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Protein

X antigen family member 2

Gene

XAGE2

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
X antigen family member 2
Short name:
XAGE-2
Alternative name(s):
Cancer/testis antigen 12.2
Short name:
CT12.2
G antigen family D member 3
Gene namesi
Name:XAGE2
Synonyms:GAGED3
AND
Name:XAGE2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:4112. XAGE2.
HGNC:30680. XAGE2B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28527.

Polymorphism and mutation databases

DMDMi21759127.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 111111X antigen family member 2PRO_0000148350Add
BLAST

Proteomic databases

PaxDbiQ96GT9.
PRIDEiQ96GT9.

Expressioni

Gene expression databases

CleanExiHS_XAGE2.
ExpressionAtlasiQ96GT9. baseline.
GenevestigatoriQ96GT9.

Organism-specific databases

HPAiHPA052507.
HPA060900.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FLJ13057Q53SE73EBI-750167,EBI-10172181
GMCL1P1Q8NEA93EBI-750167,EBI-745707

Protein-protein interaction databases

BioGridi114881. 5 interactions.
IntActiQ96GT9. 3 interactions.
MINTiMINT-1481518.
STRINGi9606.ENSP00000286049.

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiNOG118993.
GeneTreeiENSGT00760000119430.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ96GT9.
OMAiDPTPDQK.
OrthoDBiEOG7JHM82.
PhylomeDBiQ96GT9.
TreeFamiTF340669.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96GT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYR PRPRRSLQPP ELIGAMLEPT DEEPKEEKPP TKSRNPTPDQ
60 70 80 90 100
KREDDQGAAE IQVPDLEADL QELCQTKTGD GCEGGTDVKG KILPKAEHFK
110
MPEAGEGKSQ V
Length:111
Mass (Da):12,354
Last modified:December 1, 2001 - v1
Checksum:i38C93332C5BA0E14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318891, AJ318892 Genomic DNA. Translation: CAC88125.1.
AJ318880 mRNA. Translation: CAC83007.1.
BX293536 Genomic DNA. Translation: CAI40835.1.
AL953874 Genomic DNA. Translation: CAI41681.1.
BC009232 mRNA. Translation: AAH09232.1.
BC066311 mRNA. Translation: AAH66311.1.
CCDSiCCDS59525.1.
RefSeqiNP_570133.1. NM_130777.2.
XP_006724677.1. XM_006724614.2.
UniGeneiHs.409726.
Hs.522654.

Genome annotation databases

GeneIDi9502.
KEGGihsa:9502.
UCSCiuc004dqe.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318891, AJ318892 Genomic DNA. Translation: CAC88125.1.
AJ318880 mRNA. Translation: CAC83007.1.
BX293536 Genomic DNA. Translation: CAI40835.1.
AL953874 Genomic DNA. Translation: CAI41681.1.
BC009232 mRNA. Translation: AAH09232.1.
BC066311 mRNA. Translation: AAH66311.1.
CCDSiCCDS59525.1.
RefSeqiNP_570133.1. NM_130777.2.
XP_006724677.1. XM_006724614.2.
UniGeneiHs.409726.
Hs.522654.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114881. 5 interactions.
IntActiQ96GT9. 3 interactions.
MINTiMINT-1481518.
STRINGi9606.ENSP00000286049.

Polymorphism and mutation databases

DMDMi21759127.

Proteomic databases

PaxDbiQ96GT9.
PRIDEiQ96GT9.

Protocols and materials databases

DNASUi9502.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9502.
KEGGihsa:9502.
UCSCiuc004dqe.3. human.

Organism-specific databases

CTDi9502.
GeneCardsiGC0XM052397.
GC0XP052112.
HGNCiHGNC:4112. XAGE2.
HGNC:30680. XAGE2B.
HPAiHPA052507.
HPA060900.
MIMi300416. gene.
neXtProtiNX_Q96GT9.
PharmGKBiPA28527.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG118993.
GeneTreeiENSGT00760000119430.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ96GT9.
OMAiDPTPDQK.
OrthoDBiEOG7JHM82.
PhylomeDBiQ96GT9.
TreeFamiTF340669.

Miscellaneous databases

NextBioi126585.
PROiQ96GT9.
SOURCEiSearch...

Gene expression databases

CleanExiHS_XAGE2.
ExpressionAtlasiQ96GT9. baseline.
GenevestigatoriQ96GT9.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma."
    Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J., van Muijen G.N.P.
    Int. J. Cancer 99:361-369(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database."
    Brinkmann U., Vasmatzis G., Lee B., Pastan I.
    Cancer Res. 59:1445-1448(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiXAGE2_HUMAN
AccessioniPrimary (citable) accession number: Q96GT9
Secondary accession number(s): Q5HYR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: December 1, 2001
Last modified: April 29, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.