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Q96GS6 (F18A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Abhydrolase domain-containing protein FAM108A1
EC=3.-.-.-
Gene names
Name:FAM108A1
Synonyms:C19orf27
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the AB hydrolase superfamily. FAM108 family.

Sequence caution

The sequence BAB15709.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB84869.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC03419.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96GS6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96GS6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: G → GARQGHQAQGGHPQLAWVGRLGDSNNPAPGGCLLGKSWGTGAALACGYIHLL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Sequence conflict1441K → E in AAH20512. Ref.4
Isoform 3 (identifier: Q96GS6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     236-236: N → K
     237-310: Missing.
Isoform 4 (identifier: Q96GS6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     177-310: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 310290Abhydrolase domain-containing protein FAM108A1
PRO_0000297509

Sites

Active site1901Charge relay system By similarity
Active site2551Charge relay system By similarity
Active site2841Charge relay system By similarity

Natural variations

Alternative sequence1091G → GARQGHQAQGGHPQLAWVGR LGDSNNPAPGGCLLGKSWGT GAALACGYIHLL in isoform 2.
VSP_027268
Alternative sequence177 – 310134Missing in isoform 4.
VSP_027271
Alternative sequence2361N → K in isoform 3.
VSP_027269
Alternative sequence237 – 31074Missing in isoform 3.
VSP_027270

Experimental info

Sequence conflict981R → H in AAH00158. Ref.4
Sequence conflict981R → H in AAH11667. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 35FC521C6C245BA0

FASTA31033,990
        10         20         30         40         50         60 
MNGLSLSELC CLFCCPPCPG RIAAKLAFLP PEATYSLVPE PEPGPGGAGA APLGTLRASS 

        70         80         90        100        110        120 
GAPGRWKLHL TERADFQYSQ RELDTIEVFP TKSARGNRVS CMYVRCVPGA RYTVLFSHGN 

       130        140        150        160        170        180 
AVDLGQMSSF YIGLGSRLHC NIFSYDYSGY GASSGRPSER NLYADIDAAW QALRTRYGIS 

       190        200        210        220        230        240 
PDSIILYGQS IGTVPTVDLA SRYECAAVVL HSPLTSGMRV AFPDTKKTYC FDAFPNIEKV 

       250        260        270        280        290        300 
SKITSPVLII HGTEDEVIDF SHGLALYERC PKAVEPLWVE GAGHNDIELY SQYLERLRRF 

       310 
ISQELPSQRA

« Hide

Isoform 2 [UniParc].

Checksum: 0C7BD4C0C50C8792
Show »

FASTA36139,136
Isoform 3 [UniParc].

Checksum: BB7B6CD4879BD95F
Show »

FASTA23625,529
Isoform 4 [UniParc].

Checksum: 2E606EF6126C01C7
Show »

FASTA17619,048

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Cerebellum and Spleen.
[2]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Embryo.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Brain, Cervix, Colon, Muscle, Ovary, Prostate and Skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK024419 mRNA. Translation: BAB15709.1. Different initiation.
AK074043 mRNA. Translation: BAB84869.1. Different initiation.
AK289533 mRNA. Translation: BAF82222.1.
AK090438 mRNA. Translation: BAC03419.1. Different initiation.
AK074548 mRNA. Translation: BAC11052.1.
CH471139 Genomic DNA. Translation: EAW69441.1.
CH471139 Genomic DNA. Translation: EAW69444.1.
CH471139 Genomic DNA. Translation: EAW69446.1.
BC000158 mRNA. Translation: AAH00158.1.
BC009256 mRNA. Translation: AAH09256.1.
BC011667 mRNA. Translation: AAH11667.1.
BC020512 mRNA. Translation: AAH20512.1.
BC033749 mRNA. Translation: AAH33749.1.
BC035961 mRNA. Translation: AAH35961.1.
BC071644 mRNA. Translation: AAH71644.1.
BC071876 mRNA. Translation: AAH71876.1.
BC094816 mRNA. Translation: AAH94816.1.
IPIIPI00102923.
IPI00643408.
IPI00854784.
IPI00854853.
RefSeqNP_001123583.1. NM_001130111.1.
NP_112490.3. NM_031213.3.
UniGeneHs.465542.
Hs.653679.

3D structure databases

ProteinModelPortalQ96GS6.
ModBaseSearch...

Protein-protein interaction databases

IntActQ96GS6. 1 interaction.
STRINGQ96GS6.

Protein family/group databases

MEROPSS09.052.

PTM databases

PhosphoSiteQ96GS6.

Polymorphism databases

DMDM74751891.

Proteomic databases

PRIDEQ96GS6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000292577; ENSP00000292577; ENSG00000129968.
ENST00000454155; ENSP00000407632; ENSG00000129968.
GeneID81926.
KEGGhsa:81926.
UCSCuc001hkn.1. human.
uc002luf.1. human.
uc002lug.1. human.

Organism-specific databases

CTD81926.
GeneCardsGC19M001878.
H-InvDBHIX0014598.
HIX0060099.
HIX0197203.
HIX0200130.
HIX0202559.
HGNCHGNC:28756. FAM108A1.
neXtProtNX_Q96GS6.
PharmGKBPA134947443.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG09132.
GeneTreeENSGT00390000000948.
HOGENOMHBG678036.
HOVERGENHBG061270.
OrthoDBEOG46MBK6.
PhylomeDBQ96GS6.

Gene expression databases

BgeeQ96GS6.
CleanExHS_FAM108A1.
GenevestigatorQ96GS6.

Family and domain databases

ProtoNetSearch...

Other

NextBio72257.

Entry information

Entry nameF18A1_HUMAN
AccessionPrimary (citable) accession number: Q96GS6
Secondary accession number(s): A8K0G8 expand/collapse secondary AC list , D6W5Z9, Q6PJU2, Q8WUH9, Q9BWL0, Q9H7Q9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 1, 2001
Last modified: January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents