ID RUSF1_HUMAN Reviewed; 468 AA. AC Q96GQ5; Q53GL8; Q8NAJ4; Q9BVY3; Q9H887; DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot. DT 03-APR-2007, sequence version 2. DT 27-MAR-2024, entry version 146. DE RecName: Full=RUS family member 1 {ECO:0000305}; GN Name=RUSF1 {ECO:0000312|HGNC:HGNC:25848}; Synonyms=C16orf58; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Prostate, and Thyroid; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Kidney; RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., RA Tanaka A., Yokoyama S.; RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT CYS-185. RC TISSUE=Placenta, and Uterus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY RP [LARGE SCALE ANALYSIS]. RX PubMed=22814378; DOI=10.1073/pnas.1210303109; RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.; RT "N-terminal acetylome analyses and functional insights of the N-terminal RT acetyltransferase NatB."; RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-49, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [7] RP VARIANT [LARGE SCALE ANALYSIS] GLU-43. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., RA Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal cancers."; RL Science 314:268-274(2006). CC -!- INTERACTION: CC Q96GQ5; Q13520: AQP6; NbExp=3; IntAct=EBI-8636004, EBI-13059134; CC Q96GQ5; Q8N6S5: ARL6IP6; NbExp=3; IntAct=EBI-8636004, EBI-2808844; CC Q96GQ5; P23560-2: BDNF; NbExp=3; IntAct=EBI-8636004, EBI-12275524; CC Q96GQ5; Q13323: BIK; NbExp=3; IntAct=EBI-8636004, EBI-700794; CC Q96GQ5; Q6UWT4: C5orf46; NbExp=3; IntAct=EBI-8636004, EBI-11986083; CC Q96GQ5; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-8636004, EBI-1045797; CC Q96GQ5; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-8636004, EBI-11522780; CC Q96GQ5; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-8636004, EBI-6942903; CC Q96GQ5; Q68CJ9: CREB3L3; NbExp=3; IntAct=EBI-8636004, EBI-852194; CC Q96GQ5; Q6ZPD8: DGAT2L6; NbExp=3; IntAct=EBI-8636004, EBI-12831978; CC Q96GQ5; Q8N5I4: DHRSX; NbExp=3; IntAct=EBI-8636004, EBI-3923585; CC Q96GQ5; Q15125: EBP; NbExp=3; IntAct=EBI-8636004, EBI-3915253; CC Q96GQ5; Q08426: EHHADH; NbExp=3; IntAct=EBI-8636004, EBI-2339219; CC Q96GQ5; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-8636004, EBI-781551; CC Q96GQ5; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-8636004, EBI-18304435; CC Q96GQ5; O15552: FFAR2; NbExp=3; IntAct=EBI-8636004, EBI-2833872; CC Q96GQ5; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-8636004, EBI-3918971; CC Q96GQ5; P48165: GJA8; NbExp=3; IntAct=EBI-8636004, EBI-17458373; CC Q96GQ5; O15529: GPR42; NbExp=3; IntAct=EBI-8636004, EBI-18076404; CC Q96GQ5; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-8636004, EBI-18053395; CC Q96GQ5; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-8636004, EBI-3918847; CC Q96GQ5; O43464: HTRA2; NbExp=3; IntAct=EBI-8636004, EBI-517086; CC Q96GQ5; P42858: HTT; NbExp=3; IntAct=EBI-8636004, EBI-466029; CC Q96GQ5; P15260: IFNGR1; NbExp=4; IntAct=EBI-8636004, EBI-1030755; CC Q96GQ5; Q13651: IL10RA; NbExp=3; IntAct=EBI-8636004, EBI-1031656; CC Q96GQ5; P11215: ITGAM; NbExp=3; IntAct=EBI-8636004, EBI-2568251; CC Q96GQ5; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-8636004, EBI-2820517; CC Q96GQ5; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-8636004, EBI-6163737; CC Q96GQ5; Q96JQ5: MS4A4A; NbExp=3; IntAct=EBI-8636004, EBI-12820341; CC Q96GQ5; Q2M2E3: ODF4; NbExp=3; IntAct=EBI-8636004, EBI-12382569; CC Q96GQ5; Q9BQ51: PDCD1LG2; NbExp=3; IntAct=EBI-8636004, EBI-16427978; CC Q96GQ5; O15173: PGRMC2; NbExp=3; IntAct=EBI-8636004, EBI-1050125; CC Q96GQ5; P41219: PRPH; NbExp=3; IntAct=EBI-8636004, EBI-752074; CC Q96GQ5; P15151: PVR; NbExp=3; IntAct=EBI-8636004, EBI-3919694; CC Q96GQ5; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-8636004, EBI-10192441; CC Q96GQ5; Q99942: RNF5; NbExp=3; IntAct=EBI-8636004, EBI-348482; CC Q96GQ5; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-8636004, EBI-17247926; CC Q96GQ5; Q9BWM7: SFXN3; NbExp=3; IntAct=EBI-8636004, EBI-1171999; CC Q96GQ5; Q14973: SLC10A1; NbExp=3; IntAct=EBI-8636004, EBI-3923031; CC Q96GQ5; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-8636004, EBI-18159983; CC Q96GQ5; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-8636004, EBI-10262251; CC Q96GQ5; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-8636004, EBI-17295964; CC Q96GQ5; Q7Z769: SLC35E3; NbExp=3; IntAct=EBI-8636004, EBI-13389236; CC Q96GQ5; Q9NPE6: SPAG4; NbExp=3; IntAct=EBI-8636004, EBI-10819434; CC Q96GQ5; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-8636004, EBI-17280858; CC Q96GQ5; Q8N6K0: TEX29; NbExp=3; IntAct=EBI-8636004, EBI-19027521; CC Q96GQ5; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-8636004, EBI-10982110; CC Q96GQ5; Q9NWD8: TMEM248; NbExp=3; IntAct=EBI-8636004, EBI-10314986; CC Q96GQ5; Q53FP2: TMEM35A; NbExp=3; IntAct=EBI-8636004, EBI-11722971; CC Q96GQ5; Q9Y320: TMX2; NbExp=3; IntAct=EBI-8636004, EBI-6447886; CC Q96GQ5; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-8636004, EBI-10180829; CC Q96GQ5; O76024: WFS1; NbExp=3; IntAct=EBI-8636004, EBI-720609; CC Q96GQ5; Q6PEW1: ZCCHC12; NbExp=3; IntAct=EBI-8636004, EBI-748373; CC Q96GQ5; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-8636004, EBI-12837904; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane CC protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q96GQ5-1; Sequence=Displayed; CC Name=2; CC IsoId=Q96GQ5-2; Sequence=VSP_024255, VSP_024256; CC -!- SIMILARITY: Belongs to the RUS1 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK023930; BAB14730.1; -; mRNA. DR EMBL; AK092580; BAC03918.1; -; mRNA. DR EMBL; AK222913; BAD96633.1; -; mRNA. DR EMBL; BC000822; AAH00822.1; -; mRNA. DR EMBL; BC009308; AAH09308.1; -; mRNA. DR CCDS; CCDS10715.1; -. [Q96GQ5-1] DR RefSeq; NP_073581.2; NM_022744.3. [Q96GQ5-1] DR AlphaFoldDB; Q96GQ5; -. DR BioGRID; 122269; 236. DR IntAct; Q96GQ5; 87. DR MINT; Q96GQ5; -. DR STRING; 9606.ENSP00000317579; -. DR iPTMnet; Q96GQ5; -. DR PhosphoSitePlus; Q96GQ5; -. DR SwissPalm; Q96GQ5; -. DR BioMuta; C16orf58; -. DR DMDM; 143955305; -. DR EPD; Q96GQ5; -. DR jPOST; Q96GQ5; -. DR MassIVE; Q96GQ5; -. DR MaxQB; Q96GQ5; -. DR PaxDb; 9606-ENSP00000317579; -. DR PeptideAtlas; Q96GQ5; -. DR ProteomicsDB; 76653; -. [Q96GQ5-1] DR ProteomicsDB; 76654; -. [Q96GQ5-2] DR Pumba; Q96GQ5; -. DR Antibodypedia; 14220; 34 antibodies from 16 providers. DR DNASU; 64755; -. DR Ensembl; ENST00000327237.7; ENSP00000317579.2; ENSG00000140688.18. [Q96GQ5-1] DR GeneID; 64755; -. DR KEGG; hsa:64755; -. DR MANE-Select; ENST00000327237.7; ENSP00000317579.2; NM_022744.4; NP_073581.2. DR UCSC; uc002eci.4; human. [Q96GQ5-1] DR AGR; HGNC:25848; -. DR CTD; 64755; -. DR DisGeNET; 64755; -. DR GeneCards; RUSF1; -. DR HGNC; HGNC:25848; RUSF1. DR HPA; ENSG00000140688; Low tissue specificity. DR neXtProt; NX_Q96GQ5; -. DR OpenTargets; ENSG00000140688; -. DR VEuPathDB; HostDB:ENSG00000140688; -. DR eggNOG; KOG4249; Eukaryota. DR GeneTree; ENSGT00390000000050; -. DR InParanoid; Q96GQ5; -. DR OMA; PFQIWDS; -. DR OrthoDB; 1334073at2759; -. DR PhylomeDB; Q96GQ5; -. DR TreeFam; TF326424; -. DR PathwayCommons; Q96GQ5; -. DR SignaLink; Q96GQ5; -. DR BioGRID-ORCS; 64755; 12 hits in 1143 CRISPR screens. DR ChiTaRS; C16orf58; human. DR GeneWiki; C16orf58; -. DR GenomeRNAi; 64755; -. DR Pharos; Q96GQ5; Tdark. DR PRO; PR:Q96GQ5; -. DR Proteomes; UP000005640; Chromosome 16. DR RNAct; Q96GQ5; Protein. DR Bgee; ENSG00000140688; Expressed in adenohypophysis and 182 other cell types or tissues. DR ExpressionAtlas; Q96GQ5; baseline and differential. DR GO; GO:0016020; C:membrane; HDA:UniProtKB. DR InterPro; IPR006968; RUS_fam. DR PANTHER; PTHR12770:SF31; RUS FAMILY MEMBER 1; 1. DR PANTHER; PTHR12770; RUS1 FAMILY PROTEIN C16ORF58; 1. DR Pfam; PF04884; UVB_sens_prot; 1. DR Genevisible; Q96GQ5; HS. PE 1: Evidence at protein level; KW Acetylation; Alternative splicing; Membrane; Phosphoprotein; KW Reference proteome; Transmembrane; Transmembrane helix. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0007744|PubMed:22814378" FT CHAIN 2..468 FT /note="RUS family member 1" FT /id="PRO_0000282930" FT TRANSMEM 247..267 FT /note="Helical" FT /evidence="ECO:0000255" FT MOD_RES 2 FT /note="N-acetylalanine" FT /evidence="ECO:0007744|PubMed:22814378" FT MOD_RES 49 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:23186163" FT VAR_SEQ 1..262 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_024255" FT VAR_SEQ 263..338 FT /note="CFFFLTALHIYANYRAVRALVMETLNEGRLRLVLKHYLQRGEVLDPTAANRM FT EPLWTGFWPAPSLSLGVPLHRLVS -> MCLMGEGRMGRWGSWMTGYRKKGWIWCVWVM FT AEGERKRGDLSEAWIISVHWVAVQWLVGHACLCCPPPPLHCPLPH (in isoform FT 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_024256" FT VARIANT 43 FT /note="G -> E (in a breast cancer sample; somatic FT mutation)" FT /evidence="ECO:0000269|PubMed:16959974" FT /id="VAR_036485" FT VARIANT 185 FT /note="Y -> C (in dbSNP:rs17855405)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_031439" FT CONFLICT 449 FT /note="Q -> R (in Ref. 1; BAC03918)" FT /evidence="ECO:0000305" FT CONFLICT 453 FT /note="D -> G (in Ref. 1; BAB14730)" FT /evidence="ECO:0000305" SQ SEQUENCE 468 AA; 51018 MW; A945866B56ED3B83 CRC64; MADDAGLETP LCSEQFGSGE ARGCRAAADG SLQWEVGGWR WWGLSRAFTV KPEGRDAGEV GASGAPSPPL SGLQAVFLPQ GFPDSVSPDY LPYQLWDSVQ AFASSLSGSL ATQAVLLGIG VGNAKATVSA ATATWLVKDS TGMLGRIVFA WWKGSKLDCN AKQWRLFADI LNDVAMFLEI MAPVYPICFT MTVSTSNLAK CIVSVAGGAT RAALTVHQAR RNNMADVSAK DSSQETLVNL AGLLVSLLML PLVSGCPGFS LGCFFFLTAL HIYANYRAVR ALVMETLNEG RLRLVLKHYL QRGEVLDPTA ANRMEPLWTG FWPAPSLSLG VPLHRLVSSV FELQQLVEGH QESYLLCWDQ SQNQVQVVLN QKAGPKTILR AATHGLMLGA LQGDGPLPAE LEELRNRVRA GPKKESWVVV KETHEVLDML FPKFLKGLQD AGWKTEKHQL EVDEWRATWL LSPEKKVL //