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Q96GR2

- ACBG1_HUMAN

UniProt

Q96GR2 - ACBG1_HUMAN

Protein

Long-chain-fatty-acid--CoA ligase ACSBG1

Gene

ACSBG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.2 Publications

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei550 – 5501ATPBy similarity
    Binding sitei565 – 5651ATPBy similarity
    Binding sitei701 – 7011ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi282 – 2909ATPBy similarity
    Nucleotide bindingi472 – 4776ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: HGNC
    3. very long-chain fatty acid-CoA ligase activity Source: HGNC

    GO - Biological processi

    1. long-chain fatty acid metabolic process Source: HGNC
    2. myelination Source: HGNC
    3. ovarian follicle atresia Source: Ensembl
    4. response to glucocorticoid Source: Ensembl
    5. very long-chain fatty acid metabolic process Source: HGNC

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS02532-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase ACSBG1 (EC:6.2.1.3)
    Alternative name(s):
    Acyl-CoA synthetase bubblegum family member 1
    Short name:
    hBG1
    Short name:
    hsBG
    Short name:
    hsBGM
    Lipidosin
    Gene namesi
    Name:ACSBG1
    Synonyms:BGM, KIAA0631, LPD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:29567. ACSBG1.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmic vesicle By similarity. Microsome By similarity. Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. cytoplasm Source: HGNC
    2. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    3. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672648.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 724724Long-chain-fatty-acid--CoA ligase ACSBG1PRO_0000315808Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei658 – 6581PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ96GR2.
    PRIDEiQ96GR2.

    PTM databases

    PhosphoSiteiQ96GR2.

    Expressioni

    Tissue specificityi

    Expressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in all regions of brain except pituitary.2 Publications

    Gene expression databases

    ArrayExpressiQ96GR2.
    BgeeiQ96GR2.
    CleanExiHS_ACSBG1.
    GenevestigatoriQ96GR2.

    Organism-specific databases

    HPAiCAB045955.
    HPA041642.

    Interactioni

    Protein-protein interaction databases

    BioGridi116813. 2 interactions.
    IntActiQ96GR2. 1 interaction.
    MINTiMINT-8247478.
    STRINGi9606.ENSP00000258873.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96GR2.
    SMRiQ96GR2. Positions 96-627.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1022.
    HOGENOMiHOG000230004.
    HOVERGENiHBG054660.
    InParanoidiQ96GR2.
    KOiK15013.
    OMAiFYQEQKM.
    OrthoDBiEOG7B5WVB.
    PhylomeDBiQ96GR2.
    TreeFamiTF354286.

    Family and domain databases

    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96GR2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRNSGAGYG CPHGDPSMLD SRETPQESRQ DMIVRTTQEK LKTSSLTDRQ    50
    PLSKESLNHA LELSVPEKVN NAQWDAPEEA LWTTRADGRV RLRIDPSCPQ 100
    LPYTVHRMFY EALDKYGDLI ALGFKRQDKW EHISYSQYYL LARRAAKGFL 150
    KLGLKQAHSV AILGFNSPEW FFSAVGTVFA GGIVTGIYTT SSPEACQYIA 200
    YDCCANVIMV DTQKQLEKIL KIWKQLPHLK AVVIYKEPPP NKMANVYTME 250
    EFMELGNEVP EEALDAIIDT QQPNQCCVLV YTSGTTGNPK GVMLSQDNIT 300
    WTARYGSQAG DIRPAEVQQE VVVSYLPLSH IAAQIYDLWT GIQWGAQVCF 350
    AEPDALKGSL VNTLREVEPT SHMGVPRVWE KIMERIQEVA AQSGFIRRKM 400
    LLWAMSVTLE QNLTCPGSDL KPFTTRLADY LVLAKVRQAL GFAKCQKNFY 450
    GAAPMMAETQ HFFLGLNIRL YAGYGLSETS GPHFMSSPYN YRLYSSGKLV 500
    PGCRVKLVNQ DAEGIGEICL WGRTIFMGYL NMEDKTCEAI DEEGWLHTGD 550
    AGRLDADGFL YITGRLKELI ITAGGENVPP VPIEEAVKME LPIISNAMLI 600
    GDQRKFLSML LTLKCTLDPD TSDQTDNLTE QAMEFCQRVG SRATTVSEII 650
    EKKDEAVYQA IEEGIRRVNM NAAARPYHIQ KWAILERDFS ISGGELGPTM 700
    KLKRLTVLEK YKGIIDSFYQ EQKM 724
    Length:724
    Mass (Da):81,290
    Last modified:May 18, 2010 - v2
    Checksum:i2C27BA65CE95CE17
    GO

    Sequence cautioni

    The sequence BAA31606.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti194 – 1941E → V.
    Corresponds to variant rs12899901 [ dbSNP | Ensembl ].
    VAR_038314
    Natural varianti633 – 6331M → V.4 Publications
    Corresponds to variant rs2304824 [ dbSNP | Ensembl ].
    VAR_038315
    Natural varianti673 – 6731A → V.1 Publication
    Corresponds to variant rs11072735 [ dbSNP | Ensembl ].
    VAR_038316

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF179481 mRNA. Translation: AAG09404.1.
    AB014531 mRNA. Translation: BAA31606.2. Different initiation.
    AK314508 mRNA. Translation: BAG37108.1.
    AC090260 Genomic DNA. No translation available.
    AC090607 Genomic DNA. No translation available.
    CH471136 Genomic DNA. Translation: EAW99180.1.
    BC009289 mRNA. Translation: AAH09289.1.
    CCDSiCCDS10298.1.
    RefSeqiNP_001186306.1. NM_001199377.1.
    NP_055977.3. NM_015162.4.
    UniGeneiHs.655760.

    Genome annotation databases

    EnsembliENST00000258873; ENSP00000258873; ENSG00000103740.
    GeneIDi23205.
    KEGGihsa:23205.
    UCSCiuc002bdh.3. human.

    Polymorphism databases

    DMDMi296434385.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF179481 mRNA. Translation: AAG09404.1 .
    AB014531 mRNA. Translation: BAA31606.2 . Different initiation.
    AK314508 mRNA. Translation: BAG37108.1 .
    AC090260 Genomic DNA. No translation available.
    AC090607 Genomic DNA. No translation available.
    CH471136 Genomic DNA. Translation: EAW99180.1 .
    BC009289 mRNA. Translation: AAH09289.1 .
    CCDSi CCDS10298.1.
    RefSeqi NP_001186306.1. NM_001199377.1.
    NP_055977.3. NM_015162.4.
    UniGenei Hs.655760.

    3D structure databases

    ProteinModelPortali Q96GR2.
    SMRi Q96GR2. Positions 96-627.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116813. 2 interactions.
    IntActi Q96GR2. 1 interaction.
    MINTi MINT-8247478.
    STRINGi 9606.ENSP00000258873.

    PTM databases

    PhosphoSitei Q96GR2.

    Polymorphism databases

    DMDMi 296434385.

    Proteomic databases

    PaxDbi Q96GR2.
    PRIDEi Q96GR2.

    Protocols and materials databases

    DNASUi 23205.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258873 ; ENSP00000258873 ; ENSG00000103740 .
    GeneIDi 23205.
    KEGGi hsa:23205.
    UCSCi uc002bdh.3. human.

    Organism-specific databases

    CTDi 23205.
    GeneCardsi GC15M078460.
    HGNCi HGNC:29567. ACSBG1.
    HPAi CAB045955.
    HPA041642.
    MIMi 614362. gene.
    neXtProti NX_Q96GR2.
    PharmGKBi PA142672648.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1022.
    HOGENOMi HOG000230004.
    HOVERGENi HBG054660.
    InParanoidi Q96GR2.
    KOi K15013.
    OMAi FYQEQKM.
    OrthoDBi EOG7B5WVB.
    PhylomeDBi Q96GR2.
    TreeFami TF354286.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS02532-MONOMER.

    Miscellaneous databases

    ChiTaRSi ACSBG1. human.
    GeneWikii ACSBG1.
    GenomeRNAii 23205.
    NextBioi 44731.
    PROi Q96GR2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96GR2.
    Bgeei Q96GR2.
    CleanExi HS_ACSBG1.
    Genevestigatori Q96GR2.

    Family and domain databases

    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Very long-chain acyl-CoA synthetases. Human 'bubblegum' represents a new family of proteins capable of activating very long-chain fatty acids."
      Steinberg S.J., Morgenthaler J., Heinzer A.K., Smith K.D., Watkins P.A.
      J. Biol. Chem. 275:35162-35169(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ENZYME ACTIVITY, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-633.
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-633 AND VAL-673.
      Tissue: Testis.
    5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-633.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-633.
      Tissue: Skin.
    8. "The acyl-CoA synthetase 'bubblegum' (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation."
      Pei Z., Oey N.A., Zuidervaart M.M., Jia Z., Li Y., Steinberg S.J., Smith K.D., Watkins P.A.
      J. Biol. Chem. 278:47070-47078(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiACBG1_HUMAN
    AccessioniPrimary (citable) accession number: Q96GR2
    Secondary accession number(s): B2RB61
    , O75126, Q76N27, Q9HC26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3