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Q96GT9 (XAGE2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
X antigen family member 2

Short name=XAGE-2
Alternative name(s):
Cancer/testis antigen 12.2
Short name=CT12.2
G antigen family D member 3
Gene names
Name:XAGE2
Synonyms:GAGED3
AND
Name:XAGE2B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length111 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the GAGE family.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 111111X antigen family member 2
PRO_0000148350

Sequences

Sequence LengthMass (Da)Tools
Q96GT9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 38C93332C5BA0E14

FASTA11112,354
        10         20         30         40         50         60 
MSWRGRSTYR PRPRRSLQPP ELIGAMLEPT DEEPKEEKPP TKSRNPTPDQ KREDDQGAAE 

        70         80         90        100        110 
IQVPDLEADL QELCQTKTGD GCEGGTDVKG KILPKAEHFK MPEAGEGKSQ V 

« Hide

References

« Hide 'large scale' references
[1]"The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma."
Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J., van Muijen G.N.P.
Int. J. Cancer 99:361-369(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database."
Brinkmann U., Vasmatzis G., Lee B., Pastan I.
Cancer Res. 59:1445-1448(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ318891, AJ318892 Genomic DNA. Translation: CAC88125.1.
AJ318880 mRNA. Translation: CAC83007.1.
BX293536 Genomic DNA. Translation: CAI40835.1.
AL953874 Genomic DNA. Translation: CAI41681.1.
BC009232 mRNA. Translation: AAH09232.1.
BC066311 mRNA. Translation: AAH66311.1.
RefSeqNP_001073006.1. NM_001079538.1.
NP_570133.1. NM_130777.1.
UniGeneHs.522654.

3D structure databases

ProteinModelPortalQ96GT9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114881. 3 interactions.
IntActQ96GT9. 1 interaction.
MINTMINT-1481518.
STRING9606.ENSP00000286049.

Polymorphism databases

DMDM21759127.

Proteomic databases

PaxDbQ96GT9.
PRIDEQ96GT9.

Protocols and materials databases

DNASU9502.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000286049; ENSP00000286049; ENSG00000155622.
ENST00000330906; ENSP00000333775; ENSG00000185751.
ENST00000596650; ENSP00000470480; ENSG00000269076.
GeneID728242.
9502.
KEGGhsa:101060193.
hsa:728242.
hsa:9502.
UCSCuc004dqe.3. human.

Organism-specific databases

CTD728242.
9502.
GeneCardsGC0XM052397.
GC0XP052112.
HGNCHGNC:4112. XAGE2.
HGNC:30680. XAGE2B.
MIM300416. gene.
neXtProtNX_Q96GT9.
PharmGKBPA28527.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG118993.
HOGENOMHOG000237345.
HOVERGENHBG056227.
InParanoidQ96GT9.
OMATGDECED.
OrthoDBEOG7JHM82.
PhylomeDBQ96GT9.
TreeFamTF340669.

Gene expression databases

CleanExHS_XAGE2.
GenevestigatorQ96GT9.

Family and domain databases

InterProIPR008625. GAGE.
[Graphical view]
PfamPF05831. GAGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio126585.
PROQ96GT9.
SOURCESearch...

Entry information

Entry nameXAGE2_HUMAN
AccessionPrimary (citable) accession number: Q96GT9
Secondary accession number(s): Q5HYR4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM