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Protein

Uncharacterized protein C17orf59

Gene

C17orf59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C17orf59
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25939. C17orf59.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672242.

Polymorphism and mutation databases

BioMutaiC17orf59.
DMDMi296434462.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Uncharacterized protein C17orf59PRO_0000286827Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei168 – 1681PhosphoserineBy similarity
Modified residuei196 – 1961PhosphothreonineCombined sources
Modified residuei199 – 1991PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96GS4.
MaxQBiQ96GS4.
PaxDbiQ96GS4.
PRIDEiQ96GS4.

PTM databases

iPTMnetiQ96GS4.
PhosphoSiteiQ96GS4.

Expressioni

Gene expression databases

BgeeiQ96GS4.
CleanExiHS_C17orf59.
GenevisibleiQ96GS4. HS.

Organism-specific databases

HPAiHPA045415.
HPA060791.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EPS8Q129293EBI-10193358,EBI-375576
FBXO44Q9H4M34EBI-10193358,EBI-2322644
MOSP005403EBI-10193358,EBI-1757866
SHPRHQ149N83EBI-10193358,EBI-714105

Protein-protein interaction databases

BioGridi120149. 54 interactions.
IntActiQ96GS4. 4 interactions.
STRINGi9606.ENSP00000373669.

Structurei

3D structure databases

ProteinModelPortaliQ96GS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi231 – 25828Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiKOG4514. Eukaryota.
ENOG4111TSS. LUCA.
GeneTreeiENSGT00490000043453.
HOGENOMiHOG000111935.
HOVERGENiHBG060339.
InParanoidiQ96GS4.
OMAiGGANRHP.
OrthoDBiEOG72RN0K.
PhylomeDBiQ96GS4.

Family and domain databases

InterProiIPR019314. DUF2365.
[Graphical view]
PfamiPF10157. DUF2365. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96GS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSRGRPGP ETDLLAVAEH QALVFGGGPG RTSSEPPAGL RVSGEEETEN
60 70 80 90 100
VGGANRHPRT SPKTSSCGVV HRPEREALEN EPGPQGTLSG AGSRRGAPGA
110 120 130 140 150
EHEPSLSSRH KNPAPPEGKP SSGRDCRRGG PGGGMDVEQQ EEEDNDEEAA
160 170 180 190 200
AGSRAGRSFS SRLQDSRSLD GLSEACGGAG SSGSAESGAG GGRRATISSP
210 220 230 240 250
LELEGTVSRH GDLTHFVANN LQLKIRLSGA PPPPPSAPAR PCPAPAPTPT
260 270 280 290 300
PAIPPIDPEV LRDLERLSRE LGGRVDRLLR GLGGAVQELT ALSVGCIQTY
310 320 330 340 350
RDAVDSLGEA VDMSIKGMYT LLARCEELER ALQPVQGLAR QVRDIRRTLE

VLEALCK
Length:357
Mass (Da):37,226
Last modified:May 18, 2010 - v2
Checksum:iBBA89770528FA9E9
GO

Sequence cautioni

The sequence AAH09261.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH18880.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH70272.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA90889.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD96226.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti202 – 2021E → K in BAA90889 (PubMed:14702039).Curated
Sequence conflicti336 – 3361Q → R in BAA90889 (PubMed:14702039).Curated
Sequence conflicti336 – 3361Q → R in BAD96226 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129492 Genomic DNA. No translation available.
BC009261 mRNA. Translation: AAH09261.1. Different initiation.
BC018880 mRNA. Translation: AAH18880.1. Different initiation.
BC070272 mRNA. Translation: AAH70272.1. Different initiation.
AK000021 mRNA. Translation: BAA90889.1. Different initiation.
AK222506 mRNA. Translation: BAD96226.1. Different initiation.
CCDSiCCDS11133.2.
RefSeqiNP_060092.2. NM_017622.2.
UniGeneiHs.129563.

Genome annotation databases

EnsembliENST00000389017; ENSP00000373669; ENSG00000196544.
GeneIDi54785.
KEGGihsa:54785.
UCSCiuc010vut.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129492 Genomic DNA. No translation available.
BC009261 mRNA. Translation: AAH09261.1. Different initiation.
BC018880 mRNA. Translation: AAH18880.1. Different initiation.
BC070272 mRNA. Translation: AAH70272.1. Different initiation.
AK000021 mRNA. Translation: BAA90889.1. Different initiation.
AK222506 mRNA. Translation: BAD96226.1. Different initiation.
CCDSiCCDS11133.2.
RefSeqiNP_060092.2. NM_017622.2.
UniGeneiHs.129563.

3D structure databases

ProteinModelPortaliQ96GS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120149. 54 interactions.
IntActiQ96GS4. 4 interactions.
STRINGi9606.ENSP00000373669.

PTM databases

iPTMnetiQ96GS4.
PhosphoSiteiQ96GS4.

Polymorphism and mutation databases

BioMutaiC17orf59.
DMDMi296434462.

Proteomic databases

EPDiQ96GS4.
MaxQBiQ96GS4.
PaxDbiQ96GS4.
PRIDEiQ96GS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389017; ENSP00000373669; ENSG00000196544.
GeneIDi54785.
KEGGihsa:54785.
UCSCiuc010vut.3. human.

Organism-specific databases

CTDi54785.
GeneCardsiC17orf59.
H-InvDBHIX0039063.
HIX0202400.
HGNCiHGNC:25939. C17orf59.
HPAiHPA045415.
HPA060791.
neXtProtiNX_Q96GS4.
PharmGKBiPA142672242.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4514. Eukaryota.
ENOG4111TSS. LUCA.
GeneTreeiENSGT00490000043453.
HOGENOMiHOG000111935.
HOVERGENiHBG060339.
InParanoidiQ96GS4.
OMAiGGANRHP.
OrthoDBiEOG72RN0K.
PhylomeDBiQ96GS4.

Miscellaneous databases

GenomeRNAii54785.
NextBioi57449.
PROiQ96GS4.

Gene expression databases

BgeeiQ96GS4.
CleanExiHS_C17orf59.
GenevisibleiQ96GS4. HS.

Family and domain databases

InterProiIPR019314. DUF2365.
[Graphical view]
PfamiPF10157. DUF2365. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung, Ovary and Skin.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-357.
    Tissue: Adipose tissue.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-357.
    Tissue: Adipose tissue.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-196 AND SER-199, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCQ059_HUMAN
AccessioniPrimary (citable) accession number: Q96GS4
Secondary accession number(s): Q53HS4, Q9NXW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: March 16, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.