Reviewed, UniProtKB/Swiss-Prot Q96GM1 (LPPR2_HUMAN)

Names and origin

Protein names

Recommended name:
    Lipid phosphate phosphatase-related protein type 2
    EC=3.1.3.4
Alternative name(s):
    Plasticity-related gene 4 protein
      Short name=PRG-4

Gene names

Name:	LPPR2
Synonyms:	PRG4

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96GM1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96GM1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     23-47: Missing.
     317-343: NPRSAGRIRHRHGSPHPSRRTAPAVAT → LSVAQEPEVC...YLFASRDHLL

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Lipid phosphate phosphatase-related protein type 2		PRO_0000317538
Regions
	Transmembrane	12 – 32	21	Potential
	Transmembrane	69 – 89	21	Potential
	Transmembrane	129 – 149	21	Potential
	Transmembrane	210 – 230	21	Potential
	Transmembrane	239 – 259	21	Potential
	Transmembrane	266 – 286	21	Potential
Amino acid modifications
	Glycosylation	165	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	23 – 47	25	Missing in isoform 2.		VSP_031010
	Alternative sequence	317 – 343	27	NPRSA…PAVAT → LSVAQEPEVCRPHSTPARLT PSKSQNCARRGHLIPSCVSS RAPAMCSSPRVPRPRLRSEP TPLPLPLPLPAPTPSQGPSP SSPGPGGPGGGGGRGRKLLL PTPLLRDLYTLSGLYPSPFH RDNFSPYLFASRDHLL in isoform 2.		VSP_031011
	Natural variant	155	1	T → M in a colorectal cancer sample; somatic mutation. Ref.7		VAR_038546
Experimental info
	Sequence conflict	42	1	F → L in BAB14414. Ref.3
	Sequence conflict	259	1	Y → H in BAC04443. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: CB46CE2FA8503E4E	FASTA	343	36,880
	10 20 30 40 50 60 MAGGRPHLKR SFSIIPCFVF VESVLLGIVI LLAYRLEFTD TFPVHTQGFF CYDSTYAKPY 70 80 90 100 110 120 PGPEAASRVP PALVYALVTA GPTLTILLGE LARAFFPAPP SAVPVIGEST IVSGACCRFS 130 140 150 160 170 180 PPVRRLVRFL GVYSFGLFTT TIFANAGQVV TGNPTPHFLS VCRPNYTALG CLPPSPDRPG 190 200 210 220 230 240 PDRFVTDQGA CAGSPSLVAA ARRAFPCKDA ALCAYAVTYT AMYVTLVFRV KGSRLVKPSL 250 260 270 280 290 300 CLALLCPAFL VGVVRVAEYR NHWSDVLAGF LTGAAIATFL VTCVVHNFQS RPPSGRRLSP 310 320 330 340 WEDLGQAPTM DSPLEKNPRS AGRIRHRHGS PHPSRRTAPA VAT
	Isoform 2. Checksum: 3F8A866AD7A572B4	FASTA	427	45,576
	10 20 30 40 50 60 MAGGRPHLKR SFSIIPCFVF VEGFFCYDST YAKPYPGPEA ASRVPPALVY ALVTAGPTLT 70 80 90 100 110 120 ILLGELARAF FPAPPSAVPV IGESTIVSGA CCRFSPPVRR LVRFLGVYSF GLFTTTIFAN 130 140 150 160 170 180 AGQVVTGNPT PHFLSVCRPN YTALGCLPPS PDRPGPDRFV TDQGACAGSP SLVAAARRAF 190 200 210 220 230 240 PCKDAALCAY AVTYTAMYVT LVFRVKGSRL VKPSLCLALL CPAFLVGVVR VAEYRNHWSD 250 260 270 280 290 300 VLAGFLTGAA IATFLVTCVV HNFQSRPPSG RRLSPWEDLG QAPTMDSPLE KLSVAQEPEV 310 320 330 340 350 360 CRPHSTPARL TPSKSQNCAR RGHLIPSCVS SRAPAMCSSP RVPRPRLRSE PTPLPLPLPL 370 380 390 400 410 420 PAPTPSQGPS PSSPGPGGPG GGGGRGRKLL LPTPLLRDLY TLSGLYPSPF HRDNFSPYLF ASRDHLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family." Savaskan N.E., Brauer A.U., Nitsch R. Eur. J. Neurosci. 19:212-220(2004) [PubMed: 14750979] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Lipid phosphate phosphatase related proteins." Morris A.J., Sigal Y.J., McDermott M., Sciorra V.A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Caudate nucleus.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-343 (ISOFORM 2). Tissue: Amygdala.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-155.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY339628 mRNA. Translation: AAQ73540.1. AY304516 mRNA. Translation: AAP72153.1. AK094869 mRNA. Translation: BAC04443.1. AK023117 mRNA. Translation: BAB14414.1. CH471106 Genomic DNA. Translation: EAW84200.1. BC009378 mRNA. Translation: AAH09378.1. CR936652 Transcribed RNA. Translation: CAI56790.1.
IPI	IPI00166272. IPI00396363.
RefSeq	NP_073574.1.
UniGene	Hs.6846
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q96GM1.
Proteomic databases
PRIDE	Q96GM1.
Genome annotation databases
Ensembl	ENST00000251473; ENSP00000251473; ENSG00000105520; Homo sapiens. [Genome view]
GeneID	64748.
KEGG	hsa:64748.
UCSC	uc002mre.1. human. uc002mrf.1. human.
Organism-specific databases
CTD	64748.
GeneCards	GC19P011327.
Phylogenomic databases
eggNOG	prNOG11056.
HOVERGEN	Q96GM1.
InParanoid	Q96GM1.
OMA	MCSSPRV.
OrthoDB	EOG95MQQN.
PhylomeDB	Q96GM1.
Enzyme and pathway databases
BRENDA	3.1.3.4. 247.
Gene expression databases
ArrayExpress	Q96GM1.
Bgee	Q96GM1.
CleanEx	HS_PRG4.
Genevestigator	Q96GM1.
Family and domain databases
InterPro	IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	66705.

Entry information

Entry name

LPPR2_HUMAN

Accession

Primary (citable) accession number: Q96GM1
Secondary accession number(s): Q5CZ76, Q8N1U4, Q9H929

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	December 1, 2001
Last modified:	January 19, 2010
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.