Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BLOC-1-related complex subunit 6

Gene

BORCS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.1 Publication

GO - Biological processi

  • lysosome localization Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33869-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
BLOC-1-related complex subunit 6Curated
Alternative name(s):
Lysosome-dispersing protein1 Publication
Short name:
Lyspersin1 Publication
Gene namesi
Name:BORCS6Imported
Synonyms:C17orf59Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25939. BORCS6.

Subcellular locationi

GO - Cellular componenti

  • BORC complex Source: UniProtKB
  • lysosomal membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196544.
PharmGKBiPA142672242.

Polymorphism and mutation databases

BioMutaiC17orf59.
DMDMi296434462.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002868271 – 357BLOC-1-related complex subunit 6Add BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei168PhosphoserineCombined sources1
Modified residuei196PhosphothreonineCombined sources1
Modified residuei199PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96GS4.
MaxQBiQ96GS4.
PaxDbiQ96GS4.
PeptideAtlasiQ96GS4.
PRIDEiQ96GS4.

PTM databases

iPTMnetiQ96GS4.
PhosphoSitePlusiQ96GS4.

Expressioni

Gene expression databases

BgeeiENSG00000196544.
CleanExiHS_C17orf59.
GenevisibleiQ96GS4. HS.

Organism-specific databases

HPAiHPA045415.
HPA060791.

Interactioni

Subunit structurei

Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EPS8Q129293EBI-10193358,EBI-375576
FBXO44Q9H4M34EBI-10193358,EBI-2322644
MOSP005403EBI-10193358,EBI-1757866
SHPRHQ149N83EBI-10193358,EBI-714105

Protein-protein interaction databases

BioGridi120149. 54 interactors.
DIPiDIP-29465N.
IntActiQ96GS4. 30 interactors.
STRINGi9606.ENSP00000373669.

Structurei

3D structure databases

ProteinModelPortaliQ96GS4.
SMRiQ96GS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi231 – 258Pro-richAdd BLAST28

Sequence similaritiesi

Belongs to the BORCS6 family.Curated

Phylogenomic databases

eggNOGiKOG4514. Eukaryota.
ENOG4111TSS. LUCA.
GeneTreeiENSGT00490000043453.
HOGENOMiHOG000111935.
HOVERGENiHBG060339.
InParanoidiQ96GS4.
KOiK20820.
OMAiGGANRHP.
OrthoDBiEOG091G0NP7.
PhylomeDBiQ96GS4.

Family and domain databases

InterProiIPR019314. BORCS6.
[Graphical view]
PfamiPF10157. DUF2365. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96GS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSRGRPGP ETDLLAVAEH QALVFGGGPG RTSSEPPAGL RVSGEEETEN
60 70 80 90 100
VGGANRHPRT SPKTSSCGVV HRPEREALEN EPGPQGTLSG AGSRRGAPGA
110 120 130 140 150
EHEPSLSSRH KNPAPPEGKP SSGRDCRRGG PGGGMDVEQQ EEEDNDEEAA
160 170 180 190 200
AGSRAGRSFS SRLQDSRSLD GLSEACGGAG SSGSAESGAG GGRRATISSP
210 220 230 240 250
LELEGTVSRH GDLTHFVANN LQLKIRLSGA PPPPPSAPAR PCPAPAPTPT
260 270 280 290 300
PAIPPIDPEV LRDLERLSRE LGGRVDRLLR GLGGAVQELT ALSVGCIQTY
310 320 330 340 350
RDAVDSLGEA VDMSIKGMYT LLARCEELER ALQPVQGLAR QVRDIRRTLE

VLEALCK
Length:357
Mass (Da):37,226
Last modified:May 18, 2010 - v2
Checksum:iBBA89770528FA9E9
GO

Sequence cautioni

The sequence AAH09261 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH18880 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH70272 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA90889 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD96226 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202E → K in BAA90889 (PubMed:14702039).Curated1
Sequence conflicti336Q → R in BAA90889 (PubMed:14702039).Curated1
Sequence conflicti336Q → R in BAD96226 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129492 Genomic DNA. No translation available.
BC009261 mRNA. Translation: AAH09261.1. Different initiation.
BC018880 mRNA. Translation: AAH18880.1. Different initiation.
BC070272 mRNA. Translation: AAH70272.1. Different initiation.
AK000021 mRNA. Translation: BAA90889.1. Different initiation.
AK222506 mRNA. Translation: BAD96226.1. Different initiation.
CCDSiCCDS11133.2.
RefSeqiNP_060092.2. NM_017622.2.
UniGeneiHs.129563.

Genome annotation databases

EnsembliENST00000389017; ENSP00000373669; ENSG00000196544.
GeneIDi54785.
KEGGihsa:54785.
UCSCiuc010vut.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129492 Genomic DNA. No translation available.
BC009261 mRNA. Translation: AAH09261.1. Different initiation.
BC018880 mRNA. Translation: AAH18880.1. Different initiation.
BC070272 mRNA. Translation: AAH70272.1. Different initiation.
AK000021 mRNA. Translation: BAA90889.1. Different initiation.
AK222506 mRNA. Translation: BAD96226.1. Different initiation.
CCDSiCCDS11133.2.
RefSeqiNP_060092.2. NM_017622.2.
UniGeneiHs.129563.

3D structure databases

ProteinModelPortaliQ96GS4.
SMRiQ96GS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120149. 54 interactors.
DIPiDIP-29465N.
IntActiQ96GS4. 30 interactors.
STRINGi9606.ENSP00000373669.

PTM databases

iPTMnetiQ96GS4.
PhosphoSitePlusiQ96GS4.

Polymorphism and mutation databases

BioMutaiC17orf59.
DMDMi296434462.

Proteomic databases

EPDiQ96GS4.
MaxQBiQ96GS4.
PaxDbiQ96GS4.
PeptideAtlasiQ96GS4.
PRIDEiQ96GS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389017; ENSP00000373669; ENSG00000196544.
GeneIDi54785.
KEGGihsa:54785.
UCSCiuc010vut.3. human.

Organism-specific databases

CTDi54785.
GeneCardsiC17orf59.
H-InvDBHIX0039063.
HIX0202400.
HGNCiHGNC:25939. BORCS6.
HPAiHPA045415.
HPA060791.
MIMi616599. gene.
neXtProtiNX_Q96GS4.
OpenTargetsiENSG00000196544.
PharmGKBiPA142672242.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4514. Eukaryota.
ENOG4111TSS. LUCA.
GeneTreeiENSGT00490000043453.
HOGENOMiHOG000111935.
HOVERGENiHBG060339.
InParanoidiQ96GS4.
KOiK20820.
OMAiGGANRHP.
OrthoDBiEOG091G0NP7.
PhylomeDBiQ96GS4.

Enzyme and pathway databases

BioCyciZFISH:G66-33869-MONOMER.

Miscellaneous databases

GenomeRNAii54785.
PROiQ96GS4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196544.
CleanExiHS_C17orf59.
GenevisibleiQ96GS4. HS.

Family and domain databases

InterProiIPR019314. BORCS6.
[Graphical view]
PfamiPF10157. DUF2365. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBORC6_HUMAN
AccessioniPrimary (citable) accession number: Q96GS4
Secondary accession number(s): Q53HS4, Q9NXW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.