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Q96GM1 (LPPR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid phosphate phosphatase-related protein type 2

EC=3.1.3.4
Alternative name(s):
Plasticity-related gene 4 protein
Short name=PRG-4
Gene names
Name:LPPR2
Synonyms:PRG4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionphosphatidate phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96GM1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96GM1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     23-47: Missing.
     317-343: NPRSAGRIRHRHGSPHPSRRTAPAVAT → LSVAQEPEVC...YLFASRDHLL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Lipid phosphate phosphatase-related protein type 2
PRO_0000317538

Regions

Transmembrane12 – 3221Helical; Potential
Transmembrane69 – 8921Helical; Potential
Transmembrane129 – 14921Helical; Potential
Transmembrane210 – 23021Helical; Potential
Transmembrane239 – 25921Helical; Potential
Transmembrane266 – 28621Helical; Potential

Amino acid modifications

Glycosylation1651N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence23 – 4725Missing in isoform 2.
VSP_031010
Alternative sequence317 – 34327NPRSA…PAVAT → LSVAQEPEVCRPHSTPARLT PSKSQNCARRGHLIPSCVSS RAPAMCSSPRVPRPRLRSEP TPLPLPLPLPAPTPSQGPSP SSPGPGGPGGGGGRGRKLLL PTPLLRDLYTLSGLYPSPFH RDNFSPYLFASRDHLL in isoform 2.
VSP_031011
Natural variant1551T → M in a colorectal cancer sample; somatic mutation. Ref.7
VAR_038546

Experimental info

Sequence conflict421F → L in BAB14414. Ref.3
Sequence conflict2591Y → H in BAC04443. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: CB46CE2FA8503E4E

FASTA34336,880
        10         20         30         40         50         60 
MAGGRPHLKR SFSIIPCFVF VESVLLGIVI LLAYRLEFTD TFPVHTQGFF CYDSTYAKPY 

        70         80         90        100        110        120 
PGPEAASRVP PALVYALVTA GPTLTILLGE LARAFFPAPP SAVPVIGEST IVSGACCRFS 

       130        140        150        160        170        180 
PPVRRLVRFL GVYSFGLFTT TIFANAGQVV TGNPTPHFLS VCRPNYTALG CLPPSPDRPG 

       190        200        210        220        230        240 
PDRFVTDQGA CAGSPSLVAA ARRAFPCKDA ALCAYAVTYT AMYVTLVFRV KGSRLVKPSL 

       250        260        270        280        290        300 
CLALLCPAFL VGVVRVAEYR NHWSDVLAGF LTGAAIATFL VTCVVHNFQS RPPSGRRLSP 

       310        320        330        340 
WEDLGQAPTM DSPLEKNPRS AGRIRHRHGS PHPSRRTAPA VAT 

« Hide

Isoform 2 [UniParc].

Checksum: 3F8A866AD7A572B4
Show »

FASTA42745,576

References

« Hide 'large scale' references
[1]"Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family."
Savaskan N.E., Brauer A.U., Nitsch R.
Eur. J. Neurosci. 19:212-220(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Lipid phosphate phosphatase related proteins."
Morris A.J., Sigal Y.J., McDermott M., Sciorra V.A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Caudate nucleus.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-343 (ISOFORM 2).
Tissue: Amygdala.
[7]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-155.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY339628 mRNA. Translation: AAQ73540.1.
AY304516 mRNA. Translation: AAP72153.1.
AK094869 mRNA. Translation: BAC04443.1.
AK023117 mRNA. Translation: BAB14414.1.
CH471106 Genomic DNA. Translation: EAW84200.1.
BC009378 mRNA. Translation: AAH09378.1.
CR936652 Transcribed RNA. Translation: CAI56790.1.
RefSeqNP_001164106.1. NM_001170635.1.
NP_073574.2. NM_022737.2.
UniGeneHs.6846.

3D structure databases

ProteinModelPortalQ96GM1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122264. 1 interaction.

PTM databases

PhosphoSiteQ96GM1.

Polymorphism databases

DMDM74760839.

Proteomic databases

PaxDbQ96GM1.
PRIDEQ96GM1.

Protocols and materials databases

DNASU64748.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID64748.
KEGGhsa:64748.
UCSCuc002mre.2. human. [Q96GM1-1]
uc002mrf.2. human. [Q96GM1-2]

Organism-specific databases

CTD64748.
GeneCardsGC19P011466.
HPAHPA048973.
neXtProtNX_Q96GM1.

Phylogenomic databases

eggNOGNOG247263.
HOGENOMHOG000286008.
HOVERGENHBG108093.
InParanoidQ96GM1.
OMASKPQNCA.
PhylomeDBQ96GM1.

Enzyme and pathway databases

BRENDA3.1.3.4. 2681.

Gene expression databases

ArrayExpressQ96GM1.
BgeeQ96GM1.
CleanExHS_PRG4.
GenevestigatorQ96GM1.

Family and domain databases

Gene3D1.20.144.10. 1 hit.
InterProIPR028679. LPPR2.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERPTHR10165:SF15. PTHR10165:SF15. 1 hit.
PfamPF01569. PAP2. 1 hit.
[Graphical view]
SMARTSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMSSF48317. SSF48317. 1 hit.
ProtoNetSearch...

Other

ChiTaRSLPPR2. human.
GenomeRNAi64748.
NextBio66705.
PROQ96GM1.

Entry information

Entry nameLPPR2_HUMAN
AccessionPrimary (citable) accession number: Q96GM1
Secondary accession number(s): Q5CZ76, Q8N1U4, Q9H929
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM