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Protein

BLOC-1-related complex subunit 6

Gene

BORCS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.1 Publication

GO - Biological processi

  • lysosome localization Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
BLOC-1-related complex subunit 6Curated
Alternative name(s):
Lysosome-dispersing protein1 Publication
Short name:
Lyspersin1 Publication
Gene namesi
Name:BORCS6Imported
Synonyms:C17orf59Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000196544.7
HGNCiHGNC:25939 BORCS6
MIMi616599 gene
neXtProtiNX_Q96GS4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196544
PharmGKBiPA142672242

Polymorphism and mutation databases

BioMutaiC17orf59
DMDMi296434462

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002868271 – 357BLOC-1-related complex subunit 6Add BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei168PhosphoserineCombined sources1
Modified residuei196PhosphothreonineCombined sources1
Modified residuei199PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96GS4
MaxQBiQ96GS4
PaxDbiQ96GS4
PeptideAtlasiQ96GS4
PRIDEiQ96GS4
ProteomicsDBi76660

PTM databases

iPTMnetiQ96GS4
PhosphoSitePlusiQ96GS4

Expressioni

Gene expression databases

BgeeiENSG00000196544
CleanExiHS_C17orf59
GenevisibleiQ96GS4 HS

Organism-specific databases

HPAiHPA045415
HPA060791

Interactioni

Subunit structurei

Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120149, 57 interactors
DIPiDIP-29465N
IntActiQ96GS4, 36 interactors
STRINGi9606.ENSP00000373669

Structurei

3D structure databases

ProteinModelPortaliQ96GS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi231 – 258Pro-richAdd BLAST28

Sequence similaritiesi

Belongs to the BORCS6 family.Curated

Phylogenomic databases

eggNOGiKOG4514 Eukaryota
ENOG4111TSS LUCA
GeneTreeiENSGT00490000043453
HOGENOMiHOG000111935
HOVERGENiHBG060339
InParanoidiQ96GS4
KOiK20820
OMAiGGANRHP
OrthoDBiEOG091G0NP7
PhylomeDBiQ96GS4

Family and domain databases

InterProiView protein in InterPro
IPR019314 BORCS6
PANTHERiPTHR13440 PTHR13440, 1 hit
PfamiView protein in Pfam
PF10157 BORCS6, 1 hit

Sequencei

Sequence statusi: Complete.

Q96GS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSRGRPGP ETDLLAVAEH QALVFGGGPG RTSSEPPAGL RVSGEEETEN
60 70 80 90 100
VGGANRHPRT SPKTSSCGVV HRPEREALEN EPGPQGTLSG AGSRRGAPGA
110 120 130 140 150
EHEPSLSSRH KNPAPPEGKP SSGRDCRRGG PGGGMDVEQQ EEEDNDEEAA
160 170 180 190 200
AGSRAGRSFS SRLQDSRSLD GLSEACGGAG SSGSAESGAG GGRRATISSP
210 220 230 240 250
LELEGTVSRH GDLTHFVANN LQLKIRLSGA PPPPPSAPAR PCPAPAPTPT
260 270 280 290 300
PAIPPIDPEV LRDLERLSRE LGGRVDRLLR GLGGAVQELT ALSVGCIQTY
310 320 330 340 350
RDAVDSLGEA VDMSIKGMYT LLARCEELER ALQPVQGLAR QVRDIRRTLE

VLEALCK
Length:357
Mass (Da):37,226
Last modified:May 18, 2010 - v2
Checksum:iBBA89770528FA9E9
GO

Sequence cautioni

The sequence AAH09261 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH18880 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH70272 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA90889 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD96226 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202E → K in BAA90889 (PubMed:14702039).Curated1
Sequence conflicti336Q → R in BAA90889 (PubMed:14702039).Curated1
Sequence conflicti336Q → R in BAD96226 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129492 Genomic DNA No translation available.
BC009261 mRNA Translation: AAH09261.1 Different initiation.
BC018880 mRNA Translation: AAH18880.1 Different initiation.
BC070272 mRNA Translation: AAH70272.1 Different initiation.
AK000021 mRNA Translation: BAA90889.1 Different initiation.
AK222506 mRNA Translation: BAD96226.1 Different initiation.
CCDSiCCDS11133.2
RefSeqiNP_060092.2, NM_017622.2
UniGeneiHs.129563

Genome annotation databases

EnsembliENST00000389017; ENSP00000373669; ENSG00000196544
GeneIDi54785
KEGGihsa:54785
UCSCiuc010vut.3 human

Similar proteinsi

Entry informationi

Entry nameiBORC6_HUMAN
AccessioniPrimary (citable) accession number: Q96GS4
Secondary accession number(s): Q53HS4, Q9NXW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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