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Q96GQ5

- RUS1_HUMAN

UniProt

Q96GQ5 - RUS1_HUMAN

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Protein

RUS1 family protein C16orf58

Gene

C16orf58

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RUS1 family protein C16orf58
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:25848. C16orf58.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei247 – 26721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485395.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 468467RUS1 family protein C16orf58PRO_0000282930Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96GQ5.
PaxDbiQ96GQ5.
PeptideAtlasiQ96GQ5.
PRIDEiQ96GQ5.

PTM databases

PhosphoSiteiQ96GQ5.

Expressioni

Gene expression databases

BgeeiQ96GQ5.
CleanExiHS_C16orf58.
ExpressionAtlasiQ96GQ5. baseline and differential.
GenevestigatoriQ96GQ5.

Organism-specific databases

HPAiHPA024406.

Interactioni

Protein-protein interaction databases

BioGridi122269. 4 interactions.
IntActiQ96GQ5. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96GQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RUS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG269088.
GeneTreeiENSGT00390000000050.
HOGENOMiHOG000030128.
HOVERGENiHBG057219.
InParanoidiQ96GQ5.
OMAiGCFFFLT.
PhylomeDBiQ96GQ5.
TreeFamiTF326424.

Family and domain databases

InterProiIPR006968. RUS2/WXR1.
[Graphical view]
PANTHERiPTHR12770. PTHR12770. 1 hit.
PfamiPF04884. DUF647. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96GQ5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADDAGLETP LCSEQFGSGE ARGCRAAADG SLQWEVGGWR WWGLSRAFTV
60 70 80 90 100
KPEGRDAGEV GASGAPSPPL SGLQAVFLPQ GFPDSVSPDY LPYQLWDSVQ
110 120 130 140 150
AFASSLSGSL ATQAVLLGIG VGNAKATVSA ATATWLVKDS TGMLGRIVFA
160 170 180 190 200
WWKGSKLDCN AKQWRLFADI LNDVAMFLEI MAPVYPICFT MTVSTSNLAK
210 220 230 240 250
CIVSVAGGAT RAALTVHQAR RNNMADVSAK DSSQETLVNL AGLLVSLLML
260 270 280 290 300
PLVSGCPGFS LGCFFFLTAL HIYANYRAVR ALVMETLNEG RLRLVLKHYL
310 320 330 340 350
QRGEVLDPTA ANRMEPLWTG FWPAPSLSLG VPLHRLVSSV FELQQLVEGH
360 370 380 390 400
QESYLLCWDQ SQNQVQVVLN QKAGPKTILR AATHGLMLGA LQGDGPLPAE
410 420 430 440 450
LEELRNRVRA GPKKESWVVV KETHEVLDML FPKFLKGLQD AGWKTEKHQL
460
EVDEWRATWL LSPEKKVL
Length:468
Mass (Da):51,018
Last modified:April 3, 2007 - v2
Checksum:iA945866B56ED3B83
GO
Isoform 2 (identifier: Q96GQ5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-262: Missing.
     263-338: CFFFLTALHI...LGVPLHRLVS → MCLMGEGRMG...PPPLHCPLPH

Show »
Length:206
Mass (Da):23,594
Checksum:iFC5C56E239D27651
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti449 – 4491Q → R in BAC03918. (PubMed:14702039)Curated
Sequence conflicti453 – 4531D → G in BAB14730. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431G → E in a breast cancer sample; somatic mutation. 1 Publication
VAR_036485
Natural varianti185 – 1851Y → C.1 Publication
Corresponds to variant rs17855405 [ dbSNP | Ensembl ].
VAR_031439

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 262262Missing in isoform 2. 1 PublicationVSP_024255Add
BLAST
Alternative sequencei263 – 33876CFFFL…HRLVS → MCLMGEGRMGRWGSWMTGYR KKGWIWCVWVMAEGERKRGD LSEAWIISVHWVAVQWLVGH ACLCCPPPPLHCPLPH in isoform 2. 1 PublicationVSP_024256Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023930 mRNA. Translation: BAB14730.1.
AK092580 mRNA. Translation: BAC03918.1.
AK222913 mRNA. Translation: BAD96633.1.
BC000822 mRNA. Translation: AAH00822.1.
BC009308 mRNA. Translation: AAH09308.1.
CCDSiCCDS10715.1. [Q96GQ5-1]
RefSeqiNP_073581.2. NM_022744.3. [Q96GQ5-1]
UniGeneiHs.499102.
Hs.9003.

Genome annotation databases

EnsembliENST00000327237; ENSP00000317579; ENSG00000140688. [Q96GQ5-1]
ENST00000430477; ENSP00000398074; ENSG00000140688. [Q96GQ5-1]
GeneIDi64755.
KEGGihsa:64755.
UCSCiuc002ech.3. human. [Q96GQ5-2]
uc002eci.3. human. [Q96GQ5-1]

Polymorphism databases

DMDMi143955305.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023930 mRNA. Translation: BAB14730.1 .
AK092580 mRNA. Translation: BAC03918.1 .
AK222913 mRNA. Translation: BAD96633.1 .
BC000822 mRNA. Translation: AAH00822.1 .
BC009308 mRNA. Translation: AAH09308.1 .
CCDSi CCDS10715.1. [Q96GQ5-1 ]
RefSeqi NP_073581.2. NM_022744.3. [Q96GQ5-1 ]
UniGenei Hs.499102.
Hs.9003.

3D structure databases

ProteinModelPortali Q96GQ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122269. 4 interactions.
IntActi Q96GQ5. 1 interaction.

PTM databases

PhosphoSitei Q96GQ5.

Polymorphism databases

DMDMi 143955305.

Proteomic databases

MaxQBi Q96GQ5.
PaxDbi Q96GQ5.
PeptideAtlasi Q96GQ5.
PRIDEi Q96GQ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327237 ; ENSP00000317579 ; ENSG00000140688 . [Q96GQ5-1 ]
ENST00000430477 ; ENSP00000398074 ; ENSG00000140688 . [Q96GQ5-1 ]
GeneIDi 64755.
KEGGi hsa:64755.
UCSCi uc002ech.3. human. [Q96GQ5-2 ]
uc002eci.3. human. [Q96GQ5-1 ]

Organism-specific databases

CTDi 64755.
GeneCardsi GC16M031501.
H-InvDB HIX0012994.
HGNCi HGNC:25848. C16orf58.
HPAi HPA024406.
neXtProti NX_Q96GQ5.
PharmGKBi PA143485395.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG269088.
GeneTreei ENSGT00390000000050.
HOGENOMi HOG000030128.
HOVERGENi HBG057219.
InParanoidi Q96GQ5.
OMAi GCFFFLT.
PhylomeDBi Q96GQ5.
TreeFami TF326424.

Miscellaneous databases

ChiTaRSi C16orf58. human.
GeneWikii C16orf58.
GenomeRNAii 64755.
NextBioi 66721.

Gene expression databases

Bgeei Q96GQ5.
CleanExi HS_C16orf58.
ExpressionAtlasi Q96GQ5. baseline and differential.
Genevestigatori Q96GQ5.

Family and domain databases

InterProi IPR006968. RUS2/WXR1.
[Graphical view ]
PANTHERi PTHR12770. PTHR12770. 1 hit.
Pfami PF04884. DUF647. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Prostate and Thyroid.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-185.
    Tissue: Placenta and Uterus.
  4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-43.

Entry informationi

Entry nameiRUS1_HUMAN
AccessioniPrimary (citable) accession number: Q96GQ5
Secondary accession number(s): Q53GL8
, Q8NAJ4, Q9BVY3, Q9H887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 26, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3