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Protein

Long-chain-fatty-acid--CoA ligase ACSBG1

Gene

ACSBG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.2 Publications

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei550ATPBy similarity1
Binding sitei565ATPBy similarity1
Binding sitei701ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi282 – 290ATPBy similarity9
Nucleotide bindingi472 – 477ATPBy similarity6

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • decanoate--CoA ligase activity Source: UniProtKB-EC
  • long-chain fatty acid-CoA ligase activity Source: HGNC
  • very long-chain fatty acid-CoA ligase activity Source: HGNC

GO - Biological processi

  • long-chain fatty acid metabolic process Source: HGNC
  • long-chain fatty-acyl-CoA biosynthetic process Source: Reactome
  • myelination Source: HGNC
  • response to glucocorticoid Source: Ensembl
  • very long-chain fatty acid metabolic process Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS02532-MONOMER.
ZFISH:HS02532-MONOMER.
ReactomeiR-HSA-75876. Synthesis of very long-chain fatty acyl-CoAs.

Chemistry databases

SwissLipidsiSLP:000000450.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG1 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 1
Short name:
hBG1
Short name:
hsBG
Short name:
hsBGM
Lipidosin
Gene namesi
Name:ACSBG1
Synonyms:BGM, KIAA0631, LPD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:29567. ACSBG1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB-SubCell
  • cytosol Source: Reactome
  • endoplasmic reticulum Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi23205.
OpenTargetsiENSG00000103740.
PharmGKBiPA142672648.

Polymorphism and mutation databases

BioMutaiACSBG1.
DMDMi296434385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158081 – 724Long-chain-fatty-acid--CoA ligase ACSBG1Add BLAST724

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53PhosphoserineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei658PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96GR2.
PeptideAtlasiQ96GR2.
PRIDEiQ96GR2.

PTM databases

iPTMnetiQ96GR2.
PhosphoSitePlusiQ96GR2.

Expressioni

Tissue specificityi

Expressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in all regions of brain except pituitary.2 Publications

Gene expression databases

BgeeiENSG00000103740.
CleanExiHS_ACSBG1.
ExpressionAtlasiQ96GR2. baseline and differential.
GenevisibleiQ96GR2. HS.

Organism-specific databases

HPAiCAB045955.
HPA041642.

Interactioni

Protein-protein interaction databases

BioGridi116813. 2 interactors.
IntActiQ96GR2. 1 interactor.
MINTiMINT-8247478.
STRINGi9606.ENSP00000258873.

Structurei

3D structure databases

ProteinModelPortaliQ96GR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1256. Eukaryota.
COG1022. LUCA.
GeneTreeiENSGT00690000101725.
HOGENOMiHOG000230004.
HOVERGENiHBG054660.
InParanoidiQ96GR2.
KOiK15013.
OMAiTQQPNQC.
OrthoDBiEOG091G03FO.
PhylomeDBiQ96GR2.
TreeFamiTF354286.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96GR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRNSGAGYG CPHGDPSMLD SRETPQESRQ DMIVRTTQEK LKTSSLTDRQ
60 70 80 90 100
PLSKESLNHA LELSVPEKVN NAQWDAPEEA LWTTRADGRV RLRIDPSCPQ
110 120 130 140 150
LPYTVHRMFY EALDKYGDLI ALGFKRQDKW EHISYSQYYL LARRAAKGFL
160 170 180 190 200
KLGLKQAHSV AILGFNSPEW FFSAVGTVFA GGIVTGIYTT SSPEACQYIA
210 220 230 240 250
YDCCANVIMV DTQKQLEKIL KIWKQLPHLK AVVIYKEPPP NKMANVYTME
260 270 280 290 300
EFMELGNEVP EEALDAIIDT QQPNQCCVLV YTSGTTGNPK GVMLSQDNIT
310 320 330 340 350
WTARYGSQAG DIRPAEVQQE VVVSYLPLSH IAAQIYDLWT GIQWGAQVCF
360 370 380 390 400
AEPDALKGSL VNTLREVEPT SHMGVPRVWE KIMERIQEVA AQSGFIRRKM
410 420 430 440 450
LLWAMSVTLE QNLTCPGSDL KPFTTRLADY LVLAKVRQAL GFAKCQKNFY
460 470 480 490 500
GAAPMMAETQ HFFLGLNIRL YAGYGLSETS GPHFMSSPYN YRLYSSGKLV
510 520 530 540 550
PGCRVKLVNQ DAEGIGEICL WGRTIFMGYL NMEDKTCEAI DEEGWLHTGD
560 570 580 590 600
AGRLDADGFL YITGRLKELI ITAGGENVPP VPIEEAVKME LPIISNAMLI
610 620 630 640 650
GDQRKFLSML LTLKCTLDPD TSDQTDNLTE QAMEFCQRVG SRATTVSEII
660 670 680 690 700
EKKDEAVYQA IEEGIRRVNM NAAARPYHIQ KWAILERDFS ISGGELGPTM
710 720
KLKRLTVLEK YKGIIDSFYQ EQKM
Length:724
Mass (Da):81,290
Last modified:May 18, 2010 - v2
Checksum:i2C27BA65CE95CE17
GO

Sequence cautioni

The sequence BAA31606 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038314194E → V.Corresponds to variant rs12899901dbSNPEnsembl.1
Natural variantiVAR_038315633M → V.4 PublicationsCorresponds to variant rs2304824dbSNPEnsembl.1
Natural variantiVAR_038316673A → V.1 PublicationCorresponds to variant rs11072735dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179481 mRNA. Translation: AAG09404.1.
AB014531 mRNA. Translation: BAA31606.2. Different initiation.
AK314508 mRNA. Translation: BAG37108.1.
AC090260 Genomic DNA. No translation available.
AC090607 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99180.1.
BC009289 mRNA. Translation: AAH09289.1.
CCDSiCCDS10298.1.
RefSeqiNP_001186306.1. NM_001199377.1.
NP_055977.3. NM_015162.4.
UniGeneiHs.655760.

Genome annotation databases

EnsembliENST00000258873; ENSP00000258873; ENSG00000103740.
GeneIDi23205.
KEGGihsa:23205.
UCSCiuc002bdh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179481 mRNA. Translation: AAG09404.1.
AB014531 mRNA. Translation: BAA31606.2. Different initiation.
AK314508 mRNA. Translation: BAG37108.1.
AC090260 Genomic DNA. No translation available.
AC090607 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99180.1.
BC009289 mRNA. Translation: AAH09289.1.
CCDSiCCDS10298.1.
RefSeqiNP_001186306.1. NM_001199377.1.
NP_055977.3. NM_015162.4.
UniGeneiHs.655760.

3D structure databases

ProteinModelPortaliQ96GR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116813. 2 interactors.
IntActiQ96GR2. 1 interactor.
MINTiMINT-8247478.
STRINGi9606.ENSP00000258873.

Chemistry databases

SwissLipidsiSLP:000000450.

PTM databases

iPTMnetiQ96GR2.
PhosphoSitePlusiQ96GR2.

Polymorphism and mutation databases

BioMutaiACSBG1.
DMDMi296434385.

Proteomic databases

PaxDbiQ96GR2.
PeptideAtlasiQ96GR2.
PRIDEiQ96GR2.

Protocols and materials databases

DNASUi23205.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258873; ENSP00000258873; ENSG00000103740.
GeneIDi23205.
KEGGihsa:23205.
UCSCiuc002bdh.4. human.

Organism-specific databases

CTDi23205.
DisGeNETi23205.
GeneCardsiACSBG1.
HGNCiHGNC:29567. ACSBG1.
HPAiCAB045955.
HPA041642.
MIMi614362. gene.
neXtProtiNX_Q96GR2.
OpenTargetsiENSG00000103740.
PharmGKBiPA142672648.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1256. Eukaryota.
COG1022. LUCA.
GeneTreeiENSGT00690000101725.
HOGENOMiHOG000230004.
HOVERGENiHBG054660.
InParanoidiQ96GR2.
KOiK15013.
OMAiTQQPNQC.
OrthoDBiEOG091G03FO.
PhylomeDBiQ96GR2.
TreeFamiTF354286.

Enzyme and pathway databases

BioCyciMetaCyc:HS02532-MONOMER.
ZFISH:HS02532-MONOMER.
ReactomeiR-HSA-75876. Synthesis of very long-chain fatty acyl-CoAs.

Miscellaneous databases

ChiTaRSiACSBG1. human.
GeneWikiiACSBG1.
GenomeRNAii23205.
PROiQ96GR2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103740.
CleanExiHS_ACSBG1.
ExpressionAtlasiQ96GR2. baseline and differential.
GenevisibleiQ96GR2. HS.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACBG1_HUMAN
AccessioniPrimary (citable) accession number: Q96GR2
Secondary accession number(s): B2RB61
, O75126, Q76N27, Q9HC26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.