Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable ATP-dependent RNA helicase DDX27

Gene

DDX27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable ATP-dependent RNA helicase.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi262 – 2698ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX27 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 27
Gene namesi
Name:DDX27
Synonyms:RHLP
ORF Names:HSPC259, PP3241
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15837. DDX27.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 796796Probable ATP-dependent RNA helicase DDX27PRO_0000055031Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei56 – 561PhosphoserineBy similarity
Modified residuei79 – 791Phosphoserine2 Publications
Modified residuei166 – 1661Phosphoserine1 Publication
Modified residuei177 – 1771Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96GQ7.
PaxDbiQ96GQ7.
PeptideAtlasiQ96GQ7.
PRIDEiQ96GQ7.

2D gel databases

SWISS-2DPAGEQ96GQ7.

PTM databases

PhosphoSiteiQ96GQ7.

Expressioni

Gene expression databases

BgeeiQ96GQ7.
CleanExiHS_DDX27.
ExpressionAtlasiQ96GQ7. baseline and differential.
GenevestigatoriQ96GQ7.

Organism-specific databases

HPAiHPA047087.

Interactioni

Protein-protein interaction databases

BioGridi120793. 26 interactions.
IntActiQ96GQ7. 6 interactions.
MINTiMINT-1420816.

Structurei

3D structure databases

ProteinModelPortaliQ96GQ7.
SMRiQ96GQ7. Positions 218-622.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini249 – 423175Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini457 – 603147Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi195 – 2006Nuclear localization signalSequence Analysis
Motifi218 – 24629Q motifAdd
BLAST
Motifi371 – 3744DEAD box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 200157Asp/Glu/Lys-richAdd
BLAST

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0513.
GeneTreeiENSGT00550000074997.
HOVERGENiHBG106162.
InParanoidiQ96GQ7.
KOiK13181.
OMAiQFCNITT.
OrthoDBiEOG7G1V5Q.
PhylomeDBiQ96GQ7.
TreeFamiTF314780.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96GQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLAQRRRGG CEKLRAGPQA VLASGSGFCD NMLADLGLIG TIGEDDEVPV
60 70 80 90 100
EPESDSGDEE EEGPIVLGRR QKALGKNRSA DFNPDFVFTE KEGTYDGSWA
110 120 130 140 150
LADVMSQLKK KRAATTLDEK IEKVRKKRKT EDKEAKSGKL EKEKEAKEGS
160 170 180 190 200
EPKEQEDLQE NDEEGSEDEA SETDYSSADE NILTKADTLK VKDRKKKKKK
210 220 230 240 250
GQEAGGFFED ASQYDENLSF QDMNLSRPLL KAITAMGFKQ PTPIQKACIP
260 270 280 290 300
VGLLGKDICA CAATGTGKTA AFALPVLERL IYKPRQAPVT RVLVLVPTRE
310 320 330 340 350
LGIQVHSVTR QLAQFCNITT CLAVGGLDVK SQEAALRAAP DILIATPGRL
360 370 380 390 400
IDHLHNCPSF HLSSIEVLIL DEADRMLDEY FEEQMKEIIR MCSHHRQTML
410 420 430 440 450
FSATMTDEVK DLASVSLKNP VRIFVNSNTD VAPFLRQEFI RIRPNREGDR
460 470 480 490 500
EAIVAALLTR TFTDHVMLFT QTKKQAHRMH ILLGLMGLQV GELHGNLSQT
510 520 530 540 550
QRLEALRRFK DEQIDILVAT DVAARGLDIE GVKTVINFTM PNTIKHYVHR
560 570 580 590 600
VGRTARAGRA GRSVSLVGED ERKMLKEIVK AAKAPVKARI LPQDVILKFR
610 620 630 640 650
DKIEKMEKDV YAVLQLEAEE KEMQQSEAQI NTAKRLLEKG KEAVVQEPER
660 670 680 690 700
SWFQTKEERK KEKIAKALQE FDLALRGKKK RKKFMKDAKK KGEMTAEERS
710 720 730 740 750
QFEILKAQMF AERLAKRNRR AKRARAMPEE EPVRGPAKKQ KQGKKSVFDE
760 770 780 790
ELTNTSKKAL KQYRAGPSFE ERKQLGLPHQ RRGGNFKSKS RYKRRK
Length:796
Mass (Da):89,835
Last modified:March 28, 2003 - v2
Checksum:i9282C712B8F8B84A
GO

Sequence cautioni

The sequence AAF28937.1 differs from that shown.Sequencing errors.Curated
The sequence AAF28937.1 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence AAG22482.1 differs from that shown. Reason: Frameshift at positions 208, 427, 434 and 532. Curated
The sequence AAH16060.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA91284.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB14343.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti482 – 4821L → F in AAK21271 (Ref. 1) Curated
Sequence conflicti542 – 5421N → S in BAA91284 (PubMed:14702039).Curated
Sequence conflicti548 – 5481V → D in AAK95821 (Ref. 1) Curated
Sequence conflicti548 – 5481V → D in BAB14343 (PubMed:14702039).Curated
Sequence conflicti674 – 6741A → T in AAK21271 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti766 – 7661G → S.2 Publications
Corresponds to variant rs1130146 [ dbSNP | Ensembl ].
VAR_022849

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044431 mRNA. Translation: AAK95821.1.
AF336851 mRNA. Translation: AAK21271.1.
AL049766, AL357560 Genomic DNA. Translation: CAI22427.1.
AL357560, AL049766 Genomic DNA. Translation: CAH70236.1.
BC009304 mRNA. Translation: AAH09304.2.
BC011927 mRNA. Translation: AAH11927.2.
BC016060 mRNA. Translation: AAH16060.2. Different initiation.
BC126287 mRNA. Translation: AAI26288.1.
BC130275 mRNA. Translation: AAI30276.1.
BC144125 mRNA. Translation: AAI44126.1.
AK022979 mRNA. Translation: BAB14343.1. Different initiation.
AK000603 mRNA. Translation: BAA91284.1. Different initiation.
AF193054 mRNA. Translation: AAG22482.1. Frameshift.
AF161377 mRNA. Translation: AAF28937.1. Sequence problems.
CCDSiCCDS13416.1.
RefSeqiNP_060365.7. NM_017895.7.
UniGeneiHs.129261.
Hs.65234.

Genome annotation databases

EnsembliENST00000371764; ENSP00000360828; ENSG00000124228.
ENST00000622530; ENSP00000483495; ENSG00000124228.
GeneIDi55661.
KEGGihsa:55661.
UCSCiuc002xuh.3. human.

Polymorphism databases

DMDMi29427946.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044431 mRNA. Translation: AAK95821.1.
AF336851 mRNA. Translation: AAK21271.1.
AL049766, AL357560 Genomic DNA. Translation: CAI22427.1.
AL357560, AL049766 Genomic DNA. Translation: CAH70236.1.
BC009304 mRNA. Translation: AAH09304.2.
BC011927 mRNA. Translation: AAH11927.2.
BC016060 mRNA. Translation: AAH16060.2. Different initiation.
BC126287 mRNA. Translation: AAI26288.1.
BC130275 mRNA. Translation: AAI30276.1.
BC144125 mRNA. Translation: AAI44126.1.
AK022979 mRNA. Translation: BAB14343.1. Different initiation.
AK000603 mRNA. Translation: BAA91284.1. Different initiation.
AF193054 mRNA. Translation: AAG22482.1. Frameshift.
AF161377 mRNA. Translation: AAF28937.1. Sequence problems.
CCDSiCCDS13416.1.
RefSeqiNP_060365.7. NM_017895.7.
UniGeneiHs.129261.
Hs.65234.

3D structure databases

ProteinModelPortaliQ96GQ7.
SMRiQ96GQ7. Positions 218-622.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120793. 26 interactions.
IntActiQ96GQ7. 6 interactions.
MINTiMINT-1420816.

PTM databases

PhosphoSiteiQ96GQ7.

Polymorphism databases

DMDMi29427946.

2D gel databases

SWISS-2DPAGEQ96GQ7.

Proteomic databases

MaxQBiQ96GQ7.
PaxDbiQ96GQ7.
PeptideAtlasiQ96GQ7.
PRIDEiQ96GQ7.

Protocols and materials databases

DNASUi55661.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371764; ENSP00000360828; ENSG00000124228.
ENST00000622530; ENSP00000483495; ENSG00000124228.
GeneIDi55661.
KEGGihsa:55661.
UCSCiuc002xuh.3. human.

Organism-specific databases

CTDi55661.
GeneCardsiGC20P047835.
HGNCiHGNC:15837. DDX27.
HPAiHPA047087.
neXtProtiNX_Q96GQ7.
PharmGKBiPA27213.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0513.
GeneTreeiENSGT00550000074997.
HOVERGENiHBG106162.
InParanoidiQ96GQ7.
KOiK13181.
OMAiQFCNITT.
OrthoDBiEOG7G1V5Q.
PhylomeDBiQ96GQ7.
TreeFamiTF314780.

Miscellaneous databases

ChiTaRSiDDX27. human.
GeneWikiiDDX27.
GenomeRNAii55661.
NextBioi60399.
PROiQ96GQ7.

Gene expression databases

BgeeiQ96GQ7.
CleanExiHS_DDX27.
ExpressionAtlasiQ96GQ7. baseline and differential.
GenevestigatoriQ96GQ7.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Wang Y., Fan Y.-Z., Han W.-L., Yang T., Gao Y., Ma D.-L.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-766.
    Tissue: Brain, Muscle and Skin.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-796, VARIANT SER-766.
    Tissue: Stomach cancer and Teratocarcinoma.
  5. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-688.
  6. "Human partial CDS from CD34+ stem cells."
    Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 600-796.
    Tissue: Umbilical cord blood.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79; SER-166 AND SER-177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiDDX27_HUMAN
AccessioniPrimary (citable) accession number: Q96GQ7
Secondary accession number(s): A0AVB6
, B7ZLY1, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 28, 2003
Last modified: April 1, 2015
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-32 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.