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Protein

RUS1 family protein C16orf58

Gene

C16orf58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RUS1 family protein C16orf58
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25848. C16orf58.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64755.
OpenTargetsiENSG00000140688.
PharmGKBiPA143485395.

Polymorphism and mutation databases

DMDMi143955305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002829302 – 468RUS1 family protein C16orf58Add BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei49PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96GQ5.
MaxQBiQ96GQ5.
PaxDbiQ96GQ5.
PeptideAtlasiQ96GQ5.
PRIDEiQ96GQ5.

PTM databases

iPTMnetiQ96GQ5.
PhosphoSitePlusiQ96GQ5.
SwissPalmiQ96GQ5.

Expressioni

Gene expression databases

BgeeiENSG00000140688.
CleanExiHS_C16orf58.
ExpressionAtlasiQ96GQ5. baseline and differential.
GenevisibleiQ96GQ5. HS.

Organism-specific databases

HPAiHPA024406.

Interactioni

Protein-protein interaction databases

BioGridi122269. 40 interactors.
IntActiQ96GQ5. 8 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ96GQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RUS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4249. Eukaryota.
ENOG410XU74. LUCA.
GeneTreeiENSGT00390000000050.
HOGENOMiHOG000030128.
HOVERGENiHBG057219.
InParanoidiQ96GQ5.
OMAiHQEPYLL.
OrthoDBiEOG091G0BBO.
PhylomeDBiQ96GQ5.
TreeFamiTF326424.

Family and domain databases

InterProiView protein in InterPro
IPR006968. RUS_fam.
PANTHERiPTHR12770. PTHR12770. 1 hit.
PfamiView protein in Pfam
PF04884. DUF647. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96GQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADDAGLETP LCSEQFGSGE ARGCRAAADG SLQWEVGGWR WWGLSRAFTV
60 70 80 90 100
KPEGRDAGEV GASGAPSPPL SGLQAVFLPQ GFPDSVSPDY LPYQLWDSVQ
110 120 130 140 150
AFASSLSGSL ATQAVLLGIG VGNAKATVSA ATATWLVKDS TGMLGRIVFA
160 170 180 190 200
WWKGSKLDCN AKQWRLFADI LNDVAMFLEI MAPVYPICFT MTVSTSNLAK
210 220 230 240 250
CIVSVAGGAT RAALTVHQAR RNNMADVSAK DSSQETLVNL AGLLVSLLML
260 270 280 290 300
PLVSGCPGFS LGCFFFLTAL HIYANYRAVR ALVMETLNEG RLRLVLKHYL
310 320 330 340 350
QRGEVLDPTA ANRMEPLWTG FWPAPSLSLG VPLHRLVSSV FELQQLVEGH
360 370 380 390 400
QESYLLCWDQ SQNQVQVVLN QKAGPKTILR AATHGLMLGA LQGDGPLPAE
410 420 430 440 450
LEELRNRVRA GPKKESWVVV KETHEVLDML FPKFLKGLQD AGWKTEKHQL
460
EVDEWRATWL LSPEKKVL
Length:468
Mass (Da):51,018
Last modified:April 3, 2007 - v2
Checksum:iA945866B56ED3B83
GO
Isoform 2 (identifier: Q96GQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-262: Missing.
     263-338: CFFFLTALHI...LGVPLHRLVS → MCLMGEGRMG...PPPLHCPLPH

Show »
Length:206
Mass (Da):23,594
Checksum:iFC5C56E239D27651
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti449Q → R in BAC03918 (PubMed:14702039).Curated1
Sequence conflicti453D → G in BAB14730 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03648543G → E in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_031439185Y → C1 PublicationCorresponds to variant dbSNP:rs17855405Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0242551 – 262Missing in isoform 2. 1 PublicationAdd BLAST262
Alternative sequenceiVSP_024256263 – 338CFFFL…HRLVS → MCLMGEGRMGRWGSWMTGYR KKGWIWCVWVMAEGERKRGD LSEAWIISVHWVAVQWLVGH ACLCCPPPPLHCPLPH in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023930 mRNA. Translation: BAB14730.1.
AK092580 mRNA. Translation: BAC03918.1.
AK222913 mRNA. Translation: BAD96633.1.
BC000822 mRNA. Translation: AAH00822.1.
BC009308 mRNA. Translation: AAH09308.1.
CCDSiCCDS10715.1. [Q96GQ5-1]
RefSeqiNP_073581.2. NM_022744.3. [Q96GQ5-1]
UniGeneiHs.499102.
Hs.9003.

Genome annotation databases

EnsembliENST00000327237; ENSP00000317579; ENSG00000140688. [Q96GQ5-1]
ENST00000430477; ENSP00000398074; ENSG00000140688. [Q96GQ5-1]
GeneIDi64755.
KEGGihsa:64755.
UCSCiuc002eci.4. human. [Q96GQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRUS1_HUMAN
AccessioniPrimary (citable) accession number: Q96GQ5
Secondary accession number(s): Q53GL8
, Q8NAJ4, Q9BVY3, Q9H887
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: August 30, 2017
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families