Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cell division cycle-associated 7-like protein

Gene

CDCA7L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-associated 7-like protein
Alternative name(s):
Protein JPO2
Transcription factor RAM2
Gene namesi
Name:CDCA7L
Synonyms:HR1, JPO2, R1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:30777. CDCA7L.

Subcellular locationi

  • Cytoplasm
  • Nucleus

  • Note: Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672139.

Polymorphism and mutation databases

BioMutaiCDCA7L.
DMDMi74751890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Cell division cycle-associated 7-like proteinPRO_0000249313Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211PhosphoserineCombined sources
Modified residuei77 – 771PhosphothreonineCombined sources
Modified residuei79 – 791PhosphoserineCombined sources
Modified residuei105 – 1051PhosphoserineCombined sources
Modified residuei108 – 1081PhosphoserineCombined sources
Modified residuei117 – 1171PhosphoserineCombined sources
Modified residuei138 – 1381PhosphoserineCombined sources
Modified residuei139 – 1391PhosphoserineCombined sources
Modified residuei162 – 1621PhosphoserineCombined sources
Modified residuei195 – 1951PhosphoserineBy similarity
Modified residuei197 – 1971PhosphoserineBy similarity
Modified residuei261 – 2611PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96GN5.
MaxQBiQ96GN5.
PaxDbiQ96GN5.
PeptideAtlasiQ96GN5.
PRIDEiQ96GN5.

PTM databases

iPTMnetiQ96GN5.
PhosphoSiteiQ96GN5.

Expressioni

Tissue specificityi

Ubiquitous. Overexpressed in medulloblastoma.2 Publications

Inductioni

By MYC overexpression in a concentration dependent manner in neuroblastoma cell line.

Gene expression databases

BgeeiENSG00000164649.
CleanExiHS_CDCA7L.
ExpressionAtlasiQ96GN5. baseline and differential.
GenevisibleiQ96GN5. HS.

Organism-specific databases

HPAiHPA027169.

Interactioni

Subunit structurei

Interacts with MYC and PSIP1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ABT1Q9ULW33EBI-5278764,EBI-2602396
BEND7Q8N7W2-23EBI-5278764,EBI-10181188
BYSLQ138955EBI-5278764,EBI-358049
CARD9Q9H2573EBI-5278764,EBI-751319
CEP70Q8NHQ13EBI-5278764,EBI-739624
CTNNBL1Q8WYA63EBI-5278764,EBI-748128
DAXXQ9UER73EBI-5278764,EBI-77321
EIF4A3P389193EBI-5278764,EBI-299104
FAM9BQ8IZU03EBI-5278764,EBI-10175124
ING5Q8WYH83EBI-5278764,EBI-488533
KRTAP10-7P604093EBI-5278764,EBI-10172290
LMO1P258003EBI-5278764,EBI-8639312
MDFIQ997503EBI-5278764,EBI-724076
MFAP1P550813EBI-5278764,EBI-1048159
MORN3Q6PF183EBI-5278764,EBI-9675802
NOP2P460873EBI-5278764,EBI-356811
PPP1R16BQ96T493EBI-5278764,EBI-10293968
PRDM14Q9GZV83EBI-5278764,EBI-3957793
PRPF31F1T0A53EBI-5278764,EBI-10177194
SSX2IPQ9Y2D83EBI-5278764,EBI-2212028
STX11O755583EBI-5278764,EBI-714135
TADA2AO754783EBI-5278764,EBI-742268
TFPTG5E9B53EBI-5278764,EBI-10178002
TRAF3IP3Q9Y2283EBI-5278764,EBI-765817
TRIM42A1L4B63EBI-5278764,EBI-10172216
UBL4AP114413EBI-5278764,EBI-356983
UTP3Q9NQZ23EBI-5278764,EBI-714067
ZDHHC17Q8IUH52EBI-9091443,EBI-524753
ZNF250P15622-33EBI-5278764,EBI-10177272
ZNF821O755413EBI-5278764,EBI-740865

Protein-protein interaction databases

BioGridi120705. 44 interactions.
DIPiDIP-61218N.
IntActiQ96GN5. 37 interactions.
MINTiMINT-8417651.
STRINGi9606.ENSP00000383986.

Structurei

3D structure databases

ProteinModelPortaliQ96GN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 11962PSIP1-bindingAdd
BLAST
Regioni213 – 23523MYC-bindingAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IYXY. Eukaryota.
ENOG410XQV7. LUCA.
GeneTreeiENSGT00390000014657.
HOGENOMiHOG000231812.
HOVERGENiHBG060300.
InParanoidiQ96GN5.
OMAiITRRMNP.
OrthoDBiEOG091G0A11.
PhylomeDBiQ96GN5.
TreeFamiTF101076.

Family and domain databases

InterProiIPR033578. CDCA7L.
IPR018866. Znf-4CXXC_R1.
[Graphical view]
PANTHERiPTHR31169:SF4. PTHR31169:SF4. 1 hit.
PfamiPF10497. zf-4CXXC_R1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96GN5-1) [UniParc]FASTAAdd to basket
Also known as: Variant C

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELATRYQIP KEVADIFNAP SDDEEFVGFR DDVPMETLSS EESCDSFDSL
60 70 80 90 100
ESGKQQDVRF HSKYFTEELR RIFIEDTDSE TEDFAGFTQS DLNGKTNPEV
110 120 130 140 150
MVVESDLSDD GKASLVSEEE EDEEEDKATP RRSRSRRSSI GLRVAFQFPT
160 170 180 190 200
KKLANKPDKN SSSEQLFSSA RLQNEKKTIL ERKKDCRQVI QREDSTSESE
210 220 230 240 250
DDSRDESQES SDALLKRTMN IKENKAMLAQ LLAELNSMPD FFPVRTPTSA
260 270 280 290 300
SRKKTVRRAF SEGQITRRMN PTRSARPPEK FALENFTVSA AKFAEEFYSF
310 320 330 340 350
RRRKTIGGKC REYRRRHRIS SFRPVEDITE EDLENVAITV RDKIYDKVLG
360 370 380 390 400
NTCHQCRQKT IDTKTVCRNQ GCCGVRGQFC GPCLRNRYGE DVRSALLDPD
410 420 430 440 450
WVCPPCRGIC NCSYCRKRDG RCATGILIHL AKFYGYDNVK EYLESLQKEL

VEDN
Length:454
Mass (Da):52,206
Last modified:March 1, 2004 - v2
Checksum:i1FAFEC7DBD763C85
GO
Isoform 2 (identifier: Q96GN5-2) [UniParc]FASTAAdd to basket
Also known as: Variant B

The sequence of this isoform differs from the canonical sequence as follows:
     55-55: Missing.

Show »
Length:453
Mass (Da):52,078
Checksum:i4C7B2BF1134CFB74
GO
Isoform 3 (identifier: Q96GN5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Show »
Length:420
Mass (Da):48,309
Checksum:iD77BFB88C7605E4A
GO
Isoform 4 (identifier: Q96GN5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-101: Missing.

Note: No experimental confirmation available.
Show »
Length:408
Mass (Da):46,779
Checksum:i688FC9D4ED534E39
GO

Sequence cautioni

The sequence BAB14330 differs from that shown. Reason: Frameshift at position 260. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461S → G in BAG62445 (PubMed:14702039).Curated
Sequence conflicti340 – 3401V → A in CAB94887 (PubMed:17974005).Curated
Sequence conflicti345 – 3451Y → C in AAH32576 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti187 – 1871R → S.
Corresponds to variant rs35281045 [ dbSNP | Ensembl ].
VAR_050776

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3434Missing in isoform 3. 1 PublicationVSP_043806Add
BLAST
Alternative sequencei55 – 551Missing in isoform 2. 2 PublicationsVSP_020398
Alternative sequencei56 – 10146Missing in isoform 4. 1 PublicationVSP_046270Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161168 mRNA. Translation: AAO17570.1.
AY161169 mRNA. Translation: AAO17571.1.
AK022955 mRNA. Translation: BAB14330.1. Frameshift.
AK095965 mRNA. Translation: BAG53177.1.
AK300781 mRNA. Translation: BAG62445.1.
AC074379 Genomic DNA. No translation available.
AC099653 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24271.1.
CH471073 Genomic DNA. Translation: EAW93741.1.
CH471073 Genomic DNA. Translation: EAW93743.1.
BC009352 mRNA. Translation: AAH09352.2.
BC014630 mRNA. Translation: AAH14630.2.
BC025242 mRNA. Translation: AAH25242.1.
BC032576 mRNA. Translation: AAH32576.1.
BC039823 mRNA. Translation: AAH39823.1.
AL359619 mRNA. Translation: CAB94887.1.
CCDSiCCDS47558.1. [Q96GN5-5]
CCDS47559.1. [Q96GN5-4]
CCDS5374.1. [Q96GN5-1]
PIRiT50635.
RefSeqiNP_001120842.1. NM_001127370.2. [Q96GN5-4]
NP_001120843.1. NM_001127371.2. [Q96GN5-5]
NP_061189.2. NM_018719.4. [Q96GN5-1]
UniGeneiHs.744069.
Hs.745260.

Genome annotation databases

EnsembliENST00000356195; ENSP00000348523; ENSG00000164649. [Q96GN5-4]
ENST00000373934; ENSP00000363045; ENSG00000164649. [Q96GN5-5]
ENST00000406877; ENSP00000383986; ENSG00000164649. [Q96GN5-1]
GeneIDi55536.
KEGGihsa:55536.
UCSCiuc003sve.5. human. [Q96GN5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161168 mRNA. Translation: AAO17570.1.
AY161169 mRNA. Translation: AAO17571.1.
AK022955 mRNA. Translation: BAB14330.1. Frameshift.
AK095965 mRNA. Translation: BAG53177.1.
AK300781 mRNA. Translation: BAG62445.1.
AC074379 Genomic DNA. No translation available.
AC099653 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24271.1.
CH471073 Genomic DNA. Translation: EAW93741.1.
CH471073 Genomic DNA. Translation: EAW93743.1.
BC009352 mRNA. Translation: AAH09352.2.
BC014630 mRNA. Translation: AAH14630.2.
BC025242 mRNA. Translation: AAH25242.1.
BC032576 mRNA. Translation: AAH32576.1.
BC039823 mRNA. Translation: AAH39823.1.
AL359619 mRNA. Translation: CAB94887.1.
CCDSiCCDS47558.1. [Q96GN5-5]
CCDS47559.1. [Q96GN5-4]
CCDS5374.1. [Q96GN5-1]
PIRiT50635.
RefSeqiNP_001120842.1. NM_001127370.2. [Q96GN5-4]
NP_001120843.1. NM_001127371.2. [Q96GN5-5]
NP_061189.2. NM_018719.4. [Q96GN5-1]
UniGeneiHs.744069.
Hs.745260.

3D structure databases

ProteinModelPortaliQ96GN5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120705. 44 interactions.
DIPiDIP-61218N.
IntActiQ96GN5. 37 interactions.
MINTiMINT-8417651.
STRINGi9606.ENSP00000383986.

PTM databases

iPTMnetiQ96GN5.
PhosphoSiteiQ96GN5.

Polymorphism and mutation databases

BioMutaiCDCA7L.
DMDMi74751890.

Proteomic databases

EPDiQ96GN5.
MaxQBiQ96GN5.
PaxDbiQ96GN5.
PeptideAtlasiQ96GN5.
PRIDEiQ96GN5.

Protocols and materials databases

DNASUi55536.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356195; ENSP00000348523; ENSG00000164649. [Q96GN5-4]
ENST00000373934; ENSP00000363045; ENSG00000164649. [Q96GN5-5]
ENST00000406877; ENSP00000383986; ENSG00000164649. [Q96GN5-1]
GeneIDi55536.
KEGGihsa:55536.
UCSCiuc003sve.5. human. [Q96GN5-1]

Organism-specific databases

CTDi55536.
GeneCardsiCDCA7L.
HGNCiHGNC:30777. CDCA7L.
HPAiHPA027169.
MIMi609685. gene.
neXtProtiNX_Q96GN5.
PharmGKBiPA142672139.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYXY. Eukaryota.
ENOG410XQV7. LUCA.
GeneTreeiENSGT00390000014657.
HOGENOMiHOG000231812.
HOVERGENiHBG060300.
InParanoidiQ96GN5.
OMAiITRRMNP.
OrthoDBiEOG091G0A11.
PhylomeDBiQ96GN5.
TreeFamiTF101076.

Miscellaneous databases

ChiTaRSiCDCA7L. human.
GeneWikiiCDCA7L.
GenomeRNAii55536.
PROiQ96GN5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164649.
CleanExiHS_CDCA7L.
ExpressionAtlasiQ96GN5. baseline and differential.
GenevisibleiQ96GN5. HS.

Family and domain databases

InterProiIPR033578. CDCA7L.
IPR018866. Znf-4CXXC_R1.
[Graphical view]
PANTHERiPTHR31169:SF4. PTHR31169:SF4. 1 hit.
PfamiPF10497. zf-4CXXC_R1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDA7L_HUMAN
AccessioniPrimary (citable) accession number: Q96GN5
Secondary accession number(s): A4D141
, A6NF50, B3KTR5, B4DUT3, C9K0Y1, Q6PIL4, Q86YT0, Q8IXN5, Q96C70, Q9H9A2, Q9NPV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2004
Last modified: September 7, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.