: 11992404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database." Brinkmann U., Vasmatzis G., Lee B., Pastan I. Cancer Res. 59:1445-1448(1999) [PubMed: 10197611] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ318891, AJ318892 Genomic DNA. Translation: CAC88125.1. AJ318880 mRNA. Translation: CAC83007.1. BX293536 Genomic DNA. Translation: CAI40835.1. AL953874 Genomic DNA. Translation: CAI41681.1. BC009232 mRNA. Translation: AAH09232.1. BC066311 mRNA. Translation: AAH66311.1.
IPI	IPI00062756.
RefSeq	NP_001073006.1. NP_570133.1.
UniGene	Hs.522654
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96GT9. 1 interaction.
Genome annotation databases
Ensembl	ENSG00000155622. Homo sapiens. [Contig view] ENSG00000185751. Homo sapiens. [Contig view]
GeneID	728242. 9502.
KEGG	hsa:728242. hsa:9502.
Organism-specific databases
GeneCards	GC0XM052397. GC0XP052129.
H-InvDB	HIX0016746. HIX0077112.
HGNC	HGNC:4112. XAGE2.
MIM	300416. gene.
PharmGKB	PA28527.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q96GT9.
HOVERGEN	Q96GT9.
OMA	Q96GT9. ILPKAEH.
Gene expression databases
CleanEx	HS_XAGE2.
GermOnline	ENSG00000155622. Homo sapiens. ENSG00000185751. Homo sapiens.
Family and domain databases
InterPro	IPR008625. GAGE. [Graphical view]
Pfam	PF05831. GAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	126585.
SOURCE	Search...

Entry information

Entry name

GAGD3_HUMAN

Accession

Primary (citable) accession number: Q96GT9
Secondary accession number(s): Q5HYR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	December 1, 2001
Last modified:	June 16, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)