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Q96GT9

- XAGE2_HUMAN

UniProt

Q96GT9 - XAGE2_HUMAN

Protein

X antigen family member 2

Gene

XAGE2

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    X antigen family member 2
    Short name:
    XAGE-2
    Alternative name(s):
    Cancer/testis antigen 12.2
    Short name:
    CT12.2
    G antigen family D member 3
    Gene namesi
    Name:XAGE2
    Synonyms:GAGED3
    AND
    Name:XAGE2B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:4112. XAGE2.
    HGNC:30680. XAGE2B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28527.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 111111X antigen family member 2PRO_0000148350Add
    BLAST

    Proteomic databases

    PaxDbiQ96GT9.
    PRIDEiQ96GT9.

    Expressioni

    Gene expression databases

    CleanExiHS_XAGE2.
    GenevestigatoriQ96GT9.

    Interactioni

    Protein-protein interaction databases

    BioGridi114881. 3 interactions.
    IntActiQ96GT9. 1 interaction.
    MINTiMINT-1481518.
    STRINGi9606.ENSP00000286049.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96GT9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GAGE family.Curated

    Phylogenomic databases

    eggNOGiNOG118993.
    HOGENOMiHOG000237345.
    HOVERGENiHBG056227.
    InParanoidiQ96GT9.
    OMAiSWINIIS.
    OrthoDBiEOG7JHM82.
    PhylomeDBiQ96GT9.
    TreeFamiTF340669.

    Family and domain databases

    InterProiIPR008625. GAGE.
    [Graphical view]
    PfamiPF05831. GAGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96GT9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWRGRSTYR PRPRRSLQPP ELIGAMLEPT DEEPKEEKPP TKSRNPTPDQ    50
    KREDDQGAAE IQVPDLEADL QELCQTKTGD GCEGGTDVKG KILPKAEHFK 100
    MPEAGEGKSQ V 111
    Length:111
    Mass (Da):12,354
    Last modified:December 1, 2001 - v1
    Checksum:i38C93332C5BA0E14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ318891, AJ318892 Genomic DNA. Translation: CAC88125.1.
    AJ318880 mRNA. Translation: CAC83007.1.
    BX293536 Genomic DNA. Translation: CAI40835.1.
    AL953874 Genomic DNA. Translation: CAI41681.1.
    BC009232 mRNA. Translation: AAH09232.1.
    BC066311 mRNA. Translation: AAH66311.1.
    CCDSiCCDS59525.1.
    RefSeqiNP_570133.1. NM_130777.2.
    XP_006724677.1. XM_006724614.1.
    UniGeneiHs.522654.

    Genome annotation databases

    EnsembliENST00000286049; ENSP00000286049; ENSG00000155622.
    GeneIDi9502.
    KEGGihsa:728242.
    hsa:9502.
    UCSCiuc004dqe.3. human.

    Polymorphism databases

    DMDMi21759127.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ318891 , AJ318892 Genomic DNA. Translation: CAC88125.1 .
    AJ318880 mRNA. Translation: CAC83007.1 .
    BX293536 Genomic DNA. Translation: CAI40835.1 .
    AL953874 Genomic DNA. Translation: CAI41681.1 .
    BC009232 mRNA. Translation: AAH09232.1 .
    BC066311 mRNA. Translation: AAH66311.1 .
    CCDSi CCDS59525.1.
    RefSeqi NP_570133.1. NM_130777.2.
    XP_006724677.1. XM_006724614.1.
    UniGenei Hs.522654.

    3D structure databases

    ProteinModelPortali Q96GT9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114881. 3 interactions.
    IntActi Q96GT9. 1 interaction.
    MINTi MINT-1481518.
    STRINGi 9606.ENSP00000286049.

    Polymorphism databases

    DMDMi 21759127.

    Proteomic databases

    PaxDbi Q96GT9.
    PRIDEi Q96GT9.

    Protocols and materials databases

    DNASUi 9502.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000286049 ; ENSP00000286049 ; ENSG00000155622 .
    GeneIDi 9502.
    KEGGi hsa:728242.
    hsa:9502.
    UCSCi uc004dqe.3. human.

    Organism-specific databases

    CTDi 9502.
    GeneCardsi GC0XM052397.
    GC0XP052112.
    HGNCi HGNC:4112. XAGE2.
    HGNC:30680. XAGE2B.
    MIMi 300416. gene.
    neXtProti NX_Q96GT9.
    PharmGKBi PA28527.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG118993.
    HOGENOMi HOG000237345.
    HOVERGENi HBG056227.
    InParanoidi Q96GT9.
    OMAi SWINIIS.
    OrthoDBi EOG7JHM82.
    PhylomeDBi Q96GT9.
    TreeFami TF340669.

    Miscellaneous databases

    NextBioi 126585.
    PROi Q96GT9.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_XAGE2.
    Genevestigatori Q96GT9.

    Family and domain databases

    InterProi IPR008625. GAGE.
    [Graphical view ]
    Pfami PF05831. GAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma."
      Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J., van Muijen G.N.P.
      Int. J. Cancer 99:361-369(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. "Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database."
      Brinkmann U., Vasmatzis G., Lee B., Pastan I.
      Cancer Res. 59:1445-1448(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiXAGE2_HUMAN
    AccessioniPrimary (citable) accession number: Q96GT9
    Secondary accession number(s): Q5HYR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3