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Protein

Phospholipid phosphatase-related protein type 2

Gene

PLPPR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciZFISH:HS12592-MONOMER.
BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 2Curated (EC:3.1.3.4)
Alternative name(s):
Lipid phosphate phosphatase-related protein type 21 Publication
Plasticity-related gene 4 protein1 Publication
Short name:
PRG-41 Publication
Gene namesi
Name:PLPPR2Imported
Synonyms:LPPR21 Publication, PRG4By similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29566. PLPPR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64748.
OpenTargetsiENSG00000105520.

Polymorphism and mutation databases

BioMutaiLPPR2.
DMDMi74760839.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175381 – 343Phospholipid phosphatase-related protein type 2Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi165N-linked (GlcNAc...)Sequence analysis1
Modified residuei299PhosphoserineBy similarity1
Modified residuei312PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ96GM1.
PeptideAtlasiQ96GM1.
PRIDEiQ96GM1.

PTM databases

DEPODiQ96GM1.
iPTMnetiQ96GM1.
PhosphoSitePlusiQ96GM1.

Expressioni

Gene expression databases

BgeeiENSG00000105520.
CleanExiHS_PRG4.
ExpressionAtlasiQ96GM1. baseline and differential.
GenevisibleiQ96GM1. HS.

Organism-specific databases

HPAiHPA048973.

Interactioni

Protein-protein interaction databases

BioGridi122264. 23 interactors.
STRINGi9606.ENSP00000251473.

Structurei

3D structure databases

ProteinModelPortaliQ96GM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3030. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000286008.
HOVERGENiHBG108093.
InParanoidiQ96GM1.
KOiK19581.
OMAiYDSAYAK.
PhylomeDBiQ96GM1.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028679. LPPR2.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF15. PTHR10165:SF15. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96GM1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGGRPHLKR SFSIIPCFVF VESVLLGIVI LLAYRLEFTD TFPVHTQGFF
60 70 80 90 100
CYDSTYAKPY PGPEAASRVP PALVYALVTA GPTLTILLGE LARAFFPAPP
110 120 130 140 150
SAVPVIGEST IVSGACCRFS PPVRRLVRFL GVYSFGLFTT TIFANAGQVV
160 170 180 190 200
TGNPTPHFLS VCRPNYTALG CLPPSPDRPG PDRFVTDQGA CAGSPSLVAA
210 220 230 240 250
ARRAFPCKDA ALCAYAVTYT AMYVTLVFRV KGSRLVKPSL CLALLCPAFL
260 270 280 290 300
VGVVRVAEYR NHWSDVLAGF LTGAAIATFL VTCVVHNFQS RPPSGRRLSP
310 320 330 340
WEDLGQAPTM DSPLEKNPRS AGRIRHRHGS PHPSRRTAPA VAT
Length:343
Mass (Da):36,880
Last modified:December 1, 2001 - v1
Checksum:iCB46CE2FA8503E4E
GO
Isoform 2 (identifier: Q96GM1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-47: Missing.
     317-343: NPRSAGRIRHRHGSPHPSRRTAPAVAT → LSVAQEPEVC...YLFASRDHLL

Show »
Length:427
Mass (Da):45,576
Checksum:i3F8A866AD7A572B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42F → L in BAB14414 (PubMed:14702039).Curated1
Sequence conflicti259Y → H in BAC04443 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038546155T → M in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03101023 – 47Missing in isoform 2. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_031011317 – 343NPRSA…PAVAT → LSVAQEPEVCRPHSTPARLT PSKSQNCARRGHLIPSCVSS RAPAMCSSPRVPRPRLRSEP TPLPLPLPLPAPTPSQGPSP SSPGPGGPGGGGGRGRKLLL PTPLLRDLYTLSGLYPSPFH RDNFSPYLFASRDHLL in isoform 2. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY339628 mRNA. Translation: AAQ73540.1.
AY304516 mRNA. Translation: AAP72153.1.
AK094869 mRNA. Translation: BAC04443.1.
AK023117 mRNA. Translation: BAB14414.1.
CH471106 Genomic DNA. Translation: EAW84200.1.
BC009378 mRNA. Translation: AAH09378.1.
CR936652 Transcribed RNA. Translation: CAI56790.1.
CCDSiCCDS12258.1. [Q96GM1-1]
CCDS59352.1. [Q96GM1-2]
RefSeqiNP_001164106.1. NM_001170635.1. [Q96GM1-2]
NP_073574.2. NM_022737.2. [Q96GM1-1]
XP_016882637.1. XM_017027148.1. [Q96GM1-2]
UniGeneiHs.6846.

Genome annotation databases

EnsembliENST00000251473; ENSP00000251473; ENSG00000105520. [Q96GM1-1]
ENST00000591608; ENSP00000466898; ENSG00000105520. [Q96GM1-2]
GeneIDi64748.
KEGGihsa:64748.
UCSCiuc002mre.2. human. [Q96GM1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY339628 mRNA. Translation: AAQ73540.1.
AY304516 mRNA. Translation: AAP72153.1.
AK094869 mRNA. Translation: BAC04443.1.
AK023117 mRNA. Translation: BAB14414.1.
CH471106 Genomic DNA. Translation: EAW84200.1.
BC009378 mRNA. Translation: AAH09378.1.
CR936652 Transcribed RNA. Translation: CAI56790.1.
CCDSiCCDS12258.1. [Q96GM1-1]
CCDS59352.1. [Q96GM1-2]
RefSeqiNP_001164106.1. NM_001170635.1. [Q96GM1-2]
NP_073574.2. NM_022737.2. [Q96GM1-1]
XP_016882637.1. XM_017027148.1. [Q96GM1-2]
UniGeneiHs.6846.

3D structure databases

ProteinModelPortaliQ96GM1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122264. 23 interactors.
STRINGi9606.ENSP00000251473.

PTM databases

DEPODiQ96GM1.
iPTMnetiQ96GM1.
PhosphoSitePlusiQ96GM1.

Polymorphism and mutation databases

BioMutaiLPPR2.
DMDMi74760839.

Proteomic databases

PaxDbiQ96GM1.
PeptideAtlasiQ96GM1.
PRIDEiQ96GM1.

Protocols and materials databases

DNASUi64748.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251473; ENSP00000251473; ENSG00000105520. [Q96GM1-1]
ENST00000591608; ENSP00000466898; ENSG00000105520. [Q96GM1-2]
GeneIDi64748.
KEGGihsa:64748.
UCSCiuc002mre.2. human. [Q96GM1-1]

Organism-specific databases

CTDi64748.
DisGeNETi64748.
GeneCardsiLPPR2.
HGNCiHGNC:29566. PLPPR2.
HPAiHPA048973.
neXtProtiNX_Q96GM1.
OpenTargetsiENSG00000105520.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3030. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000286008.
HOVERGENiHBG108093.
InParanoidiQ96GM1.
KOiK19581.
OMAiYDSAYAK.
PhylomeDBiQ96GM1.

Enzyme and pathway databases

BioCyciZFISH:HS12592-MONOMER.
BRENDAi3.1.3.4. 2681.
ReactomeiR-HSA-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

ChiTaRSiLPPR2. human.
GenomeRNAii64748.
PROiQ96GM1.

Gene expression databases

BgeeiENSG00000105520.
CleanExiHS_PRG4.
ExpressionAtlasiQ96GM1. baseline and differential.
GenevisibleiQ96GM1. HS.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028679. LPPR2.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF15. PTHR10165:SF15. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLPR2_HUMAN
AccessioniPrimary (citable) accession number: Q96GM1
Secondary accession number(s): Q5CZ76, Q8N1U4, Q9H929
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.