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Protein

Long-chain-fatty-acid--CoA ligase ACSBG1

Gene

ACSBG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.2 Publications

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei550 – 5501ATPBy similarity
Binding sitei565 – 5651ATPBy similarity
Binding sitei701 – 7011ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi282 – 2909ATPBy similarity
Nucleotide bindingi472 – 4776ATPBy similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • long-chain fatty acid-CoA ligase activity Source: HGNC
  • very long-chain fatty acid-CoA ligase activity Source: HGNC

GO - Biological processi

  • long-chain fatty acid metabolic process Source: HGNC
  • myelination Source: HGNC
  • ovarian follicle atresia Source: Ensembl
  • response to glucocorticoid Source: Ensembl
  • very long-chain fatty acid metabolic process Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS02532-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG1 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 1
Short name:
hBG1
Short name:
hsBG
Short name:
hsBGM
Lipidosin
Gene namesi
Name:ACSBG1
Synonyms:BGM, KIAA0631, LPD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:29567. ACSBG1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  • endoplasmic reticulum Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672648.

Polymorphism and mutation databases

BioMutaiACSBG1.
DMDMi296434385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724Long-chain-fatty-acid--CoA ligase ACSBG1PRO_0000315808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei658 – 6581PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96GR2.
PRIDEiQ96GR2.

PTM databases

PhosphoSiteiQ96GR2.

Expressioni

Tissue specificityi

Expressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in all regions of brain except pituitary.2 Publications

Gene expression databases

BgeeiQ96GR2.
CleanExiHS_ACSBG1.
ExpressionAtlasiQ96GR2. baseline and differential.
GenevestigatoriQ96GR2.

Organism-specific databases

HPAiCAB045955.
HPA041642.

Interactioni

Protein-protein interaction databases

BioGridi116813. 2 interactions.
IntActiQ96GR2. 1 interaction.
MINTiMINT-8247478.
STRINGi9606.ENSP00000258873.

Structurei

3D structure databases

ProteinModelPortaliQ96GR2.
SMRiQ96GR2. Positions 96-627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1022.
GeneTreeiENSGT00690000101725.
HOGENOMiHOG000230004.
HOVERGENiHBG054660.
InParanoidiQ96GR2.
KOiK15013.
OMAiTQQPNQC.
OrthoDBiEOG7B5WVB.
PhylomeDBiQ96GR2.
TreeFamiTF354286.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96GR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRNSGAGYG CPHGDPSMLD SRETPQESRQ DMIVRTTQEK LKTSSLTDRQ
60 70 80 90 100
PLSKESLNHA LELSVPEKVN NAQWDAPEEA LWTTRADGRV RLRIDPSCPQ
110 120 130 140 150
LPYTVHRMFY EALDKYGDLI ALGFKRQDKW EHISYSQYYL LARRAAKGFL
160 170 180 190 200
KLGLKQAHSV AILGFNSPEW FFSAVGTVFA GGIVTGIYTT SSPEACQYIA
210 220 230 240 250
YDCCANVIMV DTQKQLEKIL KIWKQLPHLK AVVIYKEPPP NKMANVYTME
260 270 280 290 300
EFMELGNEVP EEALDAIIDT QQPNQCCVLV YTSGTTGNPK GVMLSQDNIT
310 320 330 340 350
WTARYGSQAG DIRPAEVQQE VVVSYLPLSH IAAQIYDLWT GIQWGAQVCF
360 370 380 390 400
AEPDALKGSL VNTLREVEPT SHMGVPRVWE KIMERIQEVA AQSGFIRRKM
410 420 430 440 450
LLWAMSVTLE QNLTCPGSDL KPFTTRLADY LVLAKVRQAL GFAKCQKNFY
460 470 480 490 500
GAAPMMAETQ HFFLGLNIRL YAGYGLSETS GPHFMSSPYN YRLYSSGKLV
510 520 530 540 550
PGCRVKLVNQ DAEGIGEICL WGRTIFMGYL NMEDKTCEAI DEEGWLHTGD
560 570 580 590 600
AGRLDADGFL YITGRLKELI ITAGGENVPP VPIEEAVKME LPIISNAMLI
610 620 630 640 650
GDQRKFLSML LTLKCTLDPD TSDQTDNLTE QAMEFCQRVG SRATTVSEII
660 670 680 690 700
EKKDEAVYQA IEEGIRRVNM NAAARPYHIQ KWAILERDFS ISGGELGPTM
710 720
KLKRLTVLEK YKGIIDSFYQ EQKM
Length:724
Mass (Da):81,290
Last modified:May 18, 2010 - v2
Checksum:i2C27BA65CE95CE17
GO

Sequence cautioni

The sequence BAA31606.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti194 – 1941E → V.
Corresponds to variant rs12899901 [ dbSNP | Ensembl ].
VAR_038314
Natural varianti633 – 6331M → V.4 Publications
Corresponds to variant rs2304824 [ dbSNP | Ensembl ].
VAR_038315
Natural varianti673 – 6731A → V.1 Publication
Corresponds to variant rs11072735 [ dbSNP | Ensembl ].
VAR_038316

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179481 mRNA. Translation: AAG09404.1.
AB014531 mRNA. Translation: BAA31606.2. Different initiation.
AK314508 mRNA. Translation: BAG37108.1.
AC090260 Genomic DNA. No translation available.
AC090607 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99180.1.
BC009289 mRNA. Translation: AAH09289.1.
CCDSiCCDS10298.1.
RefSeqiNP_001186306.1. NM_001199377.1.
NP_055977.3. NM_015162.4.
UniGeneiHs.655760.

Genome annotation databases

EnsembliENST00000258873; ENSP00000258873; ENSG00000103740.
GeneIDi23205.
KEGGihsa:23205.
UCSCiuc002bdh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179481 mRNA. Translation: AAG09404.1.
AB014531 mRNA. Translation: BAA31606.2. Different initiation.
AK314508 mRNA. Translation: BAG37108.1.
AC090260 Genomic DNA. No translation available.
AC090607 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99180.1.
BC009289 mRNA. Translation: AAH09289.1.
CCDSiCCDS10298.1.
RefSeqiNP_001186306.1. NM_001199377.1.
NP_055977.3. NM_015162.4.
UniGeneiHs.655760.

3D structure databases

ProteinModelPortaliQ96GR2.
SMRiQ96GR2. Positions 96-627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116813. 2 interactions.
IntActiQ96GR2. 1 interaction.
MINTiMINT-8247478.
STRINGi9606.ENSP00000258873.

PTM databases

PhosphoSiteiQ96GR2.

Polymorphism and mutation databases

BioMutaiACSBG1.
DMDMi296434385.

Proteomic databases

PaxDbiQ96GR2.
PRIDEiQ96GR2.

Protocols and materials databases

DNASUi23205.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258873; ENSP00000258873; ENSG00000103740.
GeneIDi23205.
KEGGihsa:23205.
UCSCiuc002bdh.3. human.

Organism-specific databases

CTDi23205.
GeneCardsiGC15M078460.
HGNCiHGNC:29567. ACSBG1.
HPAiCAB045955.
HPA041642.
MIMi614362. gene.
neXtProtiNX_Q96GR2.
PharmGKBiPA142672648.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1022.
GeneTreeiENSGT00690000101725.
HOGENOMiHOG000230004.
HOVERGENiHBG054660.
InParanoidiQ96GR2.
KOiK15013.
OMAiTQQPNQC.
OrthoDBiEOG7B5WVB.
PhylomeDBiQ96GR2.
TreeFamiTF354286.

Enzyme and pathway databases

BioCyciMetaCyc:HS02532-MONOMER.

Miscellaneous databases

ChiTaRSiACSBG1. human.
GeneWikiiACSBG1.
GenomeRNAii23205.
NextBioi44731.
PROiQ96GR2.
SOURCEiSearch...

Gene expression databases

BgeeiQ96GR2.
CleanExiHS_ACSBG1.
ExpressionAtlasiQ96GR2. baseline and differential.
GenevestigatoriQ96GR2.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Very long-chain acyl-CoA synthetases. Human 'bubblegum' represents a new family of proteins capable of activating very long-chain fatty acids."
    Steinberg S.J., Morgenthaler J., Heinzer A.K., Smith K.D., Watkins P.A.
    J. Biol. Chem. 275:35162-35169(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ENZYME ACTIVITY, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-633.
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-633 AND VAL-673.
    Tissue: Testis.
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-633.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-633.
    Tissue: Skin.
  8. "The acyl-CoA synthetase 'bubblegum' (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation."
    Pei Z., Oey N.A., Zuidervaart M.M., Jia Z., Li Y., Steinberg S.J., Smith K.D., Watkins P.A.
    J. Biol. Chem. 278:47070-47078(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiACBG1_HUMAN
AccessioniPrimary (citable) accession number: Q96GR2
Secondary accession number(s): B2RB61
, O75126, Q76N27, Q9HC26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: April 29, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.