ID F163A_HUMAN Reviewed; 167 AA. AC Q96GL9; A8K8R7; DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 27-MAR-2024, entry version 136. DE RecName: Full=Protein FAM163A; DE AltName: Full=Cebelin; DE AltName: Full=Neuroblastoma-derived secretory protein; GN Name=FAM163A; Synonyms=C1orf76, NDSP; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RX PubMed=17208556; DOI=10.1016/j.jpedsurg.2006.09.064; RA Vasudevan S.A., Russell H.V., Okcu M.F., Burlingame S.M., Liu Z.J., RA Yang J., Nuchtern J.G.; RT "Neuroblastoma-derived secretory protein messenger RNA levels correlate RT with high-risk neuroblastoma."; RL J. Pediatr. Surg. 42:148-152(2007). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Itoh N.; RT "Human Cebelin."; RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- INTERACTION: CC Q96GL9; Q86V38: ATN1; NbExp=3; IntAct=EBI-11793142, EBI-11954292; CC Q96GL9; P02489: CRYAA; NbExp=3; IntAct=EBI-11793142, EBI-6875961; CC Q96GL9; P00488: F13A1; NbExp=3; IntAct=EBI-11793142, EBI-2565863; CC Q96GL9; P22607: FGFR3; NbExp=3; IntAct=EBI-11793142, EBI-348399; CC Q96GL9; Q05329: GAD2; NbExp=3; IntAct=EBI-11793142, EBI-9304251; CC Q96GL9; O43681: GET3; NbExp=3; IntAct=EBI-11793142, EBI-2515857; CC Q96GL9; O14908-2: GIPC1; NbExp=3; IntAct=EBI-11793142, EBI-25913156; CC Q96GL9; Q14957: GRIN2C; NbExp=3; IntAct=EBI-11793142, EBI-8285963; CC Q96GL9; P06396: GSN; NbExp=3; IntAct=EBI-11793142, EBI-351506; CC Q96GL9; P04792: HSPB1; NbExp=3; IntAct=EBI-11793142, EBI-352682; CC Q96GL9; P42858: HTT; NbExp=12; IntAct=EBI-11793142, EBI-466029; CC Q96GL9; O60333-2: KIF1B; NbExp=3; IntAct=EBI-11793142, EBI-10975473; CC Q96GL9; P16284: PECAM1; NbExp=3; IntAct=EBI-11793142, EBI-716404; CC Q96GL9; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-11793142, EBI-396669; CC Q96GL9; P57060: RWDD2B; NbExp=3; IntAct=EBI-11793142, EBI-724442; CC Q96GL9; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-11793142, EBI-11724423; CC Q96GL9; P61086: UBE2K; NbExp=3; IntAct=EBI-11793142, EBI-473850; CC Q96GL9; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-11793142, EBI-741480; CC Q96GL9; P08670: VIM; NbExp=3; IntAct=EBI-11793142, EBI-353844; CC Q96GL9; O76024: WFS1; NbExp=3; IntAct=EBI-11793142, EBI-720609; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane CC protein {ECO:0000305}. CC -!- TISSUE SPECIFICITY: Highly expressed in neuroblastoma compared to other CC tissues, suggesting that it may be used as a marker for metastasis in CC bone marrow. {ECO:0000269|PubMed:17208556}. CC -!- SIMILARITY: Belongs to the FAM163 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY902195; AAX07133.1; -; mRNA. DR EMBL; AB299025; BAF96730.1; -; mRNA. DR EMBL; AK292432; BAF85121.1; -; mRNA. DR EMBL; AK313887; BAG36612.1; -; mRNA. DR EMBL; AL359853; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471067; EAW91055.1; -; Genomic_DNA. DR EMBL; BC009382; AAH09382.1; -; mRNA. DR CCDS; CCDS1333.1; -. DR RefSeq; NP_001316641.1; NM_001329712.1. DR RefSeq; NP_001316642.1; NM_001329713.1. DR RefSeq; NP_001316643.1; NM_001329714.1. DR RefSeq; NP_001316644.1; NM_001329715.1. DR RefSeq; NP_001316645.1; NM_001329716.1. DR RefSeq; NP_001316646.1; NM_001329717.1. DR RefSeq; NP_001316647.1; NM_001329718.1. DR RefSeq; NP_001316648.1; NM_001329719.1. DR RefSeq; NP_775780.1; NM_173509.2. DR RefSeq; XP_006711237.1; XM_006711174.2. DR RefSeq; XP_006711238.1; XM_006711175.2. DR RefSeq; XP_006711240.1; XM_006711177.1. DR RefSeq; XP_011507519.1; XM_011509217.1. DR RefSeq; XP_016855875.1; XM_017000386.1. DR RefSeq; XP_016855876.1; XM_017000387.1. DR RefSeq; XP_016855877.1; XM_017000388.1. DR RefSeq; XP_016855878.1; XM_017000389.1. DR RefSeq; XP_016855879.1; XM_017000390.1. DR RefSeq; XP_016855880.1; XM_017000391.1. DR RefSeq; XP_016855881.1; XM_017000392.1. DR RefSeq; XP_016855882.1; XM_017000393.1. DR AlphaFoldDB; Q96GL9; -. DR SMR; Q96GL9; -. DR BioGRID; 127166; 18. DR IntAct; Q96GL9; 26. DR MINT; Q96GL9; -. DR STRING; 9606.ENSP00000354891; -. DR iPTMnet; Q96GL9; -. DR PhosphoSitePlus; Q96GL9; -. DR BioMuta; FAM163A; -. DR DMDM; 74751887; -. DR MassIVE; Q96GL9; -. DR PaxDb; 9606-ENSP00000354891; -. DR PeptideAtlas; Q96GL9; -. DR TopDownProteomics; Q96GL9; -. DR Antibodypedia; 2490; 128 antibodies from 17 providers. DR DNASU; 148753; -. DR Ensembl; ENST00000341785.5; ENSP00000354891.4; ENSG00000143340.7. DR GeneID; 148753; -. DR KEGG; hsa:148753; -. DR MANE-Select; ENST00000341785.5; ENSP00000354891.4; NM_173509.3; NP_775780.1. DR UCSC; uc001gnj.3; human. DR AGR; HGNC:28274; -. DR CTD; 148753; -. DR DisGeNET; 148753; -. DR GeneCards; FAM163A; -. DR HGNC; HGNC:28274; FAM163A. DR HPA; ENSG00000143340; Tissue enhanced (lymphoid tissue, pituitary gland, testis). DR MIM; 611727; gene. DR neXtProt; NX_Q96GL9; -. DR OpenTargets; ENSG00000143340; -. DR PharmGKB; PA162386944; -. DR VEuPathDB; HostDB:ENSG00000143340; -. DR eggNOG; ENOG502S10V; Eukaryota. DR GeneTree; ENSGT00940000159228; -. DR HOGENOM; CLU_138617_0_0_1; -. DR InParanoid; Q96GL9; -. DR OMA; CGQPCGV; -. DR OrthoDB; 4251881at2759; -. DR PhylomeDB; Q96GL9; -. DR TreeFam; TF333084; -. DR PathwayCommons; Q96GL9; -. DR SignaLink; Q96GL9; -. DR BioGRID-ORCS; 148753; 10 hits in 1139 CRISPR screens. DR ChiTaRS; FAM163A; human. DR GenomeRNAi; 148753; -. DR Pharos; Q96GL9; Tbio. DR PRO; PR:Q96GL9; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q96GL9; Protein. DR Bgee; ENSG00000143340; Expressed in sperm and 87 other cell types or tissues. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR InterPro; IPR029379; FAM163. DR InterPro; IPR040281; FAM163A. DR PANTHER; PTHR31914; PROTEIN FAM163A; 1. DR PANTHER; PTHR31914:SF2; PROTEIN FAM163A; 1. DR Pfam; PF15069; FAM163; 1. DR Genevisible; Q96GL9; HS. PE 1: Evidence at protein level; KW Membrane; Reference proteome; Transmembrane; Transmembrane helix. FT CHAIN 1..167 FT /note="Protein FAM163A" FT /id="PRO_0000280256" FT TRANSMEM 6..26 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 167 AA; 17641 MW; 8BF4D4A6C59046F9 CRC64; MTAGTVVITG GILATVILLC IIAVLCYCRL QYYCCKKSGT EVADEEEERE HDLPTHPRGP TCNACSSQAL DGRGSLAPLT SEPCSQPCGV AASHCTTCSP YSSPFYIRTA DMVPNGGGGE RLSFAPTYYK EGGPPSLKLA APQSYPVTWP GSGREAFTNP RAISTDV //