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Protein

Scavenger receptor class F member 2

Gene

SCARF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099910-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Scavenger receptor class F member 2
Alternative name(s):
SRECRP-1
Scavenger receptor expressed by endothelial cells 2 protein
Short name:
SREC-II
Gene namesi
Name:SCARF2
Synonyms:SREC2, SREPCR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:19869. SCARF2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini44 – 441ExtracellularSequence analysisAdd BLAST398
Transmembranei442 – 462HelicalSequence analysisAdd BLAST21
Topological domaini463 – 870CytoplasmicSequence analysisAdd BLAST408

GO - Cellular componenti

  • focal adhesion Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Van den Ende-Gupta syndrome (VDEGS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by craniofacial and skeletal abnormalities that include blepharophimosis, a flat and wide nasal bridge, narrow and beaked nose, hypoplastic maxilla with or without cleft palate and everted lower lip, prominent ears, down-slanting eyes, arachnodactyly, and camptodactyly. Patients present congenital joint contractures that improve without intervention, and normal growth and development. Intelligence is normal. Rarely, enlarged cerebella can be present. Some patients experience respiratory problems due to laryngeal abnormalities.
See also OMIM:600920
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065302258C → Y in VDEGS. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi91179.
MalaCardsiSCARF2.
MIMi600920. phenotype.
Orphaneti2460. Van den Ende-Gupta syndrome.
PharmGKBiPA134908523.

Polymorphism and mutation databases

BioMutaiSCARF2.
DMDMi380865486.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 43Sequence analysisAdd BLAST43
ChainiPRO_000000773944 – 870Scavenger receptor class F member 2Add BLAST827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 98PROSITE-ProRule annotation
Glycosylationi83N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi100 ↔ 109PROSITE-ProRule annotation
Disulfide bondi126 ↔ 134PROSITE-ProRule annotation
Disulfide bondi128 ↔ 141PROSITE-ProRule annotation
Disulfide bondi143 ↔ 152PROSITE-ProRule annotation
Disulfide bondi156 ↔ 163PROSITE-ProRule annotation
Disulfide bondi158 ↔ 170PROSITE-ProRule annotation
Disulfide bondi172 ↔ 181PROSITE-ProRule annotation
Disulfide bondi185 ↔ 193PROSITE-ProRule annotation
Disulfide bondi187 ↔ 200PROSITE-ProRule annotation
Disulfide bondi202 ↔ 211PROSITE-ProRule annotation
Disulfide bondi215 ↔ 222PROSITE-ProRule annotation
Disulfide bondi217 ↔ 229PROSITE-ProRule annotation
Disulfide bondi231 ↔ 240PROSITE-ProRule annotation
Disulfide bondi244 ↔ 251PROSITE-ProRule annotation
Disulfide bondi246 ↔ 258PROSITE-ProRule annotation
Disulfide bondi260 ↔ 269PROSITE-ProRule annotation
Glycosylationi310N-linked (GlcNAc...)Sequence analysis1
Glycosylationi365N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi376 ↔ 384PROSITE-ProRule annotation
Disulfide bondi379 ↔ 391PROSITE-ProRule annotation
Disulfide bondi393 ↔ 402PROSITE-ProRule annotation
Glycosylationi403N-linked (GlcNAc...)Sequence analysis1
Modified residuei551PhosphoserineBy similarity1
Modified residuei613PhosphoserineCombined sources1
Modified residuei628PhosphotyrosineBy similarity1
Modified residuei651PhosphoserineCombined sources1
Modified residuei653PhosphoserineCombined sources1
Modified residuei710PhosphoserineBy similarity1
Modified residuei718PhosphoserineCombined sources1
Modified residuei742PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ96GP6.
PeptideAtlasiQ96GP6.
PRIDEiQ96GP6.

PTM databases

iPTMnetiQ96GP6.
PhosphoSitePlusiQ96GP6.
SwissPalmiQ96GP6.

Expressioni

Tissue specificityi

Predominantly expressed in endothelial cells. Expressed in heart, placenta, lung, kidney, spleen, small intestine and ovary.1 Publication

Gene expression databases

BgeeiENSG00000244486.
CleanExiHS_SCARF2.
ExpressionAtlasiQ96GP6. baseline and differential.
GenevisibleiQ96GP6. HS.

Organism-specific databases

HPAiHPA035079.

Interactioni

Subunit structurei

Homophilic and heterophilic interaction via its extracellular domain. Interacts with SCARF1. The heterophilic interaction with SCARF1, which is stronger than the homophilic interaction with itself, is suppressed by the presence of SCARF1 ligand such as Ac-LDL (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-1752088,EBI-389883

Protein-protein interaction databases

BioGridi124803. 4 interactors.
IntActiQ96GP6. 4 interactors.
MINTiMINT-7240909.
STRINGi9606.ENSP00000266214.

Structurei

3D structure databases

ProteinModelPortaliQ96GP6.
SMRiQ96GP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 110EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini122 – 153EGF-like 2PROSITE-ProRule annotationAdd BLAST32
Domaini148 – 182EGF-like 3PROSITE-ProRule annotationAdd BLAST35
Domaini183 – 212EGF-like 4PROSITE-ProRule annotationAdd BLAST30
Domaini213 – 241EGF-like 5PROSITE-ProRule annotationAdd BLAST29
Domaini236 – 270EGF-like 6PROSITE-ProRule annotationAdd BLAST35
Domaini372 – 403EGF-like 7PROSITE-ProRule annotationAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi648 – 847Pro-richAdd BLAST200

Sequence similaritiesi

Contains 7 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
HOGENOMiHOG000015093.
HOVERGENiHBG023166.
InParanoidiQ96GP6.
PhylomeDBiQ96GP6.
TreeFamiTF332598.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR009030. Growth_fac_rcpt_.
IPR002049. Laminin_EGF.
IPR033327. Scarf2.
[Graphical view]
PANTHERiPTHR24043:SF5. PTHR24043:SF5. 1 hit.
SMARTiSM00181. EGF. 7 hits.
SM00180. EGF_Lam. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00022. EGF_1. 7 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96GP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGAGPRGAG PARRRGAGGP PSPLLPSLLL LLLLWMLPDT VAPQELNPRG
60 70 80 90 100
RNVCRAPGSQ VPTCCAGWRQ QGDECGIAVC EGNSTCSENE VCVRPGECRC
110 120 130 140 150
RHGYFGANCD TKCPRQFWGP DCKELCSCHP HGQCEDVTGQ CTCHARRWGA
160 170 180 190 200
RCEHACQCQH GTCHPRSGAC RCEPGWWGAQ CASACYCSAT SRCDPQTGAC
210 220 230 240 250
LCHAGWWGRS CNNQCACNSS PCEQQSGRCQ CRERTFGARC DRYCQCFRGR
260 270 280 290 300
CHPVDGTCAC EPGYRGKYCR EPCPAGFYGL GCRRRCGQCK GQQPCTVAEG
310 320 330 340 350
RCLTCEPGWN GTKCDQPCAT GFYGEGCSHR CPPCRDGHAC NHVTGKCTRC
360 370 380 390 400
NAGWIGDRCE TKCSNGTYGE DCAFVCADCG SGHCDFQSGR CLCSPGVHGP
410 420 430 440 450
HCNVTCPPGL HGADCAQACS CHEDTCDPVT GACHLETNQR KGVMGAGALL
460 470 480 490 500
VLLVCLLLSL LGCCCACRGK DPTRRPRPRR ELSLGRKKAP HRLCGRFSRI
510 520 530 540 550
SMKLPRIPLR RQKLPKVVVA HHDLDNTLNC SFLEPPSGLE QPSPSWSSRA
560 570 580 590 600
SFSSFDTTDE GPVYCVPHEE APAESRDPEV PTVPAEAPAP SPVPLTTPAS
610 620 630 640 650
AEEAIPLPAS SDSERSASSV EGPGGALYAR VARREARPAR ARGEIGGLSL
660 670 680 690 700
SPSPERRKPP PPDPATKPKV SWIHGKHSAA AAGRAPSPPP PGSEAAPSPS
710 720 730 740 750
KRKRTPSDKS AHTVEHGSPR TRDPTPRPPG LPEEATALAA PSPPRARARA
760 770 780 790 800
APRPLGAHGR RRSPAKRAEA ASMLAADVRG KTRSLGRAEV ALGAQGPREK
810 820 830 840 850
PAPPQKAKRS VPPASPARAP PATETPGPEK AATDLPAPET PRKKTPIQKP
860 870
PRKKSREAAG ELGRAGAPTL
Length:870
Mass (Da):92,479
Last modified:March 21, 2012 - v4
Checksum:iDCB735A50E6E9D1F
GO
Isoform 2 (identifier: Q96GP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     474-478: Missing.

Show »
Length:865
Mass (Da):91,816
Checksum:i93B4D1E48CF6B771
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti629 – 641ARVAR…RPARA → PTTTWITHSTAAS in AAH00584 (PubMed:15489334).CuratedAdd BLAST13
Sequence conflicti750 – 768AAPRP…PAKRA → GRGPGLLEPTDAGGPPRSAP in BAC53753 (Ref. 1) CuratedAdd BLAST19
Sequence conflicti750 – 768AAPRP…PAKRA → GRGPGLLEPTDAGGPPRSAP in BAD93345 (Ref. 3) CuratedAdd BLAST19
Sequence conflicti750 – 768AAPRP…PAKRA → GRGPGLLEPTDAGGPPRSAP in EAX02965 (PubMed:11181995).CuratedAdd BLAST19
Sequence conflicti750 – 768AAPRP…PAKRA → GRGPGLLEPTDAGGPPRSAP in AAH00584 (PubMed:15489334).CuratedAdd BLAST19
Sequence conflicti750 – 768AAPRP…PAKRA → GRGPGLLEPTDAGGPPRSAP in AAH09326 (PubMed:15489334).CuratedAdd BLAST19

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059274174P → S.1 PublicationCorresponds to variant rs361566dbSNPEnsembl.1
Natural variantiVAR_065302258C → Y in VDEGS. 1 Publication1
Natural variantiVAR_055776425T → S.Corresponds to variant rs2241230dbSNPEnsembl.1
Natural variantiVAR_035837499R → C in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_055777522H → L.Corresponds to variant rs12484828dbSNPEnsembl.1
Natural variantiVAR_015148777D → E.4 PublicationsCorresponds to variant rs759611dbSNPEnsembl.1
Natural variantiVAR_015149778V → L.4 PublicationsCorresponds to variant rs759612dbSNPEnsembl.1
Natural variantiVAR_015150819A → G.Corresponds to variant rs874100dbSNPEnsembl.1
Natural variantiVAR_015151837A → G.Corresponds to variant rs874101dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042462474 – 478Missing in isoform 2. 3 Publications5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052951 mRNA. Translation: BAC53753.1.
AF522196 mRNA. Translation: AAN45861.1.
AB024433 mRNA. Translation: BAD93345.1.
AC007731 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX02965.1.
BC000584 mRNA. Translation: AAH00584.2.
BC009326 mRNA. Translation: AAH09326.2.
RefSeqiNP_699165.3. NM_153334.6.
NP_878315.2. NM_182895.4.
UniGeneiHs.474251.

Genome annotation databases

EnsembliENST00000622235; ENSP00000477564; ENSG00000244486.
GeneIDi91179.
KEGGihsa:91179.
UCSCiuc062bsr.1. human. [Q96GP6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052951 mRNA. Translation: BAC53753.1.
AF522196 mRNA. Translation: AAN45861.1.
AB024433 mRNA. Translation: BAD93345.1.
AC007731 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX02965.1.
BC000584 mRNA. Translation: AAH00584.2.
BC009326 mRNA. Translation: AAH09326.2.
RefSeqiNP_699165.3. NM_153334.6.
NP_878315.2. NM_182895.4.
UniGeneiHs.474251.

3D structure databases

ProteinModelPortaliQ96GP6.
SMRiQ96GP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124803. 4 interactors.
IntActiQ96GP6. 4 interactors.
MINTiMINT-7240909.
STRINGi9606.ENSP00000266214.

PTM databases

iPTMnetiQ96GP6.
PhosphoSitePlusiQ96GP6.
SwissPalmiQ96GP6.

Polymorphism and mutation databases

BioMutaiSCARF2.
DMDMi380865486.

Proteomic databases

PaxDbiQ96GP6.
PeptideAtlasiQ96GP6.
PRIDEiQ96GP6.

Protocols and materials databases

DNASUi91179.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000622235; ENSP00000477564; ENSG00000244486.
GeneIDi91179.
KEGGihsa:91179.
UCSCiuc062bsr.1. human. [Q96GP6-1]

Organism-specific databases

CTDi91179.
DisGeNETi91179.
GeneCardsiSCARF2.
H-InvDBHIX0213276.
HGNCiHGNC:19869. SCARF2.
HPAiHPA035079.
MalaCardsiSCARF2.
MIMi600920. phenotype.
613619. gene.
neXtProtiNX_Q96GP6.
Orphaneti2460. Van den Ende-Gupta syndrome.
PharmGKBiPA134908523.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
HOGENOMiHOG000015093.
HOVERGENiHBG023166.
InParanoidiQ96GP6.
PhylomeDBiQ96GP6.
TreeFamiTF332598.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099910-MONOMER.

Miscellaneous databases

ChiTaRSiSCARF2. human.
GenomeRNAii91179.
PROiQ96GP6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000244486.
CleanExiHS_SCARF2.
ExpressionAtlasiQ96GP6. baseline and differential.
GenevisibleiQ96GP6. HS.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR009030. Growth_fac_rcpt_.
IPR002049. Laminin_EGF.
IPR033327. Scarf2.
[Graphical view]
PANTHERiPTHR24043:SF5. PTHR24043:SF5. 1 hit.
SMARTiSM00181. EGF. 7 hits.
SM00180. EGF_Lam. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00022. EGF_1. 7 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSREC2_HUMAN
AccessioniPrimary (citable) accession number: Q96GP6
Secondary accession number(s): E5RFB8
, Q58A83, Q8IXF3, Q9BW74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 21, 2012
Last modified: November 2, 2016
This is version 138 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The conflict at position 750-768 is due to frameshifts. The frameshifted sequence is found in mouse.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.