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Q96GM1

- LPPR2_HUMAN

UniProt

Q96GM1 - LPPR2_HUMAN

Protein

Lipid phosphate phosphatase-related protein type 2

Gene

LPPR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

    GO - Molecular functioni

    1. phosphatidate phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BRENDAi3.1.3.4. 2681.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid phosphate phosphatase-related protein type 2 (EC:3.1.3.4)
    Alternative name(s):
    Plasticity-related gene 4 protein
    Short name:
    PRG-4
    Gene namesi
    Name:LPPR2
    Synonyms:PRG4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Lipid phosphate phosphatase-related protein type 2PRO_0000317538Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ96GM1.
    PRIDEiQ96GM1.

    PTM databases

    PhosphoSiteiQ96GM1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96GM1.
    BgeeiQ96GM1.
    CleanExiHS_PRG4.
    GenevestigatoriQ96GM1.

    Organism-specific databases

    HPAiHPA048973.

    Interactioni

    Protein-protein interaction databases

    BioGridi122264. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96GM1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei69 – 8921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei210 – 23021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG247263.
    HOGENOMiHOG000286008.
    HOVERGENiHBG108093.
    InParanoidiQ96GM1.
    OMAiSKPQNCA.
    PhylomeDBiQ96GM1.

    Family and domain databases

    Gene3Di1.20.144.10. 1 hit.
    InterProiIPR028679. LPPR2.
    IPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view]
    PANTHERiPTHR10165:SF15. PTHR10165:SF15. 1 hit.
    PfamiPF01569. PAP2. 1 hit.
    [Graphical view]
    SMARTiSM00014. acidPPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48317. SSF48317. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96GM1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGGRPHLKR SFSIIPCFVF VESVLLGIVI LLAYRLEFTD TFPVHTQGFF    50
    CYDSTYAKPY PGPEAASRVP PALVYALVTA GPTLTILLGE LARAFFPAPP 100
    SAVPVIGEST IVSGACCRFS PPVRRLVRFL GVYSFGLFTT TIFANAGQVV 150
    TGNPTPHFLS VCRPNYTALG CLPPSPDRPG PDRFVTDQGA CAGSPSLVAA 200
    ARRAFPCKDA ALCAYAVTYT AMYVTLVFRV KGSRLVKPSL CLALLCPAFL 250
    VGVVRVAEYR NHWSDVLAGF LTGAAIATFL VTCVVHNFQS RPPSGRRLSP 300
    WEDLGQAPTM DSPLEKNPRS AGRIRHRHGS PHPSRRTAPA VAT 343
    Length:343
    Mass (Da):36,880
    Last modified:December 1, 2001 - v1
    Checksum:iCB46CE2FA8503E4E
    GO
    Isoform 2 (identifier: Q96GM1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         23-47: Missing.
         317-343: NPRSAGRIRHRHGSPHPSRRTAPAVAT → LSVAQEPEVC...YLFASRDHLL

    Show »
    Length:427
    Mass (Da):45,576
    Checksum:i3F8A866AD7A572B4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421F → L in BAB14414. (PubMed:14702039)Curated
    Sequence conflicti259 – 2591Y → H in BAC04443. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti155 – 1551T → M in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_038546

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei23 – 4725Missing in isoform 2. 2 PublicationsVSP_031010Add
    BLAST
    Alternative sequencei317 – 34327NPRSA…PAVAT → LSVAQEPEVCRPHSTPARLT PSKSQNCARRGHLIPSCVSS RAPAMCSSPRVPRPRLRSEP TPLPLPLPLPAPTPSQGPSP SSPGPGGPGGGGGRGRKLLL PTPLLRDLYTLSGLYPSPFH RDNFSPYLFASRDHLL in isoform 2. 2 PublicationsVSP_031011Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY339628 mRNA. Translation: AAQ73540.1.
    AY304516 mRNA. Translation: AAP72153.1.
    AK094869 mRNA. Translation: BAC04443.1.
    AK023117 mRNA. Translation: BAB14414.1.
    CH471106 Genomic DNA. Translation: EAW84200.1.
    BC009378 mRNA. Translation: AAH09378.1.
    CR936652 Transcribed RNA. Translation: CAI56790.1.
    CCDSiCCDS12258.1. [Q96GM1-1]
    CCDS59352.1. [Q96GM1-2]
    RefSeqiNP_001164106.1. NM_001170635.1. [Q96GM1-2]
    NP_073574.2. NM_022737.2. [Q96GM1-1]
    UniGeneiHs.6846.

    Genome annotation databases

    GeneIDi64748.
    KEGGihsa:64748.
    UCSCiuc002mre.2. human. [Q96GM1-1]
    uc002mrf.2. human. [Q96GM1-2]

    Polymorphism databases

    DMDMi74760839.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY339628 mRNA. Translation: AAQ73540.1 .
    AY304516 mRNA. Translation: AAP72153.1 .
    AK094869 mRNA. Translation: BAC04443.1 .
    AK023117 mRNA. Translation: BAB14414.1 .
    CH471106 Genomic DNA. Translation: EAW84200.1 .
    BC009378 mRNA. Translation: AAH09378.1 .
    CR936652 Transcribed RNA. Translation: CAI56790.1 .
    CCDSi CCDS12258.1. [Q96GM1-1 ]
    CCDS59352.1. [Q96GM1-2 ]
    RefSeqi NP_001164106.1. NM_001170635.1. [Q96GM1-2 ]
    NP_073574.2. NM_022737.2. [Q96GM1-1 ]
    UniGenei Hs.6846.

    3D structure databases

    ProteinModelPortali Q96GM1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122264. 1 interaction.

    PTM databases

    PhosphoSitei Q96GM1.

    Polymorphism databases

    DMDMi 74760839.

    Proteomic databases

    PaxDbi Q96GM1.
    PRIDEi Q96GM1.

    Protocols and materials databases

    DNASUi 64748.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 64748.
    KEGGi hsa:64748.
    UCSCi uc002mre.2. human. [Q96GM1-1 ]
    uc002mrf.2. human. [Q96GM1-2 ]

    Organism-specific databases

    CTDi 64748.
    GeneCardsi GC19P011466.
    HPAi HPA048973.
    neXtProti NX_Q96GM1.

    Phylogenomic databases

    eggNOGi NOG247263.
    HOGENOMi HOG000286008.
    HOVERGENi HBG108093.
    InParanoidi Q96GM1.
    OMAi SKPQNCA.
    PhylomeDBi Q96GM1.

    Enzyme and pathway databases

    BRENDAi 3.1.3.4. 2681.

    Miscellaneous databases

    ChiTaRSi LPPR2. human.
    GenomeRNAii 64748.
    NextBioi 66705.
    PROi Q96GM1.

    Gene expression databases

    ArrayExpressi Q96GM1.
    Bgeei Q96GM1.
    CleanExi HS_PRG4.
    Genevestigatori Q96GM1.

    Family and domain databases

    Gene3Di 1.20.144.10. 1 hit.
    InterProi IPR028679. LPPR2.
    IPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view ]
    PANTHERi PTHR10165:SF15. PTHR10165:SF15. 1 hit.
    Pfami PF01569. PAP2. 1 hit.
    [Graphical view ]
    SMARTi SM00014. acidPPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48317. SSF48317. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family."
      Savaskan N.E., Brauer A.U., Nitsch R.
      Eur. J. Neurosci. 19:212-220(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Lipid phosphate phosphatase related proteins."
      Morris A.J., Sigal Y.J., McDermott M., Sciorra V.A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Caudate nucleus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-343 (ISOFORM 2).
      Tissue: Amygdala.
    7. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-155.

    Entry informationi

    Entry nameiLPPR2_HUMAN
    AccessioniPrimary (citable) accession number: Q96GM1
    Secondary accession number(s): Q5CZ76, Q8N1U4, Q9H929
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3