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Q96GQ5

- CP058_HUMAN

UniProt

Q96GQ5 - CP058_HUMAN

Protein

UPF0420 protein C16orf58

Gene

C16orf58

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UPF0420 protein C16orf58
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:25848. C16orf58.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485395.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 468467UPF0420 protein C16orf58PRO_0000282930Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ96GQ5.
    PaxDbiQ96GQ5.
    PeptideAtlasiQ96GQ5.
    PRIDEiQ96GQ5.

    PTM databases

    PhosphoSiteiQ96GQ5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96GQ5.
    BgeeiQ96GQ5.
    CleanExiHS_C16orf58.
    GenevestigatoriQ96GQ5.

    Organism-specific databases

    HPAiHPA024406.

    Interactioni

    Protein-protein interaction databases

    BioGridi122269. 1 interaction.
    IntActiQ96GQ5. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96GQ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei247 – 26721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0420 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG269088.
    HOGENOMiHOG000030128.
    HOVERGENiHBG057219.
    InParanoidiQ96GQ5.
    OMAiGCFFFLT.
    PhylomeDBiQ96GQ5.
    TreeFamiTF326424.

    Family and domain databases

    InterProiIPR006968. RUS2/WXR1.
    [Graphical view]
    PANTHERiPTHR12770. PTHR12770. 1 hit.
    PfamiPF04884. DUF647. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96GQ5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADDAGLETP LCSEQFGSGE ARGCRAAADG SLQWEVGGWR WWGLSRAFTV    50
    KPEGRDAGEV GASGAPSPPL SGLQAVFLPQ GFPDSVSPDY LPYQLWDSVQ 100
    AFASSLSGSL ATQAVLLGIG VGNAKATVSA ATATWLVKDS TGMLGRIVFA 150
    WWKGSKLDCN AKQWRLFADI LNDVAMFLEI MAPVYPICFT MTVSTSNLAK 200
    CIVSVAGGAT RAALTVHQAR RNNMADVSAK DSSQETLVNL AGLLVSLLML 250
    PLVSGCPGFS LGCFFFLTAL HIYANYRAVR ALVMETLNEG RLRLVLKHYL 300
    QRGEVLDPTA ANRMEPLWTG FWPAPSLSLG VPLHRLVSSV FELQQLVEGH 350
    QESYLLCWDQ SQNQVQVVLN QKAGPKTILR AATHGLMLGA LQGDGPLPAE 400
    LEELRNRVRA GPKKESWVVV KETHEVLDML FPKFLKGLQD AGWKTEKHQL 450
    EVDEWRATWL LSPEKKVL 468
    Length:468
    Mass (Da):51,018
    Last modified:April 3, 2007 - v2
    Checksum:iA945866B56ED3B83
    GO
    Isoform 2 (identifier: Q96GQ5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-262: Missing.
         263-338: CFFFLTALHI...LGVPLHRLVS → MCLMGEGRMG...PPPLHCPLPH

    Show »
    Length:206
    Mass (Da):23,594
    Checksum:iFC5C56E239D27651
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti449 – 4491Q → R in BAC03918. (PubMed:14702039)Curated
    Sequence conflicti453 – 4531D → G in BAB14730. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431G → E in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036485
    Natural varianti185 – 1851Y → C.1 Publication
    Corresponds to variant rs17855405 [ dbSNP | Ensembl ].
    VAR_031439

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 262262Missing in isoform 2. 1 PublicationVSP_024255Add
    BLAST
    Alternative sequencei263 – 33876CFFFL…HRLVS → MCLMGEGRMGRWGSWMTGYR KKGWIWCVWVMAEGERKRGD LSEAWIISVHWVAVQWLVGH ACLCCPPPPLHCPLPH in isoform 2. 1 PublicationVSP_024256Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023930 mRNA. Translation: BAB14730.1.
    AK092580 mRNA. Translation: BAC03918.1.
    AK222913 mRNA. Translation: BAD96633.1.
    BC000822 mRNA. Translation: AAH00822.1.
    BC009308 mRNA. Translation: AAH09308.1.
    CCDSiCCDS10715.1. [Q96GQ5-1]
    RefSeqiNP_073581.2. NM_022744.3. [Q96GQ5-1]
    UniGeneiHs.499102.
    Hs.9003.

    Genome annotation databases

    EnsembliENST00000327237; ENSP00000317579; ENSG00000140688. [Q96GQ5-1]
    GeneIDi64755.
    KEGGihsa:64755.
    UCSCiuc002ech.3. human. [Q96GQ5-2]
    uc002eci.3. human. [Q96GQ5-1]

    Polymorphism databases

    DMDMi143955305.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023930 mRNA. Translation: BAB14730.1 .
    AK092580 mRNA. Translation: BAC03918.1 .
    AK222913 mRNA. Translation: BAD96633.1 .
    BC000822 mRNA. Translation: AAH00822.1 .
    BC009308 mRNA. Translation: AAH09308.1 .
    CCDSi CCDS10715.1. [Q96GQ5-1 ]
    RefSeqi NP_073581.2. NM_022744.3. [Q96GQ5-1 ]
    UniGenei Hs.499102.
    Hs.9003.

    3D structure databases

    ProteinModelPortali Q96GQ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122269. 1 interaction.
    IntActi Q96GQ5. 1 interaction.

    PTM databases

    PhosphoSitei Q96GQ5.

    Polymorphism databases

    DMDMi 143955305.

    Proteomic databases

    MaxQBi Q96GQ5.
    PaxDbi Q96GQ5.
    PeptideAtlasi Q96GQ5.
    PRIDEi Q96GQ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000327237 ; ENSP00000317579 ; ENSG00000140688 . [Q96GQ5-1 ]
    GeneIDi 64755.
    KEGGi hsa:64755.
    UCSCi uc002ech.3. human. [Q96GQ5-2 ]
    uc002eci.3. human. [Q96GQ5-1 ]

    Organism-specific databases

    CTDi 64755.
    GeneCardsi GC16M031501.
    H-InvDB HIX0012994.
    HGNCi HGNC:25848. C16orf58.
    HPAi HPA024406.
    neXtProti NX_Q96GQ5.
    PharmGKBi PA143485395.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG269088.
    HOGENOMi HOG000030128.
    HOVERGENi HBG057219.
    InParanoidi Q96GQ5.
    OMAi GCFFFLT.
    PhylomeDBi Q96GQ5.
    TreeFami TF326424.

    Miscellaneous databases

    GeneWikii C16orf58.
    GenomeRNAii 64755.
    NextBioi 66721.

    Gene expression databases

    ArrayExpressi Q96GQ5.
    Bgeei Q96GQ5.
    CleanExi HS_C16orf58.
    Genevestigatori Q96GQ5.

    Family and domain databases

    InterProi IPR006968. RUS2/WXR1.
    [Graphical view ]
    PANTHERi PTHR12770. PTHR12770. 1 hit.
    Pfami PF04884. DUF647. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Prostate and Thyroid.
    2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-185.
      Tissue: Placenta and Uterus.
    4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-43.

    Entry informationi

    Entry nameiCP058_HUMAN
    AccessioniPrimary (citable) accession number: Q96GQ5
    Secondary accession number(s): Q53GL8
    , Q8NAJ4, Q9BVY3, Q9H887
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families
    5. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3