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Q96GT9

- XAGE2_HUMAN

UniProt

Q96GT9 - XAGE2_HUMAN

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Protein

X antigen family member 2

Gene

XAGE2

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
X antigen family member 2
Short name:
XAGE-2
Alternative name(s):
Cancer/testis antigen 12.2
Short name:
CT12.2
G antigen family D member 3
Gene namesi
Name:XAGE2
Synonyms:GAGED3
AND
Name:XAGE2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:4112. XAGE2.
HGNC:30680. XAGE2B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28527.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 111111X antigen family member 2PRO_0000148350Add
BLAST

Proteomic databases

PaxDbiQ96GT9.
PRIDEiQ96GT9.

Expressioni

Gene expression databases

CleanExiHS_XAGE2.
GenevestigatoriQ96GT9.

Interactioni

Protein-protein interaction databases

BioGridi114881. 3 interactions.
IntActiQ96GT9. 1 interaction.
MINTiMINT-1481518.
STRINGi9606.ENSP00000286049.

Structurei

3D structure databases

ProteinModelPortaliQ96GT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiNOG118993.
GeneTreeiENSGT00760000119430.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ96GT9.
OMAiSWINIIS.
OrthoDBiEOG7JHM82.
PhylomeDBiQ96GT9.
TreeFamiTF340669.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96GT9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWRGRSTYR PRPRRSLQPP ELIGAMLEPT DEEPKEEKPP TKSRNPTPDQ
60 70 80 90 100
KREDDQGAAE IQVPDLEADL QELCQTKTGD GCEGGTDVKG KILPKAEHFK
110
MPEAGEGKSQ V
Length:111
Mass (Da):12,354
Last modified:December 1, 2001 - v1
Checksum:i38C93332C5BA0E14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318891, AJ318892 Genomic DNA. Translation: CAC88125.1.
AJ318880 mRNA. Translation: CAC83007.1.
BX293536 Genomic DNA. Translation: CAI40835.1.
AL953874 Genomic DNA. Translation: CAI41681.1.
BC009232 mRNA. Translation: AAH09232.1.
BC066311 mRNA. Translation: AAH66311.1.
CCDSiCCDS59525.1.
RefSeqiNP_570133.1. NM_130777.2.
XP_006724677.1. XM_006724614.1.
UniGeneiHs.409726.
Hs.522654.

Genome annotation databases

EnsembliENST00000286049; ENSP00000286049; ENSG00000155622.
GeneIDi9502.
KEGGihsa:9502.
UCSCiuc004dqe.3. human.

Polymorphism databases

DMDMi21759127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318891 , AJ318892 Genomic DNA. Translation: CAC88125.1 .
AJ318880 mRNA. Translation: CAC83007.1 .
BX293536 Genomic DNA. Translation: CAI40835.1 .
AL953874 Genomic DNA. Translation: CAI41681.1 .
BC009232 mRNA. Translation: AAH09232.1 .
BC066311 mRNA. Translation: AAH66311.1 .
CCDSi CCDS59525.1.
RefSeqi NP_570133.1. NM_130777.2.
XP_006724677.1. XM_006724614.1.
UniGenei Hs.409726.
Hs.522654.

3D structure databases

ProteinModelPortali Q96GT9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114881. 3 interactions.
IntActi Q96GT9. 1 interaction.
MINTi MINT-1481518.
STRINGi 9606.ENSP00000286049.

Polymorphism databases

DMDMi 21759127.

Proteomic databases

PaxDbi Q96GT9.
PRIDEi Q96GT9.

Protocols and materials databases

DNASUi 9502.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000286049 ; ENSP00000286049 ; ENSG00000155622 .
GeneIDi 9502.
KEGGi hsa:9502.
UCSCi uc004dqe.3. human.

Organism-specific databases

CTDi 9502.
GeneCardsi GC0XM052397.
GC0XP052112.
HGNCi HGNC:4112. XAGE2.
HGNC:30680. XAGE2B.
MIMi 300416. gene.
neXtProti NX_Q96GT9.
PharmGKBi PA28527.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG118993.
GeneTreei ENSGT00760000119430.
HOGENOMi HOG000237345.
HOVERGENi HBG056227.
InParanoidi Q96GT9.
OMAi SWINIIS.
OrthoDBi EOG7JHM82.
PhylomeDBi Q96GT9.
TreeFami TF340669.

Miscellaneous databases

NextBioi 126585.
PROi Q96GT9.
SOURCEi Search...

Gene expression databases

CleanExi HS_XAGE2.
Genevestigatori Q96GT9.

Family and domain databases

InterProi IPR008625. GAGE.
[Graphical view ]
Pfami PF05831. GAGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma."
    Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J., van Muijen G.N.P.
    Int. J. Cancer 99:361-369(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database."
    Brinkmann U., Vasmatzis G., Lee B., Pastan I.
    Cancer Res. 59:1445-1448(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiXAGE2_HUMAN
AccessioniPrimary (citable) accession number: Q96GT9
Secondary accession number(s): Q5HYR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3