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Q96GQ5 (CP058_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UPF0420 protein C16orf58
Gene names
Name:C16orf58
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the UPF0420 family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96GQ5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96GQ5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-262: Missing.
     263-338: CFFFLTALHI...LGVPLHRLVS → MCLMGEGRMG...PPPLHCPLPH

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 468467UPF0420 protein C16orf58
PRO_0000282930

Regions

Transmembrane247 – 26721Helical; Potential

Amino acid modifications

Modified residue21N-acetylalanine Ref.4

Natural variations

Alternative sequence1 – 262262Missing in isoform 2.
VSP_024255
Alternative sequence263 – 33876CFFFL…HRLVS → MCLMGEGRMGRWGSWMTGYR KKGWIWCVWVMAEGERKRGD LSEAWIISVHWVAVQWLVGH ACLCCPPPPLHCPLPH in isoform 2.
VSP_024256
Natural variant431G → E in a breast cancer sample; somatic mutation. Ref.5
VAR_036485
Natural variant1851Y → C. Ref.3
Corresponds to variant rs17855405 [ dbSNP | Ensembl ].
VAR_031439

Experimental info

Sequence conflict4491Q → R in BAC03918. Ref.1
Sequence conflict4531D → G in BAB14730. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: A945866B56ED3B83

FASTA46851,018
        10         20         30         40         50         60 
MADDAGLETP LCSEQFGSGE ARGCRAAADG SLQWEVGGWR WWGLSRAFTV KPEGRDAGEV 

        70         80         90        100        110        120 
GASGAPSPPL SGLQAVFLPQ GFPDSVSPDY LPYQLWDSVQ AFASSLSGSL ATQAVLLGIG 

       130        140        150        160        170        180 
VGNAKATVSA ATATWLVKDS TGMLGRIVFA WWKGSKLDCN AKQWRLFADI LNDVAMFLEI 

       190        200        210        220        230        240 
MAPVYPICFT MTVSTSNLAK CIVSVAGGAT RAALTVHQAR RNNMADVSAK DSSQETLVNL 

       250        260        270        280        290        300 
AGLLVSLLML PLVSGCPGFS LGCFFFLTAL HIYANYRAVR ALVMETLNEG RLRLVLKHYL 

       310        320        330        340        350        360 
QRGEVLDPTA ANRMEPLWTG FWPAPSLSLG VPLHRLVSSV FELQQLVEGH QESYLLCWDQ 

       370        380        390        400        410        420 
SQNQVQVVLN QKAGPKTILR AATHGLMLGA LQGDGPLPAE LEELRNRVRA GPKKESWVVV 

       430        440        450        460 
KETHEVLDML FPKFLKGLQD AGWKTEKHQL EVDEWRATWL LSPEKKVL 

« Hide

Isoform 2 [UniParc].

Checksum: FC5C56E239D27651
Show »

FASTA20623,594

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Prostate and Thyroid.
[2]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-185.
Tissue: Placenta and Uterus.
[4]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-43.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK023930 mRNA. Translation: BAB14730.1.
AK092580 mRNA. Translation: BAC03918.1.
AK222913 mRNA. Translation: BAD96633.1.
BC000822 mRNA. Translation: AAH00822.1.
BC009308 mRNA. Translation: AAH09308.1.
RefSeqNP_073581.2. NM_022744.3.
UniGeneHs.499102.
Hs.9003.

3D structure databases

ProteinModelPortalQ96GQ5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122269. 1 interaction.
IntActQ96GQ5. 1 interaction.

PTM databases

PhosphoSiteQ96GQ5.

Polymorphism databases

DMDM143955305.

Proteomic databases

PaxDbQ96GQ5.
PeptideAtlasQ96GQ5.
PRIDEQ96GQ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000327237; ENSP00000317579; ENSG00000140688. [Q96GQ5-1]
GeneID64755.
KEGGhsa:64755.
UCSCuc002ech.3. human. [Q96GQ5-2]
uc002eci.3. human. [Q96GQ5-1]

Organism-specific databases

CTD64755.
GeneCardsGC16M031501.
H-InvDBHIX0012994.
HGNCHGNC:25848. C16orf58.
HPAHPA024406.
neXtProtNX_Q96GQ5.
PharmGKBPA143485395.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG269088.
HOGENOMHOG000030128.
HOVERGENHBG057219.
InParanoidQ96GQ5.
OMAGCFFFLT.
PhylomeDBQ96GQ5.
TreeFamTF326424.

Gene expression databases

ArrayExpressQ96GQ5.
BgeeQ96GQ5.
CleanExHS_C16orf58.
GenevestigatorQ96GQ5.

Family and domain databases

InterProIPR006968. RUS2/WXR1.
[Graphical view]
PANTHERPTHR12770. PTHR12770. 1 hit.
PfamPF04884. DUF647. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiC16orf58.
GenomeRNAi64755.
NextBio66721.

Entry information

Entry nameCP058_HUMAN
AccessionPrimary (citable) accession number: Q96GQ5
Secondary accession number(s): Q53GL8 expand/collapse secondary AC list , Q8NAJ4, Q9BVY3, Q9H887
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: March 19, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM