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Q96GM1

- LPPR2_HUMAN

UniProt

Q96GM1 - LPPR2_HUMAN

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Protein

Lipid phosphate phosphatase-related protein type 2

Gene

LPPR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

GO - Molecular functioni

  1. phosphatidate phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.1.3.4. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid phosphate phosphatase-related protein type 2 (EC:3.1.3.4)
Alternative name(s):
Plasticity-related gene 4 protein
Short name:
PRG-4
Gene namesi
Name:LPPR2
Synonyms:PRG4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Lipid phosphate phosphatase-related protein type 2PRO_0000317538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96GM1.
PRIDEiQ96GM1.

PTM databases

PhosphoSiteiQ96GM1.

Expressioni

Gene expression databases

BgeeiQ96GM1.
CleanExiHS_PRG4.
ExpressionAtlasiQ96GM1. baseline and differential.
GenevestigatoriQ96GM1.

Organism-specific databases

HPAiHPA048973.

Interactioni

Protein-protein interaction databases

BioGridi122264. 23 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ96GM1.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence AnalysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence AnalysisAdd
BLAST
Transmembranei210 – 23021HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST
Transmembranei266 – 28621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG247263.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000286008.
HOVERGENiHBG108093.
InParanoidiQ96GM1.
OMAiSKPQNCA.
PhylomeDBiQ96GM1.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028679. LPPR2.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF15. PTHR10165:SF15. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96GM1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGGRPHLKR SFSIIPCFVF VESVLLGIVI LLAYRLEFTD TFPVHTQGFF
60 70 80 90 100
CYDSTYAKPY PGPEAASRVP PALVYALVTA GPTLTILLGE LARAFFPAPP
110 120 130 140 150
SAVPVIGEST IVSGACCRFS PPVRRLVRFL GVYSFGLFTT TIFANAGQVV
160 170 180 190 200
TGNPTPHFLS VCRPNYTALG CLPPSPDRPG PDRFVTDQGA CAGSPSLVAA
210 220 230 240 250
ARRAFPCKDA ALCAYAVTYT AMYVTLVFRV KGSRLVKPSL CLALLCPAFL
260 270 280 290 300
VGVVRVAEYR NHWSDVLAGF LTGAAIATFL VTCVVHNFQS RPPSGRRLSP
310 320 330 340
WEDLGQAPTM DSPLEKNPRS AGRIRHRHGS PHPSRRTAPA VAT
Length:343
Mass (Da):36,880
Last modified:December 1, 2001 - v1
Checksum:iCB46CE2FA8503E4E
GO
Isoform 2 (identifier: Q96GM1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-47: Missing.
     317-343: NPRSAGRIRHRHGSPHPSRRTAPAVAT → LSVAQEPEVC...YLFASRDHLL

Show »
Length:427
Mass (Da):45,576
Checksum:i3F8A866AD7A572B4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421F → L in BAB14414. (PubMed:14702039)Curated
Sequence conflicti259 – 2591Y → H in BAC04443. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti155 – 1551T → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_038546

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei23 – 4725Missing in isoform 2. 2 PublicationsVSP_031010Add
BLAST
Alternative sequencei317 – 34327NPRSA…PAVAT → LSVAQEPEVCRPHSTPARLT PSKSQNCARRGHLIPSCVSS RAPAMCSSPRVPRPRLRSEP TPLPLPLPLPAPTPSQGPSP SSPGPGGPGGGGGRGRKLLL PTPLLRDLYTLSGLYPSPFH RDNFSPYLFASRDHLL in isoform 2. 2 PublicationsVSP_031011Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY339628 mRNA. Translation: AAQ73540.1.
AY304516 mRNA. Translation: AAP72153.1.
AK094869 mRNA. Translation: BAC04443.1.
AK023117 mRNA. Translation: BAB14414.1.
CH471106 Genomic DNA. Translation: EAW84200.1.
BC009378 mRNA. Translation: AAH09378.1.
CR936652 Transcribed RNA. Translation: CAI56790.1.
CCDSiCCDS12258.1. [Q96GM1-1]
CCDS59352.1. [Q96GM1-2]
RefSeqiNP_001164106.1. NM_001170635.1. [Q96GM1-2]
NP_073574.2. NM_022737.2. [Q96GM1-1]
UniGeneiHs.6846.

Genome annotation databases

GeneIDi64748.
KEGGihsa:64748.
UCSCiuc002mre.2. human. [Q96GM1-1]
uc002mrf.2. human. [Q96GM1-2]

Polymorphism databases

DMDMi74760839.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY339628 mRNA. Translation: AAQ73540.1 .
AY304516 mRNA. Translation: AAP72153.1 .
AK094869 mRNA. Translation: BAC04443.1 .
AK023117 mRNA. Translation: BAB14414.1 .
CH471106 Genomic DNA. Translation: EAW84200.1 .
BC009378 mRNA. Translation: AAH09378.1 .
CR936652 Transcribed RNA. Translation: CAI56790.1 .
CCDSi CCDS12258.1. [Q96GM1-1 ]
CCDS59352.1. [Q96GM1-2 ]
RefSeqi NP_001164106.1. NM_001170635.1. [Q96GM1-2 ]
NP_073574.2. NM_022737.2. [Q96GM1-1 ]
UniGenei Hs.6846.

3D structure databases

ProteinModelPortali Q96GM1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122264. 23 interactions.

PTM databases

PhosphoSitei Q96GM1.

Polymorphism databases

DMDMi 74760839.

Proteomic databases

PaxDbi Q96GM1.
PRIDEi Q96GM1.

Protocols and materials databases

DNASUi 64748.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 64748.
KEGGi hsa:64748.
UCSCi uc002mre.2. human. [Q96GM1-1 ]
uc002mrf.2. human. [Q96GM1-2 ]

Organism-specific databases

CTDi 64748.
GeneCardsi GC19P011466.
HPAi HPA048973.
neXtProti NX_Q96GM1.

Phylogenomic databases

eggNOGi NOG247263.
GeneTreei ENSGT00620000087654.
HOGENOMi HOG000286008.
HOVERGENi HBG108093.
InParanoidi Q96GM1.
OMAi SKPQNCA.
PhylomeDBi Q96GM1.

Enzyme and pathway databases

BRENDAi 3.1.3.4. 2681.

Miscellaneous databases

ChiTaRSi LPPR2. human.
GenomeRNAii 64748.
NextBioi 66705.
PROi Q96GM1.

Gene expression databases

Bgeei Q96GM1.
CleanExi HS_PRG4.
ExpressionAtlasi Q96GM1. baseline and differential.
Genevestigatori Q96GM1.

Family and domain databases

Gene3Di 1.20.144.10. 1 hit.
InterProi IPR028679. LPPR2.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view ]
PANTHERi PTHR10165:SF15. PTHR10165:SF15. 1 hit.
Pfami PF01569. PAP2. 1 hit.
[Graphical view ]
SMARTi SM00014. acidPPc. 1 hit.
[Graphical view ]
SUPFAMi SSF48317. SSF48317. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family."
    Savaskan N.E., Brauer A.U., Nitsch R.
    Eur. J. Neurosci. 19:212-220(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Lipid phosphate phosphatase related proteins."
    Morris A.J., Sigal Y.J., McDermott M., Sciorra V.A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Caudate nucleus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-343 (ISOFORM 2).
    Tissue: Amygdala.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-155.

Entry informationi

Entry nameiLPPR2_HUMAN
AccessioniPrimary (citable) accession number: Q96GM1
Secondary accession number(s): Q5CZ76, Q8N1U4, Q9H929
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3